#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8N668	uniprotkb:P35670	intact:EBI-1550112|uniprotkb:Q96GS0|uniprotkb:B4DFQ4|ensembl:ENSP00000308236	intact:EBI-11668501|uniprotkb:Q16318|uniprotkb:Q16319|uniprotkb:Q4U3V3|uniprotkb:Q59FJ9|uniprotkb:Q5T7X7|ensembl:ENSP00000242839	psi-mi:comd1_human(display_long)|uniprotkb:COMMD1(gene name)|psi-mi:COMMD1(display_short)|uniprotkb:C2orf5(gene name synonym)|uniprotkb:MURR1(gene name synonym)|uniprotkb:Protein Murr1(gene name synonym)	psi-mi:atp7b_human(display_long)|uniprotkb:ATP7B(gene name)|psi-mi:ATP7B(display_short)|uniprotkb:PWD(gene name synonym)|uniprotkb:WC1(gene name synonym)|uniprotkb:WND(gene name synonym)|uniprotkb:Copper pump 2(gene name synonym)|uniprotkb:Wilson disease-associated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2007)	pubmed:17919502|imex:IM-27763	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25464161|imex:IM-27763-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689729.1|ensembl:ENSG00000173163(gene)|ensembl:ENST00000311832(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR017920|interpro:IPR033776|interpro:IPR037351|mint:Q8N668|rcsb pdb:2H2M|reactome:R-HSA-8951664	refseq:NP_000044.2|refseq:NP_001230111.1|refseq:XP_005266487.1|refseq:NP_001317507.1|refseq:NP_001317508.1|ensembl:ENST00000242839(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034220"(ion transmembrane transport)|ensembl:ENSG00000123191(gene)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0060003"(copper ion export)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|interpro:IPR036163|interpro:IPR036412|interpro:IPR044492|rcsb pdb:2ARF|rcsb pdb:2EW9|go:"GO:0046688"(response to copper ion)|rcsb pdb:2KOY|rcsb pdb:2LQB|rcsb pdb:2N7Y|rcsb pdb:2ROP|rcsb pdb:6A71|rcsb pdb:6A72|reactome:R-HSA-936837	-	-	-	figure legend:Fig. 1a, 2a, 2b, 2d, 4b-c, 5c-d|comment:"Fig. 2b: Cells were treated overnight with 200 μM CuSO4 or bathocuproinedisulfonic acid (BCS), prior to glutathione-sepharose precipitation; no reproducible effects of CuSO4 or BCS incubation on the interaction of COMMD1-GST with ATP7B-Flag were observed."|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/03/03	2020/03/03	rogid:b4sVuz5jwndjw+8ejRFqOcLRk1I9606	rogid:wC7xp3y5M7M41Wzpmcy70jQqK4w9606	rigid:VMXTY97PFjNZ3dOOL/yKbH+HGhE	false	glutathione s tranferase tag:?-?	mutation increasing interaction strength:616-616(rs752850609)|flag tag:?-?|sufficient binding region:1-650|mutation decreasing interaction strength:626-626(rs587783299)|mutation with no effect:641-641(rs186924074)|mutation decreasing interaction strength:642-642(rs72552285)|mutation decreasing interaction strength:645-645(rs121907998)|mutation increasing interaction strength:41-41(rs201738967)|mutation increasing interaction strength:85-85(rs786204643)|mutation increasing interaction strength:486-486(rs1282624946)|mutation with no effect:492-492(rs1566580253)|mutation increasing interaction strength:532-532|mutation increasing interaction strength:541-541(rs187046823)|mutation increasing interaction strength:591-591(rs797045402)|mutation decreasing interaction strength:604-604|mutation increasing interaction strength:616-616(rs374172791)|mutation increasing interaction strength:170-170|mutation increasing interaction strength:284-284|mutation increasing interaction strength:386-386|mutation increasing interaction strength:515-515	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N668	uniprotkb:P35670	intact:EBI-1550112|uniprotkb:Q96GS0|uniprotkb:B4DFQ4|ensembl:ENSP00000308236	intact:EBI-11668501|uniprotkb:Q16318|uniprotkb:Q16319|uniprotkb:Q4U3V3|uniprotkb:Q59FJ9|uniprotkb:Q5T7X7|ensembl:ENSP00000242839	psi-mi:comd1_human(display_long)|uniprotkb:COMMD1(gene name)|psi-mi:COMMD1(display_short)|uniprotkb:C2orf5(gene name synonym)|uniprotkb:MURR1(gene name synonym)|uniprotkb:Protein Murr1(gene name synonym)	psi-mi:atp7b_human(display_long)|uniprotkb:ATP7B(gene name)|psi-mi:ATP7B(display_short)|uniprotkb:PWD(gene name synonym)|uniprotkb:WC1(gene name synonym)|uniprotkb:WND(gene name synonym)|uniprotkb:Copper pump 2(gene name synonym)|uniprotkb:Wilson disease-associated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	de et al. (2007)	pubmed:17919502|imex:IM-27763	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25464181|imex:IM-27763-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689729.1|ensembl:ENSG00000173163(gene)|ensembl:ENST00000311832(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR017920|interpro:IPR033776|interpro:IPR037351|mint:Q8N668|rcsb pdb:2H2M|reactome:R-HSA-8951664	refseq:NP_000044.2|refseq:NP_001230111.1|refseq:XP_005266487.1|refseq:NP_001317507.1|refseq:NP_001317508.1|ensembl:ENST00000242839(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034220"(ion transmembrane transport)|ensembl:ENSG00000123191(gene)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0060003"(copper ion export)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|interpro:IPR036163|interpro:IPR036412|interpro:IPR044492|rcsb pdb:2ARF|rcsb pdb:2EW9|go:"GO:0046688"(response to copper ion)|rcsb pdb:2KOY|rcsb pdb:2LQB|rcsb pdb:2N7Y|rcsb pdb:2ROP|rcsb pdb:6A71|rcsb pdb:6A72|reactome:R-HSA-936837	-	-	-	figure legend:Fig. 1b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2020/03/03	2020/03/03	rogid:b4sVuz5jwndjw+8ejRFqOcLRk1I9606	rogid:wC7xp3y5M7M41Wzpmcy70jQqK4w9606	rigid:VMXTY97PFjNZ3dOOL/yKbH+HGhE	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P35670	uniprotkb:Q8N668	intact:EBI-11668501|uniprotkb:Q16318|uniprotkb:Q16319|uniprotkb:Q4U3V3|uniprotkb:Q59FJ9|uniprotkb:Q5T7X7|ensembl:ENSP00000242839	intact:EBI-1550112|uniprotkb:Q96GS0|uniprotkb:B4DFQ4|ensembl:ENSP00000308236	psi-mi:atp7b_human(display_long)|uniprotkb:ATP7B(gene name)|psi-mi:ATP7B(display_short)|uniprotkb:PWD(gene name synonym)|uniprotkb:WC1(gene name synonym)|uniprotkb:WND(gene name synonym)|uniprotkb:Copper pump 2(gene name synonym)|uniprotkb:Wilson disease-associated protein(gene name synonym)	psi-mi:comd1_human(display_long)|uniprotkb:COMMD1(gene name)|psi-mi:COMMD1(display_short)|uniprotkb:C2orf5(gene name synonym)|uniprotkb:MURR1(gene name synonym)|uniprotkb:Protein Murr1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	de et al. (2007)	pubmed:17919502|imex:IM-27763	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25464216|imex:IM-27763-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000044.2|refseq:NP_001230111.1|refseq:XP_005266487.1|refseq:NP_001317507.1|refseq:NP_001317508.1|ensembl:ENST00000242839(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034220"(ion transmembrane transport)|ensembl:ENSG00000123191(gene)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0060003"(copper ion export)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|interpro:IPR036163|interpro:IPR036412|interpro:IPR044492|rcsb pdb:2ARF|rcsb pdb:2EW9|go:"GO:0046688"(response to copper ion)|rcsb pdb:2KOY|rcsb pdb:2LQB|rcsb pdb:2N7Y|rcsb pdb:2ROP|rcsb pdb:6A71|rcsb pdb:6A72|reactome:R-HSA-936837	refseq:NP_689729.1|ensembl:ENSG00000173163(gene)|ensembl:ENST00000311832(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR017920|interpro:IPR033776|interpro:IPR037351|mint:Q8N668|rcsb pdb:2H2M|reactome:R-HSA-8951664	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:Fig. 1e-h|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/03/03	2020/03/03	rogid:wC7xp3y5M7M41Wzpmcy70jQqK4w9606	rogid:b4sVuz5jwndjw+8ejRFqOcLRk1I9606	rigid:VMXTY97PFjNZ3dOOL/yKbH+HGhE	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q8N668	uniprotkb:P35670	intact:EBI-1550112|uniprotkb:Q96GS0|uniprotkb:B4DFQ4|ensembl:ENSP00000308236	intact:EBI-11668501|uniprotkb:Q16318|uniprotkb:Q16319|uniprotkb:Q4U3V3|uniprotkb:Q59FJ9|uniprotkb:Q5T7X7|ensembl:ENSP00000242839	psi-mi:comd1_human(display_long)|uniprotkb:COMMD1(gene name)|psi-mi:COMMD1(display_short)|uniprotkb:C2orf5(gene name synonym)|uniprotkb:MURR1(gene name synonym)|uniprotkb:Protein Murr1(gene name synonym)	psi-mi:atp7b_human(display_long)|uniprotkb:ATP7B(gene name)|psi-mi:ATP7B(display_short)|uniprotkb:PWD(gene name synonym)|uniprotkb:WC1(gene name synonym)|uniprotkb:WND(gene name synonym)|uniprotkb:Copper pump 2(gene name synonym)|uniprotkb:Wilson disease-associated protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	de et al. (2007)	pubmed:17919502|imex:IM-27763	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25467220|imex:IM-27763-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689729.1|ensembl:ENSG00000173163(gene)|ensembl:ENST00000311832(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR017920|interpro:IPR033776|interpro:IPR037351|mint:Q8N668|rcsb pdb:2H2M|reactome:R-HSA-8951664	refseq:NP_000044.2|refseq:NP_001230111.1|refseq:XP_005266487.1|refseq:NP_001317507.1|refseq:NP_001317508.1|ensembl:ENST00000242839(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005375"(copper ion transmembrane transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006825"(copper ion transport)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0015677"(copper ion import)|go:"GO:0016020"(membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034220"(ion transmembrane transport)|ensembl:ENSG00000123191(gene)|go:"GO:0043682"(P-type divalent copper transporter activity)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0060003"(copper ion export)|go:"GO:0140581"(P-type monovalent copper transporter activity)|go:"GO:1990961"(xenobiotic detoxification by transmembrane export across the plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006121(Heavy metal transport/detoxification protein)|interpro:IPR006122(Copper ion-binding)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR017969|interpro:IPR018303|interpro:IPR023298|interpro:IPR023299|interpro:IPR027256|interpro:IPR036163|interpro:IPR036412|interpro:IPR044492|rcsb pdb:2ARF|rcsb pdb:2EW9|go:"GO:0046688"(response to copper ion)|rcsb pdb:2KOY|rcsb pdb:2LQB|rcsb pdb:2N7Y|rcsb pdb:2ROP|rcsb pdb:6A71|rcsb pdb:6A72|reactome:R-HSA-936837	-	-	-	figure legend:Fig. 5b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/03/03	2020/03/09	rogid:b4sVuz5jwndjw+8ejRFqOcLRk1I9606	rogid:wC7xp3y5M7M41Wzpmcy70jQqK4w9606	rigid:VMXTY97PFjNZ3dOOL/yKbH+HGhE	false	ha tag:?-?	flag tag:?-?|mutation increasing interaction strength:85-85(rs786204643)|mutation increasing interaction strength:591-591(rs797045402)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)