#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P48740-2	intact:EBI-27109392	intact:EBI-26435098|ensembl:ENSP00000296280	-	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:pro-phe-arg(display_short)|psi-mi:EBI-27109392(display_long)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111712|imex:IM-29312-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	-	figure legend:Table 1|kinetics:Activity=11.0 pmoles/min/ug|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rogid:fAmjOYuJG0bANs/wlYoP2j92uBg-2	rigid:uZylPRBmYIRzR7dXYglHJ3LuPeM	false	sufficient binding region:450-721(IPR001254)|his tag:c-c	coumarin label:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48740-2	intact:EBI-27109435	intact:EBI-26435098|ensembl:ENSP00000296280	-	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:val-pro-arg(display_short)|psi-mi:EBI-27109435(display_long)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111721|imex:IM-29312-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	-	figure legend:Table 1|kinetics:Activity = 9.0 pmoles/min/ug|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rogid:77kvkm7bmHXepGcLSRiFVY0e0cA-2	rigid:E3S2Uywvu486V4HMTmpqEGXQgF8	false	sufficient binding region:450-721(IPR001254)|his tag:c-c	coumarin label:c-c|modified L-valine residue:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48740-2	intact:EBI-27110434	intact:EBI-26435098|ensembl:ENSP00000296280	-	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:gly-gly-arg(display_short)|psi-mi:EBI-27110434(display_long)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111738|imex:IM-29312-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	-	figure legend:Table 1|kinetics:Activity = 5.6 pmoles/min/ug|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rogid:zIDB5egM7i6IuAFFBvp0iLLiIpI-2	rigid:tAAhdY4GVKRdTe8glH5oT71UGHI	false	sufficient binding region:450-721(IPR001254)|his tag:c-c	coumarin label:c-c|modified glycine residue:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48740-2	intact:EBI-27111766	intact:EBI-26435098|ensembl:ENSP00000296280	-	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:phe-arg(display_short)|psi-mi:EBI-27111766(display_long)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111752|imex:IM-29312-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	-	figure legend:Table 1|kinetics:Activity = 1.5 pmoles/min/ug|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/12/16	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rogid:bSgwsedtxzAPzmdFF2YBgn0jPeg-2	rigid:Y8crOnZD6JMd7ZtU3+NFAQRKtbg	false	sufficient binding region:450-721(IPR001254)|his tag:c-c	coumarin label:c-c|modified L-phenylalanine residue:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48740-2	intact:EBI-27111782	intact:EBI-26435098|ensembl:ENSP00000296280	-	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:leu-arg(display_short)|psi-mi:EBI-27111782(display_long)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111768|imex:IM-29312-9	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	-	figure legend:Table 1|kinetics:Activity = 1.2 pmoles/min/ug|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rogid:d38hlrOud7f5AE8NUgRFe6b9oyg-2	rigid:FLmnXwIvL8m82SOqxMqiv9ofdxI	false	sufficient binding region:450-721(IPR001254)|his tag:c-c	coumarin label:c-c|modified L-leucine residue:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23827-PRO_0000007423	uniprotkb:P48740-2	intact:EBI-27111799	intact:EBI-26435098|ensembl:ENSP00000296280	psi-mi:p23827-pro_0000007423(display_long)|uniprotkb:eco(gene name)|psi-mi:eco(display_short)|uniprotkb:eti(gene name synonym)|uniprotkb:b2209(locus name)|uniprotkb:JW2197(locus name)	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111784|imex:IM-29312-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1029159(chain-parent)	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	chain-seq-start:21|chain-seq-end:162	-	figure legend:Table 2|inhibition:Ecotin % inhibition = 98.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	rogid:h73shhX+NPZC1ahdD8pt/IPEBN083333	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rigid:I+20YYfD8KZ2YBktWrTkQful6P4	false	his tag:c-c	sufficient binding region:450-721(IPR001254)|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23827-PRO_0000007423	intact:EBI-27109435	intact:EBI-27111799	-	psi-mi:p23827-pro_0000007423(display_long)|uniprotkb:eco(gene name)|psi-mi:eco(display_short)|uniprotkb:eti(gene name synonym)|uniprotkb:b2209(locus name)|uniprotkb:JW2197(locus name)	psi-mi:val-pro-arg(display_short)|psi-mi:EBI-27109435(display_long)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111784|imex:IM-29312-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	intact:EBI-1029159(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:162	-	figure legend:Table 2|inhibition:Ecotin % inhibition = 98.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	rogid:h73shhX+NPZC1ahdD8pt/IPEBN083333	rogid:77kvkm7bmHXepGcLSRiFVY0e0cA-2	rigid:I+20YYfD8KZ2YBktWrTkQful6P4	false	his tag:c-c	coumarin label:c-c|modified L-valine residue:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05154	uniprotkb:P48740-2	intact:EBI-722597|uniprotkb:Q07616|uniprotkb:Q9UG30|ensembl:ENSP00000333203|ensembl:ENSP00000450837|ensembl:ENSP00000451126|ensembl:ENSP00000451610	intact:EBI-26435098|ensembl:ENSP00000296280	psi-mi:ipsp_human(display_long)|uniprotkb:Serpin A5(gene name synonym)|uniprotkb:Protein C inhibitor(gene name synonym)|uniprotkb:Plasminogen activator inhibitor 3(gene name synonym)|uniprotkb:Acrosomal serine protease inhibitor(gene name synonym)|uniprotkb:SERPINA5(gene name)|psi-mi:SERPINA5(display_short)|uniprotkb:PCI(gene name synonym)|uniprotkb:PLANH3(gene name synonym)|uniprotkb:PROCI(gene name synonym)	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111809|imex:IM-29312-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000615.3|ensembl:ENSG00000188488(gene)|ensembl:ENST00000329597(transcript)|ensembl:ENST00000553780(transcript)|ensembl:ENST00000554276(transcript)|ensembl:ENST00000554866(transcript)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006869"(lipid transport)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007342"(fusion of sperm to egg plasma membrane involved in single fertilization)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032190"(acrosin binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036024"(protein C inhibitor-TMPRSS7 complex)|go:"GO:0036025"(protein C inhibitor-TMPRSS11E complex)|go:"GO:0036026"(protein C inhibitor-PLAT complex)|go:"GO:0036027"(protein C inhibitor-PLAU complex)|go:"GO:0036028"(protein C inhibitor-thrombin complex)|go:"GO:0036029"(protein C inhibitor-KLK3 complex)|go:"GO:0036030"(protein C inhibitor-plasma kallikrein complex)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0061107"(seminal vesicle development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097181"(protein C inhibitor-coagulation factor V complex)|go:"GO:0097182"(protein C inhibitor-coagulation factor Xa complex)|go:"GO:0097183"(protein C inhibitor-coagulation factor XI complex)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|rcsb pdb:1LQ8|rcsb pdb:1PAI|rcsb pdb:2HI9|rcsb pdb:2OL2|rcsb pdb:2PAI|rcsb pdb:3DY0|reactome:R-HSA-140837|reactome:R-HSA-140875|dip:DIP-29869N	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	figure legend:Table 2|inhibition:SerpinA5 % inhibition = 30.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	rogid:I0v9RvhA3PygP1kZRJzkP31jw5k9606	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rigid:cfoNHnc2v3J7Wy+LqF24ZTQl1gc	false	his tag:c-c|sufficient binding region:20-406	sufficient binding region:450-721(IPR001254)|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05154	intact:EBI-27109435	intact:EBI-722597|uniprotkb:Q07616|uniprotkb:Q9UG30|ensembl:ENSP00000333203|ensembl:ENSP00000450837|ensembl:ENSP00000451126|ensembl:ENSP00000451610	-	psi-mi:ipsp_human(display_long)|uniprotkb:Serpin A5(gene name synonym)|uniprotkb:Protein C inhibitor(gene name synonym)|uniprotkb:Plasminogen activator inhibitor 3(gene name synonym)|uniprotkb:Acrosomal serine protease inhibitor(gene name synonym)|uniprotkb:SERPINA5(gene name)|psi-mi:SERPINA5(display_short)|uniprotkb:PCI(gene name synonym)|uniprotkb:PLANH3(gene name synonym)|uniprotkb:PROCI(gene name synonym)	psi-mi:val-pro-arg(display_short)|psi-mi:EBI-27109435(display_long)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111809|imex:IM-29312-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_000615.3|ensembl:ENSG00000188488(gene)|ensembl:ENST00000329597(transcript)|ensembl:ENST00000553780(transcript)|ensembl:ENST00000554276(transcript)|ensembl:ENST00000554866(transcript)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006869"(lipid transport)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007342"(fusion of sperm to egg plasma membrane involved in single fertilization)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032190"(acrosin binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036024"(protein C inhibitor-TMPRSS7 complex)|go:"GO:0036025"(protein C inhibitor-TMPRSS11E complex)|go:"GO:0036026"(protein C inhibitor-PLAT complex)|go:"GO:0036027"(protein C inhibitor-PLAU complex)|go:"GO:0036028"(protein C inhibitor-thrombin complex)|go:"GO:0036029"(protein C inhibitor-KLK3 complex)|go:"GO:0036030"(protein C inhibitor-plasma kallikrein complex)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0061107"(seminal vesicle development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097181"(protein C inhibitor-coagulation factor V complex)|go:"GO:0097182"(protein C inhibitor-coagulation factor Xa complex)|go:"GO:0097183"(protein C inhibitor-coagulation factor XI complex)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|rcsb pdb:1LQ8|rcsb pdb:1PAI|rcsb pdb:2HI9|rcsb pdb:2OL2|rcsb pdb:2PAI|rcsb pdb:3DY0|reactome:R-HSA-140837|reactome:R-HSA-140875|dip:DIP-29869N	-	-	-	-	figure legend:Table 2|inhibition:SerpinA5 % inhibition = 30.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	rogid:I0v9RvhA3PygP1kZRJzkP31jw5k9606	rogid:77kvkm7bmHXepGcLSRiFVY0e0cA-2	rigid:cfoNHnc2v3J7Wy+LqF24ZTQl1gc	false	his tag:c-c|sufficient binding region:20-406	coumarin label:c-c|modified L-valine residue:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00974-PRO_0000016853	uniprotkb:P48740-2	intact:EBI-27111847	intact:EBI-26435098|ensembl:ENSP00000296280	psi-mi:p00974-pro_0000016853(display_long)|uniprotkb:Aprotinin(gene name synonym)|uniprotkb:Basic protease inhibitor(gene name synonym)	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111828|imex:IM-29312-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1032263(chain-parent)	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	chain-seq-start:36|chain-seq-end:93	-	figure legend:Table 2|inhibition:Aprotinin  % inhibition = 8.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	rogid:od3QcR6BgIabz+Rt21wqKd64VmI9913	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rigid:lHbhBUY02MNzHFOF4E1giQNxOr0	false	-	sufficient binding region:450-721(IPR001254)|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00974-PRO_0000016853	intact:EBI-27109435	intact:EBI-27111847	-	psi-mi:p00974-pro_0000016853(display_long)|uniprotkb:Aprotinin(gene name synonym)|uniprotkb:Basic protease inhibitor(gene name synonym)	psi-mi:val-pro-arg(display_short)|psi-mi:EBI-27109435(display_long)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111828|imex:IM-29312-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	intact:EBI-1032263(chain-parent)	-	-	chain-seq-start:36|chain-seq-end:93	-	figure legend:Table 2|inhibition:Aprotinin  % inhibition = 8.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	rogid:od3QcR6BgIabz+Rt21wqKd64VmI9913	rogid:77kvkm7bmHXepGcLSRiFVY0e0cA-2	rigid:lHbhBUY02MNzHFOF4E1giQNxOr0	false	-	coumarin label:c-c|modified L-valine residue:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03973-PRO_0000041355	uniprotkb:P48740-2	intact:EBI-27111867	intact:EBI-26435098|ensembl:ENSP00000296280	psi-mi:p03973-pro_0000041355(display_long)|uniprotkb:SLPI(gene name)|psi-mi:SLPI(display_short)|uniprotkb:WAP4(gene name synonym)|uniprotkb:WFDC4(gene name synonym)|uniprotkb:BLPI(gene name synonym)|uniprotkb:HUSI-1(gene name synonym)|uniprotkb:Mucus proteinase inhibitor(gene name synonym)|uniprotkb:Protease inhibitor WAP4(gene name synonym)|uniprotkb:Secretory leukocyte protease inhibitor(gene name synonym)|uniprotkb:Seminal proteinase inhibitor(gene name synonym)|uniprotkb:WAP four-disulfide core domain protein 4(gene name synonym)	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111852|imex:IM-29312-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-355293(chain-parent)	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	chain-seq-start:26|chain-seq-end:132	-	figure legend:Table 2|inhibition:SLP1  % inhibition = 13.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	rogid:/+2hSMGXcNoite8NPbN/9/r1fZ09606	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rigid:XttruLzJqs+39UpyJ6eD5LIJYfg	false	-	sufficient binding region:450-721(IPR001254)|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03973-PRO_0000041355	intact:EBI-27109435	intact:EBI-27111867	-	psi-mi:p03973-pro_0000041355(display_long)|uniprotkb:SLPI(gene name)|psi-mi:SLPI(display_short)|uniprotkb:WAP4(gene name synonym)|uniprotkb:WFDC4(gene name synonym)|uniprotkb:BLPI(gene name synonym)|uniprotkb:HUSI-1(gene name synonym)|uniprotkb:Mucus proteinase inhibitor(gene name synonym)|uniprotkb:Protease inhibitor WAP4(gene name synonym)|uniprotkb:Secretory leukocyte protease inhibitor(gene name synonym)|uniprotkb:Seminal proteinase inhibitor(gene name synonym)|uniprotkb:WAP four-disulfide core domain protein 4(gene name synonym)	psi-mi:val-pro-arg(display_short)|psi-mi:EBI-27109435(display_long)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111852|imex:IM-29312-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	intact:EBI-355293(chain-parent)	-	-	chain-seq-start:26|chain-seq-end:132	-	figure legend:Table 2|inhibition:SLP1  % inhibition = 13.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	rogid:/+2hSMGXcNoite8NPbN/9/r1fZ09606	rogid:77kvkm7bmHXepGcLSRiFVY0e0cA-2	rigid:XttruLzJqs+39UpyJ6eD5LIJYfg	false	-	coumarin label:c-c|modified L-valine residue:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-27111889	uniprotkb:P48740-2	chembl:ChEMBL1096339	intact:EBI-26435098|ensembl:ENSP00000296280	psi-mi:aebsf(display_short)|psi-mi:EBI-27111889(display_long)	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111874|imex:IM-29312-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	figure legend:Table 2|inhibition:AEBSF  % inhibition = 98.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	-	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	-	false	-	sufficient binding region:450-721(IPR001254)|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-27111889	intact:EBI-27109435	chembl:ChEMBL1096339	-	psi-mi:aebsf(display_short)|psi-mi:EBI-27111889(display_long)	psi-mi:val-pro-arg(display_short)|psi-mi:EBI-27109435(display_long)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111874|imex:IM-29312-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0327"(peptide)	-	-	-	-	-	figure legend:Table 2|inhibition:AEBSF  % inhibition = 98.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	-	rogid:77kvkm7bmHXepGcLSRiFVY0e0cA-2	-	false	-	coumarin label:c-c|modified L-valine residue:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:109540"	uniprotkb:P48740-2	intact:EBI-27111906	intact:EBI-26435098|ensembl:ENSP00000296280	psi-mi:3,4-dichloroisocoumarin(display_short)|psi-mi:"CHEBI:109540"(display_long)|intact:3,4-DCI(synonym)|intact:3,4-dichloro-1H-2-benzopyran-1-one(synonym)|intact:3,4-dichloro-2-benzopyran-1-one(synonym)|intact:3,4-dichloroisochromen-1-one(synonym)|intact:3,4-dichloro-1H-isochromen-1-one(iupac name)	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111891|imex:IM-29312-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	figure legend:Table 2|inhibition:AEBSF  % inhibition = 100.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	-	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	-	false	-	sufficient binding region:450-721(IPR001254)|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:109540"	intact:EBI-27109435	intact:EBI-27111906	-	psi-mi:3,4-dichloroisocoumarin(display_short)|psi-mi:"CHEBI:109540"(display_long)|intact:3,4-DCI(synonym)|intact:3,4-dichloro-1H-2-benzopyran-1-one(synonym)|intact:3,4-dichloro-2-benzopyran-1-one(synonym)|intact:3,4-dichloroisochromen-1-one(synonym)|intact:3,4-dichloro-1H-isochromen-1-one(iupac name)	psi-mi:val-pro-arg(display_short)|psi-mi:EBI-27109435(display_long)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111891|imex:IM-29312-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0327"(peptide)	-	-	-	-	-	figure legend:Table 2|inhibition:AEBSF  % inhibition = 100.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	-	rogid:77kvkm7bmHXepGcLSRiFVY0e0cA-2	-	false	-	coumarin label:c-c|modified L-valine residue:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:30270"	uniprotkb:P48740-2	intact:EBI-27111928|chebi:"CHEBI:42162"|chebi:"CHEBI:4729"|chebi:"CHEBI:30208"	intact:EBI-26435098|ensembl:ENSP00000296280	psi-mi:e64(display_short)|psi-mi:"CHEBI:30270"(display_long)|intact:"(2S,3S)-3-(N-{(S)-1-[N-(4-guanidinobutyl)carbamoyl]3-methylbutyl}carbamoyl)oxirane-2-carboxylic acid"(synonym)|intact:"(2S,3S)-3-[((1S)-1-{[4-(carbamimidamido)butyl]carbamoyl}-3-methylbutyl)carbamoyl]oxirane-2-carboxylic acid"(synonym)|intact:E 64(synonym)|intact:E-64(synonym)	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111913|imex:IM-29312-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	figure legend:Table 2|inhibition:E-64 % inhibition = 17.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	-	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	-	false	-	sufficient binding region:450-721(IPR001254)|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:30270"	intact:EBI-27109435	intact:EBI-27111928|chebi:"CHEBI:42162"|chebi:"CHEBI:4729"|chebi:"CHEBI:30208"	-	psi-mi:e64(display_short)|psi-mi:"CHEBI:30270"(display_long)|intact:"(2S,3S)-3-(N-{(S)-1-[N-(4-guanidinobutyl)carbamoyl]3-methylbutyl}carbamoyl)oxirane-2-carboxylic acid"(synonym)|intact:"(2S,3S)-3-[((1S)-1-{[4-(carbamimidamido)butyl]carbamoyl}-3-methylbutyl)carbamoyl]oxirane-2-carboxylic acid"(synonym)|intact:E 64(synonym)|intact:E-64(synonym)	psi-mi:val-pro-arg(display_short)|psi-mi:EBI-27109435(display_long)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111913|imex:IM-29312-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0327"(peptide)	-	-	-	-	-	figure legend:Table 2|inhibition:E-64 % inhibition = 17.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	-	rogid:77kvkm7bmHXepGcLSRiFVY0e0cA-2	-	false	-	coumarin label:c-c|modified L-valine residue:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:42191"	uniprotkb:P48740-2	intact:EBI-11784071|chebi:"CHEBI:42189"|chebi:"CHEBI:4735"|chebi:"CHEBI:30378"	intact:EBI-26435098|ensembl:ENSP00000296280	psi-mi:ethylenediaminetetraacetic acid(display_short)|psi-mi:"CHEBI:42191"(display_long)|intact:"(ethylenedinitrilo)tetraacetic acid, ion(4-)"(synonym)|intact:"2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate"(synonym)|intact:acide edetique(synonym)|intact:Acide ethylenediaminetetracetique(synonym)|intact:acido edetico(synonym)|intact:acidum edeticum(synonym)|intact:Edetic acid(synonym)|intact:edetic acid(synonym)|intact:EDTA(synonym)|intact:edta(synonym)|intact:"EDTA, ion(4-)"(synonym)|intact:ethylenediaminetetraacetate(synonym)|intact:ethylenediaminetetraacetic acid(synonym)|intact:Ethylenediaminetetraacetic acid(synonym)|intact:H4edta(synonym)|intact:"N,N'-1,2-Ethane diylbis-(N-(carboxymethyl)glycine)"(synonym)|intact:"{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID"(synonym)|intact:"(ethane-1,2-diyldinitrilo)tetraacetate"(iupac name)|intact:"(ethane-1,2-diyldinitrilo)tetraacetic acid"(iupac name)	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111937|imex:IM-29312-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	-	-	-	figure legend:Table 2|inhibition:E-64 % inhibition = 21.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	-	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	-	false	-	sufficient binding region:450-721(IPR001254)|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:42191"	intact:EBI-27109435	intact:EBI-11784071|chebi:"CHEBI:42189"|chebi:"CHEBI:4735"|chebi:"CHEBI:30378"	-	psi-mi:ethylenediaminetetraacetic acid(display_short)|psi-mi:"CHEBI:42191"(display_long)|intact:"(ethylenedinitrilo)tetraacetic acid, ion(4-)"(synonym)|intact:"2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate"(synonym)|intact:acide edetique(synonym)|intact:Acide ethylenediaminetetracetique(synonym)|intact:acido edetico(synonym)|intact:acidum edeticum(synonym)|intact:Edetic acid(synonym)|intact:edetic acid(synonym)|intact:EDTA(synonym)|intact:edta(synonym)|intact:"EDTA, ion(4-)"(synonym)|intact:ethylenediaminetetraacetate(synonym)|intact:ethylenediaminetetraacetic acid(synonym)|intact:Ethylenediaminetetraacetic acid(synonym)|intact:H4edta(synonym)|intact:"N,N'-1,2-Ethane diylbis-(N-(carboxymethyl)glycine)"(synonym)|intact:"{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID"(synonym)|intact:"(ethane-1,2-diyldinitrilo)tetraacetate"(iupac name)|intact:"(ethane-1,2-diyldinitrilo)tetraacetic acid"(iupac name)	psi-mi:val-pro-arg(display_short)|psi-mi:EBI-27109435(display_long)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111937|imex:IM-29312-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0327"(peptide)	-	-	-	-	-	figure legend:Table 2|inhibition:E-64 % inhibition = 21.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	-	rogid:77kvkm7bmHXepGcLSRiFVY0e0cA-2	-	false	-	coumarin label:c-c|modified L-valine residue:1-1	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48740-2	uniprotkb:P24593	intact:EBI-26435098|ensembl:ENSP00000296280	intact:EBI-720480|uniprotkb:Q5U0A3|ensembl:ENSP00000233813	psi-mi:p48740-2(display_long)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym)|uniprotkb:MASP-3(isoform synonym)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)	psi-mi:ibp5_human(display_long)|uniprotkb:IGFBP5(gene name)|psi-mi:IGFBP5(display_short)|uniprotkb:IBP5(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Cortesio et al. (2006)	imex:IM-29312|pubmed:16554018	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-27111952|imex:IM-29312-19	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127241(gene)|ensembl:ENST00000296280(transcript)|intact:EBI-6380536(isoform-parent)	go:"GO:0071407"(cellular response to organic cyclic compound)|refseq:NP_000590.1|dip:DIP-48433N|ensembl:ENSG00000115461(gene)|ensembl:ENST00000233813(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1904205"(negative regulation of skeletal muscle hypertrophy)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012213(Insulin-like growth factor binding protein 5)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|rcsb pdb:1BOE|rcsb pdb:1H59|reactome:R-HSA-381426|reactome:R-HSA-8957275|go:"GO:1901862"(negative regulation of muscle tissue development)	-	-	-	figure legend:Figure 2, 3, 4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/17	2021/10/26	rogid:tXsz/6dPTPLuD03oT3LxFm6yDA09606	rogid:NeQ0QcVrpNzyqWlmp/HvG5FIRHA9606	rigid:aouSPTpm+mcFDMNt8J7Zlw2Wnqc	false	sufficient binding region:450-721(IPR001254)|his tag:c-c	biological feature:176-177|biological feature:140-141|biological feature:135-136	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0816"(molecular weight estimation by staining)|psi-mi:"MI:0039"(edman degradation)