#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P48740 uniprotkb:O00602 intact:EBI-6380536|ensembl:ENSP00000336792|uniprotkb:A8K542|uniprotkb:A8K6M1|uniprotkb:B4E2L7|uniprotkb:O95570|uniprotkb:Q68D21|uniprotkb:Q8IUV8|uniprotkb:Q96RS4|uniprotkb:Q9UF09 intact:EBI-5282479|uniprotkb:Q5VYV5|uniprotkb:Q92596|ensembl:ENSP00000360871 psi-mi:masp1_human(display_long)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym) psi-mi:fcn1_human(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2005) pubmed:16116205|imex:IM-28427 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26357072|imex:IM-28427-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016862361.1|ensembl:ENSG00000127241(gene)|ensembl:ENST00000337774(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008233"(peptidase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0048306"(calcium-dependent protein binding)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:3DEM|rcsb pdb:3GOV|rcsb pdb:4AQB|rcsb pdb:4DJZ|rcsb pdb:4IGD|rcsb pdb:4IW4|rcsb pdb:4KKD|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-3000480|dip:DIP-61382N|refseq:NP_001027019.1|refseq:NP_001870.3|refseq:NP_624302.1 refseq:NP_001994.2|ensembl:ENSG00000085265(gene)|ensembl:ENST00000371806(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:O00602|rcsb pdb:2D39|rcsb pdb:2JHH|rcsb pdb:2JHI|rcsb pdb:2JHK|rcsb pdb:2JHL|rcsb pdb:2JHM|rcsb pdb:2WNP|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-6798695 - - - figure legend:Fig. 3A,3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/09/24 rogid:Yqzsp6f/Mg3AyvyK42mX/kQ3s389606 rogid:7qu36ZaWgX+GyX+QUbGj0RGrp4U9606 rigid:1MxXaMG+r3d22dpBslE/SFER7GI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O00187 uniprotkb:O00602 intact:EBI-7965040|uniprotkb:Q9UMV3|intact:MINT-7970114|uniprotkb:Q9ULC7|uniprotkb:Q9Y270|uniprotkb:A8MWJ2|uniprotkb:O75754|uniprotkb:Q96QG4|uniprotkb:Q9UBP3|uniprotkb:Q5TEQ5|uniprotkb:Q5TER0|uniprotkb:Q9H498|uniprotkb:Q9UC48|uniprotkb:A8K458|uniprotkb:Q9H499|uniprotkb:Q9BZH0|ensembl:ENSP00000383690 intact:EBI-5282479|uniprotkb:Q5VYV5|uniprotkb:Q92596|ensembl:ENSP00000360871 psi-mi:masp2_human(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MBL-associated serine protease 2(gene name synonym) psi-mi:fcn1_human(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Liu et al. (2005) pubmed:16116205|imex:IM-28427 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-26357076|imex:IM-28427-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_631947.1|refseq:NP_006601.2|ensembl:ENSG00000009724(gene)|ensembl:ENST00000400897(transcript)|go:"GO:0001855"(complement component C4b binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR037571|interpro:IPR043504|rcsb pdb:1Q3X|rcsb pdb:1SZB|rcsb pdb:1ZJK|rcsb pdb:3TVJ|rcsb pdb:4FXG|rcsb pdb:5JPM|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086 refseq:NP_001994.2|ensembl:ENSG00000085265(gene)|ensembl:ENST00000371806(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:O00602|rcsb pdb:2D39|rcsb pdb:2JHH|rcsb pdb:2JHI|rcsb pdb:2JHK|rcsb pdb:2JHL|rcsb pdb:2JHM|rcsb pdb:2WNP|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-6798695 - comment:mint - figure legend:Fig. 3BA, 3D|comment:Both O00187-1 and O00187-2 were observed in the complex but it was not possible to know if one or both were interacting with the prey|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/09/24 rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606 rogid:7qu36ZaWgX+GyX+QUbGj0RGrp4U9606 rigid:031XlO5M5JLwTpyR36vbt3MS04c false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) chebi:"CHEBI:59640" uniprotkb:O00602 intact:EBI-11784143 intact:EBI-5282479|uniprotkb:Q5VYV5|uniprotkb:Q92596|ensembl:ENSP00000360871 psi-mi:n-acetylglucosamine(display_short)|psi-mi:"CHEBI:59640"(display_long)|intact:N-acetylglucosamines(synonym) psi-mi:fcn1_human(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Liu et al. (2005) pubmed:16116205|imex:IM-28427 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-26357094|imex:IM-28427-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_001994.2|ensembl:ENSG00000085265(gene)|ensembl:ENST00000371806(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:O00602|rcsb pdb:2D39|rcsb pdb:2JHH|rcsb pdb:2JHI|rcsb pdb:2JHK|rcsb pdb:2JHL|rcsb pdb:2JHM|rcsb pdb:2WNP|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-6798695 - - - figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/09/24 - rogid:7qu36ZaWgX+GyX+QUbGj0RGrp4U9606 - false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) chebi:"CHEBI:59640" uniprotkb:P48740 intact:EBI-11784143 intact:EBI-6380536|ensembl:ENSP00000336792|uniprotkb:A8K542|uniprotkb:A8K6M1|uniprotkb:B4E2L7|uniprotkb:O95570|uniprotkb:Q68D21|uniprotkb:Q8IUV8|uniprotkb:Q96RS4|uniprotkb:Q9UF09 psi-mi:n-acetylglucosamine(display_short)|psi-mi:"CHEBI:59640"(display_long)|intact:N-acetylglucosamines(synonym) psi-mi:masp1_human(display_long)|uniprotkb:MASP1(gene name)|psi-mi:MASP1(display_short)|uniprotkb:CRARF(gene name synonym)|uniprotkb:CRARF1(gene name synonym)|uniprotkb:PRSS5(gene name synonym)|uniprotkb:Complement factor MASP-3(gene name synonym)|uniprotkb:Complement-activating component of Ra-reactive factor(gene name synonym)|uniprotkb:Mannose-binding lectin-associated serine protease 1(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease(gene name synonym)|uniprotkb:Ra-reactive factor serine protease p100(gene name synonym)|uniprotkb:Serine protease 5(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Liu et al. (2005) pubmed:16116205|imex:IM-28427 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-26357094|imex:IM-28427-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:XP_016862361.1|ensembl:ENSG00000127241(gene)|ensembl:ENST00000337774(transcript)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008233"(peptidase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045916"(negative regulation of complement activation)|go:"GO:0048306"(calcium-dependent protein binding)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR035914|interpro:IPR035976|interpro:IPR043504|rcsb pdb:3DEM|rcsb pdb:3GOV|rcsb pdb:4AQB|rcsb pdb:4DJZ|rcsb pdb:4IGD|rcsb pdb:4IW4|rcsb pdb:4KKD|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-3000480|dip:DIP-61382N|refseq:NP_001027019.1|refseq:NP_001870.3|refseq:NP_624302.1 - - - figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/09/24 - rogid:Yqzsp6f/Mg3AyvyK42mX/kQ3s389606 - false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) chebi:"CHEBI:59640" uniprotkb:O00187-2 intact:EBI-11784143 intact:EBI-26356134|ensembl:ENSP00000383691 psi-mi:n-acetylglucosamine(display_short)|psi-mi:"CHEBI:59640"(display_long)|intact:N-acetylglucosamines(synonym) psi-mi:o00187-2(display_long)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short)|uniprotkb:MBL-associated serine protease 2(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MAp19(isoform synonym)|uniprotkb:Small MBL-associated protein(isoform synonym)|uniprotkb:sMAP(isoform synonym) psi-mi:"MI:0004"(affinity chromatography technology) Liu et al. (2005) pubmed:16116205|imex:IM-28427 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-26357094|imex:IM-28427-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000009724(gene)|ensembl:ENST00000400898(transcript)|intact:EBI-7965040(isoform-parent) - - - figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/09/24 - rogid:HFrZYSDiESe89IQqgChsunpvyTc9606 - false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) chebi:"CHEBI:59640" uniprotkb:O00187-1 intact:EBI-11784143 intact:EBI-26357096|ensembl:ENSP00000383690 psi-mi:n-acetylglucosamine(display_short)|psi-mi:"CHEBI:59640"(display_long)|intact:N-acetylglucosamines(synonym) psi-mi:o00187-1(display_long)|uniprotkb:MBL-associated serine protease 2(gene name synonym)|uniprotkb:Mannose-binding protein-associated serine protease 2(gene name synonym)|uniprotkb:MASP2(gene name)|psi-mi:MASP2(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Liu et al. (2005) pubmed:16116205|imex:IM-28427 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-26357094|imex:IM-28427-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensembl:ENST00000400897(transcript)|ensembl:ENSG00000009724(gene)|intact:EBI-7965040(isoform-parent) - - - figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/09/24 - rogid:S48IDwjdZ8M6vIJD6iM0XplSN609606 - false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) chebi:"CHEBI:59640" uniprotkb:O00602 intact:EBI-11784143 intact:EBI-5282479|uniprotkb:Q5VYV5|uniprotkb:Q92596|ensembl:ENSP00000360871 psi-mi:n-acetylglucosamine(display_short)|psi-mi:"CHEBI:59640"(display_long)|intact:N-acetylglucosamines(synonym) psi-mi:fcn1_human(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Liu et al. (2005) pubmed:16116205|imex:IM-28427 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-26357107|imex:IM-28427-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_001994.2|ensembl:ENSG00000085265(gene)|ensembl:ENST00000371806(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:O00602|rcsb pdb:2D39|rcsb pdb:2JHH|rcsb pdb:2JHI|rcsb pdb:2JHK|rcsb pdb:2JHL|rcsb pdb:2JHM|rcsb pdb:2WNP|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-6798695 - - - figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/09/24 - rogid:7qu36ZaWgX+GyX+QUbGj0RGrp4U9606 - false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) chebi:"CHEBI:59640" uniprotkb:O00602 intact:EBI-11784143 intact:EBI-5282479|uniprotkb:Q5VYV5|uniprotkb:Q92596|ensembl:ENSP00000360871 psi-mi:n-acetylglucosamine(display_short)|psi-mi:"CHEBI:59640"(display_long)|intact:N-acetylglucosamines(synonym) psi-mi:fcn1_human(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym) psi-mi:"MI:0049"(filter binding) Liu et al. (2005) pubmed:16116205|imex:IM-28427 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-26357173|imex:IM-28427-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_001994.2|ensembl:ENSG00000085265(gene)|ensembl:ENST00000371806(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:O00602|rcsb pdb:2D39|rcsb pdb:2JHH|rcsb pdb:2JHI|rcsb pdb:2JHK|rcsb pdb:2JHL|rcsb pdb:2JHM|rcsb pdb:2WNP|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-6798695 - - - figure legend:Fig. 6A, 6B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/09/24 - rogid:7qu36ZaWgX+GyX+QUbGj0RGrp4U9606 - false - 125i radiolabel:?-? - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) chebi:"CHEBI:28800" uniprotkb:O00602 intact:EBI-15486594|chebi:"CHEBI:7201"|chebi:"CHEBI:21600" intact:EBI-5282479|uniprotkb:Q5VYV5|uniprotkb:Q92596|ensembl:ENSP00000360871 psi-mi:n-acetylgalactosamine(display_short)|psi-mi:"CHEBI:28800"(display_long)|intact:GalNAc(synonym)|intact:2-Acetamido-2-deoxygalactose(synonym)|intact:N-Acetylchondrosamine(synonym)|intact:N-Acetylgalactosamine(synonym)|intact:2-acetamido-2-deoxygalactose(iupac name) psi-mi:fcn1_human(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym) psi-mi:"MI:0049"(filter binding) Liu et al. (2005) pubmed:16116205|imex:IM-28427 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-26357179|imex:IM-28427-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_001994.2|ensembl:ENSG00000085265(gene)|ensembl:ENST00000371806(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:O00602|rcsb pdb:2D39|rcsb pdb:2JHH|rcsb pdb:2JHI|rcsb pdb:2JHK|rcsb pdb:2JHL|rcsb pdb:2JHM|rcsb pdb:2WNP|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-6798695 - - - figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/09/24 - rogid:7qu36ZaWgX+GyX+QUbGj0RGrp4U9606 - false - 125i radiolabel:?-? - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) chebi:"CHEBI:153787" uniprotkb:O00602 intact:EBI-26357185 intact:EBI-5282479|uniprotkb:Q5VYV5|uniprotkb:Q92596|ensembl:ENSP00000360871 psi-mi:6-sialyl-n-acetyllactosamine(display_short)|psi-mi:"CHEBI:153787"(display_long)|intact:"5-acetamido-3,5-dideoxy-D-glycero-beta-D-galacto-non-2-ulopyranosylonic acid-(2->6)-beta-D-galacto-hexopyranosyl-(1->4)-2-acetamido-2-deoxy-D-gluco-hexopyranose"(synonym)|intact:"NeuAc(b2-6)Gal(b1-4)GlcNAc"(synonym)|intact:WURCS=2.0/3,3,2/[a2122h-1x_1-5_2*NCC/3=O][a2112h-1b_1-5][Aad21122h-2b_2-6_5*NCC/3=O]/1-2-3/a4-b1_b6-c2(synonym) psi-mi:fcn1_human(display_long)|uniprotkb:FCN1(gene name)|psi-mi:FCN1(display_short)|uniprotkb:FCNM(gene name synonym)|uniprotkb:Collagen/fibrinogen domain-containing protein 1(gene name synonym)|uniprotkb:Ficolin-A(gene name synonym)|uniprotkb:Ficolin-alpha(gene name synonym)|uniprotkb:M-ficolin(gene name synonym) psi-mi:"MI:0049"(filter binding) Liu et al. (2005) pubmed:16116205|imex:IM-28427 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-26357190|imex:IM-28427-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_001994.2|ensembl:ENSG00000085265(gene)|ensembl:ENST00000371806(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0002752"(cell surface pattern recognition receptor signaling pathway)|go:"GO:0003823"(antigen binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043654"(recognition of apoptotic cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097367"(carbohydrate derivative binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|mint:O00602|rcsb pdb:2D39|rcsb pdb:2JHH|rcsb pdb:2JHI|rcsb pdb:2JHK|rcsb pdb:2JHL|rcsb pdb:2JHM|rcsb pdb:2WNP|reactome:R-HSA-166662|reactome:R-HSA-166663|reactome:R-HSA-2855086|reactome:R-HSA-6798695 - - - figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/09/24 2020/09/24 - rogid:7qu36ZaWgX+GyX+QUbGj0RGrp4U9606 - false - 125i radiolabel:?-? - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography)