#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O96033	uniprotkb:O96007	intact:EBI-9056334|ensembl:ENSP00000355160|ensembl:ENSP00000411022|ensembl:ENSP00000424267|ensembl:ENSP00000426274|ensembl:ENSP00000462870|ensembl:ENSP00000464663	intact:EBI-723640|ensembl:ENSP00000380157|uniprotkb:Q6IAI3	psi-mi:moc2a_human(display_long)|uniprotkb:MOCS2(gene name)|psi-mi:MOCS2(display_short)|uniprotkb:MOCO1(gene name synonym)|uniprotkb:MOCO1-A(gene name synonym)|uniprotkb:Molybdenum cofactor synthesis protein 2 small subunit(gene name synonym)|uniprotkb:Molybdenum cofactor synthesis protein 2A(gene name synonym)|uniprotkb:Molybdopterin-synthase small subunit(gene name synonym)|uniprotkb:Sulfur carrier protein MOCS2A(gene name synonym)	psi-mi:moc2b_human(display_long)|uniprotkb:Molybdenum cofactor synthesis protein 2 large subunit(gene name synonym)|uniprotkb:Molybdopterin-synthase large subunit(gene name synonym)|uniprotkb:Molybdenum cofactor synthesis protein 2B(gene name synonym)|uniprotkb:MOCO1-B(gene name synonym)|uniprotkb:MOCS2(gene name)|psi-mi:MOCS2(display_short)|uniprotkb:MCBPE(gene name synonym)|uniprotkb:MOCO1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Leimkühler et al. (2005)	pubmed:16021469|imex:IM-28608	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26564681|imex:IM-28608-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_789776.1|ensembl:ENSG00000164172(gene)|ensembl:ENST00000361377(transcript)|ensembl:ENST00000450852(transcript)|ensembl:ENST00000508922(transcript)|ensembl:ENST00000510818(transcript)|ensembl:ENST00000582677(transcript)|ensembl:ENST00000584946(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0019008"(molybdopterin synthase complex)|go:"GO:0030366"(molybdopterin synthase activity)|interpro:IPR003749(ThiamineS)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR016155(Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp)|interpro:IPR028887|interpro:IPR044672|rcsb pdb:5MPO|reactome:R-HSA-947581	refseq:NP_004522.1|ensembl:ENSG00000164172(gene)|ensembl:ENST00000396954(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0016607"(nuclear speck)|go:"GO:0019008"(molybdopterin synthase complex)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0030366"(molybdopterin synthase activity)|interpro:IPR003448(Molybdopterin biosynthesis MoaE)|interpro:IPR028888|interpro:IPR036563|rcsb pdb:4AP8|rcsb pdb:5MPO|reactome:R-HSA-947581	-	-	-	figure legend:Fig. 3|comment:MOCS2A is stated to be C-terminally carboxylated|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/14	2021/01/04	rogid:h0EZ73g+ejtx3nMPdAI4MfolDoQ9606	rogid:/++dYHIJG1TsPULtnLVHgcvhuf49606	rigid:bgjfHH/KCINm1FDRNQZuNeq18b8	false	-	mutation disrupting interaction strength:188-188(rs121908609)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:52994"	reactome:R-HSA-947582	intact:EBI-26564857	intact:EBI-26564823|wwpdb:5MPO|intenz:2.8.1.12|rhea:"RHEA:26333"	psi-mi:precursor z(display_short)|psi-mi:"CHEBI:52994"(display_long)|intact:cPMP(synonym)|intact:cyclic pyranopterin monophosphate(synonym)|intact:"8-amino-2-hydroxy-4a,5a,9,11,11a,12a-hexahydro[1,3,2]dioxaphosphinino[4',5':5,6]pyrano[3,2-g]pteridine-10,12(4H,6H)-dione 2-oxide"(iupac name)	psi-mi:mocs2-mocs2-5(display_short)|psi-mi:R-HSA-947582(display_long)|intact:Molybdopterin synthase complex(complex recommended name)|intact:"2xMOCS2A:2xMOCS2B"(complex systematic name)	psi-mi:"MI:0415"(enzymatic study)	Leimkühler et al. (2005)	pubmed:16021469|imex:IM-28608	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26564846|imex:IM-28608-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:1302"(stable complex)	-	wwpdb:4AP8(subset)|intact:EBI-26564681(exp-evidence)|complex portal:CPX-6341(complex-primary)|evidence ontology:"ECO:0000353"|efo:"Orphanet:308393"(see-also)|go:"GO:0030366"(molybdopterin synthase activity)|pubmed:16021469(see-also)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0019008"(molybdopterin synthase complex)	-	-	curated-complex:"Involved in molybdopterin cofactor (Moco) biosynthesis under anaerobic conditions converting molybdopterin precursor Z (CHEBI:52994) to molybdopterin (CHEBI:44074). This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group."|complex-assembly:Heterotetramer|disease:"Sulfite oxidase deficiency due to molybdenum cofactor deficiency type B [Orphanet:308393]: an autosomal recessive metabolic disorder characterized by neonatal onset of intractable seizures, opisthotonus, and facial dysmorphism associated with hypouricemia and elevated urinary sulfite levels. Affected individuals show severe neurologic damage and often die in early childhood."	figure legend:2,4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/12/14	2020/12/15	-	-	-	false	-	mutation disrupting interaction rate:188-188(rs121908609)|mutation disrupting interaction rate:188-188(rs121908609)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)