#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NQ76	uniprotkb:P78562	intact:EBI-1753293|ensembl:ENSP00000354341|ensembl:ENSP00000416984|uniprotkb:A1A4X9|uniprotkb:A8MTA3|uniprotkb:D2CFR4|uniprotkb:F5H5C5	intact:EBI-2827676|uniprotkb:Q99827|uniprotkb:Q2M325|uniprotkb:Q93032|uniprotkb:Q13646|uniprotkb:O00678|ensembl:ENSP00000368682	psi-mi:mepe_human(display_long)|uniprotkb:Osteoregulin(gene name synonym)|uniprotkb:MEPE(gene name)|psi-mi:MEPE(display_short)|uniprotkb:Osteoblast/osteocyte factor 45(gene name synonym)	psi-mi:phex_human(display_long)|uniprotkb:PHEX(gene name)|psi-mi:PHEX(display_short)|uniprotkb:PEX(gene name synonym)|uniprotkb:Metalloendopeptidase homolog PEX(gene name synonym)|uniprotkb:Vitamin D-resistant hypophosphatemic rickets protein(gene name synonym)|uniprotkb:X-linked hypophosphatemia protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Rowe et al. (2005)	pubmed:15664000|imex:IM-28487	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26445619|imex:IM-28487-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171624.1|refseq:NP_001171625.1|refseq:NP_001171623.1|refseq:NP_001171626.1|refseq:NP_064588.1|refseq:NP_001278112.1|ensembl:ENSG00000152595(gene)|ensembl:ENST00000361056(transcript)|ensembl:ENST00000424957(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031214"(biomineral tissue development)|go:"GO:1990430"(extracellular matrix protein binding)|interpro:IPR009837(Osteoregulin)|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:XP_006714341.1	refseq:NP_001269683.1|refseq:NP_000435.3|go:"GO:0042476"(odontogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060348"(bone development)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:1904383"(response to sodium phosphate)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|go:"GO:0030324"(lung development)|interpro:IPR018497|interpro:IPR024079|interpro:IPR042089|ensembl:ENSG00000102174(gene)|ensembl:ENST00000379374(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|go:"GO:0019637"(organophosphate metabolic process)|go:"GO:0030282"(bone mineralization)	-	-	-	comment:Reaction was zinc-dependent|figure legend:Fig. 1, 2, 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/12	2020/11/12	rogid:2gGb/VJcp/i7h4nd9HumlaPfS5k9606	rogid:K1GQP9TvXdbntXq4k5Qd3K7hoAI9606	rigid:Yd+4oBr8Mb5oKfzI4w1EDb/pM0w	false	sufficient binding region:17-525	mutation:28-40	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NQ76	uniprotkb:Q9NQ76	intact:EBI-1753293|ensembl:ENSP00000354341|ensembl:ENSP00000416984|uniprotkb:A1A4X9|uniprotkb:A8MTA3|uniprotkb:D2CFR4|uniprotkb:F5H5C5	intact:EBI-1753293|ensembl:ENSP00000354341|ensembl:ENSP00000416984|uniprotkb:A1A4X9|uniprotkb:A8MTA3|uniprotkb:D2CFR4|uniprotkb:F5H5C5	psi-mi:mepe_human(display_long)|uniprotkb:Osteoregulin(gene name synonym)|uniprotkb:MEPE(gene name)|psi-mi:MEPE(display_short)|uniprotkb:Osteoblast/osteocyte factor 45(gene name synonym)	psi-mi:mepe_human(display_long)|uniprotkb:Osteoregulin(gene name synonym)|uniprotkb:MEPE(gene name)|psi-mi:MEPE(display_short)|uniprotkb:Osteoblast/osteocyte factor 45(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Rowe et al. (2005)	pubmed:15664000|imex:IM-28487	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26445629|imex:IM-28487-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171624.1|refseq:NP_001171625.1|refseq:NP_001171623.1|refseq:NP_001171626.1|refseq:NP_064588.1|refseq:NP_001278112.1|ensembl:ENSG00000152595(gene)|ensembl:ENST00000361056(transcript)|ensembl:ENST00000424957(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031214"(biomineral tissue development)|go:"GO:1990430"(extracellular matrix protein binding)|interpro:IPR009837(Osteoregulin)|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:XP_006714341.1	refseq:NP_001171624.1|refseq:NP_001171625.1|refseq:NP_001171623.1|refseq:NP_001171626.1|refseq:NP_064588.1|refseq:NP_001278112.1|ensembl:ENSG00000152595(gene)|ensembl:ENST00000361056(transcript)|ensembl:ENST00000424957(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031214"(biomineral tissue development)|go:"GO:1990430"(extracellular matrix protein binding)|interpro:IPR009837(Osteoregulin)|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:XP_006714341.1	-	-	-	comment:Reaction was zinc-dependent|figure legend:Fig. 4,5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/12	2020/11/17	rogid:2gGb/VJcp/i7h4nd9HumlaPfS5k9606	rogid:2gGb/VJcp/i7h4nd9HumlaPfS5k9606	rigid:Yd+4oBr8Mb5oKfzI4w1EDb/pM0w	false	sufficient binding region:17-525	sufficient binding region:507-525|O-phospho-L-serine:518-518,520-520,522-522	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NQ76	uniprotkb:P78562	intact:EBI-1753293|ensembl:ENSP00000354341|ensembl:ENSP00000416984|uniprotkb:A1A4X9|uniprotkb:A8MTA3|uniprotkb:D2CFR4|uniprotkb:F5H5C5	intact:EBI-2827676|uniprotkb:Q99827|uniprotkb:Q2M325|uniprotkb:Q93032|uniprotkb:Q13646|uniprotkb:O00678|ensembl:ENSP00000368682	psi-mi:mepe_human(display_long)|uniprotkb:Osteoregulin(gene name synonym)|uniprotkb:MEPE(gene name)|psi-mi:MEPE(display_short)|uniprotkb:Osteoblast/osteocyte factor 45(gene name synonym)	psi-mi:phex_human(display_long)|uniprotkb:PHEX(gene name)|psi-mi:PHEX(display_short)|uniprotkb:PEX(gene name synonym)|uniprotkb:Metalloendopeptidase homolog PEX(gene name synonym)|uniprotkb:Vitamin D-resistant hypophosphatemic rickets protein(gene name synonym)|uniprotkb:X-linked hypophosphatemia protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Rowe et al. (2005)	pubmed:15664000|imex:IM-28487	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-26445629|imex:IM-28487-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171624.1|refseq:NP_001171625.1|refseq:NP_001171623.1|refseq:NP_001171626.1|refseq:NP_064588.1|refseq:NP_001278112.1|ensembl:ENSG00000152595(gene)|ensembl:ENST00000361056(transcript)|ensembl:ENST00000424957(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031214"(biomineral tissue development)|go:"GO:1990430"(extracellular matrix protein binding)|interpro:IPR009837(Osteoregulin)|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:XP_006714341.1	refseq:NP_001269683.1|refseq:NP_000435.3|go:"GO:0042476"(odontogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060348"(bone development)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:1904383"(response to sodium phosphate)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|go:"GO:0030324"(lung development)|interpro:IPR018497|interpro:IPR024079|interpro:IPR042089|ensembl:ENSG00000102174(gene)|ensembl:ENST00000379374(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|go:"GO:0019637"(organophosphate metabolic process)|go:"GO:0030282"(bone mineralization)	-	-	-	comment:Reaction was zinc-dependent|figure legend:Fig. 4,5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/11/12	2020/11/17	rogid:2gGb/VJcp/i7h4nd9HumlaPfS5k9606	rogid:K1GQP9TvXdbntXq4k5Qd3K7hoAI9606	rigid:Yd+4oBr8Mb5oKfzI4w1EDb/pM0w	false	sufficient binding region:17-525	mutation:28-40	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)