#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9VPQ6 uniprotkb:P17679 intact:EBI-110692|uniprotkb:Q6AWH0|uniprotkb:O18414|ensemblmetazoa:FBpp0077723 intact:EBI-3903251|uniprotkb:Q3UIH9|uniprotkb:Q7TMX8|ensembl:ENSMUSP00000033502 psi-mi:ush_drome(display_long)|uniprotkb:Protein U-shaped(gene name synonym)|uniprotkb:ush(gene name)|psi-mi:ush(display_short)|uniprotkb:CG2762(orf name) psi-mi:gata1_mouse(display_long)|uniprotkb:Gata1(gene name)|psi-mi:Gata1(display_short)|uniprotkb:Gf-1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Liew et al. (2005) pubmed:15644435|imex:IM-27656 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25400879|pdbe:1Y0J|imex:IM-27656-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_476780.1|flybase:FBgn0003963|ensemblmetazoa:FBgn0003963(gene)|ensemblmetazoa:FBtr0078063(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006963"(positive regulation of antibacterial peptide biosynthetic process)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007507"(heart development)|go:"GO:0022416"(chaeta development)|go:"GO:0030154"(cell differentiation)|go:"GO:0035167"(larval lymph gland hemopoiesis)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045611"(negative regulation of hemocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046665"(amnioserosa maintenance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048542"(lymph gland development)|go:"GO:0048749"(compound eye development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034731|interpro:IPR036236|interpro:IPR039746|rcsb pdb:1FU9|rcsb pdb:1FV5|rcsb pdb:1JN7|rcsb pdb:1Y0J|rcsb pdb:2L6Z|reactome:R-DME-8936459|reactome:R-DME-983231 refseq:XP_011245750.1|refseq:NP_032115.1|dip:DIP-40883N|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P17679|rcsb pdb:1GNF|rcsb pdb:1Y0J|rcsb pdb:2L5E|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:3VD6|rcsb pdb:3VEK|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-983231|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|ensembl:ENSMUSG00000031162(gene)|ensembl:ENSMUST00000033502(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus) - - - figure legend:Fig. 1B, 6|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/20 2020/01/20 rogid:2CAaxvMNBtN3JUFnhUgsOAMFmYM7227 rogid:zv2cIXaxDsuFj//cWvnvvL8jgiA10090 rigid:3b24tlQr0CErBdkeSepK2C1Dj5g false sufficient binding region:202-235 sufficient binding region:200-243 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) ensembl:ENSMUSG00000069919 uniprotkb:P17679 intact:EBI-25401720 intact:EBI-3903251|uniprotkb:Q3UIH9|uniprotkb:Q7TMX8|ensembl:ENSMUSP00000033502 uniprotkb:Hba-a1(gene name)|psi-mi:Hba-a1(display_short)|uniprotkb:Glnc1(gene name synonym)|uniprotkb:haemaglobin alpha 1(gene name synonym)|uniprotkb:haemaglobin alpha 2(gene name synonym)|uniprotkb:Hba-a2(gene name synonym)|ensembl:q91vb8_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000069919(display_long) psi-mi:gata1_mouse(display_long)|uniprotkb:Gata1(gene name)|psi-mi:Gata1(display_short)|uniprotkb:Gf-1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) psi-mi:"MI:0096"(pull down) Liew et al. (2005) pubmed:15644435|imex:IM-27656 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-25401730|imex:IM-27656-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NP_001077424.1(see-also)|refseq:NP_032244.2(see-also) refseq:XP_011245750.1|refseq:NP_032115.1|dip:DIP-40883N|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P17679|rcsb pdb:1GNF|rcsb pdb:1Y0J|rcsb pdb:2L5E|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:3VD6|rcsb pdb:3VEK|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-983231|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|ensembl:ENSMUSG00000031162(gene)|ensembl:ENSMUST00000033502(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus) go:"GO:0005634"(nucleus) - - figure legend:Fig. 4a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/20 2020/04/12 - rogid:zv2cIXaxDsuFj//cWvnvvL8jgiA10090 - false biotin tag:?-?|mutation disrupting interaction strength:?-?|sufficient binding region:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) ensembl:ENSMUSG00000069919 uniprotkb:O35615 intact:EBI-25401720 intact:EBI-4394596|ensembl:ENSMUSP00000058037 uniprotkb:Hba-a1(gene name)|psi-mi:Hba-a1(display_short)|uniprotkb:Glnc1(gene name synonym)|uniprotkb:haemaglobin alpha 1(gene name synonym)|uniprotkb:haemaglobin alpha 2(gene name synonym)|uniprotkb:Hba-a2(gene name synonym)|ensembl:q91vb8_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000069919(display_long) psi-mi:fog1_mouse(display_long)|uniprotkb:Zfpm1(gene name)|psi-mi:Zfpm1(display_short)|uniprotkb:Fog(gene name synonym)|uniprotkb:Fog1(gene name synonym)|uniprotkb:Friend of GATA protein 1(gene name synonym)|uniprotkb:Zinc finger protein multitype 1(gene name synonym) psi-mi:"MI:0096"(pull down) Liew et al. (2005) pubmed:15644435|imex:IM-27656 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-25401730|imex:IM-27656-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NP_001077424.1(see-also)|refseq:NP_032244.2(see-also) dip:DIP-48414N|refseq:NP_033595.1|refseq:XP_006530914.1|ensembl:ENSMUSG00000049577(gene)|ensembl:ENSMUST00000054052(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003195"(tricuspid valve formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007507"(heart development)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060377"(negative regulation of mast cell differentiation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034731|interpro:IPR036236|interpro:IPR039746|rcsb pdb:1SRK|rcsb pdb:2MPL|reactome:R-MMU-8936459|reactome:R-MMU-983231 go:"GO:0005634"(nucleus) - - figure legend:Fig. 4a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/20 2020/04/12 - rogid:z2DMVqaiqrJqxmeLnoVFYSMx8J810090 - false biotin tag:?-?|mutation disrupting interaction strength:?-?|sufficient binding region:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P17679 ensembl:ENSMUSG00000069919 intact:EBI-3903251|uniprotkb:Q3UIH9|uniprotkb:Q7TMX8|ensembl:ENSMUSP00000033502 intact:EBI-25401720 psi-mi:gata1_mouse(display_long)|uniprotkb:Gata1(gene name)|psi-mi:Gata1(display_short)|uniprotkb:Gf-1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) uniprotkb:Hba-a1(gene name)|psi-mi:Hba-a1(display_short)|uniprotkb:Glnc1(gene name synonym)|uniprotkb:haemaglobin alpha 1(gene name synonym)|uniprotkb:haemaglobin alpha 2(gene name synonym)|uniprotkb:Hba-a2(gene name synonym)|ensembl:q91vb8_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000069919(display_long) psi-mi:"MI:0096"(pull down) Liew et al. (2005) pubmed:15644435|imex:IM-27656 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25428225|imex:IM-27656-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:XP_011245750.1|refseq:NP_032115.1|dip:DIP-40883N|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P17679|rcsb pdb:1GNF|rcsb pdb:1Y0J|rcsb pdb:2L5E|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:3VD6|rcsb pdb:3VEK|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-983231|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|ensembl:ENSMUSG00000031162(gene)|ensembl:ENSMUST00000033502(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus) refseq:NP_001077424.1(see-also)|refseq:NP_032244.2(see-also) go:"GO:0005634"(nucleus) - - figure legend:Fig. 4a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/20 2020/04/12 rogid:zv2cIXaxDsuFj//cWvnvvL8jgiA10090 - - false - biotin tag:?-?|mutation disrupting interaction strength:?-?|sufficient binding region:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) ensembl:ENSMUSG00000025270 uniprotkb:P17679 intact:EBI-25401743 intact:EBI-3903251|uniprotkb:Q3UIH9|uniprotkb:Q7TMX8|ensembl:ENSMUSP00000033502 uniprotkb:Alas2(gene name)|psi-mi:Alas2(display_short)|ensembl:alas2_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000025270(display_long) psi-mi:gata1_mouse(display_long)|uniprotkb:Gata1(gene name)|psi-mi:Gata1(display_short)|uniprotkb:Gf-1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) psi-mi:"MI:0096"(pull down) Liew et al. (2005) pubmed:15644435|imex:IM-27656 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25401747|imex:IM-27656-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NM_001102446.1(see-also) refseq:XP_011245750.1|refseq:NP_032115.1|dip:DIP-40883N|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P17679|rcsb pdb:1GNF|rcsb pdb:1Y0J|rcsb pdb:2L5E|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:3VD6|rcsb pdb:3VEK|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-983231|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|ensembl:ENSMUSG00000031162(gene)|ensembl:ENSMUST00000033502(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus) - - - figure legend:Fig. 4b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/20 2020/04/12 - rogid:zv2cIXaxDsuFj//cWvnvvL8jgiA10090 - false biotin tag:?-?|sufficient binding region:?-? maltose binding protein tag:?-?|sufficient binding region:198..198-253..253(IPR000679) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) ensembl:ENSMUSG00000025270 uniprotkb:O35615 intact:EBI-25401743 intact:EBI-4394596|ensembl:ENSMUSP00000058037 uniprotkb:Alas2(gene name)|psi-mi:Alas2(display_short)|ensembl:alas2_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000025270(display_long) psi-mi:fog1_mouse(display_long)|uniprotkb:Zfpm1(gene name)|psi-mi:Zfpm1(display_short)|uniprotkb:Fog(gene name synonym)|uniprotkb:Fog1(gene name synonym)|uniprotkb:Friend of GATA protein 1(gene name synonym)|uniprotkb:Zinc finger protein multitype 1(gene name synonym) psi-mi:"MI:0096"(pull down) Liew et al. (2005) pubmed:15644435|imex:IM-27656 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25401747|imex:IM-27656-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) refseq:NM_001102446.1(see-also) dip:DIP-48414N|refseq:NP_033595.1|refseq:XP_006530914.1|ensembl:ENSMUSG00000049577(gene)|ensembl:ENSMUST00000054052(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003195"(tricuspid valve formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007507"(heart development)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060377"(negative regulation of mast cell differentiation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034731|interpro:IPR036236|interpro:IPR039746|rcsb pdb:1SRK|rcsb pdb:2MPL|reactome:R-MMU-8936459|reactome:R-MMU-983231 - - - figure legend:Fig. 4b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/20 2020/04/12 - rogid:z2DMVqaiqrJqxmeLnoVFYSMx8J810090 - false biotin tag:?-?|sufficient binding region:?-? sufficient binding region:868..868-891..891|glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9VPQ6 uniprotkb:P17679 intact:EBI-110692|uniprotkb:Q6AWH0|uniprotkb:O18414|ensemblmetazoa:FBpp0077723 intact:EBI-3903251|uniprotkb:Q3UIH9|uniprotkb:Q7TMX8|ensembl:ENSMUSP00000033502 psi-mi:ush_drome(display_long)|uniprotkb:Protein U-shaped(gene name synonym)|uniprotkb:ush(gene name)|psi-mi:ush(display_short)|uniprotkb:CG2762(orf name) psi-mi:gata1_mouse(display_long)|uniprotkb:Gata1(gene name)|psi-mi:Gata1(display_short)|uniprotkb:Gf-1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Liew et al. (2005) pubmed:15644435|imex:IM-27656 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25402214|imex:IM-27656-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_476780.1|flybase:FBgn0003963|ensemblmetazoa:FBgn0003963(gene)|ensemblmetazoa:FBtr0078063(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006963"(positive regulation of antibacterial peptide biosynthetic process)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007507"(heart development)|go:"GO:0022416"(chaeta development)|go:"GO:0030154"(cell differentiation)|go:"GO:0035167"(larval lymph gland hemopoiesis)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045611"(negative regulation of hemocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046665"(amnioserosa maintenance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048542"(lymph gland development)|go:"GO:0048749"(compound eye development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034731|interpro:IPR036236|interpro:IPR039746|rcsb pdb:1FU9|rcsb pdb:1FV5|rcsb pdb:1JN7|rcsb pdb:1Y0J|rcsb pdb:2L6Z|reactome:R-DME-8936459|reactome:R-DME-983231 refseq:XP_011245750.1|refseq:NP_032115.1|dip:DIP-40883N|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P17679|rcsb pdb:1GNF|rcsb pdb:1Y0J|rcsb pdb:2L5E|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:3VD6|rcsb pdb:3VEK|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-983231|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|ensembl:ENSMUSG00000031162(gene)|ensembl:ENSMUST00000033502(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus) - - - figure legend:Fig 5c, 7a-e. Table 1.|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/20 2020/01/21 rogid:2CAaxvMNBtN3JUFnhUgsOAMFmYM7227 rogid:zv2cIXaxDsuFj//cWvnvvL8jgiA10090 rigid:3b24tlQr0CErBdkeSepK2C1Dj5g false sufficient binding region:202..202-235..235 mutation disrupting interaction strength:205-205|mutation disrupting interaction strength:208-208|mutation with no effect:216-216|mutation with no effect:218-218|glutathione s tranferase tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P17679 ensembl:ENSMUSG00000025270 intact:EBI-3903251|uniprotkb:Q3UIH9|uniprotkb:Q7TMX8|ensembl:ENSMUSP00000033502 intact:EBI-25401743 psi-mi:gata1_mouse(display_long)|uniprotkb:Gata1(gene name)|psi-mi:Gata1(display_short)|uniprotkb:Gf-1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) uniprotkb:Alas2(gene name)|psi-mi:Alas2(display_short)|ensembl:alas2_mouse_gene(shortlabel)|psi-mi:ENSMUSG00000025270(display_long) psi-mi:"MI:0413"(electrophoretic mobility shift assay) Liew et al. (2005) pubmed:15644435|imex:IM-27656 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-25402403|imex:IM-27656-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:XP_011245750.1|refseq:NP_032115.1|dip:DIP-40883N|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P17679|rcsb pdb:1GNF|rcsb pdb:1Y0J|rcsb pdb:2L5E|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:3VD6|rcsb pdb:3VEK|reactome:R-MMU-8936459|reactome:R-MMU-8939236|reactome:R-MMU-983231|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|ensembl:ENSMUSG00000031162(gene)|ensembl:ENSMUST00000033502(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus) refseq:NM_001102446.1(see-also) - - - figure legend:Fig. 8|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/20 2020/04/12 rogid:zv2cIXaxDsuFj//cWvnvvL8jgiA10090 - - false glutathione s tranferase tag:?-?|mutation with no effect:205-205|mutation disrupting interaction strength:216-216|mutation with no effect:218-218|sufficient binding region:198..198-253..253(IPR000679) 32p radiolabel:?-?|sufficient binding region:?-? - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography)