#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BYF1	uniprotkb:P59594-PRO_0000037209	intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450	intact:EBI-25475261	psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym)	psi-mi:p59594-pro_0000037209(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Marzi et al. (2004)	pubmed:15479853|imex:IM-27894	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25507377|imex:IM-27894-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1	intact:EBI-15582614(chain-parent)	-	comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	chain-seq-start:14|chain-seq-end:667	figure legend:Fig. 2|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/09	2020/04/09	rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606	rogid:eYYsvD+lSmYl9D/Q+RGwHAX1laI694009	rigid:kYYGohKVJfLAKyoA+/BdBlGj9tk	false	-	fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9NNX6	uniprotkb:P59594-PRO_0000037209	intact:EBI-9257341|uniprotkb:A8KAM4|uniprotkb:A8MVQ9|uniprotkb:G5E9C4|uniprotkb:Q2TB19|uniprotkb:Q96QP7|uniprotkb:Q96QP8|uniprotkb:Q96QP9|uniprotkb:Q96QQ0|uniprotkb:Q96QQ1|uniprotkb:Q96QQ2|uniprotkb:Q96QQ3|uniprotkb:Q96QQ4|uniprotkb:Q96QQ5|uniprotkb:Q96QQ6|uniprotkb:Q96QQ7|uniprotkb:Q96QQ8|ensembl:ENSP00000315477	intact:EBI-25475261	psi-mi:cd209_human(display_long)|uniprotkb:CD209(gene name)|psi-mi:CD209(display_short)|uniprotkb:CLEC4L(gene name synonym)|uniprotkb:C-type lectin domain family 4 member L(gene name synonym)|uniprotkb:Dendritic cell-specific ICAM-3-grabbing non-integrin 1(gene name synonym)	psi-mi:p59594-pro_0000037209(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Marzi et al. (2004)	pubmed:15479853|imex:IM-27894	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25507393|imex:IM-27894-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138365.1|refseq:NP_001138366.1|refseq:NP_001138367.1|refseq:NP_001138368.1|refseq:NP_001138369.1|refseq:NP_066978.1|dip:DIP-60629N|ensembl:ENSG00000090659(gene)|ensembl:ENST00000315599(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0009988"(cell-cell recognition)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019079"(viral genome replication)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0043657"(host cell)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0075733"(intracellular transport of virus)|go:"GO:0097323"(B cell adhesion)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033989|rcsb pdb:1K9I|rcsb pdb:1SL4|rcsb pdb:1SL5|rcsb pdb:2B6B|rcsb pdb:2IT5|rcsb pdb:2IT6|rcsb pdb:2XR5|rcsb pdb:2XR6|rcsb pdb:6GHV|reactome:R-HSA-5621575|reactome:R-HSA-8851680	intact:EBI-15582614(chain-parent)	-	-	chain-seq-start:14|chain-seq-end:667	figure legend:Fig. 2|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/09	2020/04/09	rogid:veaQUZyFcAP3yYQgh9zN9sEzvUI9606	rogid:eYYsvD+lSmYl9D/Q+RGwHAX1laI694009	rigid:Ck/gGE9GDSNzdY1zr8wvXT88GXs	false	-	fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9H2X3	uniprotkb:P59594-PRO_0000037209	intact:EBI-1391211|uniprotkb:Q69F40|uniprotkb:Q969M4|uniprotkb:Q96QP3|uniprotkb:Q96QP4|uniprotkb:Q96QP5|uniprotkb:Q96QP6|uniprotkb:Q9BXS3|uniprotkb:Q9H2Q9|uniprotkb:Q9H8F0|uniprotkb:Q9Y2A8|uniprotkb:A6NKI4|uniprotkb:A8K8B3|ensembl:ENSP00000316228	intact:EBI-25475261	psi-mi:clc4m_human(display_long)|uniprotkb:CD209 antigen-like protein 1(gene name synonym)|uniprotkb:Dendritic cell-specific ICAM-3-grabbing non-integrin 2(gene name synonym)|uniprotkb:DC-SIGN-related protein(gene name synonym)|uniprotkb:Liver/lymph node-specific ICAM-3-grabbing non-integrin(gene name synonym)|uniprotkb:CLEC4M(gene name)|psi-mi:CLEC4M(display_short)|uniprotkb:CD209L(gene name synonym)|uniprotkb:CD209L1(gene name synonym)|uniprotkb:CD299(gene name synonym)	psi-mi:p59594-pro_0000037209(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Marzi et al. (2004)	pubmed:15479853|imex:IM-27894	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25507399|imex:IM-27894-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006722678.1|refseq:NP_001138377.1|refseq:NP_001138378.1|refseq:NP_001138379.1|refseq:NP_001138380.1|refseq:NP_001138381.1|refseq:NP_001138382.1|refseq:NP_001138383.1|refseq:NP_055072.3|ensembl:ENSG00000104938(gene)|ensembl:ENST00000327325(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0009988"(cell-cell recognition)|go:"GO:0016020"(membrane)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019079"(viral genome replication)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0043657"(host cell)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0075733"(intracellular transport of virus)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033989|rcsb pdb:1K9J|rcsb pdb:1SL6|rcsb pdb:1XAR|rcsb pdb:1XPH|rcsb pdb:1Z0Y|rcsb pdb:3JQH	intact:EBI-15582614(chain-parent)	-	-	chain-seq-start:14|chain-seq-end:667	figure legend:Fig. 2|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/04/09	2020/04/09	rogid:FR9EEv0vaGUvH/qu0Hg6gLa0yOw9606	rogid:eYYsvD+lSmYl9D/Q+RGwHAX1laI694009	rigid:zo1uhHSCASj0XUXQb7S2lQ1a8ac	false	-	fc-igg tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)