#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P59594-PRO_0000037209	intact:EBI-25487389	intact:EBI-25475261	-	psi-mi:p59594-pro_0000037209(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:mvp_chlae_protein(display_short)|psi-mi:EBI-25487389(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2003)	imex:IM-27824|pubmed:14647384	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25487299|imex:IM-27824-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15582614(chain-parent)	-	-	chain-seq-start:14|chain-seq-end:667	comment:similar to human Q14764 UniProt entry	figure legend:Fig. 1C, Table S1|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-vero)|taxid:9534("Chlorocebus (Cercopithecus) aethiops kidney cells")	-	2020/03/25	2020/03/25	rogid:eYYsvD+lSmYl9D/Q+RGwHAX1laI694009	-	-	false	tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P59594-PRO_0000037209	intact:EBI-25487391	intact:EBI-25475261	-	psi-mi:p59594-pro_0000037209(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:myo1b_chlae_protein(display_short)|psi-mi:EBI-25487391(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2003)	imex:IM-27824|pubmed:14647384	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25487299|imex:IM-27824-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15582614(chain-parent)	-	-	chain-seq-start:14|chain-seq-end:667	comment:similar to human O43795 UniProt entry	figure legend:Fig. 1C, Table S1|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-vero)|taxid:9534("Chlorocebus (Cercopithecus) aethiops kidney cells")	-	2020/03/25	2020/03/25	rogid:eYYsvD+lSmYl9D/Q+RGwHAX1laI694009	-	-	false	tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P59594-PRO_0000037209	uniprotkb:Q1LZX8	intact:EBI-25475261	intact:EBI-25487316	psi-mi:p59594-pro_0000037209(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:q1lzx8_chlae(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2003)	imex:IM-27824|pubmed:14647384	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25487299|imex:IM-27824-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-15582614(chain-parent)	go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR031588|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)	-	chain-seq-start:14|chain-seq-end:667	-	figure legend:Fig. 1C, Table S1|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-vero)|taxid:9534("Chlorocebus (Cercopithecus) aethiops kidney cells")	-	2020/03/25	2020/03/25	rogid:eYYsvD+lSmYl9D/Q+RGwHAX1laI694009	rogid:vh4QBtvXTzIcH1l7zPHi10xs2ng9534	-	false	tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9BYF1	uniprotkb:P59594-PRO_0000037209	intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450	intact:EBI-25475261	psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym)	psi-mi:p59594-pro_0000037209(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2003)	imex:IM-27824|pubmed:14647384	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25487344|imex:IM-27824-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1	intact:EBI-15582614(chain-parent)	-	comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	chain-seq-start:14|chain-seq-end:667	figure legend:Fig. 2C|caution:Prey was estimated to be ACE2 by weight by comparison to the over-expressed protein identified by western blot.|dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2020/03/25	2020/03/25	rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606	rogid:eYYsvD+lSmYl9D/Q+RGwHAX1laI694009	rigid:kYYGohKVJfLAKyoA+/BdBlGj9tk	false	-	fc-igg tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)