#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P15976 intact:EBI-25421818 intact:EBI-3909284|uniprotkb:Q96GB8|ensembl:ENSP00000365858 - psi-mi:gata1_human(display_long)|uniprotkb:GATA1(gene name)|psi-mi:GATA1(display_short)|uniprotkb:ERYF1(gene name synonym)|uniprotkb:GF1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) psi-mi:gata1_promoter_probe(display_short)|psi-mi:EBI-25421818(display_long) psi-mi:"MI:0412"(electrophoretic mobility supershift assay) Mehaffey et al. (2001) imex:IM-27086|pubmed:11675338 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25402527|imex:IM-27086-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0319"(deoxyribonucleic acid) refseq:NP_002040.1|ensembl:ENSG00000102145(gene)|ensembl:ENST00000376670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030222"(eosinophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P15976|rcsb pdb:6G0Q|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-983231|dip:DIP-41431N ddbj/embl/genbank:M59937(see-also) - - - figure legend:Figure 6|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/21 2020/02/04 rogid:Y/36ySlvsXrGtNSXa4y3Vl7iaJk9606 - - false mutation with no effect:208-208(10425) - - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:P15976 uniprotkb:O35615 intact:EBI-3909284|uniprotkb:Q96GB8|ensembl:ENSP00000365858 intact:EBI-4394596|ensembl:ENSMUSP00000058037 psi-mi:gata1_human(display_long)|uniprotkb:GATA1(gene name)|psi-mi:GATA1(display_short)|uniprotkb:ERYF1(gene name synonym)|uniprotkb:GF1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) psi-mi:fog1_mouse(display_long)|uniprotkb:Zfpm1(gene name)|psi-mi:Zfpm1(display_short)|uniprotkb:Fog(gene name synonym)|uniprotkb:Fog1(gene name synonym)|uniprotkb:Friend of GATA protein 1(gene name synonym)|uniprotkb:Zinc finger protein multitype 1(gene name synonym) psi-mi:"MI:0096"(pull down) Mehaffey et al. (2001) imex:IM-27086|pubmed:11675338 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25404169|imex:IM-27086-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002040.1|ensembl:ENSG00000102145(gene)|ensembl:ENST00000376670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030222"(eosinophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P15976|rcsb pdb:6G0Q|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-983231|dip:DIP-41431N dip:DIP-48414N|refseq:NP_033595.1|refseq:XP_006530914.1|ensembl:ENSMUSG00000049577(gene)|ensembl:ENSMUST00000054052(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003195"(tricuspid valve formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007507"(heart development)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060377"(negative regulation of mast cell differentiation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034731|interpro:IPR036236|interpro:IPR039746|rcsb pdb:1SRK|rcsb pdb:2MPL|reactome:R-MMU-8936459|reactome:R-MMU-983231 - - - figure legend:Figure 8a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/21 2020/01/22 rogid:Y/36ySlvsXrGtNSXa4y3Vl7iaJk9606 rogid:z2DMVqaiqrJqxmeLnoVFYSMx8J810090 rigid:f4X7EBlWUW7aw/eoCVACPZ2cP8k false 35s radiolabel:?-?|mutation with no effect:208-208(10425) glutathione s tranferase tag:n-n|sufficient binding region:241-295 - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:P15976 uniprotkb:O35615 intact:EBI-3909284|uniprotkb:Q96GB8|ensembl:ENSP00000365858 intact:EBI-4394596|ensembl:ENSMUSP00000058037 psi-mi:gata1_human(display_long)|uniprotkb:GATA1(gene name)|psi-mi:GATA1(display_short)|uniprotkb:ERYF1(gene name synonym)|uniprotkb:GF1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) psi-mi:fog1_mouse(display_long)|uniprotkb:Zfpm1(gene name)|psi-mi:Zfpm1(display_short)|uniprotkb:Fog(gene name synonym)|uniprotkb:Fog1(gene name synonym)|uniprotkb:Friend of GATA protein 1(gene name synonym)|uniprotkb:Zinc finger protein multitype 1(gene name synonym) psi-mi:"MI:0096"(pull down) Mehaffey et al. (2001) imex:IM-27086|pubmed:11675338 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25404345|imex:IM-27086-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002040.1|ensembl:ENSG00000102145(gene)|ensembl:ENST00000376670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030222"(eosinophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P15976|rcsb pdb:6G0Q|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-983231|dip:DIP-41431N dip:DIP-48414N|refseq:NP_033595.1|refseq:XP_006530914.1|ensembl:ENSMUSG00000049577(gene)|ensembl:ENSMUST00000054052(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003195"(tricuspid valve formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007507"(heart development)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060377"(negative regulation of mast cell differentiation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034731|interpro:IPR036236|interpro:IPR039746|rcsb pdb:1SRK|rcsb pdb:2MPL|reactome:R-MMU-8936459|reactome:R-MMU-983231 - - - figure legend:Figure 8a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/21 2020/01/22 rogid:Y/36ySlvsXrGtNSXa4y3Vl7iaJk9606 rogid:z2DMVqaiqrJqxmeLnoVFYSMx8J810090 rigid:f4X7EBlWUW7aw/eoCVACPZ2cP8k false 35s radiolabel:?-?|mutation increasing interaction strength:208-208(10425) glutathione s tranferase tag:n-n|sufficient binding region:677-760 - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:P15976 uniprotkb:O35615 intact:EBI-3909284|uniprotkb:Q96GB8|ensembl:ENSP00000365858 intact:EBI-4394596|ensembl:ENSMUSP00000058037 psi-mi:gata1_human(display_long)|uniprotkb:GATA1(gene name)|psi-mi:GATA1(display_short)|uniprotkb:ERYF1(gene name synonym)|uniprotkb:GF1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) psi-mi:fog1_mouse(display_long)|uniprotkb:Zfpm1(gene name)|psi-mi:Zfpm1(display_short)|uniprotkb:Fog(gene name synonym)|uniprotkb:Fog1(gene name synonym)|uniprotkb:Friend of GATA protein 1(gene name synonym)|uniprotkb:Zinc finger protein multitype 1(gene name synonym) psi-mi:"MI:0096"(pull down) Mehaffey et al. (2001) imex:IM-27086|pubmed:11675338 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25404359|imex:IM-27086-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002040.1|ensembl:ENSG00000102145(gene)|ensembl:ENST00000376670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030222"(eosinophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P15976|rcsb pdb:6G0Q|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-983231|dip:DIP-41431N dip:DIP-48414N|refseq:NP_033595.1|refseq:XP_006530914.1|ensembl:ENSMUSG00000049577(gene)|ensembl:ENSMUST00000054052(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003195"(tricuspid valve formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007507"(heart development)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060377"(negative regulation of mast cell differentiation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034731|interpro:IPR036236|interpro:IPR039746|rcsb pdb:1SRK|rcsb pdb:2MPL|reactome:R-MMU-8936459|reactome:R-MMU-983231 - - - figure legend:Figure 8a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/21 2020/01/22 rogid:Y/36ySlvsXrGtNSXa4y3Vl7iaJk9606 rogid:z2DMVqaiqrJqxmeLnoVFYSMx8J810090 rigid:f4X7EBlWUW7aw/eoCVACPZ2cP8k false 35s radiolabel:?-?|mutation decreasing interaction strength:208-208(10425) glutathione s tranferase tag:n-n|sufficient binding region:945-995 - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:P15976 uniprotkb:O35615 intact:EBI-3909284|uniprotkb:Q96GB8|ensembl:ENSP00000365858 intact:EBI-4394596|ensembl:ENSMUSP00000058037 psi-mi:gata1_human(display_long)|uniprotkb:GATA1(gene name)|psi-mi:GATA1(display_short)|uniprotkb:ERYF1(gene name synonym)|uniprotkb:GF1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) psi-mi:fog1_mouse(display_long)|uniprotkb:Zfpm1(gene name)|psi-mi:Zfpm1(display_short)|uniprotkb:Fog(gene name synonym)|uniprotkb:Fog1(gene name synonym)|uniprotkb:Friend of GATA protein 1(gene name synonym)|uniprotkb:Zinc finger protein multitype 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Mehaffey et al. (2001) imex:IM-27086|pubmed:11675338 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25404383|imex:IM-27086-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002040.1|ensembl:ENSG00000102145(gene)|ensembl:ENST00000376670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030222"(eosinophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P15976|rcsb pdb:6G0Q|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-983231|dip:DIP-41431N dip:DIP-48414N|refseq:NP_033595.1|refseq:XP_006530914.1|ensembl:ENSMUSG00000049577(gene)|ensembl:ENSMUST00000054052(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003195"(tricuspid valve formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007507"(heart development)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060377"(negative regulation of mast cell differentiation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034731|interpro:IPR036236|interpro:IPR039746|rcsb pdb:1SRK|rcsb pdb:2MPL|reactome:R-MMU-8936459|reactome:R-MMU-983231 - - - figure legend:Figure 8C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/01/21 2020/01/22 rogid:Y/36ySlvsXrGtNSXa4y3Vl7iaJk9606 rogid:z2DMVqaiqrJqxmeLnoVFYSMx8J810090 rigid:f4X7EBlWUW7aw/eoCVACPZ2cP8k false mutation with no effect:208-208(10425) binding-associated region:241-295|binding-associated region:677-760 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P15976 uniprotkb:O35615 intact:EBI-3909284|uniprotkb:Q96GB8|ensembl:ENSP00000365858 intact:EBI-4394596|ensembl:ENSMUSP00000058037 psi-mi:gata1_human(display_long)|uniprotkb:GATA1(gene name)|psi-mi:GATA1(display_short)|uniprotkb:ERYF1(gene name synonym)|uniprotkb:GF1(gene name synonym)|uniprotkb:Eryf1(gene name synonym)|uniprotkb:GATA-binding factor 1(gene name synonym)|uniprotkb:NF-E1 DNA-binding protein(gene name synonym) psi-mi:fog1_mouse(display_long)|uniprotkb:Zfpm1(gene name)|psi-mi:Zfpm1(display_short)|uniprotkb:Fog(gene name synonym)|uniprotkb:Fog1(gene name synonym)|uniprotkb:Friend of GATA protein 1(gene name synonym)|uniprotkb:Zinc finger protein multitype 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Mehaffey et al. (2001) imex:IM-27086|pubmed:11675338 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25404395|imex:IM-27086-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002040.1|ensembl:ENSG00000102145(gene)|ensembl:ENST00000376670(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030221"(basophil differentiation)|go:"GO:0030222"(eosinophil differentiation)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR029524|interpro:IPR039355|mint:P15976|rcsb pdb:6G0Q|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-983231|dip:DIP-41431N dip:DIP-48414N|refseq:NP_033595.1|refseq:XP_006530914.1|ensembl:ENSMUSG00000049577(gene)|ensembl:ENSMUST00000054052(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003195"(tricuspid valve formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007507"(heart development)|go:"GO:0010724"(regulation of definitive erythrocyte differentiation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060377"(negative regulation of mast cell differentiation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034731|interpro:IPR036236|interpro:IPR039746|rcsb pdb:1SRK|rcsb pdb:2MPL|reactome:R-MMU-8936459|reactome:R-MMU-983231 - - - figure legend:Figure 8C|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/01/21 2020/01/22 rogid:Y/36ySlvsXrGtNSXa4y3Vl7iaJk9606 rogid:z2DMVqaiqrJqxmeLnoVFYSMx8J810090 rigid:f4X7EBlWUW7aw/eoCVACPZ2cP8k false mutation decreasing interaction strength:208-208(10425) binding-associated region:945-995 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)