#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q4VIT4 uniprotkb:P55157 intact:EBI-22054129 intact:EBI-11614052|uniprotkb:A8K428|uniprotkb:Q08AM4|uniprotkb:Q6P5T3|ensembl:ENSP00000265517|ensembl:ENSP00000400821 psi-mi:pdia3_chlae(display_long)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP57(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym) psi-mi:mtp_human(display_long)|uniprotkb:MTTP(gene name)|psi-mi:MTTP(display_short)|uniprotkb:MTP(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Ohashi et al. (2000) pubmed:10946006|imex:IM-27800 taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25471289|imex:IM-27800-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR005788(Disulphide isomerase)|interpro:IPR041868|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR036249|interpro:IPR017937|interpro:IPR013766(Thioredoxin domain)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0042470"(melanosome) refseq:NP_000244.2|refseq:NP_001287714.1|ensembl:ENSG00000138823(gene)|ensembl:ENST00000265517(transcript)|ensembl:ENST00000457717(transcript)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006497"(protein lipidation)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008289"(lipid binding)|go:"GO:0009306"(protein secretion)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031982"(vesicle)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034377"(plasma lipoprotein particle assembly)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0120014"(phospholipid transfer activity)|go:"GO:0120019"(phosphatidylcholine transfer activity)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140344"(triglyceride transfer activity)|go:"GO:1902388"(ceramide 1-phosphate transfer activity)|go:"GO:1904121"(phosphatidylethanolamine transfer activity)|interpro:IPR001747(Lipid transport protein, N-terminal)|interpro:IPR011030(Vitellinogen, superhelical)|interpro:IPR015816(Vitellinogen, beta-sheet N-terminal)|interpro:IPR015819(Lipid transport protein, beta-sheet shell)|interpro:IPR039988|reactome:R-HSA-8866423|reactome:R-HSA-8963888 - - - figure legend:3|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2020/03/17 2020/03/17 rogid:8apkt3KHKAv+ZOLbIR9pgauhf/Y9534 rogid:ZMnGnFUwQrq2OzWC/Cwkdy7Eb4s9606 rigid:1AgIzzsKdFZSlKRrj/Zt3D1nUKY false - mutation with no effect:780-780(rs199422221) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)