#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O14964-2 uniprotkb:P35240-3 intact:EBI-21581128 intact:EBI-1014509|ensembl:ENSP00000380891|ensembl:ENSP00000384797|ensembl:ENSP00000500117|ensembl:ENSP00000500919 psi-mi:o149642(display_long)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:HRSi2(isoform synonym) psi-mi:p35240-3(display_long)|uniprotkb:II(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym) psi-mi:"MI:0018"(two hybrid) Scoles et al. (2000) imex:IM-27649|pubmed:10861283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25399437|imex:IM-27649-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O14964-2(isoform-parent) intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000397789(transcript)|ensembl:ENST00000403999(transcript)|ensembl:ENST00000672461(transcript)|ensembl:ENST00000672896(transcript) - - - dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/01/17 2020/01/17 rogid:OVmjXR+1jKDLD44PdvgOBenpaMs9606 rogid:KbT0gt29KcVwGSb15qUXv2NmNJ09606 rigid:BmoKze/UUZYxjKZJEOpabDPMKm8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O14964-2 uniprotkb:P35240-3 intact:EBI-21581128 intact:EBI-1014509|ensembl:ENSP00000380891|ensembl:ENSP00000384797|ensembl:ENSP00000500117|ensembl:ENSP00000500919 psi-mi:o149642(display_long)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:HRSi2(isoform synonym) psi-mi:p35240-3(display_long)|uniprotkb:II(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Scoles et al. (2000) imex:IM-27649|pubmed:10861283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25399452|imex:IM-27649-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O14964-2(isoform-parent) intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000397789(transcript)|ensembl:ENST00000403999(transcript)|ensembl:ENST00000672461(transcript)|ensembl:ENST00000672896(transcript) - - - figure legend:Fig 1a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-sts26t)|taxid:9606(human-sts26t cells) - 2020/01/17 2020/01/17 rogid:OVmjXR+1jKDLD44PdvgOBenpaMs9606 rogid:KbT0gt29KcVwGSb15qUXv2NmNJ09606 rigid:BmoKze/UUZYxjKZJEOpabDPMKm8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O14964-2 uniprotkb:P35240-3 intact:EBI-21581128 intact:EBI-1014509|ensembl:ENSP00000380891|ensembl:ENSP00000384797|ensembl:ENSP00000500117|ensembl:ENSP00000500919 psi-mi:o149642(display_long)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:HRSi2(isoform synonym) psi-mi:p35240-3(display_long)|uniprotkb:II(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Scoles et al. (2000) imex:IM-27649|pubmed:10861283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25399456|imex:IM-27649-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O14964-2(isoform-parent) intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000397789(transcript)|ensembl:ENST00000403999(transcript)|ensembl:ENST00000672461(transcript)|ensembl:ENST00000672896(transcript) - - - figure legend:Fig 1b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-sts26t)|taxid:9606(human-sts26t cells) - 2020/01/17 2020/01/17 rogid:OVmjXR+1jKDLD44PdvgOBenpaMs9606 rogid:KbT0gt29KcVwGSb15qUXv2NmNJ09606 rigid:BmoKze/UUZYxjKZJEOpabDPMKm8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O14964-1 uniprotkb:P35240-1 intact:EBI-21239519 intact:EBI-1014500|ensembl:ENSP00000344666 psi-mi:o149641(display_long)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:HRSi1(isoform synonym) psi-mi:p35240-1(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym) psi-mi:"MI:0096"(pull down) Scoles et al. (2000) imex:IM-27649|pubmed:10861283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25399587|imex:IM-27649-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O14964-1(isoform-parent) intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript) - - - figure legend:2b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2020/01/17 2020/01/17 rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606 rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606 rigid:VmcGwlJCjBMmqhw9BwrzFlKylvs false glutathione s tranferase tag:?-? sufficient binding region:299-595|35s radiolabel:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O14964-1 uniprotkb:P35240-1 intact:EBI-21239519 intact:EBI-1014500|ensembl:ENSP00000344666 psi-mi:o149641(display_long)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:HRSi1(isoform synonym) psi-mi:p35240-1(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym) psi-mi:"MI:0018"(two hybrid) Scoles et al. (2000) imex:IM-27649|pubmed:10861283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25399782|imex:IM-27649-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O14964-1(isoform-parent) intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript) - - - figure legend:4a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/01/17 2020/01/17 rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606 rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606 rigid:VmcGwlJCjBMmqhw9BwrzFlKylvs false - necessary binding region:306-579|sufficient binding region:1-579 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14964-2 uniprotkb:P35240-1 intact:EBI-21581128 intact:EBI-1014500|ensembl:ENSP00000344666 psi-mi:o149642(display_long)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:HRSi2(isoform synonym) psi-mi:p35240-1(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym) psi-mi:"MI:0018"(two hybrid) Scoles et al. (2000) imex:IM-27649|pubmed:10861283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25399786|imex:IM-27649-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O14964-2(isoform-parent) intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript) - - - figure legend:4a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/01/17 2020/01/17 rogid:OVmjXR+1jKDLD44PdvgOBenpaMs9606 rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606 rigid:oNjFyLNOJuLiVY+QiHRz5d1+2Ag false - sufficient binding region:1-579|necessary binding region:306-579 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14964-1 uniprotkb:P35240-3 intact:EBI-21239519 intact:EBI-1014509|ensembl:ENSP00000380891|ensembl:ENSP00000384797|ensembl:ENSP00000500117|ensembl:ENSP00000500919 psi-mi:o149641(display_long)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:HRSi1(isoform synonym) psi-mi:p35240-3(display_long)|uniprotkb:II(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym) psi-mi:"MI:0018"(two hybrid) Scoles et al. (2000) imex:IM-27649|pubmed:10861283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25399790|imex:IM-27649-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O14964-1(isoform-parent) intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000397789(transcript)|ensembl:ENST00000403999(transcript)|ensembl:ENST00000672461(transcript)|ensembl:ENST00000672896(transcript) - - - figure legend:4a, Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/01/17 2020/01/17 rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606 rogid:KbT0gt29KcVwGSb15qUXv2NmNJ09606 rigid:wdS+tg+1y12QLB6cOEdi5Jidt3Q false - sufficient binding region:363-590|necessary binding region:363-421|mutation decreasing interaction strength:360-360(rs74315492)|mutation decreasing interaction strength:46-46|mutation decreasing interaction strength:535-535(3286)|mutation decreasing interaction strength:538-538(3287) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14964-2 uniprotkb:P35240-3 intact:EBI-21581128 intact:EBI-1014509|ensembl:ENSP00000380891|ensembl:ENSP00000384797|ensembl:ENSP00000500117|ensembl:ENSP00000500919 psi-mi:o149642(display_long)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:HRSi2(isoform synonym) psi-mi:p35240-3(display_long)|uniprotkb:II(isoform synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:Schwannomin(gene name synonym) psi-mi:"MI:0018"(two hybrid) Scoles et al. (2000) imex:IM-27649|pubmed:10861283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-25399794|imex:IM-27649-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O14964-2(isoform-parent) intact:EBI-1014472(merl_human)|ensembl:ENSG00000186575(gene)|ensembl:ENST00000397789(transcript)|ensembl:ENST00000403999(transcript)|ensembl:ENST00000672461(transcript)|ensembl:ENST00000672896(transcript) - - - figure legend:4a, 4b, Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2020/01/17 2020/01/17 rogid:OVmjXR+1jKDLD44PdvgOBenpaMs9606 rogid:KbT0gt29KcVwGSb15qUXv2NmNJ09606 rigid:BmoKze/UUZYxjKZJEOpabDPMKm8 false - sufficient binding region:469-590|necessary binding region:469-518|mutation decreasing interaction strength:46-46|mutation decreasing interaction strength:360-360(3282)|mutation decreasing interaction strength:535-535(3286)|mutation decreasing interaction strength:538-538(3287) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14964-1 uniprotkb:P35240 intact:EBI-21239519 intact:EBI-1014472|uniprotkb:O95683|uniprotkb:Q8WUJ2|uniprotkb:Q969N0|uniprotkb:Q969Q3|uniprotkb:Q96T30|uniprotkb:Q96T31|uniprotkb:Q96T32|uniprotkb:Q96T33|uniprotkb:Q9BTW3|uniprotkb:Q9UNG9|uniprotkb:Q9UNH3|uniprotkb:Q9UNH4|ensembl:ENSP00000344666 psi-mi:o149641(display_long)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:HRSi1(isoform synonym) psi-mi:merl_human(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Scoles et al. (2000) imex:IM-27649|pubmed:10861283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-25399824|imex:IM-27649-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O14964-1(isoform-parent) refseq:NP_000259.1|refseq:NP_057502.2|refseq:NP_861546.1|refseq:NP_861966.1|refseq:NP_861967.1|refseq:NP_861968.1|refseq:NP_861969.1|refseq:NP_861970.1|refseq:NP_861971.1|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35240|rcsb pdb:1H4R|rcsb pdb:3U8Z|rcsb pdb:4ZRI|rcsb pdb:4ZRJ|rcsb pdb:6CDS|reactome:R-HSA-2029482|reactome:R-HSA-5627123|dip:DIP-35389N - - - figure legend:5a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-sts26t)|taxid:9606(human-sts26t cells) - 2020/01/17 2020/01/17 rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606 rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606 rigid:VmcGwlJCjBMmqhw9BwrzFlKylvs false xpress tag:?-? - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:O14964-1 uniprotkb:P35240 intact:EBI-21239519 intact:EBI-1014472|uniprotkb:O95683|uniprotkb:Q8WUJ2|uniprotkb:Q969N0|uniprotkb:Q969Q3|uniprotkb:Q96T30|uniprotkb:Q96T31|uniprotkb:Q96T32|uniprotkb:Q96T33|uniprotkb:Q9BTW3|uniprotkb:Q9UNG9|uniprotkb:Q9UNH3|uniprotkb:Q9UNH4|ensembl:ENSP00000344666 psi-mi:o149641(display_long)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)|uniprotkb:HRSi1(isoform synonym) psi-mi:merl_human(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Scoles et al. (2000) imex:IM-27649|pubmed:10861283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-25399831|imex:IM-27649-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:O14964-1(isoform-parent) refseq:NP_000259.1|refseq:NP_057502.2|refseq:NP_861546.1|refseq:NP_861966.1|refseq:NP_861967.1|refseq:NP_861968.1|refseq:NP_861969.1|refseq:NP_861970.1|refseq:NP_861971.1|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35240|rcsb pdb:1H4R|rcsb pdb:3U8Z|rcsb pdb:4ZRI|rcsb pdb:4ZRJ|rcsb pdb:6CDS|reactome:R-HSA-2029482|reactome:R-HSA-5627123|dip:DIP-35389N go:"GO:0005769"(early endosome) - - figure legend:5b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-sts26t)|taxid:9606(human-sts26t cells) - 2020/01/17 2020/01/17 rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606 rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606 rigid:VmcGwlJCjBMmqhw9BwrzFlKylvs false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)