#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q60034	uniprotkb:Q60034	intact:EBI-25642550|ensemblbacteria:AAD36708|uniprotkb:P96109	intact:EBI-25642550|ensemblbacteria:AAD36708|uniprotkb:P96109	psi-mi:dyr_thema(display_long)|uniprotkb:folA(gene name)|psi-mi:folA(display_short)|uniprotkb:dyrA(gene name synonym)|uniprotkb:TM_1641(locus name)	psi-mi:dyr_thema(display_long)|uniprotkb:folA(gene name)|psi-mi:folA(display_short)|uniprotkb:dyrA(gene name synonym)|uniprotkb:TM_1641(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Dams et al. (2000)	imex:IM-28215|pubmed:10731419	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25642569|imex:IM-28215-1|pdbe:1d1g	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050661"(NADP binding)|go:"GO:0046655"(folic acid metabolic process)|ensemblbacteria:AAD36708(transcript)|ensemblbacteria:TM_1641(gene)|go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046452"(dihydrofolate metabolic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|refseq:NP_229441.1|rcsb pdb:1CZ3|rcsb pdb:1D1G|interpro:IPR024072|interpro:IPR001796(Dihydrofolate reductase region)|refseq:WP_004082129.1	go:"GO:0050661"(NADP binding)|go:"GO:0046655"(folic acid metabolic process)|ensemblbacteria:AAD36708(transcript)|ensemblbacteria:TM_1641(gene)|go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046452"(dihydrofolate metabolic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|refseq:NP_229441.1|rcsb pdb:1CZ3|rcsb pdb:1D1G|interpro:IPR024072|interpro:IPR001796(Dihydrofolate reductase region)|refseq:WP_004082129.1	-	-	-	figure legend:Fig. 1|3d-resolution:2.1|3d-r-factors:19.6/24.2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/11	2020/07/30	rogid:M0tfRTO2OHk9umfQNEbwGgI+7EA243274	rogid:M0tfRTO2OHk9umfQNEbwGgI+7EA243274	-	false	sufficient binding region:2-169	sufficient binding region:2-169	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:44185"	uniprotkb:Q60034	intact:EBI-25764560|chebi:"CHEBI:44183"|chebi:"CHEBI:6837"	intact:EBI-25642550|ensemblbacteria:AAD36708|uniprotkb:P96109	psi-mi:methotrexate(display_short)|psi-mi:"CHEBI:44185"(display_long)|intact:4-amino-10-methylfolic acid(synonym)|intact:"4-amino-N(10)-methylpteroylglutamic acid"(synonym)|intact:Emtexate(synonym)|intact:Ledertrexate(synonym)|intact:Methotrexate(synonym)|intact:METHOTREXATE(synonym)|intact:methotrexate(synonym)|intact:methotrexatum(synonym)|intact:metotrexato(synonym)|intact:MTX(synonym)|intact:"N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid"(synonym)|intact:Rheumatrex(synonym)|intact:Trexall(synonym)|intact:"N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-L-glutamic acid"(iupac name)	psi-mi:dyr_thema(display_long)|uniprotkb:folA(gene name)|psi-mi:folA(display_short)|uniprotkb:dyrA(gene name synonym)|uniprotkb:TM_1641(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Dams et al. (2000)	imex:IM-28215|pubmed:10731419	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25642569|imex:IM-28215-1|pdbe:1d1g	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0050661"(NADP binding)|go:"GO:0046655"(folic acid metabolic process)|ensemblbacteria:AAD36708(transcript)|ensemblbacteria:TM_1641(gene)|go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046452"(dihydrofolate metabolic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|refseq:NP_229441.1|rcsb pdb:1CZ3|rcsb pdb:1D1G|interpro:IPR024072|interpro:IPR001796(Dihydrofolate reductase region)|refseq:WP_004082129.1	-	-	-	figure legend:Fig. 1|3d-resolution:2.1|3d-r-factors:19.6/24.2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/11	2020/07/30	-	rogid:M0tfRTO2OHk9umfQNEbwGgI+7EA243274	-	false	-	sufficient binding region:2-169	2	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16474"	uniprotkb:Q60034	intact:EBI-8785164|chebi:"CHEBI:44286"|chebi:"CHEBI:7425"|chebi:"CHEBI:13399"|chebi:"CHEBI:13400"|chebi:"CHEBI:21904"|chebi:"CHEBI:175555"	intact:EBI-25642550|ensemblbacteria:AAD36708|uniprotkb:P96109	psi-mi:nadph(display_short)|psi-mi:"CHEBI:16474"(display_long)|intact:dihydronicotinamide-adenine dinucleotide phosphate(synonym)|intact:NADPH(synonym)|intact:NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE(synonym)|intact:reduced nicotinamide-adenine dinucleotide phosphate(synonym)|intact:TPNH(synonym)|intact:"2'-O-phosphonoadenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}"(iupac name)	psi-mi:dyr_thema(display_long)|uniprotkb:folA(gene name)|psi-mi:folA(display_short)|uniprotkb:dyrA(gene name synonym)|uniprotkb:TM_1641(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Dams et al. (2000)	imex:IM-28215|pubmed:10731419	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25642569|imex:IM-28215-1|pdbe:1d1g	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0050661"(NADP binding)|go:"GO:0046655"(folic acid metabolic process)|ensemblbacteria:AAD36708(transcript)|ensemblbacteria:TM_1641(gene)|go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046452"(dihydrofolate metabolic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|refseq:NP_229441.1|rcsb pdb:1CZ3|rcsb pdb:1D1G|interpro:IPR024072|interpro:IPR001796(Dihydrofolate reductase region)|refseq:WP_004082129.1	-	inchi key:ACFIXJIJDZMPPO-NNYOXOHSSA-N	-	figure legend:Fig. 1|3d-resolution:2.1|3d-r-factors:19.6/24.2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/11	2020/07/30	-	rogid:M0tfRTO2OHk9umfQNEbwGgI+7EA243274	-	false	-	sufficient binding region:2-169	2	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60034	uniprotkb:Q60034	intact:EBI-25642550|ensemblbacteria:AAD36708|uniprotkb:P96109	intact:EBI-25642550|ensemblbacteria:AAD36708|uniprotkb:P96109	psi-mi:dyr_thema(display_long)|uniprotkb:folA(gene name)|psi-mi:folA(display_short)|uniprotkb:dyrA(gene name synonym)|uniprotkb:TM_1641(locus name)	psi-mi:dyr_thema(display_long)|uniprotkb:folA(gene name)|psi-mi:folA(display_short)|uniprotkb:dyrA(gene name synonym)|uniprotkb:TM_1641(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Dams et al. (2000)	imex:IM-28215|pubmed:10731419	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25642581|imex:IM-28215-3|pdbe:1cz3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0050661"(NADP binding)|go:"GO:0046655"(folic acid metabolic process)|ensemblbacteria:AAD36708(transcript)|ensemblbacteria:TM_1641(gene)|go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046452"(dihydrofolate metabolic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|refseq:NP_229441.1|rcsb pdb:1CZ3|rcsb pdb:1D1G|interpro:IPR024072|interpro:IPR001796(Dihydrofolate reductase region)|refseq:WP_004082129.1	go:"GO:0050661"(NADP binding)|go:"GO:0046655"(folic acid metabolic process)|ensemblbacteria:AAD36708(transcript)|ensemblbacteria:TM_1641(gene)|go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046452"(dihydrofolate metabolic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|refseq:NP_229441.1|rcsb pdb:1CZ3|rcsb pdb:1D1G|interpro:IPR024072|interpro:IPR001796(Dihydrofolate reductase region)|refseq:WP_004082129.1	-	-	-	figure legend:Fig. 1|3d-resolution:2.1|3d-r-factors:20.3/25.5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2020/06/11	2020/06/11	rogid:M0tfRTO2OHk9umfQNEbwGgI+7EA243274	rogid:M0tfRTO2OHk9umfQNEbwGgI+7EA243274	rigid:IOIBY59wc2HyvwBy/sIzYo6OzA0	false	sufficient binding region:2-169	sufficient binding region:2-169	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)