#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P09038	uniprotkb:P21802-1	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-15489960|ensembl:ENSP00000351276	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:p21802-1(display_long)|uniprotkb:K-sam(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)|uniprotkb:BEK(isoform synonym)|uniprotkb:FGFR2IIIc(isoform synonym)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:KSAM(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Anderson et al. (1998)	pubmed:9700203|imex:IM-27515	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22228481|imex:IM-27515-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	ensembl:ENSG00000066468(gene)|ensembl:ENST00000358487(transcript)|intact:EBI-1028658(isoform-parent)	-	-	-	figure legend:Fig. 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/25	2019/11/25	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:XW6x8AHgdb29IL3MhUFWpv4jaqE9606	rigid:GnGOir3ByIM0mJHjrbVaDtNQDT4	false	-	mutation with no effect:252-252(13272)|mutation with no effect:253-253(13273)|mutation disrupting interaction strength:267-267(13290)|sufficient binding region:1-362	2	2	psi-mi:"MI:0039"(edman degradation)	psi-mi:"MI:0039"(edman degradation)
uniprotkb:P21802-1	uniprotkb:P21802-1	intact:EBI-15489960|ensembl:ENSP00000351276	intact:EBI-15489960|ensembl:ENSP00000351276	psi-mi:p21802-1(display_long)|uniprotkb:K-sam(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)|uniprotkb:BEK(isoform synonym)|uniprotkb:FGFR2IIIc(isoform synonym)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:KSAM(gene name synonym)	psi-mi:p21802-1(display_long)|uniprotkb:K-sam(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)|uniprotkb:BEK(isoform synonym)|uniprotkb:FGFR2IIIc(isoform synonym)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:KSAM(gene name synonym)	psi-mi:"MI:0276"(blue native page)	Anderson et al. (1998)	pubmed:9700203|imex:IM-27515	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22267437|imex:IM-27515-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000066468(gene)|ensembl:ENST00000358487(transcript)|intact:EBI-1028658(isoform-parent)	ensembl:ENSG00000066468(gene)|ensembl:ENST00000358487(transcript)|intact:EBI-1028658(isoform-parent)	-	-	-	figure legend:Fig. 2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/11/25	2019/12/04	rogid:XW6x8AHgdb29IL3MhUFWpv4jaqE9606	rogid:XW6x8AHgdb29IL3MhUFWpv4jaqE9606	rigid:O7hYZgo25z5T6mYOvdfau35UHBA	false	sufficient binding region:1-362	sufficient binding region:1-362	1	1	psi-mi:"MI:0039"(edman degradation)	psi-mi:"MI:0039"(edman degradation)
uniprotkb:P09038	uniprotkb:P21802-1	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-15489960|ensembl:ENSP00000351276	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:p21802-1(display_long)|uniprotkb:K-sam(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)|uniprotkb:BEK(isoform synonym)|uniprotkb:FGFR2IIIc(isoform synonym)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:KSAM(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anderson et al. (1998)	pubmed:9700203|imex:IM-27515	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22228517|imex:IM-27515-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	ensembl:ENSG00000066468(gene)|ensembl:ENST00000358487(transcript)|intact:EBI-1028658(isoform-parent)	-	-	-	figure legend:Fig. 3, 4, Table 1, Fig. 6|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.9x10^-10(molar)|koff:6.52x10^-4(second -1)	2019/11/25	2019/11/25	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:XW6x8AHgdb29IL3MhUFWpv4jaqE9606	rigid:GnGOir3ByIM0mJHjrbVaDtNQDT4	false	-	sufficient binding region:1-362|mutation increasing interaction strength:252-252(13272)|mutation increasing interaction strength:253-253(13273)|mutation with no effect:252-252(549484)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05230	uniprotkb:P21802-1	intact:EBI-698068|uniprotkb:P07502|uniprotkb:Q16588|uniprotkb:B2R5T0|uniprotkb:D3DQF2|ensembl:ENSP00000338548|ensembl:ENSP00000352329|ensembl:ENSP00000367285|ensembl:ENSP00000396195|ensembl:ENSP00000404742|ensembl:ENSP00000479024|ensembl:ENSP00000480791|ensembl:ENSP00000480980|ensembl:ENSP00000481868	intact:EBI-15489960|ensembl:ENSP00000351276	psi-mi:fgf1_human(display_long)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:FGFA(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)	psi-mi:p21802-1(display_long)|uniprotkb:K-sam(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)|uniprotkb:BEK(isoform synonym)|uniprotkb:FGFR2IIIc(isoform synonym)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:KSAM(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anderson et al. (1998)	pubmed:9700203|imex:IM-27515	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22228539|imex:IM-27515-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000791.1|refseq:NP_001138364.1|refseq:NP_001138406.1|refseq:NP_001138407.1|refseq:NP_149127.1|refseq:NP_001244134.1|refseq:NP_001244136.1|refseq:NP_001244137.1|refseq:NP_001244138.1|refseq:NP_001244139.1|dip:DIP-3787N|ensembl:ENSG00000113578(gene)|ensembl:ENST00000337706(transcript)|ensembl:ENST00000359370(transcript)|ensembl:ENST00000378046(transcript)|ensembl:ENST00000419524(transcript)|ensembl:ENST00000441680(transcript)|ensembl:ENST00000610990(transcript)|ensembl:ENST00000612258(transcript)|ensembl:ENST00000619447(transcript)|ensembl:ENST00000621536(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AXM|rcsb pdb:1DJS|rcsb pdb:1DZC|rcsb pdb:1DZD|rcsb pdb:1E0O|rcsb pdb:1EVT|rcsb pdb:1HKN|rcsb pdb:1JQZ|rcsb pdb:1JT3|rcsb pdb:1JT4|rcsb pdb:1JT5|rcsb pdb:1JT7|rcsb pdb:1JTC|rcsb pdb:1JY0|rcsb pdb:1K5U|rcsb pdb:1K5V|rcsb pdb:1M16|rcsb pdb:1NZK|rcsb pdb:1P63|rcsb pdb:1PZZ|rcsb pdb:1Q03|rcsb pdb:1Q04|rcsb pdb:1QCT|rcsb pdb:1RG8|rcsb pdb:1RML|rcsb pdb:1RY7|rcsb pdb:1YTO|rcsb pdb:1Z2V|rcsb pdb:1Z4S|rcsb pdb:2AFG|rcsb pdb:2AQZ|rcsb pdb:2AXM|rcsb pdb:2ERM|rcsb pdb:2HW9|rcsb pdb:2HWA|rcsb pdb:2HWM|rcsb pdb:2HZ9|rcsb pdb:2K43|rcsb pdb:2K4A|rcsb pdb:2K8R|rcsb pdb:2KI4|rcsb pdb:2KI6|rcsb pdb:2NTD|rcsb pdb:2Q9X|rcsb pdb:2RQ9|rcsb pdb:3B9U|rcsb pdb:3BA4|rcsb pdb:3BA5|rcsb pdb:3BA7|rcsb pdb:3BAD|rcsb pdb:3BAG|rcsb pdb:3BAH|rcsb pdb:3BAO|rcsb pdb:3BAQ|rcsb pdb:3BAU|rcsb pdb:3BAV|rcsb pdb:3BB2|rcsb pdb:3CQA|rcsb pdb:3CRG|rcsb pdb:3CRH|rcsb pdb:3CRI|rcsb pdb:3CU1|rcsb pdb:3FGM|rcsb pdb:3FJ8|rcsb pdb:3FJ9|rcsb pdb:3FJA|rcsb pdb:3FJB|rcsb pdb:3FJC|rcsb pdb:3FJD|rcsb pdb:3FJE|rcsb pdb:3FJF|rcsb pdb:3FJH|rcsb pdb:3FJI|rcsb pdb:3FJJ|rcsb pdb:3FJK|rcsb pdb:3HOM|rcsb pdb:3JUT|rcsb pdb:3K1X|rcsb pdb:3O3Q|rcsb pdb:3OJ2|rcsb pdb:3OJM|rcsb pdb:3OJV|rcsb pdb:3UD7|rcsb pdb:3UD8|rcsb pdb:3UD9|rcsb pdb:3UDA|rcsb pdb:4J23|rcsb pdb:4Q91|rcsb pdb:4Q9G|rcsb pdb:4Q9P|rcsb pdb:4QAL|rcsb pdb:4QBC|rcsb pdb:4QBV|rcsb pdb:4QC4|rcsb pdb:4QO3|rcsb pdb:4XKI|rcsb pdb:4YOL|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190370|reactome:R-HSA-190371|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338	ensembl:ENSG00000066468(gene)|ensembl:ENST00000358487(transcript)|intact:EBI-1028658(isoform-parent)	-	-	-	figure legend:Fig. 5a, 5b, Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	koff:6.35x10^-4(second -1)|kd:7.91x10^-10(molar)	2019/11/25	2019/11/25	rogid:k1O8U8SRvl73sZ+J+gxmlUjAGow9606	rogid:XW6x8AHgdb29IL3MhUFWpv4jaqE9606	rigid:+5Wv6EysW5Hnhgdpu6JwNHUYkbU	false	-	sufficient binding region:1-362|mutation increasing interaction strength:252-252(13272)|mutation with no effect:253-253(13273)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08620	uniprotkb:P21802-1	intact:EBI-11478828|uniprotkb:B7U994|ensembl:ENSP00000168712	intact:EBI-15489960|ensembl:ENSP00000351276	psi-mi:fgf4_human(display_long)|uniprotkb:FGF4(gene name)|psi-mi:FGF4(display_short)|uniprotkb:HST(gene name synonym)|uniprotkb:HSTF1(gene name synonym)|uniprotkb:KS3(gene name synonym)|uniprotkb:Heparin secretory-transforming protein 1(gene name synonym)|uniprotkb:Heparin-binding growth factor 4(gene name synonym)|uniprotkb:Transforming protein KS3(gene name synonym)	psi-mi:p21802-1(display_long)|uniprotkb:K-sam(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)|uniprotkb:BEK(isoform synonym)|uniprotkb:FGFR2IIIc(isoform synonym)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:KSAM(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anderson et al. (1998)	pubmed:9700203|imex:IM-27515	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22228554|imex:IM-27515-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001998.1|refseq:XP_005273904.1|ensembl:ENSG00000075388(gene)|ensembl:ENST00000168712(transcript)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028239|rcsb pdb:1IJT|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853338|dip:DIP-4017N	ensembl:ENSG00000066468(gene)|ensembl:ENST00000358487(transcript)|intact:EBI-1028658(isoform-parent)	-	-	-	figure legend:Fig. 5, Table 1|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.12x10^-10(molar)|koff:6.1x10^-4(second -1)	2019/11/25	2019/11/25	rogid:3OspRhbda5HA9lURzds+F01fXHA9606	rogid:XW6x8AHgdb29IL3MhUFWpv4jaqE9606	rigid:NMv4vtUGnlQJE6qxp3eXIZ08Jk0	false	-	sufficient binding region:1-362|mutation with no effect:252-252(13272)|mutation with no effect:253-253(13273)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)