#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P09613 uniprotkb:Q9NZM1 intact:EBI-21497244 intact:EBI-1994363|uniprotkb:Q5VWW2|uniprotkb:Q5VWW3|uniprotkb:Q5VWW4|uniprotkb:Q5VWW5|uniprotkb:Q7Z642|uniprotkb:Q8IWH0|uniprotkb:Q9HBU3|uniprotkb:Q9NZM0|uniprotkb:Q9ULL3|uniprotkb:Q9Y4U4|uniprotkb:B3KQN5|ensembl:ENSP00000352208 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:myof_human(display_long)|uniprotkb:MYOF(gene name)|psi-mi:MYOF(display_short)|uniprotkb:KIAA1207(gene name synonym)|uniprotkb:FER1L3(gene name synonym)|uniprotkb:Fer-1-like protein 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_038479.1|refseq:NP_579899.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR006614(Dysferlin, C-terminal)|interpro:IPR012560(FerA)|interpro:IPR012561(FerB)|interpro:IPR012968(FerI)|interpro:IPR029999|interpro:IPR032362|interpro:IPR035892|interpro:IPR037720|interpro:IPR037721|interpro:IPR037722|interpro:IPR037723|interpro:IPR037724|interpro:IPR037725|interpro:IPR037726|mint:Q9NZM1|rcsb pdb:2DMH|rcsb pdb:2K2O|rcsb pdb:6EEL|ensembl:ENSG00000138119(gene)|ensembl:ENST00000359263(transcript)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006936"(muscle contraction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008015"(blood circulation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0061025"(membrane fusion) - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:YbWzqcootZO0/w6OLRqxZEEAu9U9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q6PIW4 intact:EBI-21497244 intact:EBI-8468390|uniprotkb:D3DVM6|intact:MINT-4940916|intact:MINT-4926768|uniprotkb:Q86V18|intact:MINT-4920988|uniprotkb:Q9H8P1|intact:MINT-4908266|intact:MINT-3069016|uniprotkb:Q9H917|uniprotkb:Q8ND59|ensembl:ENSP00000349356|ensembl:ENSP00000378924|ensembl:ENSP00000399997|ensembl:ENSP00000410811|ensembl:ENSP00000481751|ensembl:ENSP00000483126|ensembl:ENSP00000483543|ensembl:ENSP00000484551 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:figl1_human(display_long)|uniprotkb:FIGNL1(gene name)|psi-mi:FIGNL1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_001333487.1|refseq:NP_001333488.1|refseq:NP_001333489.1|refseq:NP_001333490.1|refseq:NP_001333491.1|refseq:NP_001333492.1|refseq:NP_001333493.1|refseq:NP_001333494.1|refseq:XP_011513772.1|refseq:NP_071399.2|refseq:NP_001036227.1|refseq:NP_001274421.1|refseq:NP_001274422.1|refseq:NP_001274423.1|refseq:NP_001274424.1|refseq:NP_001274425.1|refseq:XP_016867990.1|ensembl:ENSG00000132436(gene)|ensembl:ENST00000356889(transcript)|ensembl:ENST00000395556(transcript)|ensembl:ENST00000419119(transcript)|ensembl:ENST00000433017(transcript)|ensembl:ENST00000611938(transcript)|ensembl:ENST00000613602(transcript)|ensembl:ENST00000615084(transcript)|ensembl:ENST00000617389(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|mint:Q6PIW4|rcsb pdb:3D8B - - comment:mint|comment:homomint|function:May regulate osteoblast proliferation and differentiation figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:Up69HKKMMUtt3/8MYUxUCcW002c9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:O43592 intact:EBI-21497244 intact:EBI-286683|uniprotkb:A6NLH1|uniprotkb:O43784|uniprotkb:Q8WUG2|uniprotkb:Q9BVS7|ensembl:ENSP00000327821 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:xpot_human(display_long)|uniprotkb:tRNA exportin(gene name synonym)|uniprotkb:"Exportin(tRNA)"(gene name synonym)|uniprotkb:XPOT(gene name)|psi-mi:XPOT(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_009166.2|refseq:XP_016874237.1|ensembl:ENSG00000184575(gene)|ensembl:ENST00000332707(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031267"(small GTPase binding)|go:"GO:0071528"(tRNA re-export from nucleus)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040017|mint:O43592|reactome:R-HSA-6784531 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:S0p7em6zWNUHEuAYueP+ZTrKTKg9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q9Y5L0 intact:EBI-21497244 intact:EBI-1042571|uniprotkb:A4D1K9|uniprotkb:Q6NUM1|uniprotkb:Q96G71|uniprotkb:Q96GU9|uniprotkb:Q9Y3R2|uniprotkb:C9IZM0|ensembl:ENSP00000265388 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:tnpo3_human(display_long)|uniprotkb:TNPO3(gene name)|psi-mi:TNPO3(display_short)|uniprotkb:IPO12(gene name synonym)|uniprotkb:Transportin-SR(gene name synonym)|uniprotkb:Importin-12(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_001177957.2|refseq:NP_036602.1|ensembl:ENSG00000064419(gene)|ensembl:ENST00000265388(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|mint:Q9Y5L0|rcsb pdb:4C0O|rcsb pdb:4C0P|rcsb pdb:4C0Q|rcsb pdb:4OL0|rcsb pdb:6GX9 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:Xvd5fZ4wlMc6R6w2wL+JhIOOuIE9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:P40855 intact:EBI-21497244 intact:EBI-594747|uniprotkb:Q8NI97|intact:EBI-981972|uniprotkb:Q5QNY4|uniprotkb:D3DVE7|ensembl:ENSP00000357051 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:pex19_human(display_long)|uniprotkb:PEX19(gene name)|psi-mi:PEX19(display_short)|uniprotkb:HK33(gene name synonym)|uniprotkb:PXF(gene name synonym)|uniprotkb:OK/SW-cl.22(orf name)|uniprotkb:Peroxin-19(gene name synonym)|uniprotkb:Peroxisomal farnesylated protein(gene name synonym)|uniprotkb:33 kDa housekeeping protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_001180573.1|refseq:NP_002848.1|dip:DIP-24172N|ensembl:ENSG00000162735(gene)|ensembl:ENST00000368072(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0007031"(peroxisome organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016557"(peroxisome membrane biogenesis)|go:"GO:0016559"(peroxisome fission)|go:"GO:0031526"(brush border membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033328"(peroxisome membrane targeting sequence binding)|go:"GO:0036105"(peroxisome membrane class-1 targeting sequence binding)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0072663"(establishment of protein localization to peroxisome)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900131"(negative regulation of lipid binding)|interpro:IPR006708(Pex19 protein)|interpro:IPR038322|mint:P40855|rcsb pdb:2W85|rcsb pdb:2WL8|rcsb pdb:3AJB|rcsb pdb:3MK4|rcsb pdb:5LNF|reactome:R-HSA-1369062|reactome:R-HSA-9603798 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:yNnX2hPPJ7miGaz2Req0qFn0L189606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q8TEX9 intact:EBI-21497244 intact:EBI-395967|uniprotkb:Q2NL96|uniprotkb:Q86TZ9|uniprotkb:Q8NCG8|uniprotkb:Q96SJ3|uniprotkb:Q9BTI4|uniprotkb:Q9H5L0|uniprotkb:B2RN95|ensembl:ENSP00000346453|ensembl:ENSP00000494795 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:ipo4_human(display_long)|uniprotkb:IPO4(gene name)|psi-mi:IPO4(display_short)|uniprotkb:IMP4B(gene name synonym)|uniprotkb:RANBP4(gene name synonym)|uniprotkb:Importin-4b(gene name synonym)|uniprotkb:Ran-binding protein 4(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_078934.3|dip:DIP-32944N|ensembl:ENSG00000196497(gene)|ensembl:ENSG00000285248(gene)|ensembl:ENST00000354464(transcript)|ensembl:ENST00000644546(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR034085|interpro:IPR040122|mint:Q8TEX9|rcsb pdb:5XAH|rcsb pdb:5XBK - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:PVIcGG3WTf0QmYbS0vvy049EjlQ9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q9NR50 intact:EBI-21497244 intact:EBI-702257|uniprotkb:Q5QP89|uniprotkb:Q5QP90|uniprotkb:Q8NDB5|uniprotkb:Q8WV57|uniprotkb:Q9H850|uniprotkb:B2RBH8|uniprotkb:D3DPZ2|ensembl:ENSP00000353575 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:ei2bg_human(display_long)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit gamma(gene name synonym)|uniprotkb:EIF2B3(gene name)|psi-mi:EIF2B3(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_001160060.1|refseq:NP_065098.1|refseq:NP_001248347.1|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|rcsb pdb:7D45|ensembl:ENST00000360403(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000070785(gene)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021766"(hippocampus development)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR025877|interpro:IPR029044|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:wGjFfKA+E5rYJfmocP6qcTQ9+SU9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:P16615 intact:EBI-21497244 intact:EBI-358933|uniprotkb:P16614|uniprotkb:A6NDN7|uniprotkb:B4DF05|uniprotkb:Q86VJ2|ensembl:ENSP00000440045 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:at2a2_human(display_long)|uniprotkb:ATP2A2(gene name)|psi-mi:ATP2A2(display_short)|uniprotkb:ATP2B(gene name synonym)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_001672.1|refseq:NP_733765.1|refseq:XP_011536704.1|ensembl:ENSG00000174437(gene)|ensembl:ENST00000539276(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008544"(epidermis development)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014801"(longitudinal sarcoplasmic reticulum)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P16615|rcsb pdb:5ZTF|rcsb pdb:6JJU|rcsb pdb:6LLE|rcsb pdb:6LLY|rcsb pdb:6LN5|rcsb pdb:6LN6|rcsb pdb:6LN7|rcsb pdb:6LN8|rcsb pdb:6LN9|rcsb pdb:7BT2|reactome:R-HSA-1912420|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0000045"(autophagosome assembly)|refseq:XP_005253945.1|dip:DIP-33868N - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:QlJZW2fprLYahKUrHDOVs28kA2w9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:P33453 intact:EBI-21497244 intact:EBI-21497354 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:l_uuks(display_long)|uniprotkb:L(gene name)|psi-mi:L(display_short)|uniprotkb:Large structural protein(gene name synonym)|uniprotkb:Replicase(gene name synonym)|uniprotkb:Transcriptase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 go:"GO:0000166"(nucleotide binding)|go:"GO:0001882"(nucleoside binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0039696"(RNA-templated viral transcription)|interpro:IPR022531|interpro:IPR029124|interpro:IPR007099(RNA-directed RNA polymerase, negative-strand RNA virus)|interpro:IPR014385(Predicted RNA-directed RNA polymerase, Phlebovirus type)|interpro:IPR007322(RNA-dependent RNA polymerase, bunyaviral) - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:X0ZO770iWonDSj4XtUN84UWPAN0487099 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:P22025 intact:EBI-21497244 intact:EBI-21497344 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:ncap_uuks(display_long)|uniprotkb:N(gene name)|psi-mi:N(display_short)|uniprotkb:Nucleocapsid protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 go:"GO:0003723"(RNA binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019029"(helical viral capsid)|interpro:IPR009522(Phlebovirus nucleocapsid)|interpro:IPR015971(Phlebovirus nucleocapsid, subgroup) - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:Uylgxi4ganUuRCN7xyl/4wquLnQ487099 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q9BXW9 intact:EBI-21497244 intact:EBI-359343|uniprotkb:Q2LA86|uniprotkb:Q69YP9|uniprotkb:Q6PJN7|uniprotkb:Q9BQ06|uniprotkb:Q9H9T9|ensembl:ENSP00000398754|ensembl:ENSP00000502379 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:facd2_human(display_long)|uniprotkb:FANCD2(gene name)|psi-mi:FANCD2(display_short)|uniprotkb:FACD(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_001018125.1|refseq:NP_149075.2|refseq:NP_001306913.1|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR029448|mint:Q9BXW9|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|ensembl:ENSG00000144554(gene)|ensembl:ENST00000419585(transcript)|ensembl:ENST00000675286(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|reactome:R-HSA-6796648|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|dip:DIP-27606N|dip:DIP-29382N - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:9szrKioB24vbUy47a30DPUQhqkA9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:O00410 intact:EBI-21497244 intact:EBI-356424|uniprotkb:O15257|intact:EBI-1105173|uniprotkb:B4DZA0|uniprotkb:Q5T578|uniprotkb:Q86XC7|ensembl:ENSP00000350219|ensembl:ENSP00000418393|ensembl:ENSP00000499125 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:ipo5_human(display_long)|uniprotkb:IPO5(gene name)|psi-mi:IPO5(display_short)|uniprotkb:KPNB3(gene name synonym)|uniprotkb:RANBP5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_002262.3|refseq:XP_011519389.1|refseq:XP_011519390.1|refseq:XP_011519391.1|refseq:XP_011519392.1|ensembl:ENSG00000065150(gene)|ensembl:ENST00000357602(transcript)|ensembl:ENST00000490680(transcript)|ensembl:ENST00000651721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|refseq:XP_005254109.1|refseq:XP_005254110.1|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:O00410|rcsb pdb:6XTE|rcsb pdb:6XU2|reactome:R-HSA-192905|refseq:XP_016876051.1|dip:DIP-41042N - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:jBYLvkqyYyWAu1TdCVyCMh9ZHKY9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q96P70 intact:EBI-21497244 intact:EBI-356319|intact:EBI-1059309|uniprotkb:Q8N1Y1|uniprotkb:Q8N3I2|uniprotkb:Q8NCG9|uniprotkb:Q96SU6|uniprotkb:Q9NW01|uniprotkb:Q9P0A8|uniprotkb:Q9ULM8|ensembl:ENSP00000354742|uniprotkb:B1ASV5 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:ipo9_human(display_long)|uniprotkb:HSPC273(orf name)|uniprotkb:IPO9(gene name)|psi-mi:IPO9(display_short)|uniprotkb:IMP9(gene name synonym)|uniprotkb:KIAA1192(gene name synonym)|uniprotkb:RANBP9(gene name synonym)|uniprotkb:Ran-binding protein 9(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_060555.2|ensembl:ENSG00000198700(gene)|ensembl:ENST00000361565(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|mint:Q96P70|rcsb pdb:6N1Z - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:jsjQSBULeF1L2FlDcPZouMz6pJE9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q99442 intact:EBI-21497244 intact:EBI-949221|ensembl:ENSP00000337688|ensembl:ENSP00000420331|uniprotkb:O00682|uniprotkb:O00729|intact:EBI-2689278|uniprotkb:D3DNQ0 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:sec62_human(display_long)|uniprotkb:SEC62(gene name)|psi-mi:SEC62(display_short)|uniprotkb:TLOC1(gene name synonym)|uniprotkb:Translocation protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 ensembl:ENSG00000008952(gene)|ensembl:ENST00000337002(transcript)|ensembl:ENST00000480708(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR004728(Translocation protein Sec62)|rcsb pdb:7BRT|refseq:NP_003253.1 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:u7na6TjTcixVS+ZK2ygkFA1QDKY9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:O60427 intact:EBI-21497244 intact:EBI-1055473|uniprotkb:B2RAI0|uniprotkb:Q53GM5|uniprotkb:Q8N3A6|uniprotkb:Q8NCC7|uniprotkb:Q8NCG0|uniprotkb:Q96I39|uniprotkb:Q96SV3|uniprotkb:Q96T10|uniprotkb:Q9NRP8|uniprotkb:Q9NYX1|uniprotkb:A8K0I7 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:fads1_human(display_long)|uniprotkb:"Delta(5) fatty acid desaturase"(gene name synonym)|uniprotkb:FADS1(gene name)|psi-mi:FADS1(display_short)|uniprotkb:FADSD5(gene name synonym)|uniprotkb:Fatty acid desaturase 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_037534.3|interpro:IPR001199(Cytochrome b5)|interpro:IPR012171(Fatty acid/sphingolipid desaturase)|interpro:IPR005804(Fatty acid desaturase, type 1)|reactome:R-HSA-2046106|reactome:R-HSA-1989781|reactome:R-HSA-2046105|go:"GO:0000248"(C-5 sterol desaturase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006636"(unsaturated fatty acid biosynthetic process)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016213"(linoleoyl-CoA desaturase activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045485"(omega-6 fatty acid desaturase activity)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0062076"(acyl-CoA delta5-desaturase activity)|interpro:IPR036400 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:QbDub2xthvy52AHQlav+slJkEVM9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:O15260 intact:EBI-21497244 intact:EBI-1044848|uniprotkb:O60923|uniprotkb:Q9UNZ0|uniprotkb:Q9UNZ1|uniprotkb:Q5T8U6|ensembl:ENSP00000361057|ensembl:ENSP00000486049|uniprotkb:B7Z6A4 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:surf4_human(display_long)|uniprotkb:SURF4(gene name)|psi-mi:SURF4(display_short)|uniprotkb:SURF-4(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_149351.1|ensembl:ENSG00000148248(gene)|ensembl:ENSG00000280951(gene)|ensembl:ENST00000629578(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035577"(azurophil granule membrane)|interpro:IPR002995(Surfeit locus 4)|mint:O15260|reactome:R-HSA-6798695|reactome:R-HSA-6811434|ensembl:ENST00000371989(transcript)|refseq:NP_001267718.1|refseq:NP_001267721.1 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:VEkKSEfWLmSZx209HLRfoMMTzsg9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:P43487 intact:EBI-21497244 intact:EBI-1032909|uniprotkb:Q53EY3|ensembl:ENSP00000327583 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:rang_human(display_long)|uniprotkb:RANBP1(gene name)|psi-mi:RANBP1(display_short)|uniprotkb:Ran-binding protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_002873.1|ensembl:ENSG00000099901(gene)|ensembl:ENST00000331821(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046604"(positive regulation of mitotic centrosome separation)|go:"GO:0046907"(intracellular transport)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1K5D|rcsb pdb:1K5G|reactome:R-HSA-165054|refseq:NP_001265568.1|refseq:NP_001265569.1|dip:DIP-35058N - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:OWndphaUCDSO3+MGhJqcuQo2Lk09606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q92538 intact:EBI-21497244 intact:EBI-359050|uniprotkb:Q5VXX3|uniprotkb:Q96CK6|uniprotkb:Q96HZ3|uniprotkb:Q9H473|uniprotkb:Q149P0|uniprotkb:Q149P1|ensembl:ENSP00000503207|ensembl:ENSP00000503981 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:gbf1_human(display_long)|uniprotkb:GBF1(gene name)|psi-mi:GBF1(display_short)|uniprotkb:KIAA0248(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_001186307.1|refseq:NP_001186308.1|refseq:NP_004184.1|ensembl:ENSP00000503207|ensembl:ENSP00000503981|ensembl:ENST00000676993|ensembl:ENSP00000503918|ensembl:ENST00000677240|ensembl:ENSP00000503428|ensembl:ENSG00000107862(gene)|ensembl:ENST00000676513(transcript)|ensembl:ENST00000676939(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002263"(cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031252"(cell leading edge)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0060271"(cilium assembly)|go:"GO:0061162"(establishment of monopolar cell polarity)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|go:"GO:1903420"(protein localization to endoplasmic reticulum tubular network)|go:"GO:2000008"(regulation of protein localization to cell surface)|interpro:IPR000904(SEC7-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023394|interpro:IPR032691|interpro:IPR035999|mint:Q92538|reactome:R-HSA-199992|reactome:R-HSA-5620916|reactome:R-HSA-6807878|reactome:R-HSA-6811434 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:4rA/2NVw35m+b6O7/+9noI3EO4o9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q9UBV2 intact:EBI-21497244 intact:EBI-358766|uniprotkb:Q6UWT6|uniprotkb:Q9P1T9|uniprotkb:Q9UHK7|ensembl:ENSP00000337053 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:se1l1_human(display_long)|uniprotkb:SEL1L(gene name)|psi-mi:SEL1L(display_short)|uniprotkb:TSA305(gene name synonym)|uniprotkb:UNQ128/PRO1063(orf name)|uniprotkb:Suppressor of lin-12-like protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_001231913.1|refseq:NP_005056.3|ensembl:ENSG00000071537(gene)|ensembl:ENST00000336735(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009306"(protein secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0050821"(protein stabilization)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|mint:Q9UBV2|reactome:R-HSA-1912420|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-46259N - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:eufE+8nfcHK8CDl+AQ5G+3NtL+09606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q96DZ1 intact:EBI-21497244 intact:EBI-1023677|uniprotkb:O95901|uniprotkb:Q6UWN7|uniprotkb:Q9NUY7|uniprotkb:Q9UQL4|uniprotkb:B2RDB4|ensembl:ENSP00000185150|uniprotkb:B5MC72 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:erlec_human(display_long)|uniprotkb:ER lectin(gene name synonym)|uniprotkb:ERLEC1(gene name)|psi-mi:ERLEC1(display_short)|uniprotkb:XTP3TPB(gene name synonym)|uniprotkb:UNQ1878/PRO4321(orf name)|uniprotkb:C2orf30(gene name synonym)|uniprotkb:XTP3-transactivated gene B protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_001120870.1|refseq:NP_056516.2|ensembl:ENSG00000068912(gene)|ensembl:ENST00000185150(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR044865|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0036503"(ERAD pathway)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR012913(Glucosidase II beta subunit-like)|refseq:NP_001120869.1 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:eBOyI1TfCgExBrXLxSwlUZ05NXs9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q96ER3 intact:EBI-21497244 intact:EBI-721193|uniprotkb:A6NH05|ensembl:ENSP00000432487 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:saal1_human(display_long)|uniprotkb:Synoviocyte proliferation-associated in collagen-induced arthritis protein 1(gene name synonym)|uniprotkb:SAAL1(gene name)|psi-mi:SAAL1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_612430.2|ensembl:ENSG00000166788(gene)|ensembl:ENST00000524803(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold) - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:/zDVy3k3FVjctiLf1XeIeWHL9BE9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:P05023 intact:EBI-21497244 intact:EBI-358778|uniprotkb:Q16689|uniprotkb:Q6LDM4|uniprotkb:Q9UJ20|uniprotkb:Q9UJ21|uniprotkb:B2RBR6|uniprotkb:Q9UCN1|ensembl:ENSP00000295598|uniprotkb:B7Z3U6|uniprotkb:B7Z2T5|uniprotkb:F5H3A1|intact:EBI-10963133 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:at1a1_human(display_long)|uniprotkb:ATP1A1(gene name)|psi-mi:ATP1A1(display_short)|uniprotkb:Sodium pump subunit alpha-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_000692.2|refseq:NP_001153705.1|refseq:NP_001153706.1|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016791"(phosphatase activity)|ensembl:ENSG00000163399(gene)|ensembl:ENST00000295598(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031090"(organelle membrane)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031947"(negative regulation of glucocorticoid biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036126"(sperm flagellum)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0043531"(ADP binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045823"(positive regulation of heart contraction)|go:"GO:0045989"(positive regulation of striated muscle contraction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060342"(photoreceptor inner segment membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903416"(response to glycoside)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990239"(steroid hormone binding)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005775(ATPase, P-type cation exchange, alpha subunit, eukaryotic)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P05023|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|refseq:XP_016856849.1|refseq:XP_016856850.1|dip:DIP-38196N - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:uZf9iX38kcZh0Q+apz8uB17EtJw9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q9UI10 intact:EBI-21497244 intact:EBI-2340132|uniprotkb:Q53RY7|uniprotkb:Q9UIQ9|uniprotkb:Q9UJ95|uniprotkb:Q5BJF4|uniprotkb:Q9UBG4|uniprotkb:Q9BUV9|ensembl:ENSP00000233552 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:ei2bd_human(display_long)|uniprotkb:EIF2B4(gene name)|psi-mi:EIF2B4(display_short)|uniprotkb:EIF2BD(gene name synonym)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit delta(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_001029288.1|refseq:NP_056451.3|refseq:NP_751945.2|refseq:NP_001305894.1|refseq:NP_001305895.1|refseq:NP_001305896.1|refseq:NP_001305897.1|ensembl:ENSG00000115211(gene)|ensembl:ENST00000347454(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006417"(regulation of translation)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0042552"(myelination)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|mint:Q9UI10|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:ZCU4mIO5zkmBajIvBRe3b2PZINw9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:P56192 intact:EBI-21497244 intact:EBI-355848|uniprotkb:Q14895|uniprotkb:Q53H14|uniprotkb:Q96A15|uniprotkb:Q96BZ0|uniprotkb:Q9NSE0|uniprotkb:B3KVK7|ensembl:ENSP00000262027 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:symc_human(display_long)|uniprotkb:MARS1(gene name)|psi-mi:MARS1(display_short)|uniprotkb:MARS(gene name synonym)|uniprotkb:Methionyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006431"(methionyl-tRNA aminoacylation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009303"(rRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009068(S15/NS1, RNA-binding)|reactome:R-HSA-379716|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014758(Methionyl-tRNA synthetase, class Ia, N-terminal)|interpro:IPR015413("Aminoacyl-tRNA synthetase, class I (M)")|interpro:IPR023458|interpro:IPR029038|interpro:IPR033911|interpro:IPR036282|interpro:IPR041598|interpro:IPR041872|mint:P56192|rcsb pdb:2DJV|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5GL7|rcsb pdb:5GOY|rcsb pdb:5Y6L|reactome:R-HSA-2408522|refseq:NP_004981.2|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000166986(gene)|ensembl:ENST00000262027(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004825"(methionine-tRNA ligase activity)|dip:DIP-38164N - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:qNZ6XqndlF5KRn/TWFDb5T1GjEc9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q9UL33 intact:EBI-21497244 intact:EBI-747601|uniprotkb:Q6ZTA7|uniprotkb:Q9NZZ4|uniprotkb:B2R4M9|ensembl:ENSP00000301021 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:tpc2l_human(display_long)|uniprotkb:TRAPPC2L(gene name)|psi-mi:TRAPPC2L(display_short)|uniprotkb:HSPC126(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_057293.1|refseq:NP_001305453.1|refseq:NP_001305454.1|refseq:NP_001305455.1|refseq:NP_001305456.1|refseq:NP_001305457.1|refseq:NP_001305458.1|refseq:NP_001305459.1|refseq:NP_001305461.1|ensembl:ENSG00000167515(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0030008"(TRAPP complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR006722(Sedlin)|interpro:IPR011012(Longin-like)|interpro:IPR044760|reactome:R-HSA-204005|reactome:R-HSA-8876198|ensembl:ENST00000301021(transcript) - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:NTGwYJgRjRmSBfFJnmAOc1I93+89606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q9NSG2 intact:EBI-21497244 intact:EBI-11128910|uniprotkb:Q9NVJ0|uniprotkb:B3KU42|uniprotkb:Q9H8L5|uniprotkb:Q3KNQ1|uniprotkb:A6NFP1|ensembl:ENSP00000286031|ensembl:ENSP00000352276 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:ca112_human(display_long)|uniprotkb:C1orf112(gene name)|psi-mi:C1orf112(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_001306976.1|refseq:NP_001306977.1|refseq:NP_060656.2|refseq:XP_011508037.1|refseq:NP_001306979.1|refseq:NP_001306980.1|refseq:XP_016857213.1|refseq:XP_016857214.1|ensembl:ENSG00000000460(gene)|ensembl:ENST00000286031(transcript)|ensembl:ENST00000359326(transcript)|interpro:IPR027902 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:Jy6nCLVYtB3BgdCuu0RLRfmAAVc9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:O14980 intact:EBI-21497244 intact:EBI-355867|uniprotkb:A6NL14|uniprotkb:A8K1K5|uniprotkb:Q63HP8|uniprotkb:Q68CP3|uniprotkb:Q99433|uniprotkb:D6W5E2|ensembl:ENSP00000384863|ensembl:ENSP00000385559|ensembl:ENSP00000385942|ensembl:ENSP00000503167|ensembl:ENSP00000503419|ensembl:ENSP00000503482|ensembl:ENSP00000503572|ensembl:ENSP00000503809|ensembl:ENSP00000504087|ensembl:ENSP00000504198|ensembl:ENSP00000504247|ensembl:ENSP00000504543|ensembl:ENSP00000504594|ensembl:ENSP00000504848 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:xpo1_human(display_long)|uniprotkb:CRM1(gene name synonym)|uniprotkb:XPO1(gene name)|psi-mi:XPO1(display_short)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 ensembl:ENST00000678182(transcript)|ensembl:ENST00000678790(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0031267"(small GTPase binding)|mint:O14980|rcsb pdb:1W9C|rcsb pdb:2L1L|rcsb pdb:3GB8|rcsb pdb:4BSM|rcsb pdb:4BSN|rcsb pdb:5DIS|rcsb pdb:6TVO|go:"GO:0031965"(nuclear membrane)|rcsb pdb:7B51|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-168333|reactome:R-HSA-2173788|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3769402|reactome:R-HSA-450520|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-68877|reactome:R-HSA-69273|reactome:R-HSA-9634638|reactome:R-HSA-9648025|reactome:R-HSA-9707616|refseq:NP_003391.1|refseq:XP_011531399.1|ensembl:ENSG00000082898(gene)|ensembl:ENST00000401558(transcript)|ensembl:ENST00000404992(transcript)|ensembl:ENST00000406957(transcript)|ensembl:ENST00000676553(transcript)|ensembl:ENST00000676667(transcript)|ensembl:ENST00000677150(transcript)|ensembl:ENST00000677239(transcript)|ensembl:ENST00000677417(transcript)|ensembl:ENST00000677813(transcript)|ensembl:ENST00000677814(transcript)|ensembl:ENST00000677928(transcript)|ensembl:ENST00000677933(transcript)|refseq:XP_006712157.1|dip:DIP-33678N - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:wgxK39oV5wJ6mUuxM/jxqBtukEg9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q92973 intact:EBI-21497244 intact:EBI-286693|intact:EBI-1760498|uniprotkb:Q92957|uniprotkb:Q92975|intact:EBI-1965561|uniprotkb:B4DVC6|ensembl:ENSP00000336712 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:tnpo1_human(display_long)|uniprotkb:TRN(gene name synonym)|uniprotkb:TNPO1(gene name)|psi-mi:TNPO1(display_short)|uniprotkb:KPNB2(gene name synonym)|uniprotkb:MIP1(gene name synonym)|uniprotkb:Importin beta-2(gene name synonym)|uniprotkb:Karyopherin beta-2(gene name synonym)|uniprotkb:M9 region interaction protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_002261.3|refseq:NP_694858.1|refseq:XP_005248557.1|dip:DIP-29335N|ensembl:ENSG00000083312(gene)|ensembl:ENST00000337273(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|mint:Q92973|rcsb pdb:1QBK|rcsb pdb:2H4M|rcsb pdb:2OT8|rcsb pdb:2QMR|rcsb pdb:2Z5J|rcsb pdb:2Z5K|rcsb pdb:2Z5M|rcsb pdb:2Z5N|rcsb pdb:2Z5O|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:4JLQ|rcsb pdb:4OO6|rcsb pdb:5J3V|rcsb pdb:5TQC|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:7CYL|reactome:R-HSA-450513|reactome:R-HSA-5620924|reactome:R-HSA-9615933 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:n8Q3n1rmTiJAp6f8DBcBV6j6lac9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q9H4A5 intact:EBI-21497244 intact:EBI-4403434|uniprotkb:B7Z6N3|uniprotkb:B1AN09|uniprotkb:Q9NVK0|ensembl:ENSP00000271732 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:glp3l_human(display_long)|uniprotkb:GOLPH3L(gene name)|psi-mi:GOLPH3L(display_short)|uniprotkb:GPP34R(gene name synonym)|uniprotkb:GPP34-related protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_060648.2|ensembl:ENSG00000143457(gene)|ensembl:ENST00000271732(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|interpro:IPR008628(Golgi phosphoprotein 3)|interpro:IPR038261|mint:Q9H4A5 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:E+0Ru85nv0KoO/LW0kZLN1vpbFc9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q00765 intact:EBI-21497244 intact:EBI-1549827|uniprotkb:Q04198|uniprotkb:Q5QGT0|uniprotkb:Q9BWH9|uniprotkb:D3DT04|uniprotkb:B7Z681|ensembl:ENSP00000368959 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:reep5_human(display_long)|uniprotkb:REEP5(gene name)|psi-mi:REEP5(display_short)|uniprotkb:C5orf18(gene name synonym)|uniprotkb:DP1(gene name synonym)|uniprotkb:TB2(gene name synonym)|uniprotkb:Polyposis locus protein 1(gene name synonym)|uniprotkb:Protein TB2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_005660.4|ensembl:ENSG00000129625(gene)|ensembl:ENST00000379638(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032386"(regulation of intracellular transport)|go:"GO:0071782"(endoplasmic reticulum tubular network)|interpro:IPR004345(TB2/DP1 and HVA22 related protein)|reactome:R-HSA-381753 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:Z6Lzi37F0AfHZBnHri7k4EUpSRQ9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q9H6X2 intact:EBI-21497244 intact:EBI-905643|uniprotkb:Q96P02|uniprotkb:Q9NVP3|uniprotkb:J7K7G4|uniprotkb:J7KF88|uniprotkb:A8K7U8|uniprotkb:Q4ZFV6|uniprotkb:Q53QD8|intact:EBI-28987980|ensembl:ENSP00000301945 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:antr1_human(display_long)|uniprotkb:ANTXR1(gene name)|psi-mi:ANTXR1(display_short)|uniprotkb:ATR(gene name synonym)|uniprotkb:TEM8(gene name synonym)|uniprotkb:Tumor endothelial marker 8(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_060623.2|refseq:NP_115584.1|refseq:NP_444262.1|ensembl:ENSP00000301945|ensembl:ENST00000409349|ensembl:ENSP00000386494|ensembl:ENST00000409829|ensembl:ENSP00000387058|ensembl:ENST00000463335|ensembl:ENSP00000506719|ensembl:ENSG00000169604(gene)|ensembl:ENST00000303714(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022414"(reproductive process)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0046872"(metal ion binding)|go:"GO:0051015"(actin filament binding)|go:"GO:1901202"(negative regulation of extracellular matrix assembly)|go:"GO:1901998"(toxin transport)|go:"GO:1905050"(positive regulation of metallopeptidase activity)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR008399(Anthrax toxin receptor, C-terminal)|interpro:IPR008400(Anthrax toxin receptor, extracellular)|interpro:IPR017360(Anthrax toxin receptor 2)|interpro:IPR036465|rcsb pdb:3N2N|rcsb pdb:6ADL|rcsb pdb:6ADM|rcsb pdb:6ADR|rcsb pdb:6CX1|reactome:R-HSA-5210891 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:AtdL6Qm9CaH6Eb00jQly4K04AFg9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:O95373 intact:EBI-21497244 intact:EBI-286735|uniprotkb:A6NNM5|uniprotkb:Q1RMF7|uniprotkb:Q9H177|uniprotkb:Q9NTE3|uniprotkb:B2R786|intact:EBI-28976968|ensembl:ENSP00000369042 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:ipo7_human(display_long)|uniprotkb:Ran-binding protein 7(gene name synonym)|uniprotkb:IPO7(gene name)|psi-mi:IPO7(display_short)|uniprotkb:RANBP7(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 ensembl:ENSP00000369042|refseq:NP_006382.1|dip:DIP-32574N|ensembl:ENSG00000205339(gene)|ensembl:ENST00000379719(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046332"(SMAD binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:O95373 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:aaTn9E3/dTUETnNBYr38fk4ZtDo9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q9BTV4 intact:EBI-21497244 intact:EBI-721293|uniprotkb:Q7L4N5|uniprotkb:Q8NC30|uniprotkb:Q96A63|uniprotkb:Q96F19|uniprotkb:Q96JX0|uniprotkb:Q9H076|ensembl:ENSP00000303992 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:tmm43_human(display_long)|uniprotkb:TMEM43(gene name)|psi-mi:TMEM43(display_short)|uniprotkb:UNQ2564/PRO6244(orf name)|uniprotkb:Protein LUMA(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_077310.1|ensembl:ENSG00000170876(gene)|ensembl:ENST00000306077(transcript)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0071763"(nuclear membrane organization)|interpro:IPR012430(Protein of unknown function DUF1625) - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:8VCyVNtrzh7J9uJ2EjQLBhJGrfc9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 intact:EBI-11075002 intact:EBI-21497244 - psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:e9ppb4_human(display_short)|psi-mi:EBI-11075002(display_long)|uniprotkb:PEX19(gene name)|psi-mi:PEX19(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 go:"GO:0005777"(peroxisome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006708(Pex19 protein)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017986|ensembl:ENSG00000258465|ensembl:ENSP00000451235|ensembl:ENST00000556710|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|interpro:IPR038322|interpro:IPR036322|ensembl:ENSG00000162735|ensembl:ENSP00000434633|ensembl:ENST00000472750 - - no-uniprot-update: figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:NVpQ37Dunn9SfHtnoceo5ZqfLTg9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:P55060 intact:EBI-21497244 intact:EBI-286709|uniprotkb:O75432|uniprotkb:Q32M40|uniprotkb:Q9H5B7|uniprotkb:Q9NTS0|uniprotkb:Q9UP98|uniprotkb:Q9UP99|uniprotkb:Q9UPA0|uniprotkb:B2R5T4|uniprotkb:E1P5Y0|uniprotkb:A3RLL6|uniprotkb:F8W904|ensembl:ENSP00000262982 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:xpo2_human(display_long)|uniprotkb:Importin-alpha re-exporter(gene name synonym)|uniprotkb:Chromosome segregation 1-like protein(gene name synonym)|uniprotkb:Cellular apoptosis susceptibility protein(gene name synonym)|uniprotkb:CSE1L(gene name)|psi-mi:CSE1L(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:XPO2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:XP_011526901.1|refseq:NP_001307.2|refseq:NP_001243064.1|dip:DIP-32573N|ensembl:ENSG00000124207(gene)|ensembl:ENST00000262982(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR005043(CAS/CSE, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:P55060 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:5MlTHLE2eN8Cj5K4xhSt6lCheVs9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q9H4A6 intact:EBI-21497244 intact:EBI-2465479|uniprotkb:Q9UIW5|ensembl:ENSP00000265070 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:golp3_human(display_long)|uniprotkb:GOLPH3(gene name)|psi-mi:GOLPH3(display_short)|uniprotkb:GPP34(gene name synonym)|uniprotkb:Coat protein GPP34(gene name synonym)|uniprotkb:Mitochondrial DNA absence factor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_071413.1|ensembl:ENSG00000113384(gene)|ensembl:ENST00000265070(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0009101"(glycoprotein biosynthetic process)|go:"GO:0009306"(protein secretion)|go:"GO:0010467"(gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090164"(asymmetric Golgi ribbon formation)|interpro:IPR008628(Golgi phosphoprotein 3)|interpro:IPR038261|mint:Q9H4A6|rcsb pdb:3KN1 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:tHHREhHksCP+Yf9FzycM9cI+wkc9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q5W0Q7 intact:EBI-21497244 intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q14974 intact:EBI-21497244 intact:EBI-286758|uniprotkb:Q14637|uniprotkb:Q96J27|uniprotkb:Q53XN2|uniprotkb:B7ZAV6|uniprotkb:D3DTT3|intact:EBI-28976864|ensembl:ENSP00000290158|ensembl:ENSP00000464042 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:imb1_human(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Importin-90(gene name synonym)|uniprotkb:KPNB1(gene name)|psi-mi:KPNB1(display_short)|uniprotkb:NTF97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 ensembl:ENSP00000290158|ensembl:ENST00000535458|ensembl:ENSP00000438253|ensembl:ENST00000540627|ensembl:ENSP00000438964|ensembl:ENSP00000464042|refseq:NP_002256.2|refseq:NP_001263382.1|dip:DIP-6204N|ensembl:ENSG00000108424(gene)|ensembl:ENST00000290158(transcript)|ensembl:ENST00000583648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:Q14974|rcsb pdb:1F59|rcsb pdb:1IBR|rcsb pdb:1M5N|rcsb pdb:1O6O|rcsb pdb:1O6P|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:2P8Q|rcsb pdb:2Q5D|rcsb pdb:2QNA|rcsb pdb:3LWW|rcsb pdb:3W5K|rcsb pdb:6N88|rcsb pdb:6N89|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-1655829|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180746|reactome:R-HSA-2995383|reactome:R-HSA-6798695|reactome:R-HSA-909733|reactome:R-HSA-9615933|reactome:R-HSA-9636249 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:8NbS9qoyCx+M+X3KOe1+PQ3oSYk9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:P45880 intact:EBI-21497244 intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q7Z4Q2 intact:EBI-21497244 intact:EBI-1051903|uniprotkb:Q8N525|uniprotkb:Q8WV56|uniprotkb:Q96CC9|uniprotkb:Q9NWN7|uniprotkb:A8K1N4|ensembl:ENSP00000299192 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:heat3_human(display_long)|uniprotkb:HEATR3(gene name)|psi-mi:HEATR3(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_891552.1|ensembl:ENSG00000155393(gene)|ensembl:ENST00000299192(transcript)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR016024(Armadillo-type fold)|mint:Q7Z4Q2 - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:CjdYLKIHc/A29+XYy4VjNNHJSRU9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09613 uniprotkb:Q13144 intact:EBI-21497244 intact:EBI-4401110|uniprotkb:Q541Z1|uniprotkb:Q96D04|ensembl:ENSP00000497160 psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:ei2be_human(display_long)|uniprotkb:EIF2B5(gene name)|psi-mi:EIF2B5(display_short)|uniprotkb:EIF2BE(gene name synonym)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit epsilon(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-21497303|imex:IM-27097-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 refseq:NP_003898.2|ensembl:ENSG00000145191(gene)|ensembl:ENST00000648915(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0007568"(aging)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0014002"(astrocyte development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021766"(hippocampus development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042552"(myelination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029044|interpro:IPR035543|interpro:IPR044123|rcsb pdb:3JUI|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|go:"GO:0005634"(nucleus) - - - figure legend:Fig. 1, Table S1|comment:individual Gn and Gc were detected by mass spectrometry, however we only captured the bait polyprotein, since it's not possible to distinguish whether the post-processed chains were naturally occurring or artifactually produced by the experimental technique.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/06/20 2019/11/15 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rogid:158kR+Yjj/jXya10LiK3Xp0Fa5w9606 rigid:8s7u/OS9aZa7Ge7w+k3ImgRo4aE false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92538 uniprotkb:P09613 intact:EBI-359050|uniprotkb:Q5VXX3|uniprotkb:Q96CK6|uniprotkb:Q96HZ3|uniprotkb:Q9H473|uniprotkb:Q149P0|uniprotkb:Q149P1|ensembl:ENSP00000503207|ensembl:ENSP00000503981 intact:EBI-21497244 psi-mi:gbf1_human(display_long)|uniprotkb:GBF1(gene name)|psi-mi:GBF1(display_short)|uniprotkb:KIAA0248(gene name synonym) psi-mi:gp_uuks(display_long)|uniprotkb:GP(gene name)|psi-mi:GP(display_short)|uniprotkb:M polyprotein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Uckeley et al. (2019) imex:IM-27097|pubmed:31570497 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:487099(Uuk)|taxid:487099("Uukuniemi virus (strain S23)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-22030258|imex:IM-27097-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186307.1|refseq:NP_001186308.1|refseq:NP_004184.1|ensembl:ENSP00000503207|ensembl:ENSP00000503981|ensembl:ENST00000676993|ensembl:ENSP00000503918|ensembl:ENST00000677240|ensembl:ENSP00000503428|ensembl:ENSG00000107862(gene)|ensembl:ENST00000676513(transcript)|ensembl:ENST00000676939(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002263"(cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031252"(cell leading edge)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0060271"(cilium assembly)|go:"GO:0061162"(establishment of monopolar cell polarity)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|go:"GO:1903420"(protein localization to endoplasmic reticulum tubular network)|go:"GO:2000008"(regulation of protein localization to cell surface)|interpro:IPR000904(SEC7-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023394|interpro:IPR032691|interpro:IPR035999|mint:Q92538|reactome:R-HSA-199992|reactome:R-HSA-5620916|reactome:R-HSA-6807878|reactome:R-HSA-6811434 interpro:IPR010826(Phlebovirus glycoprotein G1)|interpro:IPR009878(Phlebovirus glycoprotein G2)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR043603 - - - figure legend:Fig. 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/06/20 2019/09/18 rogid:4rA/2NVw35m+b6O7/+9noI3EO4o9606 rogid:S/mRBV1H1QAkSUliNQuM73oW4jg487099 rigid:NGfWW5YwWQ9yyECHg/By3E0lzjs false - mutation with no effect:438-439|mutation with no effect:461-465 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)