#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14966	uniprotkb:Q5S007	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225389|imex:IM-27512-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:1B, Supp. fig 3|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	his tag:n-n|sufficient binding region:1-177	sufficient binding region:1-552	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:78408"	uniprotkb:O14966	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225389|imex:IM-27512-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	-	-	-	figure legend:1B, Supp. fig 3|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	-	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:1-177	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q13637	uniprotkb:Q5S007	intact:EBI-9837586|ensembl:ENSP00000356465	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225605|imex:IM-27512-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:1C, Supp. fig 3/4/6C|comment:"Deletion of a negatively charged loop (residues 317-342) in the LRRK2 ARM domain did not affect its ability to bind to the Rab32 subfamily."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	his tag:n-n|sufficient binding region:20-198|mutation:85-85	sufficient binding region:1-552	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:15996"	uniprotkb:Q13637	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-9837586|ensembl:ENSP00000356465	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225605|imex:IM-27512-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:1C, Supp. fig 3/4/6C|comment:"Deletion of a negatively charged loop (residues 317-342) in the LRRK2 ARM domain did not affect its ability to bind to the Rab32 subfamily."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	-	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:20-198|mutation:85-85	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P57729	uniprotkb:Q5S007	intact:EBI-6552718|ensembl:ENSP00000243662|uniprotkb:Q53XK7	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab38_human(display_long)|uniprotkb:RAB38(gene name)|psi-mi:RAB38(display_short)|uniprotkb:Melanoma antigen NY-MEL-1(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225626|imex:IM-27512-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123892(gene)|ensembl:ENST00000243662(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090383"(phagosome acidification)|go:"GO:1903232"(melanosome assembly)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|rcsb pdb:6HDU|rcsb pdb:6S5H|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0005802"(trans-Golgi network)|refseq:NP_071732.1|dip:DIP-60520N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:1D, Supp. Fig 2/4/6C|comment:"Deletion of a negatively charged loop (residues 317-342) in the LRRK2 ARM domain did not affect its ability to bind to the Rab32 subfamily."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	rogid:wE7byI3eUYwjSh5A01J4lL+4dFM9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	his tag:n-n|sufficient binding region:1-181|mutation:69-69	sufficient binding region:1-552|mutation with no effect:228-228,236-236,272-272,746-746,6-6,9-9	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:15996"	uniprotkb:P57729	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-6552718|ensembl:ENSP00000243662|uniprotkb:Q53XK7	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:rab38_human(display_long)|uniprotkb:RAB38(gene name)|psi-mi:RAB38(display_short)|uniprotkb:Melanoma antigen NY-MEL-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225626|imex:IM-27512-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000123892(gene)|ensembl:ENST00000243662(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090383"(phagosome acidification)|go:"GO:1903232"(melanosome assembly)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|rcsb pdb:6HDU|rcsb pdb:6S5H|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0005802"(trans-Golgi network)|refseq:NP_071732.1|dip:DIP-60520N	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:1D, Supp. Fig 2/4/6C|comment:"Deletion of a negatively charged loop (residues 317-342) in the LRRK2 ARM domain did not affect its ability to bind to the Rab32 subfamily."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	-	rogid:wE7byI3eUYwjSh5A01J4lL+4dFM9606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:1-181|mutation:69-69	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O14966	uniprotkb:Q5S007	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225645|imex:IM-27512-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:1F|comment:It is unclear if the LRRK2 L728D+L729D mutation reduces binding to Rab29 or if the fainter band is entirely due to  instability of the mutated protein.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	his tag:n-n|sufficient binding region:1-177	sufficient binding region:1-910|mutation with no effect:728-729	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:15996"	uniprotkb:O14966	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225645|imex:IM-27512-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:1F|comment:It is unclear if the LRRK2 L728D+L729D mutation reduces binding to Rab29 or if the fainter band is entirely due to  instability of the mutated protein.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	-	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:1-177	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O14966	uniprotkb:Q5S007	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225661|imex:IM-27512-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:2A|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	his tag:n-n|sufficient binding region:1-177	sufficient binding region:1-910	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:78408"	uniprotkb:O14966	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225661|imex:IM-27512-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	-	-	-	figure legend:2A|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	-	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:1-177	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O14966	uniprotkb:P57729	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	intact:EBI-6552718|ensembl:ENSP00000243662|uniprotkb:Q53XK7	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:rab38_human(display_long)|uniprotkb:RAB38(gene name)|psi-mi:RAB38(display_short)|uniprotkb:Melanoma antigen NY-MEL-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225674|imex:IM-27512-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	ensembl:ENSG00000123892(gene)|ensembl:ENST00000243662(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090383"(phagosome acidification)|go:"GO:1903232"(melanosome assembly)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|rcsb pdb:6HDU|rcsb pdb:6S5H|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0005802"(trans-Golgi network)|refseq:NP_071732.1|dip:DIP-60520N	-	-	-	figure legend:2A-2|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	rogid:wE7byI3eUYwjSh5A01J4lL+4dFM9606	-	false	his tag:n-n|sufficient binding region:1-177	sufficient binding region:1-181|mutation:69-69	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O14966	uniprotkb:Q5S007	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225674|imex:IM-27512-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:2A-2|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	his tag:n-n|sufficient binding region:1-177	sufficient binding region:1-910	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:78408"	uniprotkb:O14966	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225674|imex:IM-27512-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	-	-	-	figure legend:2A-2|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	-	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:1-177	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q13637	uniprotkb:P57729	intact:EBI-9837586|ensembl:ENSP00000356465	intact:EBI-6552718|ensembl:ENSP00000243662|uniprotkb:Q53XK7	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:rab38_human(display_long)|uniprotkb:RAB38(gene name)|psi-mi:RAB38(display_short)|uniprotkb:Melanoma antigen NY-MEL-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225692|imex:IM-27512-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENSG00000123892(gene)|ensembl:ENST00000243662(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090383"(phagosome acidification)|go:"GO:1903232"(melanosome assembly)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|rcsb pdb:6HDU|rcsb pdb:6S5H|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0005802"(trans-Golgi network)|refseq:NP_071732.1|dip:DIP-60520N	-	-	-	figure legend:2A-4|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	rogid:wE7byI3eUYwjSh5A01J4lL+4dFM9606	-	false	his tag:n-n|sufficient binding region:1-198|mutation:85-85	sufficient binding region:1-181|mutation:69-69	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q13637	uniprotkb:Q5S007	intact:EBI-9837586|ensembl:ENSP00000356465	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225692|imex:IM-27512-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:2A-4|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	his tag:n-n|sufficient binding region:1-198|mutation:85-85	sufficient binding region:1-910	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:78408"	uniprotkb:Q13637	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-9837586|ensembl:ENSP00000356465	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225692|imex:IM-27512-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:2A-4|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	-	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:1-198|mutation:85-85	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q13637	uniprotkb:Q5S007	intact:EBI-9837586|ensembl:ENSP00000356465	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225712|imex:IM-27512-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:2A-3|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	his tag:n-n|sufficient binding region:1-198|mutation:85-85	sufficient binding region:1-910	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:78408"	uniprotkb:Q13637	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-9837586|ensembl:ENSP00000356465	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225712|imex:IM-27512-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:2A-3|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	-	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:1-198|mutation:85-85	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P57729	uniprotkb:Q5S007	intact:EBI-6552718|ensembl:ENSP00000243662|uniprotkb:Q53XK7	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab38_human(display_long)|uniprotkb:RAB38(gene name)|psi-mi:RAB38(display_short)|uniprotkb:Melanoma antigen NY-MEL-1(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226158|imex:IM-27512-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123892(gene)|ensembl:ENST00000243662(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090383"(phagosome acidification)|go:"GO:1903232"(melanosome assembly)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|rcsb pdb:6HDU|rcsb pdb:6S5H|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0005802"(trans-Golgi network)|refseq:NP_071732.1|dip:DIP-60520N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:5A, Supp. Fig 6A|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	rogid:wE7byI3eUYwjSh5A01J4lL+4dFM9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	rigid:OkIdj+hJg1YjxAp4bDyvbgXk/mk	false	mutation with no effect:42-42|mutation with no effect:42-42|mutation with no effect:77-77,81-81|his tag:n-n|sufficient binding region:1-181|mutation decreasing interaction strength:39-39	sufficient binding region:1-552	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O14966	uniprotkb:Q5S007	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226181|imex:IM-27512-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:5C-1, Supp. fig 4.|comment:"It has been assumed the LRRK2  1-552 construct has been used here based on the statement :-\"LRRK2 2mut was stably  expressed and purified, and pulldowns revealed  a decrease in binding to Rab29 and Rab38 (Figure 5(c),S4).\". -Fig S4 explicitly states 1-552."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	his tag:n-n|sufficient binding region:1-177	sufficient binding region:1-552|mutation decreasing interaction strength:390-390,392-392	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:15996"	uniprotkb:O14966	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226181|imex:IM-27512-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:5C-1, Supp. fig 4.|comment:"It has been assumed the LRRK2  1-552 construct has been used here based on the statement :-\"LRRK2 2mut was stably  expressed and purified, and pulldowns revealed  a decrease in binding to Rab29 and Rab38 (Figure 5(c),S4).\". -Fig S4 explicitly states 1-552."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	-	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:1-177	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P57729	uniprotkb:Q5S007	intact:EBI-6552718|ensembl:ENSP00000243662|uniprotkb:Q53XK7	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab38_human(display_long)|uniprotkb:RAB38(gene name)|psi-mi:RAB38(display_short)|uniprotkb:Melanoma antigen NY-MEL-1(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226216|imex:IM-27512-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123892(gene)|ensembl:ENST00000243662(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090383"(phagosome acidification)|go:"GO:1903232"(melanosome assembly)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|rcsb pdb:6HDU|rcsb pdb:6S5H|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0005802"(trans-Golgi network)|refseq:NP_071732.1|dip:DIP-60520N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:5C/E, Supp. fig 6B|comment:"Figure 5:It has been assumed the LRRK2 1-552 construct has been used here from the statement :-\"LRRK2 2mut was stably  expressed and purified, and pulldowns revealed  a decrease in binding to Rab29 and Rab38 (Figure 5(c),S4).\"-Fig S4 explicitly states 1-552."|comment:"Supplementary Figure 6B:  The \"Nmut = E192Q+E193Q\" mutation has been entered as  \"E193Q+E194Q\" as there is no \"E\" at residue 192 in LRRK2."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	rogid:wE7byI3eUYwjSh5A01J4lL+4dFM9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	his tag:n-n|sufficient binding region:1-181	mutation disrupting interaction strength:390-392,386-386|mutation decreasing interaction strength:390-390,392-392|sufficient binding region:1-552|mutation disrupting interaction strength:390-392|mutation with no effect:193-194	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:15996"	uniprotkb:P57729	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-6552718|ensembl:ENSP00000243662|uniprotkb:Q53XK7	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:rab38_human(display_long)|uniprotkb:RAB38(gene name)|psi-mi:RAB38(display_short)|uniprotkb:Melanoma antigen NY-MEL-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226216|imex:IM-27512-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000123892(gene)|ensembl:ENST00000243662(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090383"(phagosome acidification)|go:"GO:1903232"(melanosome assembly)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|rcsb pdb:6HDU|rcsb pdb:6S5H|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0005802"(trans-Golgi network)|refseq:NP_071732.1|dip:DIP-60520N	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:5C/E, Supp. fig 6B|comment:"Figure 5:It has been assumed the LRRK2 1-552 construct has been used here from the statement :-\"LRRK2 2mut was stably  expressed and purified, and pulldowns revealed  a decrease in binding to Rab29 and Rab38 (Figure 5(c),S4).\"-Fig S4 explicitly states 1-552."|comment:"Supplementary Figure 6B:  The \"Nmut = E192Q+E193Q\" mutation has been entered as  \"E193Q+E194Q\" as there is no \"E\" at residue 192 in LRRK2."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	-	rogid:wE7byI3eUYwjSh5A01J4lL+4dFM9606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:1-181	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O14966	uniprotkb:Q5S007	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226322|imex:IM-27512-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:Supp. fig 3|comment:Only the LRRK2 1-910 construct showed any  binding to Rab29-GDP.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/21	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	his tag:n-n|sufficient binding region:1-177	sufficient binding region:1-910	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:17552"	uniprotkb:O14966	intact:EBI-1265684	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	psi-mi:gdp(display_short)|psi-mi:"CHEBI:17552"(display_long)	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226322|imex:IM-27512-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	-	-	-	figure legend:Supp. fig 3|comment:Only the LRRK2 1-910 construct showed any  binding to Rab29-GDP.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/21	-	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:1-177	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q13637	uniprotkb:P57729	intact:EBI-9837586|ensembl:ENSP00000356465	intact:EBI-6552718|ensembl:ENSP00000243662|uniprotkb:Q53XK7	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:rab38_human(display_long)|uniprotkb:RAB38(gene name)|psi-mi:RAB38(display_short)|uniprotkb:Melanoma antigen NY-MEL-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226452|imex:IM-27512-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	ensembl:ENSG00000123892(gene)|ensembl:ENST00000243662(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090383"(phagosome acidification)|go:"GO:1903232"(melanosome assembly)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|rcsb pdb:6HDU|rcsb pdb:6S5H|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0005802"(trans-Golgi network)|refseq:NP_071732.1|dip:DIP-60520N	-	-	-	figure legend:Supp. Fig. 4|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/21	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	rogid:wE7byI3eUYwjSh5A01J4lL+4dFM9606	-	false	his tag:n-n|sufficient binding region:20-198|mutation:85-85	sufficient binding region:1-181|mutation:69-69	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:15996"	uniprotkb:Q13637	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-9837586|ensembl:ENSP00000356465	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226452|imex:IM-27512-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:Supp. Fig. 4|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/21	-	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:20-198|mutation:85-85	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q13637	uniprotkb:Q5S007	intact:EBI-9837586|ensembl:ENSP00000356465	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0096"(pull down)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226452|imex:IM-27512-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:Supp. Fig. 4|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/21	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	his tag:n-n|sufficient binding region:20-198|mutation:85-85	sufficient binding region:1-552	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:15996"	uniprotkb:Q5S007	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225745|imex:IM-27512-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:2B-1, Table 2.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:1.2x10^-6(molar)	2019/10/31	2020/04/20	-	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	binding-associated region:?-?	sufficient binding region:1-552	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15996"	uniprotkb:P57729	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-6552718|ensembl:ENSP00000243662|uniprotkb:Q53XK7	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:rab38_human(display_long)|uniprotkb:RAB38(gene name)|psi-mi:RAB38(display_short)|uniprotkb:Melanoma antigen NY-MEL-1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225745|imex:IM-27512-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000123892(gene)|ensembl:ENST00000243662(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090383"(phagosome acidification)|go:"GO:1903232"(melanosome assembly)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|rcsb pdb:6HDU|rcsb pdb:6S5H|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0005802"(trans-Golgi network)|refseq:NP_071732.1|dip:DIP-60520N	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:2B-1, Table 2.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kcat:1.2x10^-6(molar)	2019/10/31	2020/04/20	-	rogid:wE7byI3eUYwjSh5A01J4lL+4dFM9606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:1-181|mutation:69-69	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:78408"	uniprotkb:Q5S007	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225761|imex:IM-27512-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:2B-2|kinetics:Kd values are not given in Table 2 for this interaction with GppNHp.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	-	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	binding-associated region:?-?	sufficient binding region:1-552	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:78408"	uniprotkb:P57729	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-6552718|ensembl:ENSP00000243662|uniprotkb:Q53XK7	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:rab38_human(display_long)|uniprotkb:RAB38(gene name)|psi-mi:RAB38(display_short)|uniprotkb:Melanoma antigen NY-MEL-1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22225761|imex:IM-27512-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000123892(gene)|ensembl:ENST00000243662(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090383"(phagosome acidification)|go:"GO:1903232"(melanosome assembly)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|rcsb pdb:6HDU|rcsb pdb:6S5H|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0005802"(trans-Golgi network)|refseq:NP_071732.1|dip:DIP-60520N	-	-	-	figure legend:2B-2|kinetics:Kd values are not given in Table 2 for this interaction with GppNHp.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/31	2019/11/20	-	rogid:wE7byI3eUYwjSh5A01J4lL+4dFM9606	-	false	binding-associated region:?-?	his tag:n-n|sufficient binding region:1-181	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:78408"	uniprotkb:O14966	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226108|imex:IM-27512-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	-	-	-	figure legend:2D, table 2, 5D|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.7x10^-6(molar)	2019/10/31	2019/11/20	-	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	-	false	binding-associated region:?-?|fluorophore:?-?	binding-associated region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14966	uniprotkb:Q5S007	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226108|imex:IM-27512-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:2D, table 2, 5D|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.7x10^-6(molar)	2019/10/31	2019/11/20	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	binding-associated region:?-?	mutation decreasing interaction strength:390-390,392-392|sufficient binding region:1-552	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:78408"	uniprotkb:P57729	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-6552718|ensembl:ENSP00000243662|uniprotkb:Q53XK7	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:rab38_human(display_long)|uniprotkb:RAB38(gene name)|psi-mi:RAB38(display_short)|uniprotkb:Melanoma antigen NY-MEL-1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226126|imex:IM-27512-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000123892(gene)|ensembl:ENST00000243662(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090383"(phagosome acidification)|go:"GO:1903232"(melanosome assembly)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|rcsb pdb:6HDU|rcsb pdb:6S5H|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0005802"(trans-Golgi network)|refseq:NP_071732.1|dip:DIP-60520N	-	-	-	figure legend:2C, table 2, 5B|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.4x10^-6(molar)	2019/10/31	2019/11/20	-	rogid:wE7byI3eUYwjSh5A01J4lL+4dFM9606	-	false	binding-associated region:?-?|fluorophore:?-?	binding-associated region:?-?|mutation decreasing interaction strength:39-39	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P57729	uniprotkb:Q5S007	intact:EBI-6552718|ensembl:ENSP00000243662|uniprotkb:Q53XK7	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab38_human(display_long)|uniprotkb:RAB38(gene name)|psi-mi:RAB38(display_short)|uniprotkb:Melanoma antigen NY-MEL-1(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226126|imex:IM-27512-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123892(gene)|ensembl:ENST00000243662(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090383"(phagosome acidification)|go:"GO:1903232"(melanosome assembly)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|rcsb pdb:6HDU|rcsb pdb:6S5H|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0005802"(trans-Golgi network)|refseq:NP_071732.1|dip:DIP-60520N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:2C, table 2, 5B|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.4x10^-6(molar)	2019/10/31	2019/11/20	rogid:wE7byI3eUYwjSh5A01J4lL+4dFM9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	binding-associated region:?-?|mutation decreasing interaction strength:39-39	sufficient binding region:1-552	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:78408"	uniprotkb:Q13637	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-9837586|ensembl:ENSP00000356465	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226141|imex:IM-27512-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:2E, table 2|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.2x10^-6(molar)	2019/10/31	2019/11/20	-	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	-	false	binding-associated region:?-?|fluorophore:?-?	binding-associated region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13637	uniprotkb:Q5S007	intact:EBI-9837586|ensembl:ENSP00000356465	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226141|imex:IM-27512-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:2E, table 2|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.2x10^-6(molar)	2019/10/31	2019/11/20	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	binding-associated region:?-?	sufficient binding region:1-552	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:78408"	uniprotkb:Q13637	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-9837586|ensembl:ENSP00000356465	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226263|imex:IM-27512-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	-	-	-	figure legend:5F-LHS|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.2x10^-6(molar)	2019/10/31	2019/11/20	-	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	-	false	binding-associated region:?-?|fluorophore:?-?	binding-associated region:?-?|mutation:85-85|mutation decreasing interaction strength:55-55	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13637	uniprotkb:Q5S007	intact:EBI-9837586|ensembl:ENSP00000356465	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab32_human(display_long)|uniprotkb:RAB32(gene name)|psi-mi:RAB32(display_short)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226263|imex:IM-27512-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006825.1|dip:DIP-61889N|ensembl:ENSG00000118508(gene)|ensembl:ENST00000367495(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0035650"(AP-1 adaptor complex binding)|go:"GO:0035651"(AP-3 adaptor complex binding)|go:"GO:0036461"(BLOC-2 complex binding)|go:"GO:0042470"(melanosome)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:1903232"(melanosome assembly)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:Q13637|rcsb pdb:4CYM|rcsb pdb:4CZ2|rcsb pdb:5OEC|rcsb pdb:5OED|rcsb pdb:6FF8|reactome:R-HSA-8873719|reactome:R-HSA-8876198	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:5F-LHS|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.2x10^-6(molar)	2019/10/31	2019/11/20	rogid:7WV+WUaIbjAZzNi/LqEwmJZ/Y789606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	binding-associated region:?-?|mutation:85-85|mutation decreasing interaction strength:55-55	sufficient binding region:1-552	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:78408"	uniprotkb:O14966	intact:EBI-11175273|chebi:"CHEBI:42862"	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	psi-mi:guanosine 5'-[beta,gamma-imido]triphosphate(display_short)|psi-mi:"CHEBI:78408"(display_long)|intact:5'-Guanylic acid, monoanhydride with imidodiphosphoric acid(synonym)|intact:5'-guanylylimidodiphosphate(synonym)|intact:GMP-PNP(synonym)|intact:GMP-Pnp(synonym)|intact:"Gpp(NH)-p"(synonym)|intact:"Gpp(NH)p"(synonym)|intact:Guanylyl imidodiphosphate(synonym)|intact:"5'-O-(hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl)guanosine"(iupac name)	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226281|imex:IM-27512-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	-	-	-	figure legend:5F-RHS|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.7x10^-6(molar)	2019/10/31	2019/11/20	-	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	-	false	binding-associated region:?-?|fluorophore:?-?	binding-associated region:?-?|mutation with no effect:37-37	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14966	uniprotkb:Q5S007	intact:EBI-372165|uniprotkb:B4E1K3|uniprotkb:C9JE77|ensembl:ENSP00000235932|ensembl:ENSP00000356107|ensembl:ENSP00000402910	intact:EBI-5323863|ensembl:ENSP00000298910|uniprotkb:A6NJU2|uniprotkb:Q6ZS50|uniprotkb:Q8NCX9|intact:EBI-28978369	psi-mi:rab7l_human(display_long)|uniprotkb:RAB29(gene name)|psi-mi:RAB29(display_short)|uniprotkb:RAB7L1(gene name synonym)|uniprotkb:Rab-7-like protein 1(gene name synonym)|uniprotkb:Ras-related protein Rab-29(gene name synonym)	psi-mi:lrrk2_human(display_long)|uniprotkb:LRRK2(gene name)|psi-mi:LRRK2(display_short)|uniprotkb:PARK8(gene name synonym)|uniprotkb:Dardarin(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	McGrath et al. (2019)	imex:IM-27512|pubmed:31552791	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22226281|imex:IM-27512-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129134.1|refseq:NP_003920.1|refseq:NP_001129135.1|refseq:NP_001129136.1|refseq:XP_005245626.1|refseq:XP_005245627.1|refseq:XP_005245628.1|refseq:XP_006711668.1|refseq:XP_006711669.1|refseq:XP_016858237.1|refseq:XP_016858238.1|refseq:XP_016858239.1|ensembl:ENSG00000117280(gene)|ensembl:ENST00000235932(transcript)|ensembl:ENST00000367139(transcript)|ensembl:ENST00000414729(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0009617"(response to bacterium)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0012505"(endomembrane system)|go:"GO:0019003"(GDP binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042110"(T cell activation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030697|mint:O14966|rcsb pdb:6HH2|reactome:R-HSA-8873719|dip:DIP-31215N	go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|ensembl:ENSG00000188906(gene)|ensembl:ENST00000298910(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0015631"(tubulin binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0021756"(striatum development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034211"(GTP-dependent protein kinase activity)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0035640"(exploration behavior)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035751"(regulation of lysosomal lumen pH)|go:"GO:0036479"(peroxidase inhibitor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0032473"(cytoplasmic side of mitochondrial outer membrane)|go:"GO:0090140"(regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097487"(multivesicular body, internal vesicle)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099400"(caveola neck)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051900"(regulation of mitochondrial depolarization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060628"(regulation of ER to Golgi vesicle-mediated transport)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0070997"(neuron death)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1903125"(negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1903217"(negative regulation of protein processing involved in protein targeting to mitochondrion)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904713"(beta-catenin destruction complex binding)|go:"GO:1904887"(Wnt signalosome assembly)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020859|interpro:IPR025875|interpro:IPR027417|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|mint:Q5S007|rcsb pdb:2ZEJ|rcsb pdb:3D6T|rcsb pdb:5MY9|rcsb pdb:5MYC|rcsb pdb:6DLO|rcsb pdb:6DLP|rcsb pdb:6OJE|rcsb pdb:6OJF|rcsb pdb:6VNO|rcsb pdb:6VP6|rcsb pdb:6VP7|rcsb pdb:6XAF|rcsb pdb:6XR4|rcsb pdb:7LHT|rcsb pdb:7LHW|rcsb pdb:7LI3|rcsb pdb:7LI4|reactome:R-HSA-8857538|ensembl:ENSP00000298910|refseq:NP_940980.3|dip:DIP-29684N	-	-	-	figure legend:5F-RHS|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.7x10^-6(molar)	2019/10/31	2019/11/20	rogid:iqqWBBmsxTZcMPjfgiBjdv8LzAw9606	rogid:5ZNs+6rMb4Ifz0nBk6RgYmaCFsM9606	-	false	binding-associated region:?-?|mutation with no effect:37-37	sufficient binding region:1-552	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)