#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A0A310TTQ1	uniprotkb:P02281	intact:EBI-22091321	intact:EBI-1251201|uniprotkb:Q6AZT0	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:h2b11_xenla(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091338|emdb:EMDB-9998|emdb:EMDB- 0693|emdb:EMDB-9999|imex:IM-27442-1|wwpdb:6KIU|wwpdb:6KIV|wwpdb:6KIW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	refseq:NP_001086753.1|dip:DIP-38577N|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4KHA|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W4L|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:6PA7|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:4Z66|rcsb pdb:4ZUX|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5G2E|rcsb pdb:5HQ2|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6FQ8|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K01|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:4XZQ|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6LTJ|rcsb pdb:4YS3|rcsb pdb:6N1Z|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O96|rcsb pdb:6OM3|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1AOI|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB	-	-	-	figure legend:Fig. 1, Fig. 4a, Extended Data Fig. 2, Extended Data Table 1, Extended Data Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:+nkA0I7sW2isaEdOjTHa7+jcsDw8355	rigid:5pXaUqb8SL/ezg2x9+KJbd/qK4U	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:P62799	intact:EBI-22091321	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091338|emdb:EMDB-9998|emdb:EMDB- 0693|emdb:EMDB-9999|imex:IM-27442-1|wwpdb:6KIU|wwpdb:6KIV|wwpdb:6KIW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:Fig. 1, Fig. 4a, Extended Data Fig. 2, Extended Data Table 1, Extended Data Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:5pXaUqb8SL/ezg2x9+KJbd/qK4U	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:Q03164-1	intact:EBI-22091321	intact:EBI-22091730|ensembl:ENSP00000374157	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:q03164-1(display_long)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091338|emdb:EMDB-9998|emdb:EMDB- 0693|emdb:EMDB-9999|imex:IM-27442-1|wwpdb:6KIU|wwpdb:6KIV|wwpdb:6KIW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	intact:EBI-591370(isoform-parent)|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)	-	-	-	figure legend:Fig. 1, Fig. 4a, Extended Data Fig. 2, Extended Data Table 1, Extended Data Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	rigid:5pXaUqb8SL/ezg2x9+KJbd/qK4U	false	-	binding-associated region:3754-3969	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:Q15291-1	intact:EBI-22091321	intact:EBI-22091723|ensembl:ENSP00000264515	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:q15291-1(display_long)|uniprotkb:Retinoblastoma-binding protein RBQ-3(gene name synonym)|uniprotkb:RBBP5(gene name)|psi-mi:RBBP5(display_short)|uniprotkb:RBQ3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091338|emdb:EMDB-9998|emdb:EMDB- 0693|emdb:EMDB-9999|imex:IM-27442-1|wwpdb:6KIU|wwpdb:6KIV|wwpdb:6KIW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	intact:EBI-592823(isoform-parent)|ensembl:ENSG00000117222(gene)|ensembl:ENST00000264515(transcript)	-	-	-	figure legend:Fig. 1, Fig. 4a, Extended Data Fig. 2, Extended Data Table 1, Extended Data Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:Zl8yHcbL1C6StHPyD+875Ccy6gk9606	rigid:5pXaUqb8SL/ezg2x9+KJbd/qK4U	false	-	binding-associated region:1-528	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:Q6AZJ8	intact:EBI-22091321	intact:EBI-1265425	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:q6azj8_xenla(display_long)|uniprotkb:h2ac14.L(gene name)|psi-mi:h2ac14.L(display_short)|uniprotkb:LOC494591(gene name synonym)|uniprotkb:h2ac14(gene name synonym)|uniprotkb:hist1h2aj(gene name synonym)|uniprotkb:XELAEV_18003602mg(orf name)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091338|emdb:EMDB-9998|emdb:EMDB- 0693|emdb:EMDB-9999|imex:IM-27442-1|wwpdb:6KIU|wwpdb:6KIV|wwpdb:6KIW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	refseq:NP_001087948.1|dip:DIP-38576N|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MVD|rcsb pdb:4KGC|rcsb pdb:4KHA|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K01|rcsb pdb:6K1P|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6VZ4|rcsb pdb:6W5I|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7KTQ	-	-	-	figure legend:Fig. 1, Fig. 4a, Extended Data Fig. 2, Extended Data Table 1, Extended Data Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:E7iU5tlv8Az4uOlSHgPXi/4WcnE8355	rigid:5pXaUqb8SL/ezg2x9+KJbd/qK4U	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:Q9UBL3-3	intact:EBI-22091321	intact:EBI-16130425|ensembl:ENSP00000395310	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:q9ubl3-3(display_long)|uniprotkb:ASH2L(gene name)|psi-mi:ASH2L(display_short)|uniprotkb:ASH2L1(gene name synonym)|uniprotkb:ASH2-like protein(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091338|emdb:EMDB-9998|emdb:EMDB- 0693|emdb:EMDB-9999|imex:IM-27442-1|wwpdb:6KIU|wwpdb:6KIV|wwpdb:6KIW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	ensembl:ENSG00000129691(gene)|ensembl:ENST00000428278(transcript)|intact:EBI-540797(isoform-parent)	-	-	isoform-comment:No experimental confirmation available. Contains a N-acetylmethionine at position 1.	figure legend:Fig. 1, Fig. 4a, Extended Data Fig. 2, Extended Data Table 1, Extended Data Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:ERKOFmIONf8FkZlCUVcFrYjIpck9606	rigid:5pXaUqb8SL/ezg2x9+KJbd/qK4U	false	-	binding-associated region:1-534	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:P62979	intact:EBI-22091321	intact:EBI-357375|ensembl:ENSP00000272317|ensembl:ENSP00000383981|ensembl:ENSP00000385659|uniprotkb:P14798|uniprotkb:Q6LBL4|uniprotkb:Q9BQ77|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:P62988|uniprotkb:Q29120|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:rs27a_human(display_long)|uniprotkb:RPS27A(gene name)|psi-mi:RPS27A(display_short)|uniprotkb:UBA80(gene name synonym)|uniprotkb:UBCEP1(gene name synonym)|uniprotkb:Ubiquitin carboxyl extension protein 80(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091338|emdb:EMDB-9998|emdb:EMDB- 0693|emdb:EMDB-9999|imex:IM-27442-1|wwpdb:6KIU|wwpdb:6KIV|wwpdb:6KIW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8854050|reactome:R-HSA-8951664|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9633012|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975163|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-977225|reactome:R-HSA-983168|reactome:R-HSA-975144|ensembl:ENSG00000143947(gene)|ensembl:ENST00000272317(transcript)|ensembl:ENST00000402285(transcript)|ensembl:ENST00000404735(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0010008"(endosome membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR002906(Ribosomal protein S27a)|interpro:IPR011332(Ribosomal protein, zinc-binding)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038582|mint:P62979|rcsb pdb:2KHW|rcsb pdb:2KOX|rcsb pdb:2KTF|rcsb pdb:2KWU|rcsb pdb:2KWV|rcsb pdb:2L0F|rcsb pdb:2L0T|rcsb pdb:2XK5|rcsb pdb:3AXC|rcsb pdb:3I3T|rcsb pdb:3K9P|rcsb pdb:3N30|rcsb pdb:3N32|rcsb pdb:3NHE|rcsb pdb:3NOB|rcsb pdb:3NS8|rcsb pdb:3PHD|rcsb pdb:3PHW|rcsb pdb:3TBL|rcsb pdb:3VDZ|rcsb pdb:4R62|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:5A2Q|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:5AJ0|rcsb pdb:6IP8|rcsb pdb:6J99|rcsb pdb:5FLX|rcsb pdb:6KFP|rcsb pdb:5LKS|rcsb pdb:6KG6|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SQO|rcsb pdb:5T2C|rcsb pdb:5WVO|rcsb pdb:6SQR|rcsb pdb:6SQS|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:5YDK|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6DC6|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:7K5I|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6ZXF|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|rcsb pdb:6ZXG|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|rcsb pdb:6ZXH|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-1799339|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|rcsb pdb:7A09|rcsb pdb:7BWD|reactome:R-HSA-192823|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-2565942|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-211733|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-2122947|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-2122948|reactome:R-HSA-4641258|reactome:R-HSA-2173788|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-2173791|reactome:R-HSA-5357905|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2408557|reactome:R-HSA-2467813|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-2559585|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656169|reactome:R-HSA-5656121|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6791226|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-8852276|refseq:NP_001129064.1|refseq:NP_001170884.1|refseq:NP_002945.1	-	-	-	figure legend:Fig. 1, Fig. 4a, Extended Data Fig. 2, Extended Data Table 1, Extended Data Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:2LSJafy6vjKHYZcZVx8zZaOXRis9606	rigid:5pXaUqb8SL/ezg2x9+KJbd/qK4U	false	-	-	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:P61964	intact:EBI-22091321	intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091338|emdb:EMDB-9998|emdb:EMDB- 0693|emdb:EMDB-9999|imex:IM-27442-1|wwpdb:6KIU|wwpdb:6KIV|wwpdb:6KIW	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N	-	-	-	figure legend:Fig. 1, Fig. 4a, Extended Data Fig. 2, Extended Data Table 1, Extended Data Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606	rigid:5pXaUqb8SL/ezg2x9+KJbd/qK4U	false	-	binding-associated region:1-334	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:P02281	intact:EBI-22091321	intact:EBI-1251201|uniprotkb:Q6AZT0	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:h2b11_xenla(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091757|emdb:EMDB-0694|emdb:EMDB-0695|imex:IM-27442-3|wwpdb:6KIX|wwpdb:6KIZ	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	refseq:NP_001086753.1|dip:DIP-38577N|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4KHA|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W4L|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:6PA7|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:4Z66|rcsb pdb:4ZUX|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5G2E|rcsb pdb:5HQ2|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6FQ8|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K01|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:4XZQ|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6LTJ|rcsb pdb:4YS3|rcsb pdb:6N1Z|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O96|rcsb pdb:6OM3|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1AOI|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB	-	-	-	figure legend:Fig. 3a, Extended Data Fig. 6b and c, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:+nkA0I7sW2isaEdOjTHa7+jcsDw8355	rigid:uRB+rivLIK3YVHt6fcD/N2ntsKQ	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:P62799	intact:EBI-22091321	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091757|emdb:EMDB-0694|emdb:EMDB-0695|imex:IM-27442-3|wwpdb:6KIX|wwpdb:6KIZ	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:Fig. 3a, Extended Data Fig. 6b and c, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:uRB+rivLIK3YVHt6fcD/N2ntsKQ	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:Q03164-1	intact:EBI-22091321	intact:EBI-22091730|ensembl:ENSP00000374157	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:q03164-1(display_long)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091757|emdb:EMDB-0694|emdb:EMDB-0695|imex:IM-27442-3|wwpdb:6KIX|wwpdb:6KIZ	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	intact:EBI-591370(isoform-parent)|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)	-	-	-	figure legend:Fig. 3a, Extended Data Fig. 6b and c, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	rigid:uRB+rivLIK3YVHt6fcD/N2ntsKQ	false	-	binding-associated region:3754-3969	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:Q15291-1	intact:EBI-22091321	intact:EBI-22091723|ensembl:ENSP00000264515	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:q15291-1(display_long)|uniprotkb:Retinoblastoma-binding protein RBQ-3(gene name synonym)|uniprotkb:RBBP5(gene name)|psi-mi:RBBP5(display_short)|uniprotkb:RBQ3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091757|emdb:EMDB-0694|emdb:EMDB-0695|imex:IM-27442-3|wwpdb:6KIX|wwpdb:6KIZ	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	intact:EBI-592823(isoform-parent)|ensembl:ENSG00000117222(gene)|ensembl:ENST00000264515(transcript)	-	-	-	figure legend:Fig. 3a, Extended Data Fig. 6b and c, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:Zl8yHcbL1C6StHPyD+875Ccy6gk9606	rigid:uRB+rivLIK3YVHt6fcD/N2ntsKQ	false	-	binding-associated region:1-528	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:Q6AZJ8	intact:EBI-22091321	intact:EBI-1265425	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:q6azj8_xenla(display_long)|uniprotkb:h2ac14.L(gene name)|psi-mi:h2ac14.L(display_short)|uniprotkb:LOC494591(gene name synonym)|uniprotkb:h2ac14(gene name synonym)|uniprotkb:hist1h2aj(gene name synonym)|uniprotkb:XELAEV_18003602mg(orf name)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091757|emdb:EMDB-0694|emdb:EMDB-0695|imex:IM-27442-3|wwpdb:6KIX|wwpdb:6KIZ	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	refseq:NP_001087948.1|dip:DIP-38576N|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MVD|rcsb pdb:4KGC|rcsb pdb:4KHA|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K01|rcsb pdb:6K1P|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6VZ4|rcsb pdb:6W5I|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7KTQ	-	-	-	figure legend:Fig. 3a, Extended Data Fig. 6b and c, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:E7iU5tlv8Az4uOlSHgPXi/4WcnE8355	rigid:uRB+rivLIK3YVHt6fcD/N2ntsKQ	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:Q9UBL3-3	intact:EBI-22091321	intact:EBI-16130425|ensembl:ENSP00000395310	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:q9ubl3-3(display_long)|uniprotkb:ASH2L(gene name)|psi-mi:ASH2L(display_short)|uniprotkb:ASH2L1(gene name synonym)|uniprotkb:ASH2-like protein(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091757|emdb:EMDB-0694|emdb:EMDB-0695|imex:IM-27442-3|wwpdb:6KIX|wwpdb:6KIZ	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	ensembl:ENSG00000129691(gene)|ensembl:ENST00000428278(transcript)|intact:EBI-540797(isoform-parent)	-	-	isoform-comment:No experimental confirmation available. Contains a N-acetylmethionine at position 1.	figure legend:Fig. 3a, Extended Data Fig. 6b and c, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:ERKOFmIONf8FkZlCUVcFrYjIpck9606	rigid:uRB+rivLIK3YVHt6fcD/N2ntsKQ	false	-	binding-associated region:1-534	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:P61964	intact:EBI-22091321	intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091757|emdb:EMDB-0694|emdb:EMDB-0695|imex:IM-27442-3|wwpdb:6KIX|wwpdb:6KIZ	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N	-	-	-	figure legend:Fig. 3a, Extended Data Fig. 6b and c, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606	rigid:uRB+rivLIK3YVHt6fcD/N2ntsKQ	false	-	binding-associated region:1-334	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:P02281	intact:EBI-22091321	intact:EBI-1251201|uniprotkb:Q6AZT0	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:h2b11_xenla(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091779|imex:IM-27442-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	refseq:NP_001086753.1|dip:DIP-38577N|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4KHA|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6W4L|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:6PA7|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:4Z66|rcsb pdb:4ZUX|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5G2E|rcsb pdb:5HQ2|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:6FQ8|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K01|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:4XZQ|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6LTJ|rcsb pdb:4YS3|rcsb pdb:6N1Z|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O96|rcsb pdb:6OM3|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|rcsb pdb:1AOI|rcsb pdb:1F66|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:1ZBB	-	-	-	figure legend:Fig. 4a, Extended Data Fig. 4d, Extended Data Fig. 7, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:+nkA0I7sW2isaEdOjTHa7+jcsDw8355	rigid:0CymO0O0iJ+0LNMPdK24zbk90Rk	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:P62799	intact:EBI-22091321	intact:EBI-302085|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6AZG5	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:h4_xenla(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091779|imex:IM-27442-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1AOI|rcsb pdb:1KX3|rcsb pdb:1KX4|rcsb pdb:1KX5|rcsb pdb:1M18|rcsb pdb:1M19|rcsb pdb:1M1A|rcsb pdb:1P34|rcsb pdb:1P3A|rcsb pdb:1P3B|rcsb pdb:1P3F|rcsb pdb:1P3G|rcsb pdb:1P3I|rcsb pdb:1P3K|rcsb pdb:1P3L|rcsb pdb:1P3M|rcsb pdb:1P3O|rcsb pdb:1P3P|rcsb pdb:1S32|rcsb pdb:5BSA|rcsb pdb:5CP6|rcsb pdb:5DNM|rcsb pdb:5DNN|rcsb pdb:5E5A|rcsb pdb:5F99|rcsb pdb:5HQ2|rcsb pdb:5KGF|rcsb pdb:5MLU|rcsb pdb:5NL0|rcsb pdb:5O9G|rcsb pdb:5OMX|rcsb pdb:5ONG|rcsb pdb:5ONW|rcsb pdb:5OXV|rcsb pdb:5OY7|rcsb pdb:5X0X|rcsb pdb:5X0Y|rcsb pdb:5XF6|rcsb pdb:5Z3L|rcsb pdb:5Z3O|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6FQ5|rcsb pdb:6FQ6|rcsb pdb:1ZBB|rcsb pdb:1ZLA|rcsb pdb:2F8N|rcsb pdb:2FJ7|rcsb pdb:2HUE|rcsb pdb:2IO5|rcsb pdb:2NZD|rcsb pdb:3B6F|rcsb pdb:3B6G|rcsb pdb:3C1B|rcsb pdb:3C1C|rcsb pdb:3KUY|rcsb pdb:3KWQ|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LJA|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MNN|rcsb pdb:3MVD|rcsb pdb:3O62|rcsb pdb:3REH|rcsb pdb:3REI|rcsb pdb:3REJ|rcsb pdb:3REK|rcsb pdb:3REL|rcsb pdb:3TU4|rcsb pdb:3UT9|rcsb pdb:3UTA|rcsb pdb:3UTB|rcsb pdb:4EO5|rcsb pdb:4J8U|rcsb pdb:4J8V|rcsb pdb:4J8W|rcsb pdb:4J8X|rcsb pdb:4KGC|rcsb pdb:4LD9|rcsb pdb:4R8P|rcsb pdb:4WU8|rcsb pdb:4WU9|rcsb pdb:4XUJ|rcsb pdb:4XZQ|rcsb pdb:4YS3|rcsb pdb:4Z66|rcsb pdb:4ZBJ|rcsb pdb:4ZUX|rcsb pdb:5BS7|rcsb pdb:6FQ8|rcsb pdb:6PWW|rcsb pdb:6FTX|rcsb pdb:6G0L|rcsb pdb:6GYT|rcsb pdb:6I84|rcsb pdb:6IRO|rcsb pdb:6IY2|rcsb pdb:6IY3|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K1P|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6KW3|rcsb pdb:6KW4|rcsb pdb:6KW5|rcsb pdb:6LTJ|rcsb pdb:6NE3|rcsb pdb:6NJ9|rcsb pdb:6NN6|rcsb pdb:6NOG|rcsb pdb:6NQA|rcsb pdb:6NZO|rcsb pdb:6O22|rcsb pdb:6O96|rcsb pdb:6OM3|rcsb pdb:6PA7|rcsb pdb:6PWV|refseq:NP_001087926.1|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WKR|rcsb pdb:6WZ5|rcsb pdb:6WZ9|rcsb pdb:6X0N|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7AT8|rcsb pdb:7CRO|rcsb pdb:7CRP|rcsb pdb:7CRQ|rcsb pdb:7CRR|rcsb pdb:7E8I|rcsb pdb:7K6P|rcsb pdb:7K6Q|rcsb pdb:7KTQ|rcsb pdb:6PWX|rcsb pdb:6PX1|rcsb pdb:6PX3|rcsb pdb:6R1T|rcsb pdb:6R1U|rcsb pdb:6R25|rcsb pdb:6RYR|rcsb pdb:6RYU|rcsb pdb:6S01|rcsb pdb:6T9L|rcsb pdb:6TDA|rcsb pdb:6TEM|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6UXW|rcsb pdb:6VEN|rcsb pdb:6VYP|rcsb pdb:6VZ4|rcsb pdb:6W5I|dip:DIP-37429N|refseq:XP_018095104.1|refseq:XP_018095605.1|refseq:XP_018095606.1|refseq:XP_018096302.1|refseq:XP_018097458.1|refseq:XP_018098137.1|refseq:XP_018118237.1|refseq:XP_018120359.1|refseq:XP_018120360.1	-	-	-	figure legend:Fig. 4a, Extended Data Fig. 4d, Extended Data Fig. 7, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA8355	rigid:0CymO0O0iJ+0LNMPdK24zbk90Rk	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:Q8NEZ4	intact:EBI-22091321	intact:EBI-1042997|uniprotkb:Q8NC02|uniprotkb:Q8NDF6|uniprotkb:Q9H9P4|uniprotkb:Q9NR13|uniprotkb:Q9P222|uniprotkb:Q9UDR7|ensembl:ENSP00000262189	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:kmt2c_human(display_long)|uniprotkb:KMT2C(gene name)|psi-mi:KMT2C(display_short)|uniprotkb:HALR(gene name synonym)|uniprotkb:Homologous to ALR protein(gene name synonym)|uniprotkb:KIAA1506(gene name synonym)|uniprotkb:MLL3(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091779|imex:IM-27442-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	ensembl:ENSG00000055609(gene)|ensembl:ENST00000262189(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042393"(histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0097692"(histone H3-K4 monomethylation)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|go:"GO:0005634"(nucleus)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036910|interpro:IPR037877|interpro:IPR041967|interpro:IPR041968|mint:Q8NEZ4|rcsb pdb:2YSM|rcsb pdb:2YUK|rcsb pdb:3UVL|rcsb pdb:4ERY|rcsb pdb:5F59|rcsb pdb:5F6K|rcsb pdb:6KIW|rcsb pdb:6MLC|reactome:R-HSA-3214841|reactome:R-HSA-5617472|reactome:R-HSA-8936459|refseq:NP_733751.2|ensembl:ENSP00000262189|ensembl:ENST00000682283|ensembl:ENSP00000507485|dip:DIP-48649N	-	-	-	figure legend:Fig. 4a, Extended Data Fig. 4d, Extended Data Fig. 7, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:NZg8HgfbohMT8EEgAdAgWR1AjSo9606	rigid:0CymO0O0iJ+0LNMPdK24zbk90Rk	false	-	binding-associated region:4707-4911	2	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:Q15291-1	intact:EBI-22091321	intact:EBI-22091723|ensembl:ENSP00000264515	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:q15291-1(display_long)|uniprotkb:Retinoblastoma-binding protein RBQ-3(gene name synonym)|uniprotkb:RBBP5(gene name)|psi-mi:RBBP5(display_short)|uniprotkb:RBQ3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091779|imex:IM-27442-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	intact:EBI-592823(isoform-parent)|ensembl:ENSG00000117222(gene)|ensembl:ENST00000264515(transcript)	-	-	-	figure legend:Fig. 4a, Extended Data Fig. 4d, Extended Data Fig. 7, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:Zl8yHcbL1C6StHPyD+875Ccy6gk9606	rigid:0CymO0O0iJ+0LNMPdK24zbk90Rk	false	-	binding-associated region:1-528	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:Q6AZJ8	intact:EBI-22091321	intact:EBI-1265425	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:q6azj8_xenla(display_long)|uniprotkb:h2ac14.L(gene name)|psi-mi:h2ac14.L(display_short)|uniprotkb:LOC494591(gene name synonym)|uniprotkb:h2ac14(gene name synonym)|uniprotkb:hist1h2aj(gene name synonym)|uniprotkb:XELAEV_18003602mg(orf name)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091779|imex:IM-27442-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	refseq:NP_001087948.1|dip:DIP-38576N|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|rcsb pdb:3KXB|rcsb pdb:3LEL|rcsb pdb:3LZ0|rcsb pdb:3LZ1|rcsb pdb:3MGP|rcsb pdb:3MGQ|rcsb pdb:3MGR|rcsb pdb:3MGS|rcsb pdb:3MVD|rcsb pdb:4KGC|rcsb pdb:4KHA|rcsb pdb:5Z3U|rcsb pdb:5Z3V|rcsb pdb:6ESF|rcsb pdb:6ESG|rcsb pdb:6ESH|rcsb pdb:6ESI|rcsb pdb:6J99|rcsb pdb:6JM9|rcsb pdb:6JMA|rcsb pdb:6JYL|rcsb pdb:6K01|rcsb pdb:6K1P|rcsb pdb:6UGM|rcsb pdb:6UH5|rcsb pdb:6VZ4|rcsb pdb:6W5I|rcsb pdb:6Z6P|rcsb pdb:7AT8|rcsb pdb:7KTQ	-	-	-	figure legend:Fig. 4a, Extended Data Fig. 4d, Extended Data Fig. 7, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:E7iU5tlv8Az4uOlSHgPXi/4WcnE8355	rigid:0CymO0O0iJ+0LNMPdK24zbk90Rk	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:Q9UBL3-3	intact:EBI-22091321	intact:EBI-16130425|ensembl:ENSP00000395310	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:q9ubl3-3(display_long)|uniprotkb:ASH2L(gene name)|psi-mi:ASH2L(display_short)|uniprotkb:ASH2L1(gene name synonym)|uniprotkb:ASH2-like protein(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091779|imex:IM-27442-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	ensembl:ENSG00000129691(gene)|ensembl:ENST00000428278(transcript)|intact:EBI-540797(isoform-parent)	-	-	isoform-comment:No experimental confirmation available. Contains a N-acetylmethionine at position 1.	figure legend:Fig. 4a, Extended Data Fig. 4d, Extended Data Fig. 7, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:ERKOFmIONf8FkZlCUVcFrYjIpck9606	rigid:0CymO0O0iJ+0LNMPdK24zbk90Rk	false	-	binding-associated region:1-534	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:P62979	intact:EBI-22091321	intact:EBI-357375|ensembl:ENSP00000272317|ensembl:ENSP00000383981|ensembl:ENSP00000385659|uniprotkb:P14798|uniprotkb:Q6LBL4|uniprotkb:Q9BQ77|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:P62988|uniprotkb:Q29120|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:rs27a_human(display_long)|uniprotkb:RPS27A(gene name)|psi-mi:RPS27A(display_short)|uniprotkb:UBA80(gene name synonym)|uniprotkb:UBCEP1(gene name synonym)|uniprotkb:Ubiquitin carboxyl extension protein 80(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091779|imex:IM-27442-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8854050|reactome:R-HSA-8951664|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9633012|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975163|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-977225|reactome:R-HSA-983168|reactome:R-HSA-975144|ensembl:ENSG00000143947(gene)|ensembl:ENST00000272317(transcript)|ensembl:ENST00000402285(transcript)|ensembl:ENST00000404735(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0010008"(endosome membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR002906(Ribosomal protein S27a)|interpro:IPR011332(Ribosomal protein, zinc-binding)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038582|mint:P62979|rcsb pdb:2KHW|rcsb pdb:2KOX|rcsb pdb:2KTF|rcsb pdb:2KWU|rcsb pdb:2KWV|rcsb pdb:2L0F|rcsb pdb:2L0T|rcsb pdb:2XK5|rcsb pdb:3AXC|rcsb pdb:3I3T|rcsb pdb:3K9P|rcsb pdb:3N30|rcsb pdb:3N32|rcsb pdb:3NHE|rcsb pdb:3NOB|rcsb pdb:3NS8|rcsb pdb:3PHD|rcsb pdb:3PHW|rcsb pdb:3TBL|rcsb pdb:3VDZ|rcsb pdb:4R62|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:5A2Q|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:5AJ0|rcsb pdb:6IP8|rcsb pdb:6J99|rcsb pdb:5FLX|rcsb pdb:6KFP|rcsb pdb:5LKS|rcsb pdb:6KG6|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SQO|rcsb pdb:5T2C|rcsb pdb:5WVO|rcsb pdb:6SQR|rcsb pdb:6SQS|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:5YDK|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6DC6|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:7K5I|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-156827|reactome:R-HSA-156902|rcsb pdb:6ZXF|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|rcsb pdb:6ZXG|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|rcsb pdb:6ZXH|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-1799339|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|rcsb pdb:7A09|rcsb pdb:7BWD|reactome:R-HSA-192823|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-2565942|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-211733|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-2122947|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-2122948|reactome:R-HSA-4641258|reactome:R-HSA-2173788|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-2173791|reactome:R-HSA-5357905|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2408557|reactome:R-HSA-2467813|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-2559585|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656169|reactome:R-HSA-5656121|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6791226|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-8852276|refseq:NP_001129064.1|refseq:NP_001170884.1|refseq:NP_002945.1	-	-	-	figure legend:Fig. 4a, Extended Data Fig. 4d, Extended Data Fig. 7, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:2LSJafy6vjKHYZcZVx8zZaOXRis9606	rigid:0CymO0O0iJ+0LNMPdK24zbk90Rk	false	-	-	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A310TTQ1	uniprotkb:P61964	intact:EBI-22091321	intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097	psi-mi:a0a310ttq1_xenla(display_long)|uniprotkb:XELAEV_18002543mg(orf name)	psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22091779|imex:IM-27442-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_018095591.1|refseq:XP_018095592.1|refseq:XP_018098140.1|rcsb pdb:6J99|rcsb pdb:6JYL|rcsb pdb:6K1P|interpro:IPR009072(Histone-fold)|interpro:IPR007125(Histone core)|interpro:IPR000164(Histone H3)|rcsb pdb:6Z6P|rcsb pdb:6ZHX|rcsb pdb:6ZHY|rcsb pdb:7KTQ|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046982"(protein heterodimerization activity)	refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N	-	-	-	figure legend:Fig. 4a, Extended Data Fig. 4d, Extended Data Fig. 7, Extended Data Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/17	rogid:V+If7B12RC2fu3Y11IR39ZbGQxI8355	rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606	rigid:0CymO0O0iJ+0LNMPdK24zbk90Rk	false	-	binding-associated region:1-334	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9C005	uniprotkb:Q03164-1	intact:EBI-744973|uniprotkb:D6W578|ensembl:ENSP00000295066|ensembl:ENSP00000345837	intact:EBI-22091730|ensembl:ENSP00000374157	psi-mi:dpy30_human(display_long)|uniprotkb:DPY30(gene name)|psi-mi:DPY30(display_short)|uniprotkb:Dpy-30-like protein(gene name synonym)	psi-mi:q03164-1(display_long)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22113866|imex:IM-27442-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115963.1|ensembl:ENSG00000162961(gene)|ensembl:ENST00000295066(transcript)|ensembl:ENST00000342166(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006348"|go:"GO:0016197"(endosomal transport)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR007858(Dpy-30)|interpro:IPR037856|mint:Q9C005|rcsb pdb:3G36|rcsb pdb:4RIQ|rcsb pdb:4RT4|rcsb pdb:4RTA|rcsb pdb:6E2H|rcsb pdb:6PWV|reactome:R-HSA-3214841|reactome:R-HSA-8936459|refseq:NP_001308138.1|dip:DIP-34476N	intact:EBI-591370(isoform-parent)|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)	-	-	-	figure legend:"Extended Data Fig. 1a (Mixture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/18	rogid:yC9NJhTfEIT+YyfWRSJLGbRsQkc9606	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	rigid:lh3n1C5Vlb3pcAWEuAk623O8XQk	false	-	binding-associated region:3754-3969	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C005	uniprotkb:Q15291-1	intact:EBI-744973|uniprotkb:D6W578|ensembl:ENSP00000295066|ensembl:ENSP00000345837	intact:EBI-22091723|ensembl:ENSP00000264515	psi-mi:dpy30_human(display_long)|uniprotkb:DPY30(gene name)|psi-mi:DPY30(display_short)|uniprotkb:Dpy-30-like protein(gene name synonym)	psi-mi:q15291-1(display_long)|uniprotkb:Retinoblastoma-binding protein RBQ-3(gene name synonym)|uniprotkb:RBBP5(gene name)|psi-mi:RBBP5(display_short)|uniprotkb:RBQ3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22113866|imex:IM-27442-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115963.1|ensembl:ENSG00000162961(gene)|ensembl:ENST00000295066(transcript)|ensembl:ENST00000342166(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006348"|go:"GO:0016197"(endosomal transport)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR007858(Dpy-30)|interpro:IPR037856|mint:Q9C005|rcsb pdb:3G36|rcsb pdb:4RIQ|rcsb pdb:4RT4|rcsb pdb:4RTA|rcsb pdb:6E2H|rcsb pdb:6PWV|reactome:R-HSA-3214841|reactome:R-HSA-8936459|refseq:NP_001308138.1|dip:DIP-34476N	intact:EBI-592823(isoform-parent)|ensembl:ENSG00000117222(gene)|ensembl:ENST00000264515(transcript)	-	-	-	figure legend:"Extended Data Fig. 1a (Mixture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/18	rogid:yC9NJhTfEIT+YyfWRSJLGbRsQkc9606	rogid:Zl8yHcbL1C6StHPyD+875Ccy6gk9606	rigid:lh3n1C5Vlb3pcAWEuAk623O8XQk	false	-	binding-associated region:1-528	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C005	uniprotkb:Q9UBL3-3	intact:EBI-744973|uniprotkb:D6W578|ensembl:ENSP00000295066|ensembl:ENSP00000345837	intact:EBI-16130425|ensembl:ENSP00000395310	psi-mi:dpy30_human(display_long)|uniprotkb:DPY30(gene name)|psi-mi:DPY30(display_short)|uniprotkb:Dpy-30-like protein(gene name synonym)	psi-mi:q9ubl3-3(display_long)|uniprotkb:ASH2L(gene name)|psi-mi:ASH2L(display_short)|uniprotkb:ASH2L1(gene name synonym)|uniprotkb:ASH2-like protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22113866|imex:IM-27442-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115963.1|ensembl:ENSG00000162961(gene)|ensembl:ENST00000295066(transcript)|ensembl:ENST00000342166(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006348"|go:"GO:0016197"(endosomal transport)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR007858(Dpy-30)|interpro:IPR037856|mint:Q9C005|rcsb pdb:3G36|rcsb pdb:4RIQ|rcsb pdb:4RT4|rcsb pdb:4RTA|rcsb pdb:6E2H|rcsb pdb:6PWV|reactome:R-HSA-3214841|reactome:R-HSA-8936459|refseq:NP_001308138.1|dip:DIP-34476N	ensembl:ENSG00000129691(gene)|ensembl:ENST00000428278(transcript)|intact:EBI-540797(isoform-parent)	-	-	isoform-comment:No experimental confirmation available. Contains a N-acetylmethionine at position 1.	figure legend:"Extended Data Fig. 1a (Mixture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/18	rogid:yC9NJhTfEIT+YyfWRSJLGbRsQkc9606	rogid:ERKOFmIONf8FkZlCUVcFrYjIpck9606	rigid:lh3n1C5Vlb3pcAWEuAk623O8XQk	false	-	binding-associated region:1-534	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C005	uniprotkb:P61964	intact:EBI-744973|uniprotkb:D6W578|ensembl:ENSP00000295066|ensembl:ENSP00000345837	intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097	psi-mi:dpy30_human(display_long)|uniprotkb:DPY30(gene name)|psi-mi:DPY30(display_short)|uniprotkb:Dpy-30-like protein(gene name synonym)	psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22113866|imex:IM-27442-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115963.1|ensembl:ENSG00000162961(gene)|ensembl:ENST00000295066(transcript)|ensembl:ENST00000342166(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006348"|go:"GO:0016197"(endosomal transport)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR007858(Dpy-30)|interpro:IPR037856|mint:Q9C005|rcsb pdb:3G36|rcsb pdb:4RIQ|rcsb pdb:4RT4|rcsb pdb:4RTA|rcsb pdb:6E2H|rcsb pdb:6PWV|reactome:R-HSA-3214841|reactome:R-HSA-8936459|refseq:NP_001308138.1|dip:DIP-34476N	refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N	-	-	-	figure legend:"Extended Data Fig. 1a (Mixture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/18	rogid:yC9NJhTfEIT+YyfWRSJLGbRsQkc9606	rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606	rigid:lh3n1C5Vlb3pcAWEuAk623O8XQk	false	-	binding-associated region:1-334	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C005	uniprotkb:Q8NEZ4	intact:EBI-744973|uniprotkb:D6W578|ensembl:ENSP00000295066|ensembl:ENSP00000345837	intact:EBI-1042997|uniprotkb:Q8NC02|uniprotkb:Q8NDF6|uniprotkb:Q9H9P4|uniprotkb:Q9NR13|uniprotkb:Q9P222|uniprotkb:Q9UDR7|ensembl:ENSP00000262189	psi-mi:dpy30_human(display_long)|uniprotkb:DPY30(gene name)|psi-mi:DPY30(display_short)|uniprotkb:Dpy-30-like protein(gene name synonym)	psi-mi:kmt2c_human(display_long)|uniprotkb:KMT2C(gene name)|psi-mi:KMT2C(display_short)|uniprotkb:HALR(gene name synonym)|uniprotkb:Homologous to ALR protein(gene name synonym)|uniprotkb:KIAA1506(gene name synonym)|uniprotkb:MLL3(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22117506|imex:IM-27442-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115963.1|ensembl:ENSG00000162961(gene)|ensembl:ENST00000295066(transcript)|ensembl:ENST00000342166(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006348"|go:"GO:0016197"(endosomal transport)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR007858(Dpy-30)|interpro:IPR037856|mint:Q9C005|rcsb pdb:3G36|rcsb pdb:4RIQ|rcsb pdb:4RT4|rcsb pdb:4RTA|rcsb pdb:6E2H|rcsb pdb:6PWV|reactome:R-HSA-3214841|reactome:R-HSA-8936459|refseq:NP_001308138.1|dip:DIP-34476N	ensembl:ENSG00000055609(gene)|ensembl:ENST00000262189(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042393"(histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0097692"(histone H3-K4 monomethylation)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003616(Post-SET zinc-binding region)|go:"GO:0005634"(nucleus)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036910|interpro:IPR037877|interpro:IPR041967|interpro:IPR041968|mint:Q8NEZ4|rcsb pdb:2YSM|rcsb pdb:2YUK|rcsb pdb:3UVL|rcsb pdb:4ERY|rcsb pdb:5F59|rcsb pdb:5F6K|rcsb pdb:6KIW|rcsb pdb:6MLC|reactome:R-HSA-3214841|reactome:R-HSA-5617472|reactome:R-HSA-8936459|refseq:NP_733751.2|ensembl:ENSP00000262189|ensembl:ENST00000682283|ensembl:ENSP00000507485|dip:DIP-48649N	-	-	-	figure legend:"Extended Data Fig. 7a (Mixture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/23	rogid:yC9NJhTfEIT+YyfWRSJLGbRsQkc9606	rogid:NZg8HgfbohMT8EEgAdAgWR1AjSo9606	rigid:/1wh20HU6vfqy6s+d6kBfV2vX30	false	-	binding-associated region:4707-4911	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C005	uniprotkb:Q15291-1	intact:EBI-744973|uniprotkb:D6W578|ensembl:ENSP00000295066|ensembl:ENSP00000345837	intact:EBI-22091723|ensembl:ENSP00000264515	psi-mi:dpy30_human(display_long)|uniprotkb:DPY30(gene name)|psi-mi:DPY30(display_short)|uniprotkb:Dpy-30-like protein(gene name synonym)	psi-mi:q15291-1(display_long)|uniprotkb:Retinoblastoma-binding protein RBQ-3(gene name synonym)|uniprotkb:RBBP5(gene name)|psi-mi:RBBP5(display_short)|uniprotkb:RBQ3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22117506|imex:IM-27442-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115963.1|ensembl:ENSG00000162961(gene)|ensembl:ENST00000295066(transcript)|ensembl:ENST00000342166(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006348"|go:"GO:0016197"(endosomal transport)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR007858(Dpy-30)|interpro:IPR037856|mint:Q9C005|rcsb pdb:3G36|rcsb pdb:4RIQ|rcsb pdb:4RT4|rcsb pdb:4RTA|rcsb pdb:6E2H|rcsb pdb:6PWV|reactome:R-HSA-3214841|reactome:R-HSA-8936459|refseq:NP_001308138.1|dip:DIP-34476N	intact:EBI-592823(isoform-parent)|ensembl:ENSG00000117222(gene)|ensembl:ENST00000264515(transcript)	-	-	-	figure legend:"Extended Data Fig. 7a (Mixture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/23	rogid:yC9NJhTfEIT+YyfWRSJLGbRsQkc9606	rogid:Zl8yHcbL1C6StHPyD+875Ccy6gk9606	rigid:/1wh20HU6vfqy6s+d6kBfV2vX30	false	-	binding-associated region:1-528	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C005	uniprotkb:Q9UBL3-3	intact:EBI-744973|uniprotkb:D6W578|ensembl:ENSP00000295066|ensembl:ENSP00000345837	intact:EBI-16130425|ensembl:ENSP00000395310	psi-mi:dpy30_human(display_long)|uniprotkb:DPY30(gene name)|psi-mi:DPY30(display_short)|uniprotkb:Dpy-30-like protein(gene name synonym)	psi-mi:q9ubl3-3(display_long)|uniprotkb:ASH2L(gene name)|psi-mi:ASH2L(display_short)|uniprotkb:ASH2L1(gene name synonym)|uniprotkb:ASH2-like protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22117506|imex:IM-27442-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115963.1|ensembl:ENSG00000162961(gene)|ensembl:ENST00000295066(transcript)|ensembl:ENST00000342166(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006348"|go:"GO:0016197"(endosomal transport)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR007858(Dpy-30)|interpro:IPR037856|mint:Q9C005|rcsb pdb:3G36|rcsb pdb:4RIQ|rcsb pdb:4RT4|rcsb pdb:4RTA|rcsb pdb:6E2H|rcsb pdb:6PWV|reactome:R-HSA-3214841|reactome:R-HSA-8936459|refseq:NP_001308138.1|dip:DIP-34476N	ensembl:ENSG00000129691(gene)|ensembl:ENST00000428278(transcript)|intact:EBI-540797(isoform-parent)	-	-	isoform-comment:No experimental confirmation available. Contains a N-acetylmethionine at position 1.	figure legend:"Extended Data Fig. 7a (Mixture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/23	rogid:yC9NJhTfEIT+YyfWRSJLGbRsQkc9606	rogid:ERKOFmIONf8FkZlCUVcFrYjIpck9606	rigid:/1wh20HU6vfqy6s+d6kBfV2vX30	false	-	binding-associated region:1-534	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C005	uniprotkb:P61964	intact:EBI-744973|uniprotkb:D6W578|ensembl:ENSP00000295066|ensembl:ENSP00000345837	intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097	psi-mi:dpy30_human(display_long)|uniprotkb:DPY30(gene name)|psi-mi:DPY30(display_short)|uniprotkb:Dpy-30-like protein(gene name synonym)	psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Xue et al. (2019)	pubmed:31485071|imex:IM-27442	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22117506|imex:IM-27442-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115963.1|ensembl:ENSG00000162961(gene)|ensembl:ENST00000295066(transcript)|ensembl:ENST00000342166(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006348"|go:"GO:0016197"(endosomal transport)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR007858(Dpy-30)|interpro:IPR037856|mint:Q9C005|rcsb pdb:3G36|rcsb pdb:4RIQ|rcsb pdb:4RT4|rcsb pdb:4RTA|rcsb pdb:6E2H|rcsb pdb:6PWV|reactome:R-HSA-3214841|reactome:R-HSA-8936459|refseq:NP_001308138.1|dip:DIP-34476N	refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N	-	-	-	figure legend:"Extended Data Fig. 7a (Mixture)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/10/11	2019/10/23	rogid:yC9NJhTfEIT+YyfWRSJLGbRsQkc9606	rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606	rigid:/1wh20HU6vfqy6s+d6kBfV2vX30	false	-	binding-associated region:1-334	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)