#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05067-PRO_0000000092	uniprotkb:P05067-PRO_0000000092	intact:EBI-821758	intact:EBI-821758	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22275489|imex:IM-27565-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:672|chain-seq-end:713	chain-seq-start:672|chain-seq-end:713	figure legend:1A-E,  8 A/B, Supp. fig. 2.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2020/04/20	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:cKD4D1MnREsSp9G3FMjXsPLwG4g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22275503|imex:IM-27565-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:1A-E, 2, 8 A/B, supp. fig. 2|comment:The inhibitory effect on aggregation of ab-42 is the highest with the full-length apoE4  followed by the NTF, CTF and HDF.|comment:"Fragments of apoE (Apoe4) and full length Apoe3 and Apoe4,  both in the lipid-free and in the lipidated forms,  interact with Ab-42  to delay the kinetics of fibrillization."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2020/04/20	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	sufficient binding region:1-167|sufficient binding region:238-299|sufficient binding region:168-237|mutation increasing interaction strength:112-112(rs429358)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22275503|imex:IM-27565-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:1A-E, 2, 8 A/B, supp. fig. 2|comment:The inhibitory effect on aggregation of ab-42 is the highest with the full-length apoE4  followed by the NTF, CTF and HDF.|comment:"Fragments of apoE (Apoe4) and full length Apoe3 and Apoe4,  both in the lipid-free and in the lipidated forms,  interact with Ab-42  to delay the kinetics of fibrillization."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2020/04/20	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	sufficient binding region:1-167|sufficient binding region:238-299|sufficient binding region:168-237|mutation increasing interaction strength:112-112(rs429358)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P05067-PRO_0000000092	intact:EBI-821758	intact:EBI-821758	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22276113|imex:IM-27565-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:672|chain-seq-end:713	chain-seq-start:672|chain-seq-end:713	figure legend:3, Supp. fig. 3|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/11	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:cKD4D1MnREsSp9G3FMjXsPLwG4g	false	tetramethyl rhodamine label:n-n	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22276096|imex:IM-27565-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:3,  Supp. fig.3|comment:The inhibitory effect on aggregation of ab-42 is the highest with the full-length apoE4  followed by the NTF, CTF and HDF.|comment:Both apoE3 and apoE4  delay the kinetics of aggregation of Ab42 both in  lipid-free as well as in lipidated forms.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/11	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	sufficient binding region:1-167|sufficient binding region:238-299|sufficient binding region:168-237|mutation increasing interaction strength:112-112(RCV000019448.33)	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:1232"(aggregation assay)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22276096|imex:IM-27565-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:3,  Supp. fig.3|comment:The inhibitory effect on aggregation of ab-42 is the highest with the full-length apoE4  followed by the NTF, CTF and HDF.|comment:Both apoE3 and apoE4  delay the kinetics of aggregation of Ab42 both in  lipid-free as well as in lipidated forms.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/11	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	sufficient binding region:1-167|sufficient binding region:238-299|sufficient binding region:168-237|mutation increasing interaction strength:112-112(RCV000019448.33)	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22276153|imex:IM-27565-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:5A, 8C, Supp. fig 10.|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:Native tryptophan residues in apoE are the FRET donor and  EDANS tagged to ab-42 is the acceptor.  The slow time-dependent increase of FRET is consistent with interactions  of apoE with species of Ab42 such as the ‘oligomers’ that form in a time-dependent manner.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/11	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	sufficient binding region:1-167|sufficient binding region:238-299|sufficient binding region:168-237|mutation increasing interaction strength:112-112(rs429358)	fluorophore:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22276153|imex:IM-27565-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:5A, 8C, Supp. fig 10.|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:Native tryptophan residues in apoE are the FRET donor and  EDANS tagged to ab-42 is the acceptor.  The slow time-dependent increase of FRET is consistent with interactions  of apoE with species of Ab42 such as the ‘oligomers’ that form in a time-dependent manner.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/11	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	sufficient binding region:1-167|sufficient binding region:238-299|sufficient binding region:168-237|mutation increasing interaction strength:112-112(rs429358)	fluorophore:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22276230|imex:IM-27565-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:5B, Supp. fig 6|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:"Figure 5B shows that the kinetics of FRET  efficiency between apoE and Ab are similar for all the  five cysteine mutants. Similar results are obtained with EDANS-labelled lipidated apoE (Suppl Fig. 6)"|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/11	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	fluorophore:62-62|mutation:62-62|fluorophore:139-139|mutation:112-112(rs429358)|mutation:139-139|fluorophore:210-210|mutation:210-210|fluorophore:247-247|mutation:247-247|fluorophore:276-276|mutation:276-276	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22276230|imex:IM-27565-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:5B, Supp. fig 6|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:"Figure 5B shows that the kinetics of FRET  efficiency between apoE and Ab are similar for all the  five cysteine mutants. Similar results are obtained with EDANS-labelled lipidated apoE (Suppl Fig. 6)"|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/11	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	fluorophore:62-62|mutation:62-62|fluorophore:139-139|mutation:112-112(rs429358)|mutation:139-139|fluorophore:210-210|mutation:210-210|fluorophore:247-247|mutation:247-247|fluorophore:276-276|mutation:276-276	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22276281|imex:IM-27565-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6A,7A, 8D, Supp. fig 7,8.|comment:"The APOE*4  variant :P02649  VAR_000652.  It has been assumed the APOE mutation \"W247C\" is a typo and was meant to be A247C."|comment:"Figure 7:FRET is measured as a decrease in donor fluorescence at t=14hrs, rather than FRET efficiency."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/11	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:247-247|fluorophore:247-247|mutation increasing interaction strength:112-112	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22276281|imex:IM-27565-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6A,7A, 8D, Supp. fig 7,8.|comment:"The APOE*4  variant :P02649  VAR_000652.  It has been assumed the APOE mutation \"W247C\" is a typo and was meant to be A247C."|comment:"Figure 7:FRET is measured as a decrease in donor fluorescence at t=14hrs, rather than FRET efficiency."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/11	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:247-247|fluorophore:247-247|mutation increasing interaction strength:112-112	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P02649-PRO_0000001987	intact:EBI-9209835	intact:EBI-9209835	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22276316|imex:IM-27565-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-1222467(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:19|chain-seq-end:317	figure legend:6A-2, 7A-2, 8D, Supp. Fig. 7|comment:"The APOE*4  variant :P02649  VAR_000652.  It has been assumed the APOE mutation \"W247C\" is a typo and was meant to be A247C."|comment:"The reduction of the FRET signal is very small in  the presence of the (unlabelled) APOE4  fragments but high in  the presence of the full-length apoE4."|comment:"Figure 7: FRET is measured as a decrease in donor fluorescence at t=14hrs, rather than FRET efficiency. This effect is reversed in the presence of a competitor, full length APOE, but less so in the presence of NTF and CTF mixed together."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/11	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation increasing interaction strength:112-112	fluorophore:247-247|mutation:247-247|mutation:112-112	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22276316|imex:IM-27565-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6A-2, 7A-2, 8D, Supp. Fig. 7|comment:"The APOE*4  variant :P02649  VAR_000652.  It has been assumed the APOE mutation \"W247C\" is a typo and was meant to be A247C."|comment:"The reduction of the FRET signal is very small in  the presence of the (unlabelled) APOE4  fragments but high in  the presence of the full-length apoE4."|comment:"Figure 7: FRET is measured as a decrease in donor fluorescence at t=14hrs, rather than FRET efficiency. This effect is reversed in the presence of a competitor, full length APOE, but less so in the presence of NTF and CTF mixed together."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/11	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation increasing interaction strength:112-112	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22276316|imex:IM-27565-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6A-2, 7A-2, 8D, Supp. Fig. 7|comment:"The APOE*4  variant :P02649  VAR_000652.  It has been assumed the APOE mutation \"W247C\" is a typo and was meant to be A247C."|comment:"The reduction of the FRET signal is very small in  the presence of the (unlabelled) APOE4  fragments but high in  the presence of the full-length apoE4."|comment:"Figure 7: FRET is measured as a decrease in donor fluorescence at t=14hrs, rather than FRET efficiency. This effect is reversed in the presence of a competitor, full length APOE, but less so in the presence of NTF and CTF mixed together."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/11	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation increasing interaction strength:112-112	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P02649-PRO_0000001987	intact:EBI-9209835	intact:EBI-9209835	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22302528|imex:IM-27565-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-1222467(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:19|chain-seq-end:317	figure legend:6B,7B|comment:"The APOE*4  variant :P02649  VAR_000652.  It has been assumed the APOE mutation \"W247C\" is a typo and was meant to be A247C."|comment:"Figure 7:FRET is measured as a decrease in donor fluorescence rather than FRET efficiency."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:247-247|fluorophore:247-247|sufficient binding region:238-299	mutation:112-112|mutation:102-102|fluorophore:102-102|sufficient binding region:1-167	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22302528|imex:IM-27565-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6B,7B|comment:"The APOE*4  variant :P02649  VAR_000652.  It has been assumed the APOE mutation \"W247C\" is a typo and was meant to be A247C."|comment:"Figure 7:FRET is measured as a decrease in donor fluorescence rather than FRET efficiency."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:247-247|fluorophore:247-247|sufficient binding region:238-299	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22302528|imex:IM-27565-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6B,7B|comment:"The APOE*4  variant :P02649  VAR_000652.  It has been assumed the APOE mutation \"W247C\" is a typo and was meant to be A247C."|comment:"Figure 7:FRET is measured as a decrease in donor fluorescence rather than FRET efficiency."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:247-247|fluorophore:247-247|sufficient binding region:238-299	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P02649-PRO_0000001987	intact:EBI-9209835	intact:EBI-9209835	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303349|imex:IM-27565-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-1222467(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:19|chain-seq-end:317	figure legend:6B-2,7B-2|comment:"The APOE*4  variant :P02649  VAR_000652.  It has been assumed the APOE mutation \"W247C\" is a typo and was meant to be A247C."|comment:FRET is reduced strongly in the presence of  unlabelled full-length apoE4 but affected modestly in  the presence of unlabelled NTF or CTF or NTF +  CTF.|comment:"Figure 7:FRET is measured as a decrease in donor fluorescence rather than FRET efficiency."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	-	mutation:247-247|fluorophore:247-247|sufficient binding region:238-299	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P02649-PRO_0000001987	intact:EBI-9209835	intact:EBI-9209835	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303349|imex:IM-27565-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-1222467(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:19|chain-seq-end:317	figure legend:6B-2,7B-2|comment:"The APOE*4  variant :P02649  VAR_000652.  It has been assumed the APOE mutation \"W247C\" is a typo and was meant to be A247C."|comment:FRET is reduced strongly in the presence of  unlabelled full-length apoE4 but affected modestly in  the presence of unlabelled NTF or CTF or NTF +  CTF.|comment:"Figure 7:FRET is measured as a decrease in donor fluorescence rather than FRET efficiency."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	-	mutation:112-112|mutation:102-102|fluorophore:102-102|sufficient binding region:1-167	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303349|imex:IM-27565-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6B-2,7B-2|comment:"The APOE*4  variant :P02649  VAR_000652.  It has been assumed the APOE mutation \"W247C\" is a typo and was meant to be A247C."|comment:FRET is reduced strongly in the presence of  unlabelled full-length apoE4 but affected modestly in  the presence of unlabelled NTF or CTF or NTF +  CTF.|comment:"Figure 7:FRET is measured as a decrease in donor fluorescence rather than FRET efficiency."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	-	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303349|imex:IM-27565-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6B-2,7B-2|comment:"The APOE*4  variant :P02649  VAR_000652.  It has been assumed the APOE mutation \"W247C\" is a typo and was meant to be A247C."|comment:FRET is reduced strongly in the presence of  unlabelled full-length apoE4 but affected modestly in  the presence of unlabelled NTF or CTF or NTF +  CTF.|comment:"Figure 7:FRET is measured as a decrease in donor fluorescence rather than FRET efficiency."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	-	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303416|imex:IM-27565-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6C|comment:"The APOE*4  variant :P02649  VAR_000652."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:112-112|mutation:102-102|fluorophore:102-102|sufficient binding region:1-167	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303416|imex:IM-27565-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6C|comment:"The APOE*4  variant :P02649  VAR_000652."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:112-112|mutation:102-102|fluorophore:102-102|sufficient binding region:1-167	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P02649-PRO_0000001987	intact:EBI-9209835	intact:EBI-9209835	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303441|imex:IM-27565-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-1222467(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:19|chain-seq-end:317	figure legend:6C-2|comment:"The APOE*4  variant :P02649  VAR_000652."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:102-102|fluorophore:102-102|sufficient binding region:1-167|mutation:112-112	mutation:112-112	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303441|imex:IM-27565-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6C-2|comment:"The APOE*4  variant :P02649  VAR_000652."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:102-102|fluorophore:102-102|sufficient binding region:1-167|mutation:112-112	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303441|imex:IM-27565-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6C-2|comment:"The APOE*4  variant :P02649  VAR_000652."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:102-102|fluorophore:102-102|sufficient binding region:1-167|mutation:112-112	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P02649-PRO_0000001987	intact:EBI-9209835	intact:EBI-9209835	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303466|imex:IM-27565-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-1222467(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:19|chain-seq-end:317	figure legend:6C-3|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:The presence of an excess amount of CTF appears to enhance the FRET between the EDANS-NTF and TMR-Ab42.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:102-102|fluorophore:102-102|sufficient binding region:1-167|mutation:112-112	sufficient binding region:238-299	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303466|imex:IM-27565-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6C-3|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:The presence of an excess amount of CTF appears to enhance the FRET between the EDANS-NTF and TMR-Ab42.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:102-102|fluorophore:102-102|sufficient binding region:1-167|mutation:112-112	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303466|imex:IM-27565-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6C-3|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:The presence of an excess amount of CTF appears to enhance the FRET between the EDANS-NTF and TMR-Ab42.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:102-102|fluorophore:102-102|sufficient binding region:1-167|mutation:112-112	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P02649-PRO_0000001987	intact:EBI-9209835	intact:EBI-9209835	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303486|imex:IM-27565-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-1222467(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:19|chain-seq-end:317	figure legend:6C-4|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:The NTF fragment is a less effective competitor than the full length protein.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:112-112|mutation:102-102|fluorophore:102-102|sufficient binding region:1-167	mutation:112-112|sufficient binding region:1-167	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303486|imex:IM-27565-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6C-4|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:The NTF fragment is a less effective competitor than the full length protein.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:112-112|mutation:102-102|fluorophore:102-102|sufficient binding region:1-167	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303486|imex:IM-27565-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6C-4|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:The NTF fragment is a less effective competitor than the full length protein.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:112-112|mutation:102-102|fluorophore:102-102|sufficient binding region:1-167	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303507|imex:IM-27565-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6D|comment:"The APOE*4  variant :P02649  VAR_000652."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:247-247|fluorophore:247-247|sufficient binding region:238-299	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303507|imex:IM-27565-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6D|comment:"The APOE*4  variant :P02649  VAR_000652."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:247-247|fluorophore:247-247|sufficient binding region:238-299	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P02649-PRO_0000001987	intact:EBI-9209835	intact:EBI-9209835	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303532|imex:IM-27565-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-1222467(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:19|chain-seq-end:317	figure legend:6D-2|comment:"The APOE*4  variant :P02649  VAR_000652."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	-	mutation:247-247|fluorophore:247-247|sufficient binding region:238-299	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303532|imex:IM-27565-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6D-2|comment:"The APOE*4  variant :P02649  VAR_000652."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	-	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303532|imex:IM-27565-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6D-2|comment:"The APOE*4  variant :P02649  VAR_000652."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	-	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P02649-PRO_0000001987	intact:EBI-9209835	intact:EBI-9209835	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303555|imex:IM-27565-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-1222467(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:19|chain-seq-end:317	figure legend:6D-3|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:The CTF and NTF fragments are less effective competitors than full length  APOE.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:112-112|sufficient binding region:1-167	mutation:247-247|fluorophore:247-247|sufficient binding region:238-299	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303555|imex:IM-27565-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6D-3|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:The CTF and NTF fragments are less effective competitors than full length  APOE.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:112-112|sufficient binding region:1-167	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303555|imex:IM-27565-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6D-3|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:The CTF and NTF fragments are less effective competitors than full length  APOE.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:112-112|sufficient binding region:1-167	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P02649-PRO_0000001987	intact:EBI-9209835	intact:EBI-9209835	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303589|imex:IM-27565-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-1222467(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:19|chain-seq-end:317	figure legend:6D-4|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:The CTF and NTF fragments are less effective competitors than full length  APOE.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	sufficient binding region:238-299	mutation:247-247|fluorophore:247-247|sufficient binding region:238-299	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303589|imex:IM-27565-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6D-4|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:The CTF and NTF fragments are less effective competitors than full length  APOE.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	sufficient binding region:238-299	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22303589|imex:IM-27565-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:6D-4|comment:"The APOE*4  variant :P02649  VAR_000652."|comment:The CTF and NTF fragments are less effective competitors than full length  APOE.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/12	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	sufficient binding region:238-299	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304736|imex:IM-27565-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:Supp. fig. 1|comment:The inhibitory effect on aggregation of ab-42 is the highest with the full-length apoE4  followed by the NTF, CTF and HDF.|comment:"Fragments of apoE (Apoe4) and full length Apoe3 and Apoe4,  both in the lipid-free and in the lipidated forms,  interact with Ab-42  to delay the kinetics of fibrillization."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/13	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	sufficient binding region:1-167|sufficient binding region:238-299|sufficient binding region:168-237|mutation increasing interaction strength:112-112(rs429358)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304736|imex:IM-27565-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:Supp. fig. 1|comment:The inhibitory effect on aggregation of ab-42 is the highest with the full-length apoE4  followed by the NTF, CTF and HDF.|comment:"Fragments of apoE (Apoe4) and full length Apoe3 and Apoe4,  both in the lipid-free and in the lipidated forms,  interact with Ab-42  to delay the kinetics of fibrillization."|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/13	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	sufficient binding region:1-167|sufficient binding region:238-299|sufficient binding region:168-237|mutation increasing interaction strength:112-112(rs429358)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P05067-PRO_0000000092	intact:EBI-821758	intact:EBI-821758	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304755|imex:IM-27565-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:672|chain-seq-end:713	chain-seq-start:672|chain-seq-end:713	figure legend:Supp. fig. 1.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/13	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:cKD4D1MnREsSp9G3FMjXsPLwG4g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05067-PRO_0000000092	uniprotkb:P05067-PRO_0000000092	intact:EBI-821758	intact:EBI-821758	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304760|imex:IM-27565-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-77613(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:672|chain-seq-end:713	chain-seq-start:672|chain-seq-end:713	figure legend:Supp. fig. 5.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/13	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:cKD4D1MnREsSp9G3FMjXsPLwG4g	false	fluorophore:n-n	fluorophore:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304850|imex:IM-27565-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:Supp. fig.9D|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/13	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:112-112(RCV000019448.33)	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304850|imex:IM-27565-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:Supp. fig.9D|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/13	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:112-112(RCV000019448.33)	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0052"(fluorescence correlation spectroscopy)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304917|imex:IM-27565-44	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:Supp. fig.9E-I|comment:apoE-Ab form complexes that are highly heterogeneous and oligomeric in nature.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/13	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:112-112(RCV000019448.33)	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649-PRO_0000001987	uniprotkb:P05067-PRO_0000000092	intact:EBI-9209835	intact:EBI-821758	psi-mi:p02649-pro_0000001987(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0052"(fluorescence correlation spectroscopy)	Ghosh et al. (2019)	pubmed:31287614|imex:IM-27565	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22304917|imex:IM-27565-44	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222467(chain-parent)	intact:EBI-77613(chain-parent)	-	chain-seq-start:19|chain-seq-end:317	chain-seq-start:672|chain-seq-end:713	figure legend:Supp. fig.9E-I|comment:apoE-Ab form complexes that are highly heterogeneous and oligomeric in nature.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/06	2019/12/13	rogid:A45dZkOiCyV6pYa/hl5j35nNVlg9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:jeQlLBnVu1FvKFAAhj0p+XA63xk	false	mutation:112-112(RCV000019448.33)	tetramethyl rhodamine label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)