#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15539	uniprotkb:Q96SZ5	intact:EBI-12017832|ensembl:ENSP00000319308|uniprotkb:E9PMP5|uniprotkb:Q53XA9|uniprotkb:Q599J0	intact:EBI-11102284|uniprotkb:B1AL29|ensembl:ENSP00000362888	psi-mi:rgs5_human(display_long)|uniprotkb:RGS5(gene name)|psi-mi:RGS5(display_short)	psi-mi:aedo_human(display_long)|uniprotkb:ADO(gene name)|psi-mi:ADO(display_short)|uniprotkb:C10orf22(gene name synonym)|uniprotkb:Cysteamine dioxygenase(gene name synonym)	psi-mi:"MI:2404"(oxidase assay)	Masson et al. (2019)	pubmed:31273118|imex:IM-27372	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21497511|imex:IM-27372-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143248(gene)|ensembl:ENST00000313961(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034955|interpro:IPR034956|interpro:IPR036305|rcsb pdb:2CRP|reactome:R-HSA-416476|reactome:R-HSA-418594|refseq:NP_001182232.1|refseq:NP_001241677.1|refseq:NP_001241678.1|refseq:NP_003608.1	refseq:NP_116193.2|ensembl:ENSG00000181915(gene)|ensembl:ENST00000373783(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0046872"(metal ion binding)|go:"GO:0047800"(cysteamine dioxygenase activity)|interpro:IPR011051(Cupin, RmlC-type)|interpro:IPR012864(Protein of unknown function DUF1637)|interpro:IPR014710(RmlC-like jelly roll fold)|reactome:R-HSA-1614558	-	-	-	figure legend:Fig 3. Fig S14|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/09	2019/07/09	rogid:fNeN1LPfYdPH34E6XzcZKwKSLqA9606	rogid:Sg0NAGER2ACs/2TjB8h3Pjg4bRc9606	rigid:5LAl7dinjNjsGeCK1WdgLsk1CrQ	false	L-cysteine sulfinic acid:2-2|binding-associated region:2-15	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49798	uniprotkb:Q96SZ5	intact:EBI-9688865|uniprotkb:A7XA56|uniprotkb:A7XA58|uniprotkb:A7XA59|uniprotkb:A7YVV7|uniprotkb:B1APZ3|ensembl:ENSP00000356885	intact:EBI-11102284|uniprotkb:B1AL29|ensembl:ENSP00000362888	psi-mi:rgs4_human(display_long)|uniprotkb:RGS4(gene name)|psi-mi:RGS4(display_short)	psi-mi:aedo_human(display_long)|uniprotkb:ADO(gene name)|psi-mi:ADO(display_short)|uniprotkb:C10orf22(gene name synonym)|uniprotkb:Cysteamine dioxygenase(gene name synonym)	psi-mi:"MI:2404"(oxidase assay)	Masson et al. (2019)	pubmed:31273118|imex:IM-27372	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21497517|imex:IM-27372-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59092N|refseq:NP_001095915.1|refseq:NP_001106851.1|refseq:NP_001106852.1|refseq:NP_005604.1|ensembl:ENSG00000117152(gene)|ensembl:ENST00000367909(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0043278"(response to morphine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060160"(negative regulation of dopamine receptor signaling pathway)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:1900924"(negative regulation of glycine import across plasma membrane)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034952|interpro:IPR034953|interpro:IPR036305|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-418597	refseq:NP_116193.2|ensembl:ENSG00000181915(gene)|ensembl:ENST00000373783(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0046872"(metal ion binding)|go:"GO:0047800"(cysteamine dioxygenase activity)|interpro:IPR011051(Cupin, RmlC-type)|interpro:IPR012864(Protein of unknown function DUF1637)|interpro:IPR014710(RmlC-like jelly roll fold)|reactome:R-HSA-1614558	-	-	-	figure legend:Fig S13, Fig S14|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/09	2020/09/27	rogid:txTUJ5lIHkBDZ4palUD4jGSZAA89606	rogid:Sg0NAGER2ACs/2TjB8h3Pjg4bRc9606	rigid:0p4qbIR3e6X6RObZgZcpKoWm1CI	false	binding-associated region:2-15|L-cysteine sulfinic acid:2-2	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0396"(predetermined participant)