#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UJY1	uniprotkb:Q9BQI3	intact:EBI-739074|uniprotkb:Q6FIH3|uniprotkb:Q9UKS3|ensembl:ENSP00000281938|uniprotkb:B2R6A6	intact:EBI-640377|uniprotkb:Q8NBW3|uniprotkb:Q9HC02|uniprotkb:Q9NYE0|uniprotkb:Q9P0V6|uniprotkb:Q9P1J5|uniprotkb:Q9P2H8|uniprotkb:Q9UHG4|uniprotkb:A8K2R2|uniprotkb:Q549K6|ensembl:ENSP00000199389	psi-mi:hspb8_human(display_long)|uniprotkb:HSPB8(gene name)|psi-mi:HSPB8(display_short)|uniprotkb:CRYAC(gene name synonym)|uniprotkb:E2IG1(gene name synonym)|uniprotkb:HSP22(gene name synonym)|uniprotkb:PP1629(orf name)|uniprotkb:Alpha-crystallin C chain(gene name synonym)|uniprotkb:Small stress protein-like protein HSP22(gene name synonym)|uniprotkb:E2-induced gene 1 protein(gene name synonym)|uniprotkb:Protein kinase H11(gene name synonym)	psi-mi:e2ak1_human(display_long)|uniprotkb:Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase(gene name synonym)|uniprotkb:Hemin-sensitive initiation factor 2-alpha kinase(gene name synonym)|uniprotkb:Heme-regulated inhibitor(gene name synonym)|uniprotkb:Heme-controlled repressor(gene name synonym)|uniprotkb:EIF2AK1(gene name)|psi-mi:EIF2AK1(display_short)|uniprotkb:HRI(gene name synonym)|uniprotkb:KIAA1369(gene name synonym)|uniprotkb:PRO1362(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abdel-Nour et al. (2019)	imex:IM-27164|pubmed:31273097	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21496183|imex:IM-27164-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152137(gene)|ensembl:ENST00000281938(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0101031"(chaperone complex)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR042790|interpro:IPR043254|reactome:R-HSA-3371571|refseq:NP_055180.1	refseq:NP_001127807.1|refseq:NP_055228.2|go:"GO:0045993"(negative regulation of translational initiation by iron)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046986"(negative regulation of hemoglobin biosynthetic process)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|ensembl:ENSG00000086232(gene)|ensembl:ENST00000199389(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006909"(phagocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0020037"(heme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0042803"(protein homodimerization activity)|reactome:R-HSA-9648895|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	-	-	-	figure legend:Fig 4f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/07/08	2019/07/16	rogid:SXMGg+TeGqU6CI+A4ypCqCGNYks9606	rogid:MeYyxgmklJVF/JTjyfZ8UaHGcGc9606	rigid:2RnGCvMu7mdWNxbCMLa1sh1dGlU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BQI3	uniprotkb:P11142	intact:EBI-640377|uniprotkb:Q8NBW3|uniprotkb:Q9HC02|uniprotkb:Q9NYE0|uniprotkb:Q9P0V6|uniprotkb:Q9P1J5|uniprotkb:Q9P2H8|uniprotkb:Q9UHG4|uniprotkb:A8K2R2|uniprotkb:Q549K6|ensembl:ENSP00000199389	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	psi-mi:e2ak1_human(display_long)|uniprotkb:Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase(gene name synonym)|uniprotkb:Hemin-sensitive initiation factor 2-alpha kinase(gene name synonym)|uniprotkb:Heme-regulated inhibitor(gene name synonym)|uniprotkb:Heme-controlled repressor(gene name synonym)|uniprotkb:EIF2AK1(gene name)|psi-mi:EIF2AK1(display_short)|uniprotkb:HRI(gene name synonym)|uniprotkb:KIAA1369(gene name synonym)|uniprotkb:PRO1362(orf name)	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Abdel-Nour et al. (2019)	imex:IM-27164|pubmed:31273097	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21496209|imex:IM-27164-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001127807.1|refseq:NP_055228.2|go:"GO:0045993"(negative regulation of translational initiation by iron)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046986"(negative regulation of hemoglobin biosynthetic process)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|ensembl:ENSG00000086232(gene)|ensembl:ENST00000199389(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006909"(phagocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0020037"(heme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0042803"(protein homodimerization activity)|reactome:R-HSA-9648895|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N	-	-	-	figure legend:Fig S6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/07/08	2019/07/16	rogid:MeYyxgmklJVF/JTjyfZ8UaHGcGc9606	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	rigid:zXAJeIpYl3mXJy1/nnzEe4aMk8c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UJY1	uniprotkb:Q9Y239-1	intact:EBI-739074|uniprotkb:Q6FIH3|uniprotkb:Q9UKS3|ensembl:ENSP00000281938|uniprotkb:B2R6A6	intact:EBI-21496194|ensembl:ENSP00000222823	psi-mi:hspb8_human(display_long)|uniprotkb:HSPB8(gene name)|psi-mi:HSPB8(display_short)|uniprotkb:CRYAC(gene name synonym)|uniprotkb:E2IG1(gene name synonym)|uniprotkb:HSP22(gene name synonym)|uniprotkb:PP1629(orf name)|uniprotkb:Alpha-crystallin C chain(gene name synonym)|uniprotkb:Small stress protein-like protein HSP22(gene name synonym)|uniprotkb:E2-induced gene 1 protein(gene name synonym)|uniprotkb:Protein kinase H11(gene name synonym)	psi-mi:q9y239-1(display_long)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abdel-Nour et al. (2019)	imex:IM-27164|pubmed:31273097	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21496201|imex:IM-27164-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152137(gene)|ensembl:ENST00000281938(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0101031"(chaperone complex)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR042790|interpro:IPR043254|reactome:R-HSA-3371571|refseq:NP_055180.1	intact:EBI-1051262(isoform-parent)|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)	-	-	-	figure legend:Fig 4g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/07/08	2019/07/09	rogid:SXMGg+TeGqU6CI+A4ypCqCGNYks9606	rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606	rigid:PJelHs6t5J4oGFVEiY7/jKBK6S8	false	v5 tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UJY1	uniprotkb:Q9HC29-1	intact:EBI-739074|uniprotkb:Q6FIH3|uniprotkb:Q9UKS3|ensembl:ENSP00000281938|uniprotkb:B2R6A6	intact:EBI-21496213|ensembl:ENSP00000300589	psi-mi:hspb8_human(display_long)|uniprotkb:HSPB8(gene name)|psi-mi:HSPB8(display_short)|uniprotkb:CRYAC(gene name synonym)|uniprotkb:E2IG1(gene name synonym)|uniprotkb:HSP22(gene name synonym)|uniprotkb:PP1629(orf name)|uniprotkb:Alpha-crystallin C chain(gene name synonym)|uniprotkb:Small stress protein-like protein HSP22(gene name synonym)|uniprotkb:E2-induced gene 1 protein(gene name synonym)|uniprotkb:Protein kinase H11(gene name synonym)	psi-mi:q9hc29-1(display_long)|uniprotkb:NOD2(gene name)|psi-mi:NOD2(display_short)|uniprotkb:CARD15(gene name synonym)|uniprotkb:IBD1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 15(gene name synonym)|uniprotkb:Inflammatory bowel disease protein 1(gene name synonym)|uniprotkb:Nod2(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abdel-Nour et al. (2019)	imex:IM-27164|pubmed:31273097	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21496223|imex:IM-27164-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152137(gene)|ensembl:ENST00000281938(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0101031"(chaperone complex)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR042790|interpro:IPR043254|reactome:R-HSA-3371571|refseq:NP_055180.1	intact:EBI-7445625(isoform-parent)|ensembl:ENSG00000167207(gene)|ensembl:ENST00000300589(transcript)	-	-	isoform-comment:Can activate NF-kappa-B. More abundant.	figure legend:Fig S20A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/07/08	2019/07/09	rogid:SXMGg+TeGqU6CI+A4ypCqCGNYks9606	rogid:cEF3hnDQW90TWXNDH/uqW6/wMhI9606	rigid:IveYCVlWGFo6CPVK5uwppitkDYg	false	v5 tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UJY1	uniprotkb:Q9HC29-1	intact:EBI-739074|uniprotkb:Q6FIH3|uniprotkb:Q9UKS3|ensembl:ENSP00000281938|uniprotkb:B2R6A6	intact:EBI-21496213|ensembl:ENSP00000300589	psi-mi:hspb8_human(display_long)|uniprotkb:HSPB8(gene name)|psi-mi:HSPB8(display_short)|uniprotkb:CRYAC(gene name synonym)|uniprotkb:E2IG1(gene name synonym)|uniprotkb:HSP22(gene name synonym)|uniprotkb:PP1629(orf name)|uniprotkb:Alpha-crystallin C chain(gene name synonym)|uniprotkb:Small stress protein-like protein HSP22(gene name synonym)|uniprotkb:E2-induced gene 1 protein(gene name synonym)|uniprotkb:Protein kinase H11(gene name synonym)	psi-mi:q9hc29-1(display_long)|uniprotkb:NOD2(gene name)|psi-mi:NOD2(display_short)|uniprotkb:CARD15(gene name synonym)|uniprotkb:IBD1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 15(gene name synonym)|uniprotkb:Inflammatory bowel disease protein 1(gene name synonym)|uniprotkb:Nod2(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Abdel-Nour et al. (2019)	imex:IM-27164|pubmed:31273097	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21496231|imex:IM-27164-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152137(gene)|ensembl:ENST00000281938(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0101031"(chaperone complex)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR042790|interpro:IPR043254|reactome:R-HSA-3371571|refseq:NP_055180.1	intact:EBI-7445625(isoform-parent)|ensembl:ENSG00000167207(gene)|ensembl:ENST00000300589(transcript)	-	-	isoform-comment:Can activate NF-kappa-B. More abundant.	figure legend:Fig S20B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/07/08	2019/07/09	rogid:SXMGg+TeGqU6CI+A4ypCqCGNYks9606	rogid:cEF3hnDQW90TWXNDH/uqW6/wMhI9606	rigid:IveYCVlWGFo6CPVK5uwppitkDYg	false	v5 tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)