#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-21926813	intact:EBI-21926813	-	-	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	-	false	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	binding-associated region:?-?|sufficient binding region:1-74|binding-associated region:37-37	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q16595	-	intact:EBI-949340|ensembl:ENSP00000419243|uniprotkb:O15545|uniprotkb:O95656|uniprotkb:Q15294|uniprotkb:Q5VZ01|uniprotkb:A8MXJ6|uniprotkb:C9JJ89	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:frda_human(display_long)|uniprotkb:Friedreich ataxia protein(gene name synonym)|uniprotkb:FXN(gene name)|psi-mi:FXN(display_short)|uniprotkb:FRDA(gene name synonym)|uniprotkb:X25(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	ensembl:ENSG00000165060(gene)|ensembl:ENST00000484259(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006811"(ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010039"(response to iron ion)|go:"GO:0010722"(regulation of ferrochelatase activity)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0019230"(proprioception)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0051349"(positive regulation of lyase activity)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904231"(positive regulation of succinate dehydrogenase activity)|go:"GO:1904234"(positive regulation of aconitate hydratase activity)|go:"GO:1990221"(L-cysteine desulfurase complex)|interpro:IPR002908(Frataxin-like)|interpro:IPR017789(Frataxin)|interpro:IPR020895|interpro:IPR036524|rcsb pdb:1EKG|rcsb pdb:1LY7|rcsb pdb:3S4M|rcsb pdb:3S5D|rcsb pdb:3S5E|rcsb pdb:3S5F|rcsb pdb:3T3J|rcsb pdb:3T3K|rcsb pdb:3T3L|rcsb pdb:3T3T|rcsb pdb:3T3X|rcsb pdb:5KZ5|rcsb pdb:6NZU|reactome:R-HSA-1268020|reactome:R-HSA-1362409|refseq:NP_000135.2|refseq:NP_001155178.1|refseq:NP_852090.1	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:enHzDdgfTff5Y6To5z6k+6rpRMk9606	-	false	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	sufficient binding region:81-210|binding-associated region:?-?|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q16595	-	intact:EBI-949340|ensembl:ENSP00000419243|uniprotkb:O15545|uniprotkb:O95656|uniprotkb:Q15294|uniprotkb:Q5VZ01|uniprotkb:A8MXJ6|uniprotkb:C9JJ89	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:frda_human(display_long)|uniprotkb:Friedreich ataxia protein(gene name synonym)|uniprotkb:FXN(gene name)|psi-mi:FXN(display_short)|uniprotkb:FRDA(gene name synonym)|uniprotkb:X25(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	ensembl:ENSG00000165060(gene)|ensembl:ENST00000484259(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006811"(ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010039"(response to iron ion)|go:"GO:0010722"(regulation of ferrochelatase activity)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0019230"(proprioception)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0051349"(positive regulation of lyase activity)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904231"(positive regulation of succinate dehydrogenase activity)|go:"GO:1904234"(positive regulation of aconitate hydratase activity)|go:"GO:1990221"(L-cysteine desulfurase complex)|interpro:IPR002908(Frataxin-like)|interpro:IPR017789(Frataxin)|interpro:IPR020895|interpro:IPR036524|rcsb pdb:1EKG|rcsb pdb:1LY7|rcsb pdb:3S4M|rcsb pdb:3S5D|rcsb pdb:3S5E|rcsb pdb:3S5F|rcsb pdb:3T3J|rcsb pdb:3T3K|rcsb pdb:3T3L|rcsb pdb:3T3T|rcsb pdb:3T3X|rcsb pdb:5KZ5|rcsb pdb:6NZU|reactome:R-HSA-1268020|reactome:R-HSA-1362409|refseq:NP_000135.2|refseq:NP_001155178.1|refseq:NP_852090.1	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:enHzDdgfTff5Y6To5z6k+6rpRMk9606	-	false	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	binding-associated region:?-?|sufficient binding region:81-210|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q9H1K1	-	intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity)	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606	-	false	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	sufficient binding region:35-157|binding-associated region:?-?|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q9H1K1	-	intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity)	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606	-	false	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	binding-associated region:?-?|sufficient binding region:35-157|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q9HD34	-	intact:EBI-3920810|ensembl:ENSP00000418787|uniprotkb:A8K543|uniprotkb:Q5XKP1	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:lyrm4_human(display_long)|uniprotkb:LYRM4(gene name)|psi-mi:LYRM4(display_short)|uniprotkb:C6orf149(gene name synonym)|uniprotkb:ISD11(gene name synonym)|uniprotkb:CGI-203(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	refseq:NP_001158313.1|ensembl:ENSG00000214113(gene)|ensembl:ENST00000330636(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016604"(nuclear body)|go:"GO:1990221"(L-cysteine desulfurase complex)|interpro:IPR008011(Complex 1 LYR protein)|rcsb pdb:5USR|rcsb pdb:5WGB|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6ODD|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|refseq:NP_065141.3	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:42Smt00XZS1ZIumThh+hX/ARM7M9606	-	false	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	his tag:?-?|sufficient binding region:1-91|binding-associated region:?-?|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q9HD34	-	intact:EBI-3920810|ensembl:ENSP00000418787|uniprotkb:A8K543|uniprotkb:Q5XKP1	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:lyrm4_human(display_long)|uniprotkb:LYRM4(gene name)|psi-mi:LYRM4(display_short)|uniprotkb:C6orf149(gene name synonym)|uniprotkb:ISD11(gene name synonym)|uniprotkb:CGI-203(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	refseq:NP_001158313.1|ensembl:ENSG00000214113(gene)|ensembl:ENST00000330636(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016604"(nuclear body)|go:"GO:1990221"(L-cysteine desulfurase complex)|interpro:IPR008011(Complex 1 LYR protein)|rcsb pdb:5USR|rcsb pdb:5WGB|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6ODD|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|refseq:NP_065141.3	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:42Smt00XZS1ZIumThh+hX/ARM7M9606	-	false	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	binding-associated region:?-?|sufficient binding region:1-91|his tag:?-?|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18405"	intact:EBI-21926813	intact:EBI-8851905|chebi:"CHEBI:8668"|chebi:"CHEBI:14977"|chebi:"CHEBI:26424"|chebi:"CHEBI:358848"|chebi:"CHEBI:45145"|chebi:"CHEBI:234571"	-	psi-mi:pyridoxal 5'-phosphate(display_short)|psi-mi:"CHEBI:18405"(display_long)|intact:"3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate"(synonym)|intact:codecarboxylase(synonym)|intact:"Phosphoric acid mono-(4-formyl-5-hydroxy-6-methyl-pyridin-3-ylmethyl) ester"(synonym)|intact:pyridoxal  5-monophosphoric acid ester(synonym)|intact:"pyridoxal 5'-(dihydrogen phosphate)"(synonym)|intact:Pyridoxal 5'-phosphate(synonym)|intact:Pyridoxal 5-phosphate(synonym)|intact:Pyridoxal phosphate(synonym)|intact:PYRIDOXAL-5'-PHOSPHATE(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate"(iupac name)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-N	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	-	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	-	false	binding-associated region:?-?	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18405"	intact:EBI-21926813	intact:EBI-8851905|chebi:"CHEBI:8668"|chebi:"CHEBI:14977"|chebi:"CHEBI:26424"|chebi:"CHEBI:358848"|chebi:"CHEBI:45145"|chebi:"CHEBI:234571"	-	psi-mi:pyridoxal 5'-phosphate(display_short)|psi-mi:"CHEBI:18405"(display_long)|intact:"3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate"(synonym)|intact:codecarboxylase(synonym)|intact:"Phosphoric acid mono-(4-formyl-5-hydroxy-6-methyl-pyridin-3-ylmethyl) ester"(synonym)|intact:pyridoxal  5-monophosphoric acid ester(synonym)|intact:"pyridoxal 5'-(dihydrogen phosphate)"(synonym)|intact:Pyridoxal 5'-phosphate(synonym)|intact:Pyridoxal 5-phosphate(synonym)|intact:Pyridoxal phosphate(synonym)|intact:PYRIDOXAL-5'-PHOSPHATE(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate"(iupac name)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-N	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	-	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	-	false	binding-associated region:?-?	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q9Y697-2	-	intact:EBI-10962075|ensembl:ENSP00000363198|ensembl:ENSP00000380570	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:q9y697-2(display_long)|uniprotkb:NFS1(gene name)|psi-mi:NFS1(display_short)|uniprotkb:NIFS(gene name synonym)|uniprotkb:HUSSY-08(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	intact:EBI-1751791(isoform-parent)|uniprotkb:Q9Y697-2(isoform-parent)|ensembl:ENSG00000244005(gene)|ensembl:ENST00000374085(transcript)|ensembl:ENST00000397425(transcript)	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:uDJY7pQiWR7uKc3pax0jWAGPCcw9606	-	false	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	sufficient binding region:1-397|binding-associated region:198-198|binding-associated region:?-?|binding-associated region:?-?|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q9Y697-2	-	intact:EBI-10962075|ensembl:ENSP00000363198|ensembl:ENSP00000380570	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:q9y697-2(display_long)|uniprotkb:NFS1(gene name)|psi-mi:NFS1(display_short)|uniprotkb:NIFS(gene name synonym)|uniprotkb:HUSSY-08(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	intact:EBI-1751791(isoform-parent)|uniprotkb:Q9Y697-2(isoform-parent)|ensembl:ENSG00000244005(gene)|ensembl:ENST00000374085(transcript)|ensembl:ENST00000397425(transcript)	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:uDJY7pQiWR7uKc3pax0jWAGPCcw9606	-	false	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	sufficient binding region:1-397|binding-associated region:198-198|binding-associated region:?-?|binding-associated region:?-?|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:132316"	intact:EBI-21926813	intact:EBI-21926834	-	psi-mi:s-dodecanoyl-4'-phosphopantetheine(display_short)|psi-mi:"CHEBI:132316"(display_long)|intact:dodecanoyl-4'-phosphopantetheine(synonym)|intact:lauroyl-4-phosphopantetheine(synonym)|intact:S-dodecanoyl-D-pantetheine 4'-phosphate(synonym)|intact:S-lauroyl-4-phosphopantetheine(synonym)|intact:S-lauroyl-D-pantetheine 4'-phosphate(synonym)|intact:"S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate"(iupac name)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	-	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	-	false	binding-associated region:?-?	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:132316"	intact:EBI-21926813	intact:EBI-21926834	-	psi-mi:s-dodecanoyl-4'-phosphopantetheine(display_short)|psi-mi:"CHEBI:132316"(display_long)|intact:dodecanoyl-4'-phosphopantetheine(synonym)|intact:lauroyl-4-phosphopantetheine(synonym)|intact:S-dodecanoyl-D-pantetheine 4'-phosphate(synonym)|intact:S-lauroyl-4-phosphopantetheine(synonym)|intact:S-lauroyl-D-pantetheine 4'-phosphate(synonym)|intact:"S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate"(iupac name)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	-	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	-	false	binding-associated region:?-?	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29105"	intact:EBI-21926813	intact:EBI-968340	-	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	-	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	-	false	binding-associated region:?-?	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29105"	intact:EBI-21926813	intact:EBI-968340	-	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926826|imex:IM-27175-1|emdb:EMD-0560|pdbe:6NZU	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplementary Table 1, Fig. 1a, b, Supplementary Figure 4|3d-resolution:3.2Å|comment:More specifically, the interaction detection method is Cryo-EM with 3D refinement|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/09	-	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	-	false	binding-associated region:?-?	sufficient binding region:1-74|binding-associated region:37-37|binding-associated region:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H1K1	uniprotkb:Q9Y697	intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623	intact:EBI-1751791|uniprotkb:E1P5R8|uniprotkb:Q6P0L8|uniprotkb:Q9NTZ5|uniprotkb:Q9Y481|uniprotkb:B3KMA5|uniprotkb:B4DXK9|uniprotkb:F5GYK5|ensembl:ENSP00000363205	psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym)	psi-mi:nfs1_human(display_long)|uniprotkb:NFS1(gene name)|psi-mi:NFS1(display_short)|uniprotkb:NIFS(gene name synonym)|uniprotkb:HUSSY-08(orf name)	psi-mi:"MI:0969"(bio-layer interferometry)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926930|imex:IM-27175-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity)	refseq:NP_001185918.1|refseq:NP_066923.3|ensembl:ENSG00000244005(gene)|ensembl:ENST00000374092(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031071"(cysteine desulfurase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|interpro:IPR000192(Aminotransferase, class V/Cysteine desulphurase)|interpro:IPR010240(Cysteine desulphurase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR016454(Cysteine desulphurase, NifS)|interpro:IPR020578|rcsb pdb:5KZ5|rcsb pdb:5USR|rcsb pdb:5WGB|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|reactome:R-HSA-947581	-	-	-	figure legend:Table 1, Supplementary Figure 1d|caution:"Impact of FXN mutations is on the whole of SDAU complex (NFS1-ISD11-ACP-ISCU); SDAU is not a functional complex without FXN so we couldn't have the possibility of generating a complex portal identifier so as to be taken as a participant"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.32x10^-6 ~0.94(molar)	2019/07/19	2019/10/07	rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606	rogid:tSeWDc9Ch78CnCC2Co+vzC2CWvg9606	rigid:e86O6aqYqrYSam4/t/UJBT97f3M	false	sufficient binding region:35-167|biotin tag:?-?	sufficient binding region:56-457	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H1K1	uniprotkb:Q9HD34	intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623	intact:EBI-3920810|ensembl:ENSP00000418787|uniprotkb:A8K543|uniprotkb:Q5XKP1	psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym)	psi-mi:lyrm4_human(display_long)|uniprotkb:LYRM4(gene name)|psi-mi:LYRM4(display_short)|uniprotkb:C6orf149(gene name synonym)|uniprotkb:ISD11(gene name synonym)|uniprotkb:CGI-203(orf name)	psi-mi:"MI:0969"(bio-layer interferometry)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926930|imex:IM-27175-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity)	refseq:NP_001158313.1|ensembl:ENSG00000214113(gene)|ensembl:ENST00000330636(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016604"(nuclear body)|go:"GO:1990221"(L-cysteine desulfurase complex)|interpro:IPR008011(Complex 1 LYR protein)|rcsb pdb:5USR|rcsb pdb:5WGB|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6ODD|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|refseq:NP_065141.3	-	-	-	figure legend:Table 1, Supplementary Figure 1d|caution:"Impact of FXN mutations is on the whole of SDAU complex (NFS1-ISD11-ACP-ISCU); SDAU is not a functional complex without FXN so we couldn't have the possibility of generating a complex portal identifier so as to be taken as a participant"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.32x10^-6 ~0.94(molar)	2019/07/19	2019/10/07	rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606	rogid:42Smt00XZS1ZIumThh+hX/ARM7M9606	rigid:e86O6aqYqrYSam4/t/UJBT97f3M	false	sufficient binding region:35-167|biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H1K1	intact:EBI-21926813	intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623	-	psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:0969"(bio-layer interferometry)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926930|imex:IM-27175-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Table 1, Supplementary Figure 1d|caution:"Impact of FXN mutations is on the whole of SDAU complex (NFS1-ISD11-ACP-ISCU); SDAU is not a functional complex without FXN so we couldn't have the possibility of generating a complex portal identifier so as to be taken as a participant"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.32x10^-6 ~0.94(molar)	2019/07/19	2019/10/07	rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rigid:e86O6aqYqrYSam4/t/UJBT97f3M	false	sufficient binding region:35-167|biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H1K1	uniprotkb:Q16595	intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623	intact:EBI-949340|ensembl:ENSP00000419243|uniprotkb:O15545|uniprotkb:O95656|uniprotkb:Q15294|uniprotkb:Q5VZ01|uniprotkb:A8MXJ6|uniprotkb:C9JJ89	psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym)	psi-mi:frda_human(display_long)|uniprotkb:Friedreich ataxia protein(gene name synonym)|uniprotkb:FXN(gene name)|psi-mi:FXN(display_short)|uniprotkb:FRDA(gene name synonym)|uniprotkb:X25(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21926930|imex:IM-27175-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity)	ensembl:ENSG00000165060(gene)|ensembl:ENST00000484259(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006811"(ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010039"(response to iron ion)|go:"GO:0010722"(regulation of ferrochelatase activity)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0019230"(proprioception)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0051349"(positive regulation of lyase activity)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904231"(positive regulation of succinate dehydrogenase activity)|go:"GO:1904234"(positive regulation of aconitate hydratase activity)|go:"GO:1990221"(L-cysteine desulfurase complex)|interpro:IPR002908(Frataxin-like)|interpro:IPR017789(Frataxin)|interpro:IPR020895|interpro:IPR036524|rcsb pdb:1EKG|rcsb pdb:1LY7|rcsb pdb:3S4M|rcsb pdb:3S5D|rcsb pdb:3S5E|rcsb pdb:3S5F|rcsb pdb:3T3J|rcsb pdb:3T3K|rcsb pdb:3T3L|rcsb pdb:3T3T|rcsb pdb:3T3X|rcsb pdb:5KZ5|rcsb pdb:6NZU|reactome:R-HSA-1268020|reactome:R-HSA-1362409|refseq:NP_000135.2|refseq:NP_001155178.1|refseq:NP_852090.1	-	-	-	figure legend:Table 1, Supplementary Figure 1d|caution:"Impact of FXN mutations is on the whole of SDAU complex (NFS1-ISD11-ACP-ISCU); SDAU is not a functional complex without FXN so we couldn't have the possibility of generating a complex portal identifier so as to be taken as a participant"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.32x10^-6 ~0.94(molar)	2019/07/19	2019/10/07	rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606	rogid:enHzDdgfTff5Y6To5z6k+6rpRMk9606	rigid:e86O6aqYqrYSam4/t/UJBT97f3M	false	sufficient binding region:35-167|biotin tag:?-?	sufficient binding region:81-210|mutation decreasing interaction strength:124-124|mutation disrupting interaction strength:146-146|mutation decreasing interaction strength:151-151|mutation disrupting interaction strength:155-155|mutation decreasing interaction strength:163-163|mutation disrupting interaction strength:165-165	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y697	uniprotkb:Q16595	intact:EBI-1751791|uniprotkb:E1P5R8|uniprotkb:Q6P0L8|uniprotkb:Q9NTZ5|uniprotkb:Q9Y481|uniprotkb:B3KMA5|uniprotkb:B4DXK9|uniprotkb:F5GYK5|ensembl:ENSP00000363205	intact:EBI-949340|ensembl:ENSP00000419243|uniprotkb:O15545|uniprotkb:O95656|uniprotkb:Q15294|uniprotkb:Q5VZ01|uniprotkb:A8MXJ6|uniprotkb:C9JJ89	psi-mi:nfs1_human(display_long)|uniprotkb:NFS1(gene name)|psi-mi:NFS1(display_short)|uniprotkb:NIFS(gene name synonym)|uniprotkb:HUSSY-08(orf name)	psi-mi:frda_human(display_long)|uniprotkb:Friedreich ataxia protein(gene name synonym)|uniprotkb:FXN(gene name)|psi-mi:FXN(display_short)|uniprotkb:FRDA(gene name synonym)|uniprotkb:X25(gene name synonym)	psi-mi:"MI:1311"(differential scanning calorimetry)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21928001|imex:IM-27175-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185918.1|refseq:NP_066923.3|ensembl:ENSG00000244005(gene)|ensembl:ENST00000374092(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031071"(cysteine desulfurase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|interpro:IPR000192(Aminotransferase, class V/Cysteine desulphurase)|interpro:IPR010240(Cysteine desulphurase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR016454(Cysteine desulphurase, NifS)|interpro:IPR020578|rcsb pdb:5KZ5|rcsb pdb:5USR|rcsb pdb:5WGB|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|reactome:R-HSA-947581	ensembl:ENSG00000165060(gene)|ensembl:ENST00000484259(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006811"(ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010039"(response to iron ion)|go:"GO:0010722"(regulation of ferrochelatase activity)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0019230"(proprioception)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0051349"(positive regulation of lyase activity)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904231"(positive regulation of succinate dehydrogenase activity)|go:"GO:1904234"(positive regulation of aconitate hydratase activity)|go:"GO:1990221"(L-cysteine desulfurase complex)|interpro:IPR002908(Frataxin-like)|interpro:IPR017789(Frataxin)|interpro:IPR020895|interpro:IPR036524|rcsb pdb:1EKG|rcsb pdb:1LY7|rcsb pdb:3S4M|rcsb pdb:3S5D|rcsb pdb:3S5E|rcsb pdb:3S5F|rcsb pdb:3T3J|rcsb pdb:3T3K|rcsb pdb:3T3L|rcsb pdb:3T3T|rcsb pdb:3T3X|rcsb pdb:5KZ5|rcsb pdb:6NZU|reactome:R-HSA-1268020|reactome:R-HSA-1362409|refseq:NP_000135.2|refseq:NP_001155178.1|refseq:NP_852090.1	-	-	-	figure legend:Table 1|caution:From the given melting temperature of the individual mutations, it is not possible to infer effects of the mutations. The difference in melting point can tell us about the overall stability of the interaction, but very little detail is available on the binding site|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	melting point:339.6x1^1 ~0.23(kelvin)	2019/07/19	2019/07/30	rogid:tSeWDc9Ch78CnCC2Co+vzC2CWvg9606	rogid:enHzDdgfTff5Y6To5z6k+6rpRMk9606	rigid:DUa0UOFDVCbmaOU67C7zhhZucaU	false	sufficient binding region:56-457	sufficient binding region:81-210|mutation with complex effect:124-124|mutation with complex effect:146-146|mutation with complex effect:151-151|mutation with complex effect:155-155|mutation with complex effect:163-163|mutation with complex effect:165-165	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q16595	-	intact:EBI-949340|ensembl:ENSP00000419243|uniprotkb:O15545|uniprotkb:O95656|uniprotkb:Q15294|uniprotkb:Q5VZ01|uniprotkb:A8MXJ6|uniprotkb:C9JJ89	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:frda_human(display_long)|uniprotkb:Friedreich ataxia protein(gene name synonym)|uniprotkb:FXN(gene name)|psi-mi:FXN(display_short)|uniprotkb:FRDA(gene name synonym)|uniprotkb:X25(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21942347|imex:IM-27175-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	ensembl:ENSG00000165060(gene)|ensembl:ENST00000484259(transcript)|go:"GO:0004322"(ferroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006811"(ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010039"(response to iron ion)|go:"GO:0010722"(regulation of ferrochelatase activity)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0019230"(proprioception)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0034986"(iron chaperone activity)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0051349"(positive regulation of lyase activity)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904231"(positive regulation of succinate dehydrogenase activity)|go:"GO:1904234"(positive regulation of aconitate hydratase activity)|go:"GO:1990221"(L-cysteine desulfurase complex)|interpro:IPR002908(Frataxin-like)|interpro:IPR017789(Frataxin)|interpro:IPR020895|interpro:IPR036524|rcsb pdb:1EKG|rcsb pdb:1LY7|rcsb pdb:3S4M|rcsb pdb:3S5D|rcsb pdb:3S5E|rcsb pdb:3S5F|rcsb pdb:3T3J|rcsb pdb:3T3K|rcsb pdb:3T3L|rcsb pdb:3T3T|rcsb pdb:3T3X|rcsb pdb:5KZ5|rcsb pdb:6NZU|reactome:R-HSA-1268020|reactome:R-HSA-1362409|refseq:NP_000135.2|refseq:NP_001155178.1|refseq:NP_852090.1	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 4, Supplementary Figure 7|3d-resolution:0.99 Å|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/07	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:enHzDdgfTff5Y6To5z6k+6rpRMk9606	-	false	sufficient binding region:1-74	sufficient binding region:81-210	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q9H1K1	-	intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21942347|imex:IM-27175-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity)	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 4, Supplementary Figure 7|3d-resolution:0.99 Å|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/07	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606	-	false	sufficient binding region:1-74	sufficient binding region:35-157	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q9HD34	-	intact:EBI-3920810|ensembl:ENSP00000418787|uniprotkb:A8K543|uniprotkb:Q5XKP1	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:lyrm4_human(display_long)|uniprotkb:LYRM4(gene name)|psi-mi:LYRM4(display_short)|uniprotkb:C6orf149(gene name synonym)|uniprotkb:ISD11(gene name synonym)|uniprotkb:CGI-203(orf name)	psi-mi:"MI:0826"(x ray scattering)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21942347|imex:IM-27175-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	refseq:NP_001158313.1|ensembl:ENSG00000214113(gene)|ensembl:ENST00000330636(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016604"(nuclear body)|go:"GO:1990221"(L-cysteine desulfurase complex)|interpro:IPR008011(Complex 1 LYR protein)|rcsb pdb:5USR|rcsb pdb:5WGB|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6ODD|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|refseq:NP_065141.3	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 4, Supplementary Figure 7|3d-resolution:0.99 Å|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/07	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:42Smt00XZS1ZIumThh+hX/ARM7M9606	-	false	sufficient binding region:1-74	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q9Y697	-	intact:EBI-1751791|uniprotkb:E1P5R8|uniprotkb:Q6P0L8|uniprotkb:Q9NTZ5|uniprotkb:Q9Y481|uniprotkb:B3KMA5|uniprotkb:B4DXK9|uniprotkb:F5GYK5|ensembl:ENSP00000363205	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:nfs1_human(display_long)|uniprotkb:NFS1(gene name)|psi-mi:NFS1(display_short)|uniprotkb:NIFS(gene name synonym)|uniprotkb:HUSSY-08(orf name)	psi-mi:"MI:0826"(x ray scattering)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21942347|imex:IM-27175-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	refseq:NP_001185918.1|refseq:NP_066923.3|ensembl:ENSG00000244005(gene)|ensembl:ENST00000374092(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031071"(cysteine desulfurase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|interpro:IPR000192(Aminotransferase, class V/Cysteine desulphurase)|interpro:IPR010240(Cysteine desulphurase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR016454(Cysteine desulphurase, NifS)|interpro:IPR020578|rcsb pdb:5KZ5|rcsb pdb:5USR|rcsb pdb:5WGB|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|reactome:R-HSA-947581	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 4, Supplementary Figure 7|3d-resolution:0.99 Å|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/07	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:tSeWDc9Ch78CnCC2Co+vzC2CWvg9606	-	false	sufficient binding region:1-74	sufficient binding region:56-457	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18405"	intact:EBI-21926813	intact:EBI-8851905|chebi:"CHEBI:8668"|chebi:"CHEBI:14977"|chebi:"CHEBI:26424"|chebi:"CHEBI:358848"|chebi:"CHEBI:45145"|chebi:"CHEBI:234571"	-	psi-mi:pyridoxal 5'-phosphate(display_short)|psi-mi:"CHEBI:18405"(display_long)|intact:"3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate"(synonym)|intact:codecarboxylase(synonym)|intact:"Phosphoric acid mono-(4-formyl-5-hydroxy-6-methyl-pyridin-3-ylmethyl) ester"(synonym)|intact:pyridoxal  5-monophosphoric acid ester(synonym)|intact:"pyridoxal 5'-(dihydrogen phosphate)"(synonym)|intact:Pyridoxal 5'-phosphate(synonym)|intact:Pyridoxal 5-phosphate(synonym)|intact:Pyridoxal phosphate(synonym)|intact:PYRIDOXAL-5'-PHOSPHATE(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate"(iupac name)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:0826"(x ray scattering)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21942347|imex:IM-27175-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-N	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplementary Table 4, Supplementary Figure 7|3d-resolution:0.99 Å|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/07	-	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	-	false	-	sufficient binding region:1-74	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:132316"	intact:EBI-21926813	intact:EBI-21926834	-	psi-mi:s-dodecanoyl-4'-phosphopantetheine(display_short)|psi-mi:"CHEBI:132316"(display_long)|intact:dodecanoyl-4'-phosphopantetheine(synonym)|intact:lauroyl-4-phosphopantetheine(synonym)|intact:S-dodecanoyl-D-pantetheine 4'-phosphate(synonym)|intact:S-lauroyl-4-phosphopantetheine(synonym)|intact:S-lauroyl-D-pantetheine 4'-phosphate(synonym)|intact:"S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate"(iupac name)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:0826"(x ray scattering)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21942347|imex:IM-27175-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplementary Table 4, Supplementary Figure 7|3d-resolution:0.99 Å|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/07	-	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	-	false	-	sufficient binding region:1-74	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29105"	intact:EBI-21926813	intact:EBI-968340	-	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:0826"(x ray scattering)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21942347|imex:IM-27175-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplementary Table 4, Supplementary Figure 7|3d-resolution:0.99 Å|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/07	-	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	-	false	-	sufficient binding region:1-74	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q9H1K1	-	intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21942391|imex:IM-27175-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity)	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 4, Supplementary Figure 7|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/07	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606	-	false	sufficient binding region:1-74	sufficient binding region:35-157	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q9HD34	-	intact:EBI-3920810|ensembl:ENSP00000418787|uniprotkb:A8K543|uniprotkb:Q5XKP1	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:lyrm4_human(display_long)|uniprotkb:LYRM4(gene name)|psi-mi:LYRM4(display_short)|uniprotkb:C6orf149(gene name synonym)|uniprotkb:ISD11(gene name synonym)|uniprotkb:CGI-203(orf name)	psi-mi:"MI:0826"(x ray scattering)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21942391|imex:IM-27175-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	refseq:NP_001158313.1|ensembl:ENSG00000214113(gene)|ensembl:ENST00000330636(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0016604"(nuclear body)|go:"GO:1990221"(L-cysteine desulfurase complex)|interpro:IPR008011(Complex 1 LYR protein)|rcsb pdb:5USR|rcsb pdb:5WGB|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6ODD|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|refseq:NP_065141.3	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 4, Supplementary Figure 7|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/07	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:42Smt00XZS1ZIumThh+hX/ARM7M9606	-	false	sufficient binding region:1-74	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21926813	uniprotkb:Q9Y697	-	intact:EBI-1751791|uniprotkb:E1P5R8|uniprotkb:Q6P0L8|uniprotkb:Q9NTZ5|uniprotkb:Q9Y481|uniprotkb:B3KMA5|uniprotkb:B4DXK9|uniprotkb:F5GYK5|ensembl:ENSP00000363205	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:nfs1_human(display_long)|uniprotkb:NFS1(gene name)|psi-mi:NFS1(display_short)|uniprotkb:NIFS(gene name synonym)|uniprotkb:HUSSY-08(orf name)	psi-mi:"MI:0826"(x ray scattering)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:562(ecolx)|taxid:562(Escherichia coli)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21942391|imex:IM-27175-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:A0A437HBF4(uniprot-removed-ac)	refseq:NP_001185918.1|refseq:NP_066923.3|ensembl:ENSG00000244005(gene)|ensembl:ENST00000374092(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0018283"(iron incorporation into metallo-sulfur cluster)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031071"(cysteine desulfurase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051536"(iron-sulfur cluster binding)|interpro:IPR000192(Aminotransferase, class V/Cysteine desulphurase)|interpro:IPR010240(Cysteine desulphurase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR016454(Cysteine desulphurase, NifS)|interpro:IPR020578|rcsb pdb:5KZ5|rcsb pdb:5USR|rcsb pdb:5WGB|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|reactome:R-HSA-947581	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	figure legend:Supplementary Table 4, Supplementary Figure 7|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/07	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	rogid:tSeWDc9Ch78CnCC2Co+vzC2CWvg9606	-	false	sufficient binding region:1-74	sufficient binding region:56-457	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:18405"	intact:EBI-21926813	intact:EBI-8851905|chebi:"CHEBI:8668"|chebi:"CHEBI:14977"|chebi:"CHEBI:26424"|chebi:"CHEBI:358848"|chebi:"CHEBI:45145"|chebi:"CHEBI:234571"	-	psi-mi:pyridoxal 5'-phosphate(display_short)|psi-mi:"CHEBI:18405"(display_long)|intact:"3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde"(synonym)|intact:"3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate"(synonym)|intact:codecarboxylase(synonym)|intact:"Phosphoric acid mono-(4-formyl-5-hydroxy-6-methyl-pyridin-3-ylmethyl) ester"(synonym)|intact:pyridoxal  5-monophosphoric acid ester(synonym)|intact:"pyridoxal 5'-(dihydrogen phosphate)"(synonym)|intact:Pyridoxal 5'-phosphate(synonym)|intact:Pyridoxal 5-phosphate(synonym)|intact:Pyridoxal phosphate(synonym)|intact:PYRIDOXAL-5'-PHOSPHATE(synonym)|intact:"(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate"(iupac name)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:0826"(x ray scattering)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21942391|imex:IM-27175-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	inchi key:NGVDGCNFYWLIFO-UHFFFAOYSA-N	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplementary Table 4, Supplementary Figure 7|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/07	-	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	-	false	-	sufficient binding region:1-74	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:132316"	intact:EBI-21926813	intact:EBI-21926834	-	psi-mi:s-dodecanoyl-4'-phosphopantetheine(display_short)|psi-mi:"CHEBI:132316"(display_long)|intact:dodecanoyl-4'-phosphopantetheine(synonym)|intact:lauroyl-4-phosphopantetheine(synonym)|intact:S-dodecanoyl-D-pantetheine 4'-phosphate(synonym)|intact:S-lauroyl-4-phosphopantetheine(synonym)|intact:S-lauroyl-D-pantetheine 4'-phosphate(synonym)|intact:"S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate"(iupac name)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:0826"(x ray scattering)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21942391|imex:IM-27175-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplementary Table 4, Supplementary Figure 7|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/07	-	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	-	false	-	sufficient binding region:1-74	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:29105"	intact:EBI-21926813	intact:EBI-968340	-	psi-mi:"zinc(2+)"(display_short)|psi-mi:"CHEBI:29105"(display_long)	psi-mi:a0a437hbf4_ecolx(display_short)|psi-mi:EBI-21926813(display_long)|uniprotkb:acpP(gene name)|psi-mi:acpP(display_short)|uniprotkb:DQL48_09575(orf name)	psi-mi:"MI:0826"(x ray scattering)	Fox et al. (2019)	pubmed:31101807|imex:IM-27175	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21942391|imex:IM-27175-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	uniprotkb:A0A437HBF4(uniprot-removed-ac)	-	-	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	figure legend:Supplementary Table 4, Supplementary Figure 7|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/19	2019/10/07	-	rogid:QLE13yoHfia69IvwhdD61xR/Ejw562	-	false	-	sufficient binding region:1-74	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)