#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49770	uniprotkb:Q13144	intact:EBI-718773|uniprotkb:O43201|ensembl:ENSP00000266126	intact:EBI-4401110|uniprotkb:Q541Z1|uniprotkb:Q96D04|ensembl:ENSP00000497160	psi-mi:ei2bb_human(display_long)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:S20I15(gene name synonym)|uniprotkb:S20III15(gene name synonym)|uniprotkb:EIF2B2(gene name)|psi-mi:EIF2B2(display_short)|uniprotkb:EIF2BB(gene name synonym)	psi-mi:ei2be_human(display_long)|uniprotkb:EIF2B5(gene name)|psi-mi:EIF2B5(display_short)|uniprotkb:EIF2BE(gene name synonym)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit epsilon(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465031|emdb:EMD-9842|emdb:EMD-9841|wwpdb:6k72|wwpdb:6k71|emdb:EMD-9840|imex:IM-27159-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055054.1|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007417"(central nervous system development)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0042552"(myelination)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|ensembl:ENSG00000119718(gene)|ensembl:ENST00000266126(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	refseq:NP_003898.2|ensembl:ENSG00000145191(gene)|ensembl:ENST00000648915(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0007568"(aging)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0014002"(astrocyte development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0021766"(hippocampus development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042552"(myelination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029044|interpro:IPR035543|interpro:IPR044123|rcsb pdb:3JUI|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|go:"GO:0005634"(nucleus)	-	-	-	figure legend:Fig 1a, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/07	2019/07/08	rogid:CLCdt90SBzvMUBXSQDb6DTy3Yz09606	rogid:158kR+Yjj/jXya10LiK3Xp0Fa5w9606	rigid:042/oc/5H71gFbvpPEHytGEbZTM	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P49770	uniprotkb:P05198	intact:EBI-718773|uniprotkb:O43201|ensembl:ENSP00000266126	intact:EBI-1056162|ensembl:ENSP00000256383|ensembl:ENSP00000425299	psi-mi:ei2bb_human(display_long)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:S20I15(gene name synonym)|uniprotkb:S20III15(gene name synonym)|uniprotkb:EIF2B2(gene name)|psi-mi:EIF2B2(display_short)|uniprotkb:EIF2BB(gene name synonym)	psi-mi:if2a_human(display_long)|uniprotkb:EIF2S1(gene name)|psi-mi:EIF2S1(display_short)|uniprotkb:EIF2A(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465031|emdb:EMD-9842|emdb:EMD-9841|wwpdb:6k72|wwpdb:6k71|emdb:EMD-9840|imex:IM-27159-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055054.1|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007417"(central nervous system development)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0042552"(myelination)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|ensembl:ENSG00000119718(gene)|ensembl:ENST00000266126(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	refseq:NP_004085.1|ensembl:ENSG00000134001(gene)|ensembl:ENST00000256383(transcript)|ensembl:ENST00000466499(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|mint:P05198|rcsb pdb:1KL9|rcsb pdb:1Q8K|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:6YBV|rcsb pdb:6ZMW|rcsb pdb:6ZP4|rcsb pdb:7A09|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|reactome:R-HSA-156827|reactome:R-HSA-381042|reactome:R-HSA-382556|reactome:R-HSA-72649|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72731|reactome:R-HSA-9633012|reactome:R-HSA-9648895|dip:DIP-39418N	-	-	-	figure legend:Fig 1a, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/07	2019/07/08	rogid:CLCdt90SBzvMUBXSQDb6DTy3Yz09606	rogid:hG3fLbQuFpe5z8zS/bt/TnpEpzA9606	rigid:042/oc/5H71gFbvpPEHytGEbZTM	false	-	-	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P49770	uniprotkb:P41091	intact:EBI-718773|uniprotkb:O43201|ensembl:ENSP00000266126	intact:EBI-1054228|uniprotkb:B5BTZ4|intact:EBI-11602611|uniprotkb:A0A024RBY4|uniprotkb:A8K2Y2|uniprotkb:B2R5N2|uniprotkb:Q53HK3|ensembl:ENSP00000253039	psi-mi:ei2bb_human(display_long)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:S20I15(gene name synonym)|uniprotkb:S20III15(gene name synonym)|uniprotkb:EIF2B2(gene name)|psi-mi:EIF2B2(display_short)|uniprotkb:EIF2BB(gene name synonym)	psi-mi:if2g_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 2 subunit gamma X(gene name synonym)|uniprotkb:EIF2S3(gene name)|psi-mi:EIF2S3(display_short)|uniprotkb:EIF2G(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465031|emdb:EMD-9842|emdb:EMD-9841|wwpdb:6k72|wwpdb:6k71|emdb:EMD-9840|imex:IM-27159-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055054.1|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007417"(central nervous system development)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0042552"(myelination)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|ensembl:ENSG00000119718(gene)|ensembl:ENST00000266126(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	refseq:NP_001406.1|ensembl:ENSG00000130741(gene)|ensembl:ENST00000253039(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045903"(positive regulation of translational fidelity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR044127|interpro:IPR044128|rcsb pdb:6FEC|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6YBV|rcsb pdb:6ZMW|rcsb pdb:6ZP4|rcsb pdb:7A09|rcsb pdb:7D43|reactome:R-HSA-156827|reactome:R-HSA-381042|reactome:R-HSA-382556|reactome:R-HSA-72649|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72731|reactome:R-HSA-9633012|reactome:R-HSA-9648895|interpro:IPR027417	-	-	-	figure legend:Fig 1a, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/07	2019/07/08	rogid:CLCdt90SBzvMUBXSQDb6DTy3Yz09606	rogid:6uBTiGTvEKMfS0NqkKGIaSR61j89606	rigid:042/oc/5H71gFbvpPEHytGEbZTM	false	-	his tag:c-c|flag tag:c-c	2	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P49770	uniprotkb:Q14232-1	intact:EBI-718773|uniprotkb:O43201|ensembl:ENSP00000266126	intact:EBI-21465020	psi-mi:ei2bb_human(display_long)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:S20I15(gene name synonym)|uniprotkb:S20III15(gene name synonym)|uniprotkb:EIF2B2(gene name)|psi-mi:EIF2B2(display_short)|uniprotkb:EIF2BB(gene name synonym)	psi-mi:q14232-1(display_long)|uniprotkb:EIF2B1(gene name)|psi-mi:EIF2B1(display_short)|uniprotkb:EIF2BA(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465031|emdb:EMD-9842|emdb:EMD-9841|wwpdb:6k72|wwpdb:6k71|emdb:EMD-9840|imex:IM-27159-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055054.1|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007417"(central nervous system development)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0042552"(myelination)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|ensembl:ENSG00000119718(gene)|ensembl:ENST00000266126(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	uniprotkb:Q14232-1(isoform-parent)	-	-	-	figure legend:Fig 1a, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/07	2019/07/08	rogid:CLCdt90SBzvMUBXSQDb6DTy3Yz09606	rogid:HAThUj88pwaLd6kmAlO5s1xtntM9606	rigid:042/oc/5H71gFbvpPEHytGEbZTM	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P49770	uniprotkb:Q9NR50-1	intact:EBI-718773|uniprotkb:O43201|ensembl:ENSP00000266126	intact:EBI-21465026	psi-mi:ei2bb_human(display_long)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:S20I15(gene name synonym)|uniprotkb:S20III15(gene name synonym)|uniprotkb:EIF2B2(gene name)|psi-mi:EIF2B2(display_short)|uniprotkb:EIF2BB(gene name synonym)	psi-mi:q9nr50-1(display_long)|uniprotkb:EIF2B3(gene name)|psi-mi:EIF2B3(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465031|emdb:EMD-9842|emdb:EMD-9841|wwpdb:6k72|wwpdb:6k71|emdb:EMD-9840|imex:IM-27159-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055054.1|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007417"(central nervous system development)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0042552"(myelination)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|ensembl:ENSG00000119718(gene)|ensembl:ENST00000266126(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	uniprotkb:Q9NR50-1(isoform-parent)	-	-	-	figure legend:Fig 1a, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/07	2019/07/08	rogid:CLCdt90SBzvMUBXSQDb6DTy3Yz09606	rogid:wGjFfKA+E5rYJfmocP6qcTQ9+SU9606	rigid:042/oc/5H71gFbvpPEHytGEbZTM	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P49770	uniprotkb:Q9UI10-1	intact:EBI-718773|uniprotkb:O43201|ensembl:ENSP00000266126	intact:EBI-21465013|ensembl:ENSP00000233552	psi-mi:ei2bb_human(display_long)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:S20I15(gene name synonym)|uniprotkb:S20III15(gene name synonym)|uniprotkb:EIF2B2(gene name)|psi-mi:EIF2B2(display_short)|uniprotkb:EIF2BB(gene name synonym)	psi-mi:q9ui10-1(display_long)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit delta(gene name synonym)|uniprotkb:EIF2B4(gene name)|psi-mi:EIF2B4(display_short)|uniprotkb:EIF2BD(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465031|emdb:EMD-9842|emdb:EMD-9841|wwpdb:6k72|wwpdb:6k71|emdb:EMD-9840|imex:IM-27159-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055054.1|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007417"(central nervous system development)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0042552"(myelination)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|rcsb pdb:6CAJ|rcsb pdb:6EZO|rcsb pdb:6K71|rcsb pdb:6K72|rcsb pdb:6O81|rcsb pdb:6O85|rcsb pdb:6O9Z|rcsb pdb:7D43|rcsb pdb:7D44|rcsb pdb:7D45|rcsb pdb:7D46|rcsb pdb:7L70|rcsb pdb:7L7G|reactome:R-HSA-72731|ensembl:ENSG00000119718(gene)|ensembl:ENST00000266126(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	intact:EBI-2340132(isoform-parent)|ensembl:ENSG00000115211(gene)|ensembl:ENST00000347454(transcript)	-	-	-	figure legend:Fig 1a, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/07	2019/07/08	rogid:CLCdt90SBzvMUBXSQDb6DTy3Yz09606	rogid:ZCU4mIO5zkmBajIvBRe3b2PZINw9606	rigid:042/oc/5H71gFbvpPEHytGEbZTM	false	-	-	2	2	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9USP0	uniprotkb:Q9UT76	intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep"	intact:EBI-16198490|ensemblfungi:"SPAC343.14c.1:pep"	psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym)	psi-mi:ei2bb_schpo(display_long)|uniprotkb:tif222(gene name)|psi-mi:tif222(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:SPAC343.14c(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465056|wwpdb:6JLY|imex:IM-27159-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731	ensemblfungi:SPAC343.14c(gene)|ensemblfungi:SPAC343.14c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR027363|interpro:IPR037171|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61959N|reactome:R-SPO-72731|refseq:NP_593435.1	-	crc64:6FAACEBEBD50995A	crc64:19F324EF0135628B	figure legend:Fig S8, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2019/07/07	2019/07/08	rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812	rogid:CdgxUzS5DQmX2n5eBqgB34LDb0M284812	rigid:iP9y9yRb+e9tB3+VQSghbe7udZ4	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9USP0	uniprotkb:Q09924	intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep"	intact:EBI-16198531|ensemblfungi:"SPAC21E11.06.1:pep"	psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym)	psi-mi:ei2bd_schpo(display_long)|uniprotkb:tif224(gene name)|psi-mi:tif224(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit delta(gene name synonym)|uniprotkb:SPAC21E11.06(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465056|wwpdb:6JLY|imex:IM-27159-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731	ensemblfungi:SPAC21E11.06(gene)|ensemblfungi:SPAC21E11.06.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61961N|reactome:R-SPO-72731|refseq:NP_594503.1	-	crc64:6FAACEBEBD50995A	crc64:3C7029EBDFEF6EAF	figure legend:Fig S8, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2019/07/07	2019/07/08	rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812	rogid:Aks4E/RvLZMqA0n5KidtcX9m5KQ284812	rigid:iP9y9yRb+e9tB3+VQSghbe7udZ4	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9USP0	uniprotkb:P56287	intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep"	intact:EBI-16198550|ensemblfungi:"SPAC8C9.15c.1:pep"	psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym)	psi-mi:ei2be_schpo(display_long)|uniprotkb:tif225(gene name)|psi-mi:tif225(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit epsilon(gene name synonym)|uniprotkb:SPAC8C9.15c(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465056|wwpdb:6JLY|imex:IM-27159-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731	ensemblfungi:SPAC8C9.15c(gene)|ensemblfungi:SPAC8C9.15c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0031369"(translation initiation factor binding)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR005835(Nucleotidyl transferase)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029044|interpro:IPR035543|interpro:IPR044123|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61962N|reactome:R-SPO-72731|refseq:NP_594285.1	-	crc64:6FAACEBEBD50995A	crc64:D399547CBD82C4BC	figure legend:Fig S8, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2019/07/07	2019/07/08	rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812	rogid:u2wJRy6HbBwJAiu7vj8mrMncIpc284812	rigid:iP9y9yRb+e9tB3+VQSghbe7udZ4	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9USP0	uniprotkb:P56288	intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep"	intact:EBI-16198511|ensemblfungi:"SPAC4D7.09.1:pep"	psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym)	psi-mi:ei2bg_schpo(display_long)|uniprotkb:tif223(gene name)|psi-mi:tif223(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit gamma(gene name synonym)|uniprotkb:SPAC4D7.09(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465056|wwpdb:6JLY|imex:IM-27159-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731	ensemblfungi:SPAC4D7.09(gene)|ensemblfungi:SPAC4D7.09.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|interpro:IPR005835(Nucleotidyl transferase)|interpro:IPR029044|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61960N|reactome:R-SPO-72731|refseq:NP_594962.2	-	crc64:6FAACEBEBD50995A	crc64:242987543BE43021	figure legend:Fig S8, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2019/07/07	2019/07/08	rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812	rogid:EXcyv765uE6fEfVJSuVYPQFWPy4284812	rigid:iP9y9yRb+e9tB3+VQSghbe7udZ4	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9USP0	uniprotkb:P20459	intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep"	intact:EBI-8915|uniprotkb:E9P8T6|ensemblfungi:YJR007W|uniprotkb:D6VWI2	psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym)	psi-mi:if2a_yeast(display_long)|uniprotkb:SUI2(gene name)|psi-mi:SUI2(display_short)|uniprotkb:TIF211(gene name synonym)|uniprotkb:YJR007W(locus name)|uniprotkb:J1429(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465056|wwpdb:6JLY|imex:IM-27159-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731	interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|rcsb pdb:1Q46|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6JLY|rcsb pdb:6JLZ|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-156827|reactome:R-SCE-381042|reactome:R-SCE-72649|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|ensemblfungi:YJR007W(gene)|ensemblfungi:YJR007W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|refseq:NP_012540.3|sgd:S000003767|mint:P20459|dip:DIP-2327N	-	crc64:6FAACEBEBD50995A	crc64:AF4F1C80303A4E98	figure legend:Fig S8, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2019/07/07	2019/07/08	rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812	rogid:9/iGImP9/c8HSYwgmItME27z7lE559292	rigid:iP9y9yRb+e9tB3+VQSghbe7udZ4	false	-	his tag:c-c|flag tag:c-c	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9USP0	uniprotkb:Q9UT76	intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep"	intact:EBI-16198490|ensemblfungi:"SPAC343.14c.1:pep"	psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym)	psi-mi:ei2bb_schpo(display_long)|uniprotkb:tif222(gene name)|psi-mi:tif222(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit beta(gene name synonym)|uniprotkb:SPAC343.14c(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465069|imex:IM-27159-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731	ensemblfungi:SPAC343.14c(gene)|ensemblfungi:SPAC343.14c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR027363|interpro:IPR037171|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61959N|reactome:R-SPO-72731|refseq:NP_593435.1	-	crc64:6FAACEBEBD50995A	crc64:19F324EF0135628B	figure legend:Fig S8, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2019/07/07	2019/07/08	rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812	rogid:CdgxUzS5DQmX2n5eBqgB34LDb0M284812	rigid:iP9y9yRb+e9tB3+VQSghbe7udZ4	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9USP0	uniprotkb:Q09924	intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep"	intact:EBI-16198531|ensemblfungi:"SPAC21E11.06.1:pep"	psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym)	psi-mi:ei2bd_schpo(display_long)|uniprotkb:tif224(gene name)|psi-mi:tif224(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit delta(gene name synonym)|uniprotkb:SPAC21E11.06(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465069|imex:IM-27159-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731	ensemblfungi:SPAC21E11.06(gene)|ensemblfungi:SPAC21E11.06.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61961N|reactome:R-SPO-72731|refseq:NP_594503.1	-	crc64:6FAACEBEBD50995A	crc64:3C7029EBDFEF6EAF	figure legend:Fig S8, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2019/07/07	2019/07/08	rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812	rogid:Aks4E/RvLZMqA0n5KidtcX9m5KQ284812	rigid:iP9y9yRb+e9tB3+VQSghbe7udZ4	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9USP0	uniprotkb:P56287	intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep"	intact:EBI-16198550|ensemblfungi:"SPAC8C9.15c.1:pep"	psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym)	psi-mi:ei2be_schpo(display_long)|uniprotkb:tif225(gene name)|psi-mi:tif225(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit epsilon(gene name synonym)|uniprotkb:SPAC8C9.15c(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465069|imex:IM-27159-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731	ensemblfungi:SPAC8C9.15c(gene)|ensemblfungi:SPAC8C9.15c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0031369"(translation initiation factor binding)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR005835(Nucleotidyl transferase)|interpro:IPR011004(Trimeric LpxA-like)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR029044|interpro:IPR035543|interpro:IPR044123|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61962N|reactome:R-SPO-72731|refseq:NP_594285.1	-	crc64:6FAACEBEBD50995A	crc64:D399547CBD82C4BC	figure legend:Fig S8, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2019/07/07	2019/07/08	rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812	rogid:u2wJRy6HbBwJAiu7vj8mrMncIpc284812	rigid:iP9y9yRb+e9tB3+VQSghbe7udZ4	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9USP0	uniprotkb:P56288	intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep"	intact:EBI-16198511|ensemblfungi:"SPAC4D7.09.1:pep"	psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym)	psi-mi:ei2bg_schpo(display_long)|uniprotkb:tif223(gene name)|psi-mi:tif223(display_short)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit gamma(gene name synonym)|uniprotkb:SPAC4D7.09(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465069|imex:IM-27159-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731	ensemblfungi:SPAC4D7.09(gene)|ensemblfungi:SPAC4D7.09.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|interpro:IPR005835(Nucleotidyl transferase)|interpro:IPR029044|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|dip:DIP-61960N|reactome:R-SPO-72731|refseq:NP_594962.2	-	crc64:6FAACEBEBD50995A	crc64:242987543BE43021	figure legend:Fig S8, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2019/07/07	2019/07/08	rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812	rogid:EXcyv765uE6fEfVJSuVYPQFWPy4284812	rigid:iP9y9yRb+e9tB3+VQSghbe7udZ4	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q9USP0	uniprotkb:P20459	intact:EBI-1793476|ensemblfungi:"SPCC11E10.07c.1:pep"	intact:EBI-8915|uniprotkb:E9P8T6|ensemblfungi:YJR007W|uniprotkb:D6VWI2	psi-mi:ei2ba_schpo(display_long)|uniprotkb:tif221(gene name)|psi-mi:tif221(display_short)|uniprotkb:SPCC11E10.07c(orf name)|uniprotkb:eIF-2B GDP-GTP exchange factor subunit alpha(gene name synonym)	psi-mi:if2a_yeast(display_long)|uniprotkb:SUI2(gene name)|psi-mi:SUI2(display_short)|uniprotkb:TIF211(gene name synonym)|uniprotkb:YJR007W(locus name)|uniprotkb:J1429(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Kashiwagi et al. (2019)	pubmed:31048492|imex:IM-27159	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21465069|imex:IM-27159-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_588203.1|dip:DIP-61958N|mint:Q9USP0|ensemblfungi:SPCC11E10.07c(gene)|ensemblfungi:SPCC11E10.07c.1(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0006413"(translational initiation)|interpro:IPR000649(Initiation factor 2B related)|interpro:IPR037171|interpro:IPR042528|interpro:IPR042529|rcsb pdb:5B04|rcsb pdb:6JLY|rcsb pdb:6JLZ|reactome:R-SPO-72731	interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|rcsb pdb:1Q46|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3J81|rcsb pdb:3JAP|rcsb pdb:3JAQ|rcsb pdb:6FYX|rcsb pdb:6FYY|rcsb pdb:6GSM|rcsb pdb:6GSN|rcsb pdb:6I3M|rcsb pdb:6I7T|rcsb pdb:6JLY|rcsb pdb:6JLZ|rcsb pdb:6QG0|rcsb pdb:6QG1|rcsb pdb:6QG2|rcsb pdb:6QG3|rcsb pdb:6QG5|rcsb pdb:6QG6|reactome:R-SCE-156827|reactome:R-SCE-381042|reactome:R-SCE-72649|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72731|ensemblfungi:YJR007W(gene)|ensemblfungi:YJR007W_mRNA(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0043614"(multi-eIF complex)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|refseq:NP_012540.3|sgd:S000003767|mint:P20459|dip:DIP-2327N	-	crc64:6FAACEBEBD50995A	crc64:AF4F1C80303A4E98	figure legend:Fig S8, Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2019/07/07	2019/07/08	rogid:GCNnhLA7rY1yBrs8W46fDTvJ/SQ284812	rogid:9/iGImP9/c8HSYwgmItME27z7lE559292	rigid:iP9y9yRb+e9tB3+VQSghbe7udZ4	false	-	his tag:c-c|flag tag:c-c|O-phospho-L-serine:52-52	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)