#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q01201	uniprotkb:Q9NPC8	intact:EBI-357837|uniprotkb:Q6GTX7|uniprotkb:Q9UEI7|intact:EBI-28977965|ensembl:ENSP00000221452|ensembl:ENSP00000485826	intact:EBI-12695166|ensembl:ENSP00000304502|uniprotkb:Q9BXH7	psi-mi:relb_human(display_long)|uniprotkb:RELB(gene name)|psi-mi:RELB(display_short)|uniprotkb:I-Rel(gene name synonym)	psi-mi:six2_human(display_long)|uniprotkb:SIX2(gene name)|psi-mi:SIX2(display_short)|uniprotkb:Sine oculis homeobox homolog 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2019)	pubmed:30894749|imex:IM-28133	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21464948|imex:IM-28133-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006500.2|ensembl:ENSP00000221452|ensembl:ENSP00000485826|dip:DIP-27531N|ensembl:ENSG00000104856(gene)|ensembl:ENST00000221452(transcript)|ensembl:ENST00000625761(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034097"(response to cytokine)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071470"(cellular response to osmotic stress)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030496|interpro:IPR032397|interpro:IPR032399|interpro:IPR032400|interpro:IPR033926|interpro:IPR037059|reactome:R-HSA-5607761|reactome:R-HSA-5621575|reactome:R-HSA-5676590	ensembl:ENSG00000170577(gene)|ensembl:ENST00000303077(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0016477"(cell migration)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0072006"(nephron development)|go:"GO:0072028"(nephron morphogenesis)|go:"GO:0072038"(mesenchymal stem cell maintenance involved in nephron morphogenesis)|go:"GO:0072137"(condensed mesenchymal cell proliferation)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0090189"(regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097168"(mesenchymal stem cell proliferation)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR031701|refseq:NP_058628.3	-	-	-	figure legend:Fig 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/07/05	2019/07/06	rogid:Z86381sTm70DDTlOVNTvJOHiWug9606	rogid:SfhTkvvAsAMMrx9Jrt5Qv9GV1f09606	rigid:F+HtR0nq5LNqGU9r8+hE/yp9Qiw	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q04206-1	uniprotkb:Q9NPC8	intact:EBI-10826776|ensembl:ENSP00000384273	intact:EBI-12695166|ensembl:ENSP00000304502|uniprotkb:Q9BXH7	psi-mi:q04206-1(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)|uniprotkb:p65(isoform synonym)|uniprotkb:RELA(gene name)|psi-mi:RELA(display_short)|uniprotkb:NFKB3(gene name synonym)	psi-mi:six2_human(display_long)|uniprotkb:SIX2(gene name)|psi-mi:SIX2(display_short)|uniprotkb:Sine oculis homeobox homolog 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2019)	pubmed:30894749|imex:IM-28133	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21464959|imex:IM-28133-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-73886(isoform-parent)|ensembl:ENSG00000173039(gene)|ensembl:ENST00000406246(transcript)	ensembl:ENSG00000170577(gene)|ensembl:ENST00000303077(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0016477"(cell migration)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0072006"(nephron development)|go:"GO:0072028"(nephron morphogenesis)|go:"GO:0072038"(mesenchymal stem cell maintenance involved in nephron morphogenesis)|go:"GO:0072137"(condensed mesenchymal cell proliferation)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0090189"(regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097168"(mesenchymal stem cell proliferation)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR031701|refseq:NP_058628.3	-	-	-	figure legend:Fig 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/07/05	2019/07/06	rogid:w/ClZ7PzdLH1LLxTGrk22KUz8V49606	rogid:SfhTkvvAsAMMrx9Jrt5Qv9GV1f09606	rigid:8koq2c1FJVW6rpHH28PjwIQ/sd8	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-4399559	uniprotkb:Q9NPC8	dip:DIP-24261N	intact:EBI-12695166|ensembl:ENSP00000304502|uniprotkb:Q9BXH7	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:six2_human(display_long)|uniprotkb:SIX2(gene name)|psi-mi:SIX2(display_short)|uniprotkb:Sine oculis homeobox homolog 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Liu et al. (2019)	pubmed:30894749|imex:IM-28133	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21464984|imex:IM-28133-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	ensembl:ENSG00000170577(gene)|ensembl:ENST00000303077(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0016477"(cell migration)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0072006"(nephron development)|go:"GO:0072028"(nephron morphogenesis)|go:"GO:0072038"(mesenchymal stem cell maintenance involved in nephron morphogenesis)|go:"GO:0072137"(condensed mesenchymal cell proliferation)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0090189"(regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097168"(mesenchymal stem cell proliferation)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR031701|refseq:NP_058628.3	-	no-uniprot-update:	-	figure legend:Exp Data Fig 3m|antagonist:NF-kB-inducing kinase -NIK, also known as MAP3K14.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/07/05	2019/07/06	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:SfhTkvvAsAMMrx9Jrt5Qv9GV1f09606	rigid:ITnbyKcyVPMosS4Hz+L4on1U1nk	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NPC8	uniprotkb:Q04206-1	intact:EBI-12695166|ensembl:ENSP00000304502|uniprotkb:Q9BXH7	intact:EBI-10826776|ensembl:ENSP00000384273	psi-mi:six2_human(display_long)|uniprotkb:SIX2(gene name)|psi-mi:SIX2(display_short)|uniprotkb:Sine oculis homeobox homolog 2(gene name synonym)	psi-mi:q04206-1(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)|uniprotkb:p65(isoform synonym)|uniprotkb:RELA(gene name)|psi-mi:RELA(display_short)|uniprotkb:NFKB3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2019)	pubmed:30894749|imex:IM-28133	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21464974|imex:IM-28133-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170577(gene)|ensembl:ENST00000303077(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0016477"(cell migration)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0072006"(nephron development)|go:"GO:0072028"(nephron morphogenesis)|go:"GO:0072038"(mesenchymal stem cell maintenance involved in nephron morphogenesis)|go:"GO:0072137"(condensed mesenchymal cell proliferation)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0090189"(regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097168"(mesenchymal stem cell proliferation)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR031701|refseq:NP_058628.3	intact:EBI-73886(isoform-parent)|ensembl:ENSG00000173039(gene)|ensembl:ENST00000406246(transcript)	-	-	-	figure legend:Fig 3d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2019/07/05	2019/07/06	rogid:SfhTkvvAsAMMrx9Jrt5Qv9GV1f09606	rogid:w/ClZ7PzdLH1LLxTGrk22KUz8V49606	rigid:8koq2c1FJVW6rpHH28PjwIQ/sd8	false	-	binding-associated region:473-522	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)