#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P60852	uniprotkb:P21754	intact:EBI-21279624|ensembl:ENSP00000278853	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	psi-mi:zp1_human(display_long)|uniprotkb:ZP1(gene name)|psi-mi:ZP1(display_short)|uniprotkb:Zona pellucida glycoprotein 1(gene name synonym)	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2019)	pubmed:30810869|imex:IM-26907	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21279768|imex:IM-26907-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000278853(transcript)|ensembl:ENSG00000149506(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0007338"(single fertilization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343|go:"GO:0005576"(extracellular region)|refseq:NP_997224.2	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Supplementary 5A-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2019/03/21	2019/03/21	rogid:FIyfLbZKJtaYlh0CCN8lzpln+Dw9606	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rigid:TSG6L2H9ZCB5Z1hxPN135MWvWSQ	false	flag tag:25..25-26..26|mutation with no effect:570-570|mutation with no effect:410-410	ha tag:22..22-23..23	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P60852	uniprotkb:Q05996	intact:EBI-21279624|ensembl:ENSP00000278853	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	psi-mi:zp1_human(display_long)|uniprotkb:ZP1(gene name)|psi-mi:ZP1(display_short)|uniprotkb:Zona pellucida glycoprotein 1(gene name synonym)	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2019)	pubmed:30810869|imex:IM-26907	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21279768|imex:IM-26907-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000278853(transcript)|ensembl:ENSG00000149506(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0007338"(single fertilization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343|go:"GO:0005576"(extracellular region)|refseq:NP_997224.2	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Supplementary 5A-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2019/03/21	2019/03/21	rogid:FIyfLbZKJtaYlh0CCN8lzpln+Dw9606	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rigid:TSG6L2H9ZCB5Z1hxPN135MWvWSQ	false	flag tag:25..25-26..26|mutation with no effect:570-570|mutation with no effect:410-410	myc tag:38..38-39..39	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P60852	uniprotkb:Q12836	intact:EBI-21279624|ensembl:ENSP00000278853	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	psi-mi:zp1_human(display_long)|uniprotkb:ZP1(gene name)|psi-mi:ZP1(display_short)|uniprotkb:Zona pellucida glycoprotein 1(gene name synonym)	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2019)	pubmed:30810869|imex:IM-26907	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21279768|imex:IM-26907-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000278853(transcript)|ensembl:ENSG00000149506(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0007338"(single fertilization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343|go:"GO:0005576"(extracellular region)|refseq:NP_997224.2	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Supplementary 5A-1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2019/03/21	2019/03/21	rogid:FIyfLbZKJtaYlh0CCN8lzpln+Dw9606	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rigid:TSG6L2H9ZCB5Z1hxPN135MWvWSQ	false	flag tag:25..25-26..26|mutation with no effect:570-570|mutation with no effect:410-410	v5 tag:18..18-19..19	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q05996	uniprotkb:P21754	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2019)	pubmed:30810869|imex:IM-26907	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21279790|imex:IM-26907-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Supplementary 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2019/03/21	2019/03/21	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rigid:TSG6L2H9ZCB5Z1hxPN135MWvWSQ	false	mutation with no effect:372-372|myc tag:38..38-39..39	ha tag:22..22-23..23	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q05996	uniprotkb:P60852	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	intact:EBI-21279624|ensembl:ENSP00000278853	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:zp1_human(display_long)|uniprotkb:ZP1(gene name)|psi-mi:ZP1(display_short)|uniprotkb:Zona pellucida glycoprotein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2019)	pubmed:30810869|imex:IM-26907	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21279790|imex:IM-26907-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	ensembl:ENST00000278853(transcript)|ensembl:ENSG00000149506(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0007338"(single fertilization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343|go:"GO:0005576"(extracellular region)|refseq:NP_997224.2	-	-	-	figure legend:Supplementary 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2019/03/21	2019/03/21	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rogid:FIyfLbZKJtaYlh0CCN8lzpln+Dw9606	rigid:TSG6L2H9ZCB5Z1hxPN135MWvWSQ	false	mutation with no effect:372-372|myc tag:38..38-39..39	flag tag:25..25-26..26	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q05996	uniprotkb:Q12836	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2019)	pubmed:30810869|imex:IM-26907	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21279790|imex:IM-26907-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Supplementary 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2019/03/21	2019/03/21	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rigid:TSG6L2H9ZCB5Z1hxPN135MWvWSQ	false	mutation with no effect:372-372|myc tag:38..38-39..39	v5 tag:18..18-19..19	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P21754	uniprotkb:Q05996	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	intact:EBI-1755919|uniprotkb:Q4VAN9|uniprotkb:Q4VAP0|uniprotkb:B2R7J2|uniprotkb:Q4VAP1|ensembl:ENSP00000458991|ensembl:ENSP00000492703|ensembl:ENSP00000460971	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:zp2_human(display_long)|uniprotkb:ZP2(gene name)|psi-mi:ZP2(display_short)|uniprotkb:ZPA(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 2(gene name synonym)|uniprotkb:Zona pellucida protein A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2019)	pubmed:30810869|imex:IM-26907	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21279818|imex:IM-26907-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_003451.1|refseq:NP_001277033.1|ensembl:ENSG00000103310(gene)|ensembl:ENSG00000284588(gene)|ensembl:ENST00000574002(transcript)|ensembl:ENST00000574091(transcript)|ensembl:ENST00000638300(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0060468"(prevention of polyspermy)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Supplementary 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2019/03/21	2019/03/21	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rogid:D35m0zItHMAdG2P/Ioser7DJ6qA9606	rigid:TSG6L2H9ZCB5Z1hxPN135MWvWSQ	false	ha tag:22..22-23..23|mutation increasing interaction strength:255-255	myc tag:38..38-39..39	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P21754	uniprotkb:Q12836	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	intact:EBI-11783805|uniprotkb:B2RAE1|ensembl:ENSP00000355529|ensembl:ENSP00000482304	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:zp4_human(display_long)|uniprotkb:ZP4(gene name)|psi-mi:ZP4(display_short)|uniprotkb:ZPB(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 4(gene name synonym)|uniprotkb:Zona pellucida protein B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2019)	pubmed:30810869|imex:IM-26907	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21279818|imex:IM-26907-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	refseq:NP_067009.1|ensembl:ENSG00000116996(gene)|ensembl:ENST00000366570(transcript)|ensembl:ENST00000611898(transcript)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032190"(acrosin binding)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343	-	-	-	figure legend:Supplementary 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2019/03/21	2019/03/21	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rogid:EbF8oXDmO4WkY9og1cLR11ab8cI9606	rigid:TSG6L2H9ZCB5Z1hxPN135MWvWSQ	false	ha tag:22..22-23..23|mutation increasing interaction strength:255-255	v5 tag:18..18-19..19	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P21754	uniprotkb:P60852	intact:EBI-11783624|uniprotkb:Q06633|uniprotkb:Q29RW0|ensembl:ENSP00000378326	intact:EBI-21279624|ensembl:ENSP00000278853	psi-mi:zp3_human(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZP3A(gene name synonym)|uniprotkb:ZP3B(gene name synonym)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:ZP3A/ZP3B(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)|uniprotkb:Zona pellucida protein C(gene name synonym)	psi-mi:zp1_human(display_long)|uniprotkb:ZP1(gene name)|psi-mi:ZP1(display_short)|uniprotkb:Zona pellucida glycoprotein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2019)	pubmed:30810869|imex:IM-26907	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21279818|imex:IM-26907-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103824.1|refseq:NP_009086.4|ensembl:ENSG00000188372(gene)|ensembl:ENST00000394857(transcript)|go:"GO:0001809"(positive regulation of type IV hypersensitivity)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002922"(positive regulation of humoral immune response)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048599"(oocyte development)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000360"(negative regulation of binding of sperm to zona pellucida)|go:"GO:2000368"(positive regulation of acrosomal vesicle exocytosis)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000388"(positive regulation of antral ovarian follicle growth)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|reactome:R-HSA-2534343	ensembl:ENST00000278853(transcript)|ensembl:ENSG00000149506(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0007338"(single fertilization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0035805"(egg coat)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000519(P-type trefoil)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017957|interpro:IPR017977|interpro:IPR042235|reactome:R-HSA-2534343|go:"GO:0005576"(extracellular region)|refseq:NP_997224.2	-	-	-	figure legend:Supplementary 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2019/03/21	2019/03/21	rogid:5K4H6EgJwGfkFBSuBoEi6+70FAk9606	rogid:FIyfLbZKJtaYlh0CCN8lzpln+Dw9606	rigid:TSG6L2H9ZCB5Z1hxPN135MWvWSQ	false	ha tag:22..22-23..23|mutation increasing interaction strength:255-255	flag tag:25..25-26..26	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)