#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P57789	uniprotkb:P57789	intact:EBI-5235664|uniprotkb:B2RCT3|uniprotkb:Q8TDK7|uniprotkb:Q8TDK8|uniprotkb:Q9HB59|uniprotkb:B2R8T4|uniprotkb:B5TJL4|uniprotkb:Q6B014|ensembl:ENSP00000343104	intact:EBI-5235664|uniprotkb:B2RCT3|uniprotkb:Q8TDK7|uniprotkb:Q8TDK8|uniprotkb:Q9HB59|uniprotkb:B2R8T4|uniprotkb:B5TJL4|uniprotkb:Q6B014|ensembl:ENSP00000343104	psi-mi:kcnka_human(display_long)|uniprotkb:KCNK10(gene name)|psi-mi:KCNK10(display_short)|uniprotkb:TREK2(gene name synonym)|uniprotkb:Outward rectifying potassium channel protein TREK-2(gene name synonym)|uniprotkb:"TREK-2 K(+) channel subunit"(gene name synonym)	psi-mi:kcnka_human(display_long)|uniprotkb:KCNK10(gene name)|psi-mi:KCNK10(display_short)|uniprotkb:TREK2(gene name synonym)|uniprotkb:Outward rectifying potassium channel protein TREK-2(gene name synonym)|uniprotkb:"TREK-2 K(+) channel subunit"(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Schewe et al. (2019)	pubmed:30792303|imex:IM-27177	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21917790|imex:IM-27177-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066984.1|refseq:NP_612190.1|refseq:NP_612191.1|dip:DIP-44050N|ensembl:ENSG00000100433(gene)|ensembl:ENST00000340700(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007613"(memory)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|rcsb pdb:4BW5|rcsb pdb:4XDJ|rcsb pdb:4XDK|rcsb pdb:4XDL|reactome:R-HSA-1299503|reactome:R-HSA-5576886	refseq:NP_066984.1|refseq:NP_612190.1|refseq:NP_612191.1|dip:DIP-44050N|ensembl:ENSG00000100433(gene)|ensembl:ENST00000340700(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007613"(memory)|go:"GO:0022841"(potassium ion leak channel activity)|go:"GO:0030322"(stabilization of membrane potential)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR003280(Potassium channel, two pore-domain)|interpro:IPR003976(Potassium channel, two pore-domain, TREK)|interpro:IPR013099(Ion transport 2)|rcsb pdb:4BW5|rcsb pdb:4XDJ|rcsb pdb:4XDK|rcsb pdb:4XDL|reactome:R-HSA-1299503|reactome:R-HSA-5576886	-	-	-	figure legend:Fig. 2A; fig. S3, A to C|3d-resolution:4.1 A|comment:"Brominated BL-1249 (channel activator)  was present, but no electron density for either the bromine atoms or BL-1249 was seen."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/07/16	2019/07/17	rogid:TILspz2BicB+A1MAQe9ArAFP1/Y9606	rogid:TILspz2BicB+A1MAQe9ArAFP1/Y9606	rigid:kQUK4mIkAQ4W3ahrWY9uh07gzPE	false	binding-associated region:67-340	binding-associated region:67-340	4	0	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)