#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03692	uniprotkb:P00581	intact:EBI-8664802|intact:MINT-1513747	intact:EBI-8664634|intact:MINT-1513442	psi-mi:helic_bpt7(display_long)|uniprotkb:Gene product 4(gene name synonym)|uniprotkb:4(locus name)	psi-mi:dpol_bpt7(display_long)|uniprotkb:Gene product 5(gene name synonym)|uniprotkb:5(locus name)	psi-mi:"MI:0410"(3D electron microscopy)	Gao et al. (2019)	pubmed:30679383|imex:IM-27024	taxid:10760(bpt7)|taxid:10760(Enterobacteria phage T7)	taxid:10760(bpt7)|taxid:10760(Enterobacteria phage T7)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21255496|wwpdb:6N9V|wwpdb:6N9W|wwpdb:6N9X|emdb:EMD-0380|emdb:EMD-0381|emdb:EMD-0382|imex:IM-27024-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003677"(DNA binding)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003896"(DNA primase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013237(Phage P4 alpha, zinc-binding)|refseq:NP_041977.1|interpro:IPR027417|rcsb pdb:1CR4|rcsb pdb:1E0K|rcsb pdb:1NUI|refseq:NP_041975.1|rcsb pdb:1E0J|rcsb pdb:1CR1|rcsb pdb:1CR0|rcsb pdb:1Q57|rcsb pdb:1CR2|interpro:IPR007694(DNA helicase, DnaB-like, C-terminal)|interpro:IPR034154|rcsb pdb:5IKN|rcsb pdb:6N7I|rcsb pdb:6N7N|rcsb pdb:6N7S|rcsb pdb:6N7T|rcsb pdb:6N7V|rcsb pdb:6N9U|rcsb pdb:6N9V|rcsb pdb:6N9W|rcsb pdb:6N9X	interpro:IPR002298(DNA polymerase A)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR019760|interpro:IPR034699|interpro:IPR036397|interpro:IPR043502|rcsb pdb:1SKR|rcsb pdb:1SKS|rcsb pdb:1SKW|rcsb pdb:1SL0|rcsb pdb:1SL1|rcsb pdb:1SL2|rcsb pdb:1T7P|rcsb pdb:1T8E|rcsb pdb:1TK0|rcsb pdb:1TK5|rcsb pdb:1TK8|interpro:IPR001098(DNA-directed DNA polymerase, family A)|rcsb pdb:1TKD|rcsb pdb:1X9M|rcsb pdb:1X9W|rcsb pdb:1ZYQ|rcsb pdb:2AJQ|rcsb pdb:5IKN|rcsb pdb:6N7W|rcsb pdb:6N9U|rcsb pdb:6N9V|rcsb pdb:6N9W|rcsb pdb:6N9X|rcsb pdb:6P7E|rcsb pdb:1X9S|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004529"(exodeoxyribonuclease activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0090592"(DNA synthesis involved in DNA replication)|refseq:NP_041982.1|dip:DIP-41665N	-	comment:mint|function:DNA primase synthesizes RNA primers necessary for replication by DNA polymerase. It also functions as an ATP-dependent unwinding protein. Has a 5'->3' helicase activity; 4a also has a DNA primase activity	comment:mint	figure legend:Fig.1, Fig. S5, Table S1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/02/27	2019/03/12	rogid:8NMSvm5jMFpiKZJepG/bj/JxkTo10760	rogid:Tlmcx5VE1Ap7B/S+A25RqinIycU10760	rigid:QtBpsx2lcqdafiuP1eAHZ83bMzA	false	mutation:343-343	mutation:5-5|mutation:7-7	6	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P00581	uniprotkb:Q14F07	intact:EBI-8664634|intact:MINT-1513442	intact:EBI-21255516	psi-mi:dpol_bpt7(display_long)|uniprotkb:Gene product 5(gene name synonym)|uniprotkb:5(locus name)	psi-mi:q14f07_ecolx(display_long)|uniprotkb:trxA(gene name)|psi-mi:trxA(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Gao et al. (2019)	pubmed:30679383|imex:IM-27024	taxid:10760(bpt7)|taxid:10760(Enterobacteria phage T7)	taxid:562(ecolx)|taxid:562(Escherichia coli)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21255506|wwpdb:6N7W|emdb:EMD-0365|imex:IM-27024-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002298(DNA polymerase A)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR019760|interpro:IPR034699|interpro:IPR036397|interpro:IPR043502|rcsb pdb:1SKR|rcsb pdb:1SKS|rcsb pdb:1SKW|rcsb pdb:1SL0|rcsb pdb:1SL1|rcsb pdb:1SL2|rcsb pdb:1T7P|rcsb pdb:1T8E|rcsb pdb:1TK0|rcsb pdb:1TK5|rcsb pdb:1TK8|interpro:IPR001098(DNA-directed DNA polymerase, family A)|rcsb pdb:1TKD|rcsb pdb:1X9M|rcsb pdb:1X9W|rcsb pdb:1ZYQ|rcsb pdb:2AJQ|rcsb pdb:5IKN|rcsb pdb:6N7W|rcsb pdb:6N9U|rcsb pdb:6N9V|rcsb pdb:6N9W|rcsb pdb:6N9X|rcsb pdb:6P7E|rcsb pdb:1X9S|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004529"(exodeoxyribonuclease activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0090592"(DNA synthesis involved in DNA replication)|refseq:NP_041982.1|dip:DIP-41665N	go:"GO:0006662"(glycerol ether metabolic process)|go:"GO:0015035"(protein-disulfide reductase activity)|interpro:IPR005746(Thioredoxin)|interpro:IPR036249|interpro:IPR017937|interpro:IPR013766(Thioredoxin domain)	-	comment:mint	-	figure legend:Fig. S8E, S9B, Table S1|comment:Stoichiometry remained unspecified since they are fragments of a bigger complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/02/27	2019/03/12	rogid:Tlmcx5VE1Ap7B/S+A25RqinIycU10760	rogid:2VA2itycvpz96rDIYVcYqOAm/S0562	rigid:TPMs3JisH0rryd7Mqbdz1DCPwRE	false	mutation:5-5|mutation:7-7	sufficient binding region:36-144	-	-	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P03692	uniprotkb:P03692	intact:EBI-8664802|intact:MINT-1513747	intact:EBI-8664802|intact:MINT-1513747	psi-mi:helic_bpt7(display_long)|uniprotkb:Gene product 4(gene name synonym)|uniprotkb:4(locus name)	psi-mi:helic_bpt7(display_long)|uniprotkb:Gene product 4(gene name synonym)|uniprotkb:4(locus name)	psi-mi:"MI:0071"(molecular sieving)	Gao et al. (2019)	pubmed:30679383|imex:IM-27024	taxid:10760(bpt7)|taxid:10760(Enterobacteria phage T7)	taxid:10760(bpt7)|taxid:10760(Enterobacteria phage T7)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21255545|imex:IM-27024-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003677"(DNA binding)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003896"(DNA primase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013237(Phage P4 alpha, zinc-binding)|refseq:NP_041977.1|interpro:IPR027417|rcsb pdb:1CR4|rcsb pdb:1E0K|rcsb pdb:1NUI|refseq:NP_041975.1|rcsb pdb:1E0J|rcsb pdb:1CR1|rcsb pdb:1CR0|rcsb pdb:1Q57|rcsb pdb:1CR2|interpro:IPR007694(DNA helicase, DnaB-like, C-terminal)|interpro:IPR034154|rcsb pdb:5IKN|rcsb pdb:6N7I|rcsb pdb:6N7N|rcsb pdb:6N7S|rcsb pdb:6N7T|rcsb pdb:6N7V|rcsb pdb:6N9U|rcsb pdb:6N9V|rcsb pdb:6N9W|rcsb pdb:6N9X	go:"GO:0003677"(DNA binding)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003896"(DNA primase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013237(Phage P4 alpha, zinc-binding)|refseq:NP_041977.1|interpro:IPR027417|rcsb pdb:1CR4|rcsb pdb:1E0K|rcsb pdb:1NUI|refseq:NP_041975.1|rcsb pdb:1E0J|rcsb pdb:1CR1|rcsb pdb:1CR0|rcsb pdb:1Q57|rcsb pdb:1CR2|interpro:IPR007694(DNA helicase, DnaB-like, C-terminal)|interpro:IPR034154|rcsb pdb:5IKN|rcsb pdb:6N7I|rcsb pdb:6N7N|rcsb pdb:6N7S|rcsb pdb:6N7T|rcsb pdb:6N7V|rcsb pdb:6N9U|rcsb pdb:6N9V|rcsb pdb:6N9W|rcsb pdb:6N9X	go:"GO:0051260"(protein homooligomerization)	comment:mint|function:DNA primase synthesizes RNA primers necessary for replication by DNA polymerase. It also functions as an ATP-dependent unwinding protein. Has a 5'->3' helicase activity; 4a also has a DNA primase activity	comment:mint|function:DNA primase synthesizes RNA primers necessary for replication by DNA polymerase. It also functions as an ATP-dependent unwinding protein. Has a 5'->3' helicase activity; 4a also has a DNA primase activity	figure legend:Fig.1B|comment:Complex formed in the presence of single-stranded DNA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/02/27	2019/03/12	rogid:8NMSvm5jMFpiKZJepG/bj/JxkTo10760	rogid:8NMSvm5jMFpiKZJepG/bj/JxkTo10760	rigid:pOoqvktJdQiXbFkcXz3KpK4i+Jk	false	mutation:343-343	mutation:343-343	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)