#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-4399559	uniprotkb:P54725	dip:DIP-24261N	intact:EBI-746453|uniprotkb:Q59EU8|uniprotkb:Q5M7Z1|uniprotkb:K7ESE3|ensembl:ENSP00000467024	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:rd23a_human(display_long)|uniprotkb:RAD23A(gene name)|psi-mi:RAD23A(display_short)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21202717|imex:IM-26819-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_005044.1|refseq:NP_001257291.1|refseq:NP_001257292.1|dip:DIP-34442N|ensembl:ENSG00000179262(gene)|ensembl:ENST00000586534(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0019900"(kinase binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0070628"(proteasome binding)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|interpro:IPR041811|mint:P54725|rcsb pdb:1DV0|rcsb pdb:1F4I|rcsb pdb:1IFY|rcsb pdb:1OQY|rcsb pdb:1P98|rcsb pdb:1P9D|rcsb pdb:1QZE|rcsb pdb:1TP4|rcsb pdb:1ZO6|rcsb pdb:2WYQ|rcsb pdb:5XBO|rcsb pdb:6W2G|rcsb pdb:6W2H|rcsb pdb:6W2I|reactome:R-HSA-5689877|reactome:R-HSA-5696394|reactome:R-HSA-5696395	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:l/29QSvlTrWQMG3wLyeb/QxeaiU9606	rigid:gCU8kfQWkj6hg5GN7ZKBVmRVpOI	false	glutathione s tranferase tag:?-?	binding-associated region:298-363	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P54725	uniprotkb:Q15843	intact:EBI-746453|uniprotkb:Q59EU8|uniprotkb:Q5M7Z1|uniprotkb:K7ESE3|ensembl:ENSP00000467024	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:rd23a_human(display_long)|uniprotkb:RAD23A(gene name)|psi-mi:RAD23A(display_short)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21202748|imex:IM-26819-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005044.1|refseq:NP_001257291.1|refseq:NP_001257292.1|dip:DIP-34442N|ensembl:ENSG00000179262(gene)|ensembl:ENST00000586534(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0019900"(kinase binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0070628"(proteasome binding)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|interpro:IPR041811|mint:P54725|rcsb pdb:1DV0|rcsb pdb:1F4I|rcsb pdb:1IFY|rcsb pdb:1OQY|rcsb pdb:1P98|rcsb pdb:1P9D|rcsb pdb:1QZE|rcsb pdb:1TP4|rcsb pdb:1ZO6|rcsb pdb:2WYQ|rcsb pdb:5XBO|rcsb pdb:6W2G|rcsb pdb:6W2H|rcsb pdb:6W2I|reactome:R-HSA-5689877|reactome:R-HSA-5696394|reactome:R-HSA-5696395	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:l/29QSvlTrWQMG3wLyeb/QxeaiU9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:5TP/+Sb4DC9EKjlxqdvM5gKTJwE	false	binding-associated region:298-363	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UNA4	uniprotkb:Q15843	intact:EBI-741774|ensembl:ENSP00000462664|uniprotkb:Q8N590|uniprotkb:Q9H0S1|uniprotkb:Q9NYH6	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:poli_human(display_long)|uniprotkb:Eta2(gene name synonym)|uniprotkb:RAD30 homolog B(gene name synonym)|uniprotkb:POLI(gene name)|psi-mi:POLI(display_short)|uniprotkb:RAD30B(gene name synonym)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21202782|imex:IM-26819-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1T3N|rcsb pdb:1ZET|rcsb pdb:2ALZ|rcsb pdb:2DPI|rcsb pdb:2DPJ|rcsb pdb:2FLL|rcsb pdb:2FLN|rcsb pdb:2FLP|rcsb pdb:2KHU|rcsb pdb:2KHW|rcsb pdb:2KTF|rcsb pdb:2L0F|rcsb pdb:2L0G|rcsb pdb:2MBB|rcsb pdb:3EPG|rcsb pdb:3EPI|rcsb pdb:3G6V|rcsb pdb:3G6X|rcsb pdb:3G6Y|rcsb pdb:3GV5|rcsb pdb:3GV7|rcsb pdb:3GV8|rcsb pdb:3H40|rcsb pdb:3H4B|rcsb pdb:3H4D|ensembl:ENSG00000101751(gene)|ensembl:ENST00000579534(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0016607"(nuclear speck)|go:"GO:0019985"(translesion synthesis)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR017961|interpro:IPR036775|interpro:IPR043128|interpro:IPR043502|mint:Q9UNA4|refseq:NP_009126.2|rcsb pdb:3NGD|rcsb pdb:3OSN|rcsb pdb:3Q8P|rcsb pdb:3Q8Q|rcsb pdb:3Q8R|rcsb pdb:3Q8S|rcsb pdb:4EBC|rcsb pdb:4EBD|rcsb pdb:4EBE|rcsb pdb:4EYI|rcsb pdb:4FS1|rcsb pdb:4FS2|rcsb pdb:5KT2|rcsb pdb:5KT3|rcsb pdb:5KT4|rcsb pdb:5KT5|rcsb pdb:5KT6|rcsb pdb:5KT7|rcsb pdb:5ULW|rcsb pdb:5ULX|reactome:R-HSA-5656121|reactome:R-HSA-5656169|rcsb pdb:4EYH	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:iH6WfDK+UIzw5XQSHo9wWSfnrJU9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:mJxKMGixeSSYnpcmswdhwv/hLzw	false	binding-associated region:643-715	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9UMX0	uniprotkb:Q15843	intact:EBI-741480|uniprotkb:Q8IXS9|uniprotkb:Q8N2Q3|uniprotkb:Q9H0T8|uniprotkb:Q9H3R4|uniprotkb:Q9HAZ5|intact:EBI-28967608|ensembl:ENSP00000365576|uniprotkb:Q5T6J5|uniprotkb:Q5T6J9|uniprotkb:A0A024R284	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:ubql1_human(display_long)|uniprotkb:Protein linking IAP with cytoskeleton 1(gene name synonym)|uniprotkb:UBQLN1(gene name)|psi-mi:UBQLN1(display_short)|uniprotkb:DA41(gene name synonym)|uniprotkb:PLIC1(gene name synonym)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21202796|imex:IM-26819-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000257468|ensembl:ENSP00000257468|ensembl:ENSP00000365576|ensembl:ENSG00000135018(gene)|ensembl:ENST00000376395(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000502"(proteasome complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035973"(aggrephagy)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097352"(autophagosome maturation)|go:"GO:1901340"(negative regulation of store-operated calcium channel activity)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028430|interpro:IPR029071|mint:Q9UMX0|rcsb pdb:2JY5|rcsb pdb:2JY6|rcsb pdb:2KLC|reactome:R-HSA-8856825|refseq:NP_038466.2|refseq:NP_444295.1|dip:DIP-41629N	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:nCFfZbGCTvRYaXhQ4R99XblslvM9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:DgE3jMjC8Pzn/YQLU7ZVr6i7Ayg	false	binding-associated region:516-589	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O15037	uniprotkb:Q15843	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21202807|imex:IM-26819-81	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:P4tsMh/IBYRG/l1gst8cdtFuQ/I	false	binding-associated region:598-678	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13191	uniprotkb:Q15843	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21202870|imex:IM-26819-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:VzgGsrYnSQD61jQoxznXYhM0CRo	false	binding-associated region:916-982	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-4399559	uniprotkb:Q9UNA4	dip:DIP-24261N	intact:EBI-741774|ensembl:ENSP00000462664|uniprotkb:Q8N590|uniprotkb:Q9H0S1|uniprotkb:Q9NYH6	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:poli_human(display_long)|uniprotkb:Eta2(gene name synonym)|uniprotkb:RAD30 homolog B(gene name synonym)|uniprotkb:POLI(gene name)|psi-mi:POLI(display_short)|uniprotkb:RAD30B(gene name synonym)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21202923|imex:IM-26819-61	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	rcsb pdb:1T3N|rcsb pdb:1ZET|rcsb pdb:2ALZ|rcsb pdb:2DPI|rcsb pdb:2DPJ|rcsb pdb:2FLL|rcsb pdb:2FLN|rcsb pdb:2FLP|rcsb pdb:2KHU|rcsb pdb:2KHW|rcsb pdb:2KTF|rcsb pdb:2L0F|rcsb pdb:2L0G|rcsb pdb:2MBB|rcsb pdb:3EPG|rcsb pdb:3EPI|rcsb pdb:3G6V|rcsb pdb:3G6X|rcsb pdb:3G6Y|rcsb pdb:3GV5|rcsb pdb:3GV7|rcsb pdb:3GV8|rcsb pdb:3H40|rcsb pdb:3H4B|rcsb pdb:3H4D|ensembl:ENSG00000101751(gene)|ensembl:ENST00000579534(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0016607"(nuclear speck)|go:"GO:0019985"(translesion synthesis)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR017961|interpro:IPR036775|interpro:IPR043128|interpro:IPR043502|mint:Q9UNA4|refseq:NP_009126.2|rcsb pdb:3NGD|rcsb pdb:3OSN|rcsb pdb:3Q8P|rcsb pdb:3Q8Q|rcsb pdb:3Q8R|rcsb pdb:3Q8S|rcsb pdb:4EBC|rcsb pdb:4EBD|rcsb pdb:4EBE|rcsb pdb:4EYI|rcsb pdb:4FS1|rcsb pdb:4FS2|rcsb pdb:5KT2|rcsb pdb:5KT3|rcsb pdb:5KT4|rcsb pdb:5KT5|rcsb pdb:5KT6|rcsb pdb:5KT7|rcsb pdb:5ULW|rcsb pdb:5ULX|reactome:R-HSA-5656121|reactome:R-HSA-5656169|rcsb pdb:4EYH	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:iH6WfDK+UIzw5XQSHo9wWSfnrJU9606	rigid:GZ25T1YL3nbrV3Qx+wNBCCyDFg8	false	glutathione s tranferase tag:?-?	binding-associated region:643-715	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-4399559	uniprotkb:Q9UMX0	dip:DIP-24261N	intact:EBI-741480|uniprotkb:Q8IXS9|uniprotkb:Q8N2Q3|uniprotkb:Q9H0T8|uniprotkb:Q9H3R4|uniprotkb:Q9HAZ5|intact:EBI-28967608|ensembl:ENSP00000365576|uniprotkb:Q5T6J5|uniprotkb:Q5T6J9|uniprotkb:A0A024R284	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:ubql1_human(display_long)|uniprotkb:Protein linking IAP with cytoskeleton 1(gene name synonym)|uniprotkb:UBQLN1(gene name)|psi-mi:UBQLN1(display_short)|uniprotkb:DA41(gene name synonym)|uniprotkb:PLIC1(gene name synonym)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21202931|imex:IM-26819-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	ensembl:ENST00000257468|ensembl:ENSP00000257468|ensembl:ENSP00000365576|ensembl:ENSG00000135018(gene)|ensembl:ENST00000376395(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000502"(proteasome complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035973"(aggrephagy)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097352"(autophagosome maturation)|go:"GO:1901340"(negative regulation of store-operated calcium channel activity)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028430|interpro:IPR029071|mint:Q9UMX0|rcsb pdb:2JY5|rcsb pdb:2JY6|rcsb pdb:2KLC|reactome:R-HSA-8856825|refseq:NP_038466.2|refseq:NP_444295.1|dip:DIP-41629N	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:nCFfZbGCTvRYaXhQ4R99XblslvM9606	rigid:jSaLdZnL2iHW9loueiblCId6K3I	false	glutathione s tranferase tag:?-?	binding-associated region:516-589	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-4399559	uniprotkb:O15037	dip:DIP-24261N	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21202939|imex:IM-26819-63	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rigid:6kle8ohkhdKreOSiGrdl9Ofv4n4	false	glutathione s tranferase tag:?-?	binding-associated region:598-678	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-4399559	uniprotkb:Q13191	dip:DIP-24261N	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21202947|imex:IM-26819-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	rigid:c4huDpe33iQas5jo+gGZxFAPiNw	false	glutathione s tranferase tag:?-?	binding-associated region:916-982	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-4399559	uniprotkb:Q92995	dip:DIP-24261N	intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21203064|imex:IM-26819-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606	rigid:NH4fY2aBctxNTw8AdnEdxOp5xws	false	glutathione s tranferase tag:?-?	binding-associated region:689-769	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-4399559	uniprotkb:Q13501	dip:DIP-24261N	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21203072|imex:IM-26819-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	rigid:i4P8a1Tm2cgWF+QX5NuIoti4coc	false	glutathione s tranferase tag:?-?	binding-associated region:385-440	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-4399559	uniprotkb:Q96S82	dip:DIP-24261N	intact:EBI-348604|uniprotkb:Q96I03|ensembl:ENSP00000378518|ensembl:ENSP00000454828|ensembl:ENSP00000457703|ensembl:ENSP00000457708|ensembl:ENSP00000500164|ensembl:ENSP00000500266|ensembl:ENSP00000500442|ensembl:ENSP00000500520|ensembl:ENSP00000500882|ensembl:ENSP00000354883|uniprotkb:D3DW57	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:ubl7_human(display_long)|uniprotkb:Ubiquitin-like protein SB132(gene name synonym)|uniprotkb:Bone marrow stromal cell ubiquitin-like protein(gene name synonym)|uniprotkb:UBL7(gene name)|psi-mi:UBL7(display_short)|uniprotkb:BMSCUBP(gene name synonym)|uniprotkb:SB132(orf name)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21203080|imex:IM-26819-65	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_116296.1|refseq:NP_957717.1|ensembl:ENST00000361351(transcript)|ensembl:ENST00000395081(transcript)|ensembl:ENST00000564488(transcript)|ensembl:ENST00000565335(transcript)|ensembl:ENST00000567435(transcript)|ensembl:ENST00000673054(transcript)|ensembl:ENST00000673073(transcript)|ensembl:ENST00000673120(transcript)|ensembl:ENST00000673153(transcript)|ensembl:ENST00000673461(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|rcsb pdb:2CWB|rcsb pdb:2DEN|ensembl:ENSG00000138629(gene)|ensembl:ENSG00000288408(gene)|refseq:NP_001273668.1|refseq:NP_001273669.1|refseq:NP_001273670.1|refseq:NP_001273671.1	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:4E0ErEIkP/AQb+OHRuOd5wbXU/s9606	rigid:Tq3pMGLGfz5AJo+xq5loAddonqs	false	glutathione s tranferase tag:?-?	binding-associated region:283-380	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-4399559	uniprotkb:O75113	dip:DIP-24261N	intact:EBI-5278391|uniprotkb:A7MD49|uniprotkb:Q2YDX1|ensembl:ENSP00000262384	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:n4bp1_human(display_long)|uniprotkb:N4BP1(gene name)|psi-mi:N4BP1(display_short)|uniprotkb:KIAA0615(gene name synonym)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21203088|imex:IM-26819-83	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_694574.3|dip:DIP-41205N|ensembl:ENSG00000102921(gene)|ensembl:ENST00000262384(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003729"(mRNA binding)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016605"(PML body)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|interpro:IPR021869|rcsb pdb:6Q3V	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:DjuEYSvNvt5wy7oD2kareuxfDxM9606	rigid:xKSkbTVJ2xu5OuVpSmfFxmwylzE	false	glutathione s tranferase tag:?-?	binding-associated region:813-896	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-4399559	uniprotkb:Q86VP1	dip:DIP-24261N	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21203096|imex:IM-26819-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	rigid:o7GhmdkP3nFC+ceV5BhVOmMyHpE	false	glutathione s tranferase tag:?-?	binding-associated region:741-789	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-4399559	uniprotkb:Q9Y508	dip:DIP-24261N	intact:EBI-723587|uniprotkb:Q6N0B0|uniprotkb:B2RDQ9|uniprotkb:B4DWY5|uniprotkb:E1P627|ensembl:ENSP00000244061	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:rn114_human(display_long)|uniprotkb:Zinc finger protein 313(gene name synonym)|uniprotkb:RNF114(gene name)|psi-mi:RNF114(display_short)|uniprotkb:ZNF313(gene name synonym)|uniprotkb:ZNF228(gene name synonym)|uniprotkb:Zinc finger protein 228(gene name synonym)|uniprotkb:RING finger protein 114(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF114(gene name synonym)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21203104|imex:IM-26819-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_061153.1|ensembl:ENSG00000124226(gene)|ensembl:ENST00000244061(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008598(Drought induced 19)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|interpro:IPR034734|interpro:IPR042716|reactome:R-HSA-983168	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:R1fX8xaGuIhy/M6cLzPeyfJBf649606	rigid:um8Cpn4mQmomMhQhDyRaoYz6BvA	false	glutathione s tranferase tag:?-?	binding-associated region:192-228	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-4399559	uniprotkb:Q8IY57	dip:DIP-24261N	intact:EBI-2842031|uniprotkb:A8K5P0|uniprotkb:Q99710|uniprotkb:B4DFU3|uniprotkb:G3V465|ensembl:ENSP00000439256	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:yaf2_human(display_long)|uniprotkb:YAF2(gene name)|psi-mi:YAF2(display_short)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21203112|imex:IM-26819-85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_001177906.1|refseq:NP_001177908.1|refseq:NP_005739.2|refseq:NP_001177909.1|ensembl:ENSG00000015153(gene)|ensembl:ENST00000534854(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR038039|interpro:IPR039958|mint:Q8IY57|rcsb pdb:2D9G|reactome:R-HSA-8939243|reactome:R-HSA-8953750|dip:DIP-44919N	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:x+0HcNK10qVfo3nfvTjMdF/zb649606	rigid:3ACa1Bn1jR7+gqmqro3LaPgkAGo	false	glutathione s tranferase tag:?-?	binding-associated region:19-54	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-4399559	uniprotkb:Q96G74	dip:DIP-24261N	intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21203120|imex:IM-26819-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606	rigid:CbbDMxXx3FztLp6Va9CkWioclEU	false	glutathione s tranferase tag:?-?	binding-associated region:392-427	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-4399559	uniprotkb:P55036	dip:DIP-24261N	intact:EBI-359318|uniprotkb:Q5VWC5|uniprotkb:Q9NS92|uniprotkb:D3DV16|ensembl:ENSP00000357879	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:psmd4_human(display_long)|uniprotkb:PSMD4(gene name)|psi-mi:PSMD4(display_short)|uniprotkb:MCB1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:Antisecretory factor 1(gene name synonym)	psi-mi:"MI:0084"(phage display)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21203128|imex:IM-26819-67	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_002801.1|dip:DIP-38189N|ensembl:ENSG00000159352(gene)|ensembl:ENST00000368884(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|mint:P55036|rcsb pdb:1P9C|rcsb pdb:1P9D|rcsb pdb:1UEL|rcsb pdb:1YX4|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:2KDE|rcsb pdb:2KDF|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6MUN|rcsb pdb:6U19|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	no-uniprot-update:	-	figure legend:table 1 fig.1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/20	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:FTJG3ns3Ag/Y3xP3yEydGxppRcA9606	rigid:gW/QZb7sobNtZlBRlg2vAIffAOQ	false	glutathione s tranferase tag:?-?	binding-associated region:271-377	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O75113	uniprotkb:Q15843	intact:EBI-5278391|uniprotkb:A7MD49|uniprotkb:Q2YDX1|ensembl:ENSP00000262384	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:n4bp1_human(display_long)|uniprotkb:N4BP1(gene name)|psi-mi:N4BP1(display_short)|uniprotkb:KIAA0615(gene name synonym)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21203145|imex:IM-26819-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694574.3|dip:DIP-41205N|ensembl:ENSG00000102921(gene)|ensembl:ENST00000262384(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003729"(mRNA binding)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016605"(PML body)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|interpro:IPR021869|rcsb pdb:6Q3V	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:DjuEYSvNvt5wy7oD2kareuxfDxM9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:B8hVNmgHmTVfgeHnKz7OFK1Aags	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation causing an interaction:72-72	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54725	uniprotkb:Q15843	intact:EBI-746453|uniprotkb:Q59EU8|uniprotkb:Q5M7Z1|uniprotkb:K7ESE3|ensembl:ENSP00000467024	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:rd23a_human(display_long)|uniprotkb:RAD23A(gene name)|psi-mi:RAD23A(display_short)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221136|imex:IM-26819-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005044.1|refseq:NP_001257291.1|refseq:NP_001257292.1|dip:DIP-34442N|ensembl:ENSG00000179262(gene)|ensembl:ENST00000586534(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0019900"(kinase binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0070628"(proteasome binding)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|interpro:IPR041811|mint:P54725|rcsb pdb:1DV0|rcsb pdb:1F4I|rcsb pdb:1IFY|rcsb pdb:1OQY|rcsb pdb:1P98|rcsb pdb:1P9D|rcsb pdb:1QZE|rcsb pdb:1TP4|rcsb pdb:1ZO6|rcsb pdb:2WYQ|rcsb pdb:5XBO|rcsb pdb:6W2G|rcsb pdb:6W2H|rcsb pdb:6W2I|reactome:R-HSA-5689877|reactome:R-HSA-5696394|reactome:R-HSA-5696395	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:l/29QSvlTrWQMG3wLyeb/QxeaiU9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:5TP/+Sb4DC9EKjlxqdvM5gKTJwE	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation disrupting interaction:44-44|mutation increasing interaction:72-72	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UNA4	uniprotkb:Q15843	intact:EBI-741774|ensembl:ENSP00000462664|uniprotkb:Q8N590|uniprotkb:Q9H0S1|uniprotkb:Q9NYH6	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:poli_human(display_long)|uniprotkb:Eta2(gene name synonym)|uniprotkb:RAD30 homolog B(gene name synonym)|uniprotkb:POLI(gene name)|psi-mi:POLI(display_short)|uniprotkb:RAD30B(gene name synonym)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221148|imex:IM-26819-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1T3N|rcsb pdb:1ZET|rcsb pdb:2ALZ|rcsb pdb:2DPI|rcsb pdb:2DPJ|rcsb pdb:2FLL|rcsb pdb:2FLN|rcsb pdb:2FLP|rcsb pdb:2KHU|rcsb pdb:2KHW|rcsb pdb:2KTF|rcsb pdb:2L0F|rcsb pdb:2L0G|rcsb pdb:2MBB|rcsb pdb:3EPG|rcsb pdb:3EPI|rcsb pdb:3G6V|rcsb pdb:3G6X|rcsb pdb:3G6Y|rcsb pdb:3GV5|rcsb pdb:3GV7|rcsb pdb:3GV8|rcsb pdb:3H40|rcsb pdb:3H4B|rcsb pdb:3H4D|ensembl:ENSG00000101751(gene)|ensembl:ENST00000579534(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0016607"(nuclear speck)|go:"GO:0019985"(translesion synthesis)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR017961|interpro:IPR036775|interpro:IPR043128|interpro:IPR043502|mint:Q9UNA4|refseq:NP_009126.2|rcsb pdb:3NGD|rcsb pdb:3OSN|rcsb pdb:3Q8P|rcsb pdb:3Q8Q|rcsb pdb:3Q8R|rcsb pdb:3Q8S|rcsb pdb:4EBC|rcsb pdb:4EBD|rcsb pdb:4EBE|rcsb pdb:4EYI|rcsb pdb:4FS1|rcsb pdb:4FS2|rcsb pdb:5KT2|rcsb pdb:5KT3|rcsb pdb:5KT4|rcsb pdb:5KT5|rcsb pdb:5KT6|rcsb pdb:5KT7|rcsb pdb:5ULW|rcsb pdb:5ULX|reactome:R-HSA-5656121|reactome:R-HSA-5656169|rcsb pdb:4EYH	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:iH6WfDK+UIzw5XQSHo9wWSfnrJU9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:mJxKMGixeSSYnpcmswdhwv/hLzw	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation disrupting interaction:44-44|mutation increasing interaction:72-72	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IY57	uniprotkb:Q15843	intact:EBI-2842031|uniprotkb:A8K5P0|uniprotkb:Q99710|uniprotkb:B4DFU3|uniprotkb:G3V465|ensembl:ENSP00000439256	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:yaf2_human(display_long)|uniprotkb:YAF2(gene name)|psi-mi:YAF2(display_short)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221158|imex:IM-26819-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177906.1|refseq:NP_001177908.1|refseq:NP_005739.2|refseq:NP_001177909.1|ensembl:ENSG00000015153(gene)|ensembl:ENST00000534854(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR038039|interpro:IPR039958|mint:Q8IY57|rcsb pdb:2D9G|reactome:R-HSA-8939243|reactome:R-HSA-8953750|dip:DIP-44919N	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:x+0HcNK10qVfo3nfvTjMdF/zb649606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:suj7sV8/MFhrZfqhKcVQ82SSAO4	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation disrupting interaction:44-44|mutation increasing interaction:72-72	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S82	uniprotkb:Q15843	intact:EBI-348604|uniprotkb:Q96I03|ensembl:ENSP00000378518|ensembl:ENSP00000454828|ensembl:ENSP00000457703|ensembl:ENSP00000457708|ensembl:ENSP00000500164|ensembl:ENSP00000500266|ensembl:ENSP00000500442|ensembl:ENSP00000500520|ensembl:ENSP00000500882|ensembl:ENSP00000354883|uniprotkb:D3DW57	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:ubl7_human(display_long)|uniprotkb:Ubiquitin-like protein SB132(gene name synonym)|uniprotkb:Bone marrow stromal cell ubiquitin-like protein(gene name synonym)|uniprotkb:UBL7(gene name)|psi-mi:UBL7(display_short)|uniprotkb:BMSCUBP(gene name synonym)|uniprotkb:SB132(orf name)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221186|imex:IM-26819-69	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116296.1|refseq:NP_957717.1|ensembl:ENST00000361351(transcript)|ensembl:ENST00000395081(transcript)|ensembl:ENST00000564488(transcript)|ensembl:ENST00000565335(transcript)|ensembl:ENST00000567435(transcript)|ensembl:ENST00000673054(transcript)|ensembl:ENST00000673073(transcript)|ensembl:ENST00000673120(transcript)|ensembl:ENST00000673153(transcript)|ensembl:ENST00000673461(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|rcsb pdb:2CWB|rcsb pdb:2DEN|ensembl:ENSG00000138629(gene)|ensembl:ENSG00000288408(gene)|refseq:NP_001273668.1|refseq:NP_001273669.1|refseq:NP_001273670.1|refseq:NP_001273671.1	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:4E0ErEIkP/AQb+OHRuOd5wbXU/s9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:1HAHvFtKI4pGzVGsWG8IcK9gJlE	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation decreasing interaction:44-44|mutation increasing interaction:72-72	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15037	uniprotkb:Q15843	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221198|imex:IM-26819-71	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:P4tsMh/IBYRG/l1gst8cdtFuQ/I	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation disrupting interaction:44-44|mutation decreasing interaction:72-72	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96G74	intact:EBI-4399559	intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7	dip:DIP-24261N	psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221210|imex:IM-26819-87	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	-	-	no-uniprot-update:	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:CbbDMxXx3FztLp6Va9CkWioclEU	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation disrupting interaction:44-44	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y508	intact:EBI-4399559	intact:EBI-723587|uniprotkb:Q6N0B0|uniprotkb:B2RDQ9|uniprotkb:B4DWY5|uniprotkb:E1P627|ensembl:ENSP00000244061	dip:DIP-24261N	psi-mi:rn114_human(display_long)|uniprotkb:Zinc finger protein 313(gene name synonym)|uniprotkb:RNF114(gene name)|psi-mi:RNF114(display_short)|uniprotkb:ZNF313(gene name synonym)|uniprotkb:ZNF228(gene name synonym)|uniprotkb:Zinc finger protein 228(gene name synonym)|uniprotkb:RING finger protein 114(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF114(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221220|imex:IM-26819-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061153.1|ensembl:ENSG00000124226(gene)|ensembl:ENST00000244061(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008598(Drought induced 19)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|interpro:IPR034734|interpro:IPR042716|reactome:R-HSA-983168	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	-	-	no-uniprot-update:	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:R1fX8xaGuIhy/M6cLzPeyfJBf649606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:um8Cpn4mQmomMhQhDyRaoYz6BvA	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation decreasing interaction:44-44	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IY57	intact:EBI-4399559	intact:EBI-2842031|uniprotkb:A8K5P0|uniprotkb:Q99710|uniprotkb:B4DFU3|uniprotkb:G3V465|ensembl:ENSP00000439256	dip:DIP-24261N	psi-mi:yaf2_human(display_long)|uniprotkb:YAF2(gene name)|psi-mi:YAF2(display_short)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221230|imex:IM-26819-88	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177906.1|refseq:NP_001177908.1|refseq:NP_005739.2|refseq:NP_001177909.1|ensembl:ENSG00000015153(gene)|ensembl:ENST00000534854(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR038039|interpro:IPR039958|mint:Q8IY57|rcsb pdb:2D9G|reactome:R-HSA-8939243|reactome:R-HSA-8953750|dip:DIP-44919N	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	-	-	no-uniprot-update:	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/03/12	rogid:x+0HcNK10qVfo3nfvTjMdF/zb649606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:3ACa1Bn1jR7+gqmqro3LaPgkAGo	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation disrupting interaction:44-44	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96S82	intact:EBI-4399559	intact:EBI-348604|uniprotkb:Q96I03|ensembl:ENSP00000378518|ensembl:ENSP00000454828|ensembl:ENSP00000457703|ensembl:ENSP00000457708|ensembl:ENSP00000500164|ensembl:ENSP00000500266|ensembl:ENSP00000500442|ensembl:ENSP00000500520|ensembl:ENSP00000500882|ensembl:ENSP00000354883|uniprotkb:D3DW57	dip:DIP-24261N	psi-mi:ubl7_human(display_long)|uniprotkb:Ubiquitin-like protein SB132(gene name synonym)|uniprotkb:Bone marrow stromal cell ubiquitin-like protein(gene name synonym)|uniprotkb:UBL7(gene name)|psi-mi:UBL7(display_short)|uniprotkb:BMSCUBP(gene name synonym)|uniprotkb:SB132(orf name)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221240|imex:IM-26819-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116296.1|refseq:NP_957717.1|ensembl:ENST00000361351(transcript)|ensembl:ENST00000395081(transcript)|ensembl:ENST00000564488(transcript)|ensembl:ENST00000565335(transcript)|ensembl:ENST00000567435(transcript)|ensembl:ENST00000673054(transcript)|ensembl:ENST00000673073(transcript)|ensembl:ENST00000673120(transcript)|ensembl:ENST00000673153(transcript)|ensembl:ENST00000673461(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|rcsb pdb:2CWB|rcsb pdb:2DEN|ensembl:ENSG00000138629(gene)|ensembl:ENSG00000288408(gene)|refseq:NP_001273668.1|refseq:NP_001273669.1|refseq:NP_001273670.1|refseq:NP_001273671.1	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	-	-	no-uniprot-update:	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:4E0ErEIkP/AQb+OHRuOd5wbXU/s9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:Tq3pMGLGfz5AJo+xq5loAddonqs	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation decreasing interaction:44-44	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75113	intact:EBI-4399559	intact:EBI-5278391|uniprotkb:A7MD49|uniprotkb:Q2YDX1|ensembl:ENSP00000262384	dip:DIP-24261N	psi-mi:n4bp1_human(display_long)|uniprotkb:N4BP1(gene name)|psi-mi:N4BP1(display_short)|uniprotkb:KIAA0615(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221250|imex:IM-26819-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694574.3|dip:DIP-41205N|ensembl:ENSG00000102921(gene)|ensembl:ENST00000262384(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003729"(mRNA binding)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016605"(PML body)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|interpro:IPR021869|rcsb pdb:6Q3V	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	-	-	no-uniprot-update:	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:DjuEYSvNvt5wy7oD2kareuxfDxM9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:xKSkbTVJ2xu5OuVpSmfFxmwylzE	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation disrupting interaction:44-44	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54725	intact:EBI-4399559	intact:EBI-746453|uniprotkb:Q59EU8|uniprotkb:Q5M7Z1|uniprotkb:K7ESE3|ensembl:ENSP00000467024	dip:DIP-24261N	psi-mi:rd23a_human(display_long)|uniprotkb:RAD23A(gene name)|psi-mi:RAD23A(display_short)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221270|imex:IM-26819-73	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005044.1|refseq:NP_001257291.1|refseq:NP_001257292.1|dip:DIP-34442N|ensembl:ENSG00000179262(gene)|ensembl:ENST00000586534(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0019900"(kinase binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0070628"(proteasome binding)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|interpro:IPR041811|mint:P54725|rcsb pdb:1DV0|rcsb pdb:1F4I|rcsb pdb:1IFY|rcsb pdb:1OQY|rcsb pdb:1P98|rcsb pdb:1P9D|rcsb pdb:1QZE|rcsb pdb:1TP4|rcsb pdb:1ZO6|rcsb pdb:2WYQ|rcsb pdb:5XBO|rcsb pdb:6W2G|rcsb pdb:6W2H|rcsb pdb:6W2I|reactome:R-HSA-5689877|reactome:R-HSA-5696394|reactome:R-HSA-5696395	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	-	-	no-uniprot-update:	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:l/29QSvlTrWQMG3wLyeb/QxeaiU9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:gCU8kfQWkj6hg5GN7ZKBVmRVpOI	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation decreasing interaction:44-44	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UNA4	intact:EBI-4399559	intact:EBI-741774|ensembl:ENSP00000462664|uniprotkb:Q8N590|uniprotkb:Q9H0S1|uniprotkb:Q9NYH6	dip:DIP-24261N	psi-mi:poli_human(display_long)|uniprotkb:Eta2(gene name synonym)|uniprotkb:RAD30 homolog B(gene name synonym)|uniprotkb:POLI(gene name)|psi-mi:POLI(display_short)|uniprotkb:RAD30B(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221280|imex:IM-26819-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1T3N|rcsb pdb:1ZET|rcsb pdb:2ALZ|rcsb pdb:2DPI|rcsb pdb:2DPJ|rcsb pdb:2FLL|rcsb pdb:2FLN|rcsb pdb:2FLP|rcsb pdb:2KHU|rcsb pdb:2KHW|rcsb pdb:2KTF|rcsb pdb:2L0F|rcsb pdb:2L0G|rcsb pdb:2MBB|rcsb pdb:3EPG|rcsb pdb:3EPI|rcsb pdb:3G6V|rcsb pdb:3G6X|rcsb pdb:3G6Y|rcsb pdb:3GV5|rcsb pdb:3GV7|rcsb pdb:3GV8|rcsb pdb:3H40|rcsb pdb:3H4B|rcsb pdb:3H4D|ensembl:ENSG00000101751(gene)|ensembl:ENST00000579534(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0016607"(nuclear speck)|go:"GO:0019985"(translesion synthesis)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR017961|interpro:IPR036775|interpro:IPR043128|interpro:IPR043502|mint:Q9UNA4|refseq:NP_009126.2|rcsb pdb:3NGD|rcsb pdb:3OSN|rcsb pdb:3Q8P|rcsb pdb:3Q8Q|rcsb pdb:3Q8R|rcsb pdb:3Q8S|rcsb pdb:4EBC|rcsb pdb:4EBD|rcsb pdb:4EBE|rcsb pdb:4EYI|rcsb pdb:4FS1|rcsb pdb:4FS2|rcsb pdb:5KT2|rcsb pdb:5KT3|rcsb pdb:5KT4|rcsb pdb:5KT5|rcsb pdb:5KT6|rcsb pdb:5KT7|rcsb pdb:5ULW|rcsb pdb:5ULX|reactome:R-HSA-5656121|reactome:R-HSA-5656169|rcsb pdb:4EYH	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	-	-	no-uniprot-update:	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:iH6WfDK+UIzw5XQSHo9wWSfnrJU9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:GZ25T1YL3nbrV3Qx+wNBCCyDFg8	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation decreasing interaction:44-44	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15843	uniprotkb:O15037	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221404|imex:IM-26819-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	-	-	-	figure legend:fig 3c, fig 5b|comment:"T‐Rex‐flag‐NEDD8 cell lysates were therefore incubated with the purified proteins bound to glutathione‐Sepharose beads and affinity‐purified proteins were analysed by western blotting with anti‐flag antibody (Fig. 3C). As observed, the purified UBDs considerably differ in their ability to bind neddylated substrates, KHNYN being the one displaying the highest binding efficiency. In addition, the UBD of KHNYN was the only one able to bind both neddylated substrates and unconjugated flag‐NEDD8, as detected by longer exposure."|comment:"To further confirm that the molecular determinants governing NEDD8 recognition are found in the C‐terminal 52 residues of KHNYN, we generated two chimeras by swapping the amino acid regions corresponding to the three α‐helices. The first chimeric construct, KN, contains the N‐terminal unique region of KHNYN (aa 598–634) and the α‐helices of N4BP1 (aa 854–896), while in the NK construct the last three helices of KHNYN (aa 635–678) are fused to the N‐terminal region of N4BP1 (aa 813–852) (Fig. 5C). The purified recombinant proteins were analysed by pull‐down assays for the ability to bind neddylated substrates in the T‐Rex‐flag‐NEDD8 cells. As shown, the chimeric construct NK retains the properties of wild‐type KHNYN, as it is able to bind to conjugated and monomeric NEDD8."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rigid:P4tsMh/IBYRG/l1gst8cdtFuQ/I	false	flag tag:?-?	sufficient binding region:627-678|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15843	uniprotkb:O15037	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221416|imex:IM-26819-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	-	-	-	figure legend:fig 6a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rigid:P4tsMh/IBYRG/l1gst8cdtFuQ/I	false	glutathione s tranferase tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-4399559	uniprotkb:O15037	dip:DIP-24261N	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221424|imex:IM-26819-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	-	no-uniprot-update:	-	figure legend:fig 6a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/03/12	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rigid:6kle8ohkhdKreOSiGrdl9Ofv4n4	false	glutathione s tranferase tag:?-?	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15037	uniprotkb:Q13616	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221450|imex:IM-26819-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N	-	-	-	figure legend:fig 6c|comment:"As shown in Fig. 6C, several neddylated substrates were affinity purified by the GST fusion of the KHNYN ubiquitin‐binding domain, among them CUL1 and CUL2, both of which bound to KHNYN in their neddylated forms. Conversely, no significant association was observed with the other constructs. Similar results were obtained for CUL3 and CUL4 (data not shown)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	rigid:lt05uYhiwtGpNWH3Uqgpo8A8pXQ	false	sufficient binding region:598-678|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15037	uniprotkb:Q13617	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221450|imex:IM-26819-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553	-	-	-	figure legend:fig 6c|comment:"As shown in Fig. 6C, several neddylated substrates were affinity purified by the GST fusion of the KHNYN ubiquitin‐binding domain, among them CUL1 and CUL2, both of which bound to KHNYN in their neddylated forms. Conversely, no significant association was observed with the other constructs. Similar results were obtained for CUL3 and CUL4 (data not shown)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	rigid:lt05uYhiwtGpNWH3Uqgpo8A8pXQ	false	sufficient binding region:598-678|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15037	uniprotkb:Q15843	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221450|imex:IM-26819-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:fig 6c|comment:"As shown in Fig. 6C, several neddylated substrates were affinity purified by the GST fusion of the KHNYN ubiquitin‐binding domain, among them CUL1 and CUL2, both of which bound to KHNYN in their neddylated forms. Conversely, no significant association was observed with the other constructs. Similar results were obtained for CUL3 and CUL4 (data not shown)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:lt05uYhiwtGpNWH3Uqgpo8A8pXQ	false	sufficient binding region:598-678|glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15037	uniprotkb:Q15843	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221469|imex:IM-26819-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:fig 6e|antagonist:MLN4924  inhibitor of NEDD8 activation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:NttM4sV8DIbrYm7dCKbMa+ZIhAQ	false	glutathione s tranferase tag:?-?|binding-associated region:598-678	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15037	uniprotkb:Q13617	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221469|imex:IM-26819-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553	-	-	-	figure legend:fig 6e|antagonist:MLN4924  inhibitor of NEDD8 activation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	rigid:NttM4sV8DIbrYm7dCKbMa+ZIhAQ	false	glutathione s tranferase tag:?-?|binding-associated region:598-678	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15037	uniprotkb:Q15843	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221481|imex:IM-26819-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	-	-	-	figure legend:fig 6f f5d f5c|comment:". Finally, we compared the interaction of KHNYN with ubiquitinated and neddylated substrates after treatment with USP8, the deneddylating enzyme NEDP1 or MLN4924 (Fig. 6F). As shown, the interaction with flag‐tagged cellular proteins was similarly disrupted after MLN4924 or NEDP1 treatments (Fig. 6F lanes 6 and 7). Interestingly, the interaction with ubiquitinated substrates was partly affected by the removal of neddylated proteins (lane 7), suggesting that a fraction of ubiquitinated substrates recovered by pull‐down are associated with cullin‐based complexes."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rigid:4PlcNSvh/RvYx9wfYKpJAU3taFY	false	glutathione s tranferase tag:?-?|binding-associated region:598-678	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15037	intact:EBI-4399559	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	dip:DIP-24261N	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221481|imex:IM-26819-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	-	-	no-uniprot-update:	figure legend:fig 6f f5d f5c|comment:". Finally, we compared the interaction of KHNYN with ubiquitinated and neddylated substrates after treatment with USP8, the deneddylating enzyme NEDP1 or MLN4924 (Fig. 6F). As shown, the interaction with flag‐tagged cellular proteins was similarly disrupted after MLN4924 or NEDP1 treatments (Fig. 6F lanes 6 and 7). Interestingly, the interaction with ubiquitinated substrates was partly affected by the removal of neddylated proteins (lane 7), suggesting that a fraction of ubiquitinated substrates recovered by pull‐down are associated with cullin‐based complexes."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/21	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:4PlcNSvh/RvYx9wfYKpJAU3taFY	false	glutathione s tranferase tag:?-?|binding-associated region:598-678	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15843	uniprotkb:O15037	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-21222635|imex:IM-26819-77	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	-	-	-	figure legend:fig 11b|comment:"To confirm our model, we mutated residues Glu31 and Glu32 in NEDD8 by substituting them with the corresponding residues in ubiquitin (Glu31Gln and Glu32Asp) or with an opposite charge (Glu31Lys and Glu32Lys). These mutants, together with the Ile44Ala and the Ala72Arg mutants, were assayed in a pull‐down experiment against the purified CUBAN domain (Fig. 11B). As shown, there is a clear loss of binding when mutating the hydrophobic patch key residue Ile44, while the Ala72Arg mutation reduces the binding efficiency as previously shown. In addition, there is a reduction in binding efficiency when using the mutants H25F and R38E, but not K26D and R33E, in the electrostatic binding surface of CUBAN domain (Fig. 11C)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/22	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rigid:P4tsMh/IBYRG/l1gst8cdtFuQ/I	false	glutathione s tranferase tag:?-?|mutation increasing interaction:31-31|mutation disrupting interaction:44-44|mutation decreasing interaction:72-72|mutation decreasing interaction:31-32|mutation decreasing interaction:31-31|mutation decreasing interaction:31-31|mutation decreasing interaction:32-32|mutation disrupting interaction:31-32	binding-associated region:598-678	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15843	uniprotkb:O15037	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-21222710|imex:IM-26819-79	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	-	-	-	figure legend:fig 11c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/22	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rigid:P4tsMh/IBYRG/l1gst8cdtFuQ/I	false	-	mutation decreasing interaction:647-647|glutathione s tranferase tag:?-?|binding-associated region:598-678|mutation decreasing interaction:647-647|mutation decreasing interaction:651-651|mutation decreasing interaction:652-652|mutation decreasing interaction:659-659|mutation decreasing interaction:664-664	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13501	intact:EBI-4399559	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	dip:DIP-24261N	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21254400|imex:IM-26819-90	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	-	-	no-uniprot-update:	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/03/12	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:i4P8a1Tm2cgWF+QX5NuIoti4coc	false	green fluorescent protein tag:?-?	glutathione s tranferase tag:?-?|mutation disrupting interaction:44-44	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15843	uniprotkb:O15037	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:"MI:0096"(pull down)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-22049684|imex:IM-26819-91	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	-	-	-	figure legend:fig 7c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/09/23	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rigid:P4tsMh/IBYRG/l1gst8cdtFuQ/I	false	mutation increasing interaction:72-72	binding-associated region:598-678|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15843	uniprotkb:O15037	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-21221441|imex:IM-26819-75	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	-	-	-	figure legend:fig 6b|comment:"As shown in Fig. 6A, analogously to the isolated CUBAN domain, the full‐length protein shows a marked preference for NEDD8. The essential role of the CUBAN domain in the recognition of NEDD8 and neddylated substrates was also confirmed by coimmunoprecipitation in HeLa cells transiently transfected with flag‐KHNYN (Fig. 6B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/02/19	2019/02/21	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rigid:P4tsMh/IBYRG/l1gst8cdtFuQ/I	false	-	flag tag:n-n|binding-associated region:627-678	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15843	uniprotkb:O15037	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-21222588|imex:IM-26819-59	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	-	-	-	figure legend:fig 7b|comment:"ITC titration of NEDD8 with the KHNYN domain shows an exothermic binding thermogram (Fig. 7B). The uncertainty in the early steps of the exponential curve allows only rough indications of the binding affinity of the CUBAN domain of KHNYN in complex with NEDD8 that was evaluated to be around 24 ± 2 μm. Finally, NEDD8 A72R mutation causes a reduction in the interaction efficiency (44 ± 7 μm) while binding of KHNYN for ubiquitin was nearly undetectable in these conditions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:24.0x10^-6 ~2.0(molar)	2019/02/19	2019/02/22	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rigid:P4tsMh/IBYRG/l1gst8cdtFuQ/I	false	mutation decreasing interaction:72-72	binding-associated region:598-678	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15843	uniprotkb:O15037	intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420	intact:EBI-6148525|uniprotkb:Q86TZ6|uniprotkb:Q8IUQ2|uniprotkb:Q96BA9|ensembl:ENSP00000251343|ensembl:ENSP00000450799|ensembl:ENSP00000451106	psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short)	psi-mi:khnyn_human(display_long)|uniprotkb:KHNYN(gene name)|psi-mi:KHNYN(display_short)|uniprotkb:KH and NYN domain-containing protein(gene name synonym)|uniprotkb:KIAA0323(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Castagnoli et al. (2019)	pubmed:30659753|imex:IM-26819	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-21222621|imex:IM-26819-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N	refseq:NP_056114.1|refseq:XP_005267531.1|refseq:NP_001277185.1|refseq:NP_001277186.1|ensembl:ENSG00000100441(gene)|ensembl:ENST00000251343(transcript)|ensembl:ENST00000553935(transcript)|ensembl:ENST00000556842(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR021869|interpro:IPR036612|mint:O15037|rcsb pdb:2N5M|rcsb pdb:2N7K	-	-	-	figure legend:fig 9; fig 10; fig 12|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/19	2019/02/22	rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606	rogid:vZgxwA7yR6mbBzxBvjkhMmhv5fY9606	rigid:P4tsMh/IBYRG/l1gst8cdtFuQ/I	false	-	binding-associated region:598-678	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)