#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14867	uniprotkb:P18507-2	intact:EBI-6258308|ensembl:ENSP00000023897|ensembl:ENSP00000377517|ensembl:ENSP00000393097|ensembl:ENSP00000415441|ensembl:ENSP00000489738|ensembl:ENSP00000489839|ensembl:ENSP00000490320|ensembl:ENSP00000490804|uniprotkb:D3DQK6|uniprotkb:Q8N629	intact:EBI-15096952|ensembl:ENSP00000491909	psi-mi:gbra1_human(display_long)|uniprotkb:GABRA1(gene name)|psi-mi:GABRA1(display_short)|uniprotkb:"GABA(A) receptor subunit alpha-1"(gene name synonym)	psi-mi:p18507-2(display_long)|uniprotkb:GABRG2(gene name)|psi-mi:GABRG2(display_short)|uniprotkb:"GABA(A) receptor subunit gamma-2"(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Laverty et al. (2019)	imex:IM-27101|pubmed:30602789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21019796|imex:IM-27101-1|emdb:EMD-4411|wwpdb:6I53	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005237"(inhibitory extracellular ligand-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050809"(diazepam binding)|go:"GO:0050877"(nervous system process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001390(Gamma-aminobutyric-acid A receptor, alpha subunit)|interpro:IPR005431(Gamma-aminobutyric-acid A receptor, alpha 1 subunit)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:6CDU|rcsb pdb:6D1S|rcsb pdb:6D6T|rcsb pdb:6D6U|rcsb pdb:6HUG|rcsb pdb:6HUJ|rcsb pdb:6HUK|rcsb pdb:6HUO|rcsb pdb:6HUP|rcsb pdb:6I53|rcsb pdb:6X3S|rcsb pdb:6X3T|rcsb pdb:6X3U|rcsb pdb:6X3V|rcsb pdb:6X3W|rcsb pdb:6X3X|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|rcsb pdb:6X3Z|rcsb pdb:6X40|reactome:R-HSA-1236394|reactome:R-HSA-977443|ensembl:ENSG00000022355(gene)|ensembl:ENST00000023897(transcript)|ensembl:ENST00000393943(transcript)|ensembl:ENST00000428797(transcript)|ensembl:ENST00000437025(transcript)|ensembl:ENST00000635880(transcript)|ensembl:ENST00000636573(transcript)|ensembl:ENST00000637827(transcript)|ensembl:ENST00000638112(transcript)|refseq:NP_000797.2|refseq:NP_001121115.1|refseq:NP_001121116.1|refseq:NP_001121117.1|refseq:NP_001121120.1	intact:EBI-9008430(isoform-parent)|ensembl:ENSG00000113327(gene)|ensembl:ENST00000639213(transcript)	-	-	-	figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/01/18	2019/06/19	rogid:6wrRTf2MOYgoKk0RgswgfaI5d+c9606	rogid:GYAYUqYIIDq45hwOUeeUuuCf6UM9606	rigid:6NhQeyf3Bbh8BkK5sQku7U9gZfQ	false	flag tag:n-n	rho tag:c-c	2	1	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P14867	uniprotkb:P28472-2	intact:EBI-6258308|ensembl:ENSP00000023897|ensembl:ENSP00000377517|ensembl:ENSP00000393097|ensembl:ENSP00000415441|ensembl:ENSP00000489738|ensembl:ENSP00000489839|ensembl:ENSP00000490320|ensembl:ENSP00000490804|uniprotkb:D3DQK6|uniprotkb:Q8N629	intact:EBI-21019798|ensembl:ENSP00000299267	psi-mi:gbra1_human(display_long)|uniprotkb:GABRA1(gene name)|psi-mi:GABRA1(display_short)|uniprotkb:"GABA(A) receptor subunit alpha-1"(gene name synonym)	psi-mi:p28472-2(display_long)|uniprotkb:"GABA(A) receptor subunit beta-3"(gene name synonym)|uniprotkb:GABRB3(gene name)|psi-mi:GABRB3(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Laverty et al. (2019)	imex:IM-27101|pubmed:30602789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21019796|imex:IM-27101-1|emdb:EMD-4411|wwpdb:6I53	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005237"(inhibitory extracellular ligand-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050809"(diazepam binding)|go:"GO:0050877"(nervous system process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001390(Gamma-aminobutyric-acid A receptor, alpha subunit)|interpro:IPR005431(Gamma-aminobutyric-acid A receptor, alpha 1 subunit)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:6CDU|rcsb pdb:6D1S|rcsb pdb:6D6T|rcsb pdb:6D6U|rcsb pdb:6HUG|rcsb pdb:6HUJ|rcsb pdb:6HUK|rcsb pdb:6HUO|rcsb pdb:6HUP|rcsb pdb:6I53|rcsb pdb:6X3S|rcsb pdb:6X3T|rcsb pdb:6X3U|rcsb pdb:6X3V|rcsb pdb:6X3W|rcsb pdb:6X3X|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|rcsb pdb:6X3Z|rcsb pdb:6X40|reactome:R-HSA-1236394|reactome:R-HSA-977443|ensembl:ENSG00000022355(gene)|ensembl:ENST00000023897(transcript)|ensembl:ENST00000393943(transcript)|ensembl:ENST00000428797(transcript)|ensembl:ENST00000437025(transcript)|ensembl:ENST00000635880(transcript)|ensembl:ENST00000636573(transcript)|ensembl:ENST00000637827(transcript)|ensembl:ENST00000638112(transcript)|refseq:NP_000797.2|refseq:NP_001121115.1|refseq:NP_001121116.1|refseq:NP_001121117.1|refseq:NP_001121120.1	ensembl:ENSG00000166206(gene)|ensembl:ENST00000299267(transcript)|intact:EBI-6258252(isoform-parent)|uniprotkb:P28472-2(isoform-parent)	-	-	isoform-comment:"Variant in position: 11:P->S (in ECA5, the mutant protein is hyperglycosylated and has reduced mean current densities compared to wild-type, dbSNP:rs25409). Variant in position: 15:S->F (in ECA5, the mutant protein is hyperglycosylated and has reduced mean current densities compared to wild-type)."	figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/01/18	2019/06/19	rogid:6wrRTf2MOYgoKk0RgswgfaI5d+c9606	rogid:PNJz+zVtSHupD24M9t6FS4isQsM9606	rigid:6NhQeyf3Bbh8BkK5sQku7U9gZfQ	false	flag tag:n-n	-	2	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P18507-2	uniprotkb:P28472-2	intact:EBI-15096952|ensembl:ENSP00000491909	intact:EBI-21019798|ensembl:ENSP00000299267	psi-mi:p18507-2(display_long)|uniprotkb:GABRG2(gene name)|psi-mi:GABRG2(display_short)|uniprotkb:"GABA(A) receptor subunit gamma-2"(gene name synonym)	psi-mi:p28472-2(display_long)|uniprotkb:"GABA(A) receptor subunit beta-3"(gene name synonym)|uniprotkb:GABRB3(gene name)|psi-mi:GABRB3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Laverty et al. (2019)	imex:IM-27101|pubmed:30602789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21453036|imex:IM-27101-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-9008430(isoform-parent)|ensembl:ENSG00000113327(gene)|ensembl:ENST00000639213(transcript)	ensembl:ENSG00000166206(gene)|ensembl:ENST00000299267(transcript)|intact:EBI-6258252(isoform-parent)|uniprotkb:P28472-2(isoform-parent)	-	-	isoform-comment:"Variant in position: 11:P->S (in ECA5, the mutant protein is hyperglycosylated and has reduced mean current densities compared to wild-type, dbSNP:rs25409). Variant in position: 15:S->F (in ECA5, the mutant protein is hyperglycosylated and has reduced mean current densities compared to wild-type)."	figure legend:Extd Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/01/18	2019/06/19	rogid:GYAYUqYIIDq45hwOUeeUuuCf6UM9606	rogid:PNJz+zVtSHupD24M9t6FS4isQsM9606	rigid:6NhQeyf3Bbh8BkK5sQku7U9gZfQ	false	rho tag:c-c	-	1	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P18507-2	uniprotkb:P14867	intact:EBI-15096952|ensembl:ENSP00000491909	intact:EBI-6258308|ensembl:ENSP00000023897|ensembl:ENSP00000377517|ensembl:ENSP00000393097|ensembl:ENSP00000415441|ensembl:ENSP00000489738|ensembl:ENSP00000489839|ensembl:ENSP00000490320|ensembl:ENSP00000490804|uniprotkb:D3DQK6|uniprotkb:Q8N629	psi-mi:p18507-2(display_long)|uniprotkb:GABRG2(gene name)|psi-mi:GABRG2(display_short)|uniprotkb:"GABA(A) receptor subunit gamma-2"(gene name synonym)	psi-mi:gbra1_human(display_long)|uniprotkb:GABRA1(gene name)|psi-mi:GABRA1(display_short)|uniprotkb:"GABA(A) receptor subunit alpha-1"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Laverty et al. (2019)	imex:IM-27101|pubmed:30602789	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21453036|imex:IM-27101-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-9008430(isoform-parent)|ensembl:ENSG00000113327(gene)|ensembl:ENST00000639213(transcript)	go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005237"(inhibitory extracellular ligand-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008144"(obsolete drug binding)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050809"(diazepam binding)|go:"GO:0050877"(nervous system process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001390(Gamma-aminobutyric-acid A receptor, alpha subunit)|interpro:IPR005431(Gamma-aminobutyric-acid A receptor, alpha 1 subunit)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:6CDU|rcsb pdb:6D1S|rcsb pdb:6D6T|rcsb pdb:6D6U|rcsb pdb:6HUG|rcsb pdb:6HUJ|rcsb pdb:6HUK|rcsb pdb:6HUO|rcsb pdb:6HUP|rcsb pdb:6I53|rcsb pdb:6X3S|rcsb pdb:6X3T|rcsb pdb:6X3U|rcsb pdb:6X3V|rcsb pdb:6X3W|rcsb pdb:6X3X|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|rcsb pdb:6X3Z|rcsb pdb:6X40|reactome:R-HSA-1236394|reactome:R-HSA-977443|ensembl:ENSG00000022355(gene)|ensembl:ENST00000023897(transcript)|ensembl:ENST00000393943(transcript)|ensembl:ENST00000428797(transcript)|ensembl:ENST00000437025(transcript)|ensembl:ENST00000635880(transcript)|ensembl:ENST00000636573(transcript)|ensembl:ENST00000637827(transcript)|ensembl:ENST00000638112(transcript)|refseq:NP_000797.2|refseq:NP_001121115.1|refseq:NP_001121116.1|refseq:NP_001121117.1|refseq:NP_001121120.1	-	-	-	figure legend:Extd Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/01/18	2019/06/19	rogid:GYAYUqYIIDq45hwOUeeUuuCf6UM9606	rogid:6wrRTf2MOYgoKk0RgswgfaI5d+c9606	rigid:6NhQeyf3Bbh8BkK5sQku7U9gZfQ	false	rho tag:c-c	flag tag:n-n	1	2	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0396"(predetermined participant)|psi-mi:"MI:2287"(identification by structure determination)