#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:28563"	uniprotkb:P01031	intact:EBI-21446956|chebi:"CHEBI:10406"|chebi:"CHEBI:41167"|chebi:"CHEBI:22807"	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	psi-mi:beta-d-mannose(display_short)|psi-mi:"CHEBI:28563"(display_long)|intact:BETA-D-MANNOSE(synonym)|intact:beta-D-Mannose(synonym)|intact:beta-D-mannose(synonym)|intact:beta-D-mannopyranose(iupac name)	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339939|wwpdb:6h03|imex:IM-27630-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	emdb:EMD-0106(see-also)|emdb:EMD-0111(see-also)|emdb:EMD-0112(see-also)|emdb:EMD-0113(see-also)|emdb:EMD-0110(see-also)	-	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	figure legend:Supplementary table 1|comment:The authors have stated that NAG specifically binds to  C6, C7, C8A, C8B and C9.  They also stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/05/06	-	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:28563"	uniprotkb:P13671	intact:EBI-21446956|chebi:"CHEBI:10406"|chebi:"CHEBI:41167"|chebi:"CHEBI:22807"	intact:EBI-1753221|ensembl:ENSP00000263413|ensembl:ENSP00000338861	psi-mi:beta-d-mannose(display_short)|psi-mi:"CHEBI:28563"(display_long)|intact:BETA-D-MANNOSE(synonym)|intact:beta-D-Mannose(synonym)|intact:beta-D-mannose(synonym)|intact:beta-D-mannopyranose(iupac name)	psi-mi:co6_human(display_long)|uniprotkb:C6(gene name)|psi-mi:C6(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339939|wwpdb:6h03|imex:IM-27630-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000056.2|refseq:NP_001108603.2|ensembl:ENSG00000039537(gene)|ensembl:ENST00000263413(transcript)|ensembl:ENST00000337836(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR035976|interpro:IPR036055|interpro:IPR036383|rcsb pdb:3T5O|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	emdb:EMD-0106(see-also)|emdb:EMD-0111(see-also)|emdb:EMD-0112(see-also)|emdb:EMD-0113(see-also)|emdb:EMD-0110(see-also)	-	-	figure legend:Supplementary table 1|comment:The authors have stated that NAG specifically binds to  C6, C7, C8A, C8B and C9.  They also stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/05/06	-	rogid:GfycGXFpIoDx8sLZwxVYVMaJp4g9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:28563"	uniprotkb:P10643	intact:EBI-21446956|chebi:"CHEBI:10406"|chebi:"CHEBI:41167"|chebi:"CHEBI:22807"	intact:EBI-2872846|uniprotkb:A8K2T4|uniprotkb:Q92489|uniprotkb:Q6P3T5|ensembl:ENSP00000322061	psi-mi:beta-d-mannose(display_short)|psi-mi:"CHEBI:28563"(display_long)|intact:BETA-D-MANNOSE(synonym)|intact:beta-D-Mannose(synonym)|intact:beta-D-mannose(synonym)|intact:beta-D-mannopyranose(iupac name)	psi-mi:co7_human(display_long)|uniprotkb:C7(gene name)|psi-mi:C7(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339939|wwpdb:6h03|imex:IM-27630-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000578.2|ensembl:ENSG00000112936(gene)|ensembl:ENST00000313164(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR035976|interpro:IPR036055|interpro:IPR036383|interpro:IPR037564|interpro:IPR040729|rcsb pdb:2WCY|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	emdb:EMD-0106(see-also)|emdb:EMD-0111(see-also)|emdb:EMD-0112(see-also)|emdb:EMD-0113(see-also)|emdb:EMD-0110(see-also)	-	-	figure legend:Supplementary table 1|comment:The authors have stated that NAG specifically binds to  C6, C7, C8A, C8B and C9.  They also stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/05/06	-	rogid:RJDxSLqEzP1N71ZWcSspzpBI8+k9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:28563"	uniprotkb:P07357	intact:EBI-21446956|chebi:"CHEBI:10406"|chebi:"CHEBI:41167"|chebi:"CHEBI:22807"	intact:EBI-9021639|uniprotkb:Q9H130|uniprotkb:A2RUI4|uniprotkb:Q13668|uniprotkb:A2RUI5|ensembl:ENSP00000354458	psi-mi:beta-d-mannose(display_short)|psi-mi:"CHEBI:28563"(display_long)|intact:BETA-D-MANNOSE(synonym)|intact:beta-D-Mannose(synonym)|intact:beta-D-mannose(synonym)|intact:beta-D-mannopyranose(iupac name)	psi-mi:co8a_human(display_long)|uniprotkb:C8A(gene name)|psi-mi:C8A(display_short)|uniprotkb:Complement component 8 subunit alpha(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339939|wwpdb:6h03|imex:IM-27630-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000553.1|dip:DIP-1125N|ensembl:ENSG00000157131(gene)|ensembl:ENST00000361249(transcript)|go:"GO:0001848"(complement binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0016020"(membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR036055|interpro:IPR036383|interpro:IPR037565|rcsb pdb:2QOS|rcsb pdb:2QQH|rcsb pdb:2RD7|rcsb pdb:3OJY|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	emdb:EMD-0106(see-also)|emdb:EMD-0111(see-also)|emdb:EMD-0112(see-also)|emdb:EMD-0113(see-also)|emdb:EMD-0110(see-also)	-	-	figure legend:Supplementary table 1|comment:The authors have stated that NAG specifically binds to  C6, C7, C8A, C8B and C9.  They also stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/05/06	-	rogid:yxjkH/5pI3e1Sq3z4cycR2D7BqA9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:28563"	uniprotkb:P07358	intact:EBI-21446956|chebi:"CHEBI:10406"|chebi:"CHEBI:41167"|chebi:"CHEBI:22807"	intact:EBI-12523855|uniprotkb:A1L4K7|ensembl:ENSP00000360281	psi-mi:beta-d-mannose(display_short)|psi-mi:"CHEBI:28563"(display_long)|intact:BETA-D-MANNOSE(synonym)|intact:beta-D-Mannose(synonym)|intact:beta-D-mannose(synonym)|intact:beta-D-mannopyranose(iupac name)	psi-mi:co8b_human(display_long)|uniprotkb:C8B(gene name)|psi-mi:C8B(display_short)|uniprotkb:Complement component 8 subunit beta(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339939|wwpdb:6h03|imex:IM-27630-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000057.2|refseq:XP_016857724.1|ensembl:ENSG00000021852(gene)|ensembl:ENST00000371237(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0016020"(membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR036055|interpro:IPR036383|interpro:IPR037566|rcsb pdb:3OJY|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	emdb:EMD-0106(see-also)|emdb:EMD-0111(see-also)|emdb:EMD-0112(see-also)|emdb:EMD-0113(see-also)|emdb:EMD-0110(see-also)	-	-	figure legend:Supplementary table 1|comment:The authors have stated that NAG specifically binds to  C6, C7, C8A, C8B and C9.  They also stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/05/06	-	rogid:jevm2nY8n6750D+nkigfM5lmoYI9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:28563"	uniprotkb:P07360	intact:EBI-21446956|chebi:"CHEBI:10406"|chebi:"CHEBI:41167"|chebi:"CHEBI:22807"	intact:EBI-9021652|uniprotkb:Q5SQ07|uniprotkb:Q14CT8|uniprotkb:Q14CU0|ensembl:ENSP00000360697	psi-mi:beta-d-mannose(display_short)|psi-mi:"CHEBI:28563"(display_long)|intact:BETA-D-MANNOSE(synonym)|intact:beta-D-Mannose(synonym)|intact:beta-D-mannose(synonym)|intact:beta-D-mannopyranose(iupac name)	psi-mi:co8g_human(display_long)|uniprotkb:C8G(gene name)|psi-mi:C8G(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339939|wwpdb:6h03|imex:IM-27630-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000597.2|ensembl:ENSG00000176919(gene)|ensembl:ENST00000371634(transcript)|go:"GO:0001848"(complement binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0019841"(retinol binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|interpro:IPR022272|interpro:IPR043245|rcsb pdb:1IW2|rcsb pdb:1LF7|rcsb pdb:2OVA|rcsb pdb:2OVD|rcsb pdb:2OVE|rcsb pdb:2QOS|rcsb pdb:2RD7|rcsb pdb:3OJY|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606|interpro:IPR002968(Alpha-1-microglobulin)	emdb:EMD-0106(see-also)|emdb:EMD-0111(see-also)|emdb:EMD-0112(see-also)|emdb:EMD-0113(see-also)|emdb:EMD-0110(see-also)	-	-	figure legend:Supplementary table 1|comment:The authors have stated that NAG specifically binds to  C6, C7, C8A, C8B and C9.  They also stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/05/06	-	rogid:YU8/KH6FgbBJ00DBO2oEOWZqT0w9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:28563"	uniprotkb:P02748	intact:EBI-21446956|chebi:"CHEBI:10406"|chebi:"CHEBI:41167"|chebi:"CHEBI:22807"	intact:EBI-6677628|ensembl:ENSP00000263408	psi-mi:beta-d-mannose(display_short)|psi-mi:"CHEBI:28563"(display_long)|intact:BETA-D-MANNOSE(synonym)|intact:beta-D-Mannose(synonym)|intact:beta-D-mannose(synonym)|intact:beta-D-mannopyranose(iupac name)	psi-mi:co9_human(display_long)|uniprotkb:C9(gene name)|psi-mi:C9(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339939|wwpdb:6h03|imex:IM-27630-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001728.1|dip:DIP-1124N|ensembl:ENSG00000113600(gene)|ensembl:ENST00000263408(transcript)|go:"GO:0001906"(cell killing)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR036055|interpro:IPR036383|interpro:IPR037567|rcsb pdb:5FMW|rcsb pdb:6DLW|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	emdb:EMD-0106(see-also)|emdb:EMD-0111(see-also)|emdb:EMD-0112(see-also)|emdb:EMD-0113(see-also)|emdb:EMD-0110(see-also)	-	-	figure legend:Supplementary table 1|comment:The authors have stated that NAG specifically binds to  C6, C7, C8A, C8B and C9.  They also stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/05/06	-	rogid:XzPZJ9OUi00H+87so48Q/n+GXds9606	-	false	-	-	1	18	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:28563"	chebi:"CHEBI:506227"	intact:EBI-21446956|chebi:"CHEBI:10406"|chebi:"CHEBI:41167"|chebi:"CHEBI:22807"	intact:EBI-11787141	psi-mi:beta-d-mannose(display_short)|psi-mi:"CHEBI:28563"(display_long)|intact:BETA-D-MANNOSE(synonym)|intact:beta-D-Mannose(synonym)|intact:beta-D-mannose(synonym)|intact:beta-D-mannopyranose(iupac name)	psi-mi:n-acetyl-d-glucosamine(display_short)|psi-mi:"CHEBI:506227"(display_long)|intact:2-Acetamido-2-deoxy-D-glucose(synonym)|intact:GlcNAc(synonym)|intact:N-Acetyl-D-glucosamine(synonym)|intact:N-acetyl-D-glucosamine(synonym)|intact:N-Acetylchitosamine(synonym)|intact:2-acetamido-2-deoxy-D-glucopyranose(iupac name)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339939|wwpdb:6h03|imex:IM-27630-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	emdb:EMD-0106(see-also)|emdb:EMD-0111(see-also)|emdb:EMD-0112(see-also)|emdb:EMD-0113(see-also)|emdb:EMD-0110(see-also)	-	-	figure legend:Supplementary table 1|comment:The authors have stated that NAG specifically binds to  C6, C7, C8A, C8B and C9.  They also stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/05/06	-	-	-	false	-	-	1	79	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P01031	uniprotkb:P13671	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	intact:EBI-1753221|ensembl:ENSP00000263413|ensembl:ENSP00000338861	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:co6_human(display_long)|uniprotkb:C6(gene name)|psi-mi:C6(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339955|imex:IM-27630-3|wwpdb:6h04	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	refseq:NP_000056.2|refseq:NP_001108603.2|ensembl:ENSG00000039537(gene)|ensembl:ENST00000263413(transcript)|ensembl:ENST00000337836(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR035976|interpro:IPR036055|interpro:IPR036383|rcsb pdb:3T5O|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	emdb:EMD-0107(see-also)|emdb:EMD-0109(see-also)|emdb:EMD-0110(see-also)	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	-	figure legend:Supplementary table 1-2|comment:The authors have stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/01/10	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	rogid:GfycGXFpIoDx8sLZwxVYVMaJp4g9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P01031	uniprotkb:P10643	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	intact:EBI-2872846|uniprotkb:A8K2T4|uniprotkb:Q92489|uniprotkb:Q6P3T5|ensembl:ENSP00000322061	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:co7_human(display_long)|uniprotkb:C7(gene name)|psi-mi:C7(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339955|imex:IM-27630-3|wwpdb:6h04	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	refseq:NP_000578.2|ensembl:ENSG00000112936(gene)|ensembl:ENST00000313164(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR035976|interpro:IPR036055|interpro:IPR036383|interpro:IPR037564|interpro:IPR040729|rcsb pdb:2WCY|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	emdb:EMD-0107(see-also)|emdb:EMD-0109(see-also)|emdb:EMD-0110(see-also)	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	-	figure legend:Supplementary table 1-2|comment:The authors have stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/01/10	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	rogid:RJDxSLqEzP1N71ZWcSspzpBI8+k9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P01031	uniprotkb:P07357	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	intact:EBI-9021639|uniprotkb:Q9H130|uniprotkb:A2RUI4|uniprotkb:Q13668|uniprotkb:A2RUI5|ensembl:ENSP00000354458	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:co8a_human(display_long)|uniprotkb:C8A(gene name)|psi-mi:C8A(display_short)|uniprotkb:Complement component 8 subunit alpha(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339955|imex:IM-27630-3|wwpdb:6h04	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	refseq:NP_000553.1|dip:DIP-1125N|ensembl:ENSG00000157131(gene)|ensembl:ENST00000361249(transcript)|go:"GO:0001848"(complement binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0016020"(membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR036055|interpro:IPR036383|interpro:IPR037565|rcsb pdb:2QOS|rcsb pdb:2QQH|rcsb pdb:2RD7|rcsb pdb:3OJY|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	emdb:EMD-0107(see-also)|emdb:EMD-0109(see-also)|emdb:EMD-0110(see-also)	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	-	figure legend:Supplementary table 1-2|comment:The authors have stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/01/10	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	rogid:yxjkH/5pI3e1Sq3z4cycR2D7BqA9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P01031	uniprotkb:P07358	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	intact:EBI-12523855|uniprotkb:A1L4K7|ensembl:ENSP00000360281	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:co8b_human(display_long)|uniprotkb:C8B(gene name)|psi-mi:C8B(display_short)|uniprotkb:Complement component 8 subunit beta(gene name synonym)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339955|imex:IM-27630-3|wwpdb:6h04	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	refseq:NP_000057.2|refseq:XP_016857724.1|ensembl:ENSG00000021852(gene)|ensembl:ENST00000371237(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0016020"(membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR036055|interpro:IPR036383|interpro:IPR037566|rcsb pdb:3OJY|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	emdb:EMD-0107(see-also)|emdb:EMD-0109(see-also)|emdb:EMD-0110(see-also)	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	-	figure legend:Supplementary table 1-2|comment:The authors have stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/01/10	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	rogid:jevm2nY8n6750D+nkigfM5lmoYI9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P01031	uniprotkb:P07360	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	intact:EBI-9021652|uniprotkb:Q5SQ07|uniprotkb:Q14CT8|uniprotkb:Q14CU0|ensembl:ENSP00000360697	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:co8g_human(display_long)|uniprotkb:C8G(gene name)|psi-mi:C8G(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339955|imex:IM-27630-3|wwpdb:6h04	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	refseq:NP_000597.2|ensembl:ENSG00000176919(gene)|ensembl:ENST00000371634(transcript)|go:"GO:0001848"(complement binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0019841"(retinol binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|interpro:IPR022272|interpro:IPR043245|rcsb pdb:1IW2|rcsb pdb:1LF7|rcsb pdb:2OVA|rcsb pdb:2OVD|rcsb pdb:2OVE|rcsb pdb:2QOS|rcsb pdb:2RD7|rcsb pdb:3OJY|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606|interpro:IPR002968(Alpha-1-microglobulin)	emdb:EMD-0107(see-also)|emdb:EMD-0109(see-also)|emdb:EMD-0110(see-also)	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	-	figure legend:Supplementary table 1-2|comment:The authors have stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/01/10	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	rogid:YU8/KH6FgbBJ00DBO2oEOWZqT0w9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P01031	uniprotkb:P02748	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	intact:EBI-6677628|ensembl:ENSP00000263408	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:co9_human(display_long)|uniprotkb:C9(gene name)|psi-mi:C9(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339955|imex:IM-27630-3|wwpdb:6h04	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	refseq:NP_001728.1|dip:DIP-1124N|ensembl:ENSG00000113600(gene)|ensembl:ENST00000263408(transcript)|go:"GO:0001906"(cell killing)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR036055|interpro:IPR036383|interpro:IPR037567|rcsb pdb:5FMW|rcsb pdb:6DLW|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	emdb:EMD-0107(see-also)|emdb:EMD-0109(see-also)|emdb:EMD-0110(see-also)	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	-	figure legend:Supplementary table 1-2|comment:The authors have stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/01/10	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	rogid:XzPZJ9OUi00H+87so48Q/n+GXds9606	-	false	-	-	1	18	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
chebi:"CHEBI:506227"	uniprotkb:P01031	intact:EBI-11787141	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	psi-mi:n-acetyl-d-glucosamine(display_short)|psi-mi:"CHEBI:506227"(display_long)|intact:2-Acetamido-2-deoxy-D-glucose(synonym)|intact:GlcNAc(synonym)|intact:N-Acetyl-D-glucosamine(synonym)|intact:N-acetyl-D-glucosamine(synonym)|intact:N-Acetylchitosamine(synonym)|intact:2-acetamido-2-deoxy-D-glucopyranose(iupac name)	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:"MI:2339"(electron microscopy 3D single particle reconstruction)	Menny et al. (2018)	imex:IM-27630|pubmed:30552328	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-25339955|imex:IM-27630-3|wwpdb:6h04	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	emdb:EMD-0107(see-also)|emdb:EMD-0109(see-also)|emdb:EMD-0110(see-also)	-	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	figure legend:Supplementary table 1-2|comment:The authors have stated that all proteins have NAG bound to them.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/20	2020/01/10	-	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	-	false	-	-	76	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)