#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P35221 uniprotkb:Q8IUR7-1 intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669 intact:EBI-21199783|ensembl:ENSP00000419413 psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short) psi-mi:q8iur7-1(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0018"(two hybrid) Gul et al. (2018) pubmed:30482882|imex:IM-26816 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21199790|imex:IM-26816-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467 ensembl:ENSG00000114098(gene)|ensembl:ENST00000469044(transcript)|intact:EBI-1049469(isoform-parent) - - - figure legend:Figure 1b|comment:Full-length Armc8alpha does not bind with alpha-E-catenin; only the c-terminal construct does the binding|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2019/02/15 2019/02/15 rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606 rogid:9QXdCIwU8zeZ94oQ7JJNDVD2NDk9606 rigid:3F9nds1vXNWLd4mX81sVE662aMk false - sufficient binding region:268-659 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13835 uniprotkb:Q8IUR7-1 intact:EBI-2513407|ensembl:ENSP00000263946|ensembl:ENSP00000295597|uniprotkb:O00645|uniprotkb:Q14CA0|uniprotkb:Q15152 intact:EBI-21199783|ensembl:ENSP00000419413 psi-mi:pkp1_human(display_long)|uniprotkb:PKP1(gene name)|psi-mi:PKP1(display_short)|uniprotkb:Band 6 protein(gene name synonym) psi-mi:q8iur7-1(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0018"(two hybrid) Gul et al. (2018) pubmed:30482882|imex:IM-26816 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21199796|imex:IM-26816-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0005912"(adherens junction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030057"(desmosome)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0045296"(cadherin binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028432|interpro:IPR028435|mint:Q13835|reactome:R-HSA-351906|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|rcsb pdb:1XM9|ensembl:ENSG00000081277(gene)|ensembl:ENST00000263946(transcript)|ensembl:ENST00000352845(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|refseq:NP_000290.2|refseq:NP_001005337.1 ensembl:ENSG00000114098(gene)|ensembl:ENST00000469044(transcript)|intact:EBI-1049469(isoform-parent) - - - figure legend:Figure 1c|comment:Full-length Armc8alpha does not bind with pkp1; only the c-terminal construct does the binding|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2019/02/15 2019/02/15 rogid:j2bzqEmWBUDLVnjl2JX/i4nI8P49606 rogid:9QXdCIwU8zeZ94oQ7JJNDVD2NDk9606 rigid:SRRqjs/b2gxUmKTO6D7TNCN0bcQ false - sufficient binding region:268-659 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99959 uniprotkb:Q8IUR7-1 intact:EBI-702235|intact:EBI-2692870|uniprotkb:D3DUW9|uniprotkb:Q99960|uniprotkb:Q4VC01|uniprotkb:B8QFA1|uniprotkb:B8QGS6|uniprotkb:B8QGS7|uniprotkb:A0AV37|ensembl:ENSP00000070846 intact:EBI-21199783|ensembl:ENSP00000419413 psi-mi:pkp2_human(display_long)|uniprotkb:PKP2(gene name)|psi-mi:PKP2(display_short) psi-mi:q8iur7-1(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0018"(two hybrid) Gul et al. (2018) pubmed:30482882|imex:IM-26816 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21199803|imex:IM-26816-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004563.2|refseq:NP_001005242.2|ensembl:ENSG00000057294(gene)|ensembl:ENST00000070846(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002159"(desmosome assembly)|go:"GO:0002934"(desmosome organization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007507"(heart development)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048496"(maintenance of animal organ identity)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086019"(cell-cell signaling involved in cardiac conduction)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086083"(cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|mint:Q99959|rcsb pdb:3TT9|reactome:R-HSA-6805567|reactome:R-HSA-6809371 ensembl:ENSG00000114098(gene)|ensembl:ENST00000469044(transcript)|intact:EBI-1049469(isoform-parent) - - - figure legend:Figure 1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2019/02/15 2019/02/15 rogid:kwGWMlk4SDz0xARlBMD1dY9fehQ9606 rogid:9QXdCIwU8zeZ94oQ7JJNDVD2NDk9606 rigid:iK3PcJnCx3YEiy5ksYs2XNUBcPc false - sufficient binding region:268-659 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y446 uniprotkb:Q8IUR7-1 intact:EBI-2880227|ensembl:ENSP00000331678|uniprotkb:F8J390|uniprotkb:Q53EX8 intact:EBI-21199783|ensembl:ENSP00000419413 psi-mi:pkp3_human(display_long)|uniprotkb:PKP3(gene name)|psi-mi:PKP3(display_short) psi-mi:q8iur7-1(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0018"(two hybrid) Gul et al. (2018) pubmed:30482882|imex:IM-26816 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21199809|imex:IM-26816-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000184363(gene)|ensembl:ENST00000331563(transcript)|go:"GO:0002159"(desmosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006417"(regulation of translation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0001533"(cornified envelope)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028434|interpro:IPR028435|mint:Q9Y446|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|refseq:NP_001289958.1|refseq:NP_009114.1 ensembl:ENSG00000114098(gene)|ensembl:ENST00000469044(transcript)|intact:EBI-1049469(isoform-parent) - - - figure legend:Figure 1c, Figure 5c|comment:Full-length Armc8alpha does not bind with pkp3; only the c-terminal construct does the binding|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2019/02/15 2019/02/15 rogid:zGNbdze5MA5Mnf8m9IWZsxAPjAQ9606 rogid:9QXdCIwU8zeZ94oQ7JJNDVD2NDk9606 rigid:80Mb3B+5lN8Wl1Hhj742HrPGRHs false necessary binding region:1-349 sufficient binding region:268-659 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99569 uniprotkb:Q8IUR7-6 intact:EBI-726447|uniprotkb:Q86W91|ensembl:ENSP00000374409 intact:EBI-11942961|ensembl:ENSP00000351221|ensembl:ENSP00000420440 psi-mi:pkp4_human(display_long)|uniprotkb:p0071(gene name synonym)|uniprotkb:PKP4(gene name)|psi-mi:PKP4(display_short) psi-mi:q8iur7-6(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0018"(two hybrid) Gul et al. (2018) pubmed:30482882|imex:IM-26816 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21199826|imex:IM-26816-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001005476.1|refseq:NP_003619.2|refseq:NP_001291898.1|refseq:NP_001291899.1|refseq:XP_011510318.1|ensembl:ENST00000389757|ensembl:ENSP00000374407|ensembl:ENSP00000374409|ensembl:ENSG00000144283(gene)|ensembl:ENST00000389759(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001533"(cornified envelope)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030496"(midbody)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|interpro:IPR028443|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273 intact:EBI-1049469(isoform-parent)|ensembl:ENSG00000114098(gene)|ensembl:ENST00000358441(transcript)|ensembl:ENST00000471453(transcript)|uniprotkb:Q8IUR7-6(isoform-parent) - - - figure legend:Figure 5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2019/02/15 2019/02/15 rogid:Ii0+JmsNuDEPLxwiTJ8utGeaq4Q9606 rogid:An68MVXHUk8/cK2wBkxhNOIQl8A9606 rigid:53z9aN52+kW0PewulJ+KMX3SZa0 false sufficient binding region:993..993-1192 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99569 uniprotkb:Q8IUR7-1 intact:EBI-726447|uniprotkb:Q86W91|ensembl:ENSP00000374409 intact:EBI-21199783|ensembl:ENSP00000419413 psi-mi:pkp4_human(display_long)|uniprotkb:p0071(gene name synonym)|uniprotkb:PKP4(gene name)|psi-mi:PKP4(display_short) psi-mi:q8iur7-1(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0018"(two hybrid) Gul et al. (2018) pubmed:30482882|imex:IM-26816 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21199838|imex:IM-26816-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001005476.1|refseq:NP_003619.2|refseq:NP_001291898.1|refseq:NP_001291899.1|refseq:XP_011510318.1|ensembl:ENST00000389757|ensembl:ENSP00000374407|ensembl:ENSP00000374409|ensembl:ENSG00000144283(gene)|ensembl:ENST00000389759(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001533"(cornified envelope)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030496"(midbody)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0072686"(mitotic spindle)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|interpro:IPR028443|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273 ensembl:ENSG00000114098(gene)|ensembl:ENST00000469044(transcript)|intact:EBI-1049469(isoform-parent) - - - figure legend:Figure 5b, Figure 1d|comment:Full-length Armc8alpha does not bind with pkp4; only the c-terminal construct does the binding|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2019/02/15 2019/02/15 rogid:Ii0+JmsNuDEPLxwiTJ8utGeaq4Q9606 rogid:9QXdCIwU8zeZ94oQ7JJNDVD2NDk9606 rigid:o8Kwxz1fSVH7lFymOx7JxM9cHGA false sufficient binding region:993..993-1192 sufficient binding region:268-659 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y446 uniprotkb:Q8IUR7-6 intact:EBI-2880227|ensembl:ENSP00000331678|uniprotkb:F8J390|uniprotkb:Q53EX8 intact:EBI-11942961|ensembl:ENSP00000351221|ensembl:ENSP00000420440 psi-mi:pkp3_human(display_long)|uniprotkb:PKP3(gene name)|psi-mi:PKP3(display_short) psi-mi:q8iur7-6(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0018"(two hybrid) Gul et al. (2018) pubmed:30482882|imex:IM-26816 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21199853|imex:IM-26816-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000184363(gene)|ensembl:ENST00000331563(transcript)|go:"GO:0002159"(desmosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006417"(regulation of translation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0001533"(cornified envelope)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028434|interpro:IPR028435|mint:Q9Y446|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|refseq:NP_001289958.1|refseq:NP_009114.1 intact:EBI-1049469(isoform-parent)|ensembl:ENSG00000114098(gene)|ensembl:ENST00000358441(transcript)|ensembl:ENST00000471453(transcript)|uniprotkb:Q8IUR7-6(isoform-parent) - - - figure legend:Figure 5c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2019/02/15 2019/02/15 rogid:zGNbdze5MA5Mnf8m9IWZsxAPjAQ9606 rogid:An68MVXHUk8/cK2wBkxhNOIQl8A9606 rigid:CzE6qiHtPw1YrK2ZbRPAGa9+K90 false necessary binding region:1-349 sufficient binding region:200..200-385 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y446 uniprotkb:Q8IUR7-6 intact:EBI-2880227|ensembl:ENSP00000331678|uniprotkb:F8J390|uniprotkb:Q53EX8 intact:EBI-11942961|ensembl:ENSP00000351221|ensembl:ENSP00000420440 psi-mi:pkp3_human(display_long)|uniprotkb:PKP3(gene name)|psi-mi:PKP3(display_short) psi-mi:q8iur7-6(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0018"(two hybrid) Gul et al. (2018) pubmed:30482882|imex:IM-26816 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21199858|imex:IM-26816-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000184363(gene)|ensembl:ENST00000331563(transcript)|go:"GO:0002159"(desmosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006417"(regulation of translation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0001533"(cornified envelope)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028434|interpro:IPR028435|mint:Q9Y446|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|refseq:NP_001289958.1|refseq:NP_009114.1 intact:EBI-1049469(isoform-parent)|ensembl:ENSG00000114098(gene)|ensembl:ENST00000358441(transcript)|ensembl:ENST00000471453(transcript)|uniprotkb:Q8IUR7-6(isoform-parent) - - - figure legend:Figure 5c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2019/02/15 2019/02/15 rogid:zGNbdze5MA5Mnf8m9IWZsxAPjAQ9606 rogid:An68MVXHUk8/cK2wBkxhNOIQl8A9606 rigid:CzE6qiHtPw1YrK2ZbRPAGa9+K90 false necessary binding region:1-349 sufficient binding region:200..200-385 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y446 uniprotkb:Q9UI47 intact:EBI-2880227|ensembl:ENSP00000331678|uniprotkb:F8J390|uniprotkb:Q53EX8 intact:EBI-3937546|uniprotkb:Q6P056|uniprotkb:Q5VSR2|ensembl:ENSP00000389714|ensembl:ENSP00000508047|ensembl:ENSP00000508371 psi-mi:pkp3_human(display_long)|uniprotkb:PKP3(gene name)|psi-mi:PKP3(display_short) psi-mi:ctna3_human(display_long)|uniprotkb:CTNNA3(gene name)|psi-mi:CTNNA3(display_short)|uniprotkb:Alpha T-catenin(gene name synonym)|uniprotkb:Cadherin-associated protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gul et al. (2018) pubmed:30482882|imex:IM-26816 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21199885|imex:IM-26816-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000184363(gene)|ensembl:ENST00000331563(transcript)|go:"GO:0002159"(desmosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006417"(regulation of translation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0001533"(cornified envelope)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028434|interpro:IPR028435|mint:Q9Y446|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|refseq:NP_001289958.1|refseq:NP_009114.1 ensembl:ENSG00000183230(gene)|ensembl:ENST00000433211(transcript)|ensembl:ENST00000682758(transcript)|ensembl:ENST00000684154(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007015"(actin filament organization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|refseq:NP_001120856.1|refseq:NP_037398.2 - - - figure legend:Figure 5c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2019/02/15 2019/02/15 rogid:zGNbdze5MA5Mnf8m9IWZsxAPjAQ9606 rogid:lN7D/dH5lMAkRUKOIXZkdvZSK9E9606 rigid:0yDu8vx9jJwZMZIBnOX+E8q6WAU false necessary binding region:1-349 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y446 uniprotkb:Q8IUR7 intact:EBI-2880227|ensembl:ENSP00000331678|uniprotkb:F8J390|uniprotkb:Q53EX8 intact:EBI-1049469|uniprotkb:Q6PIL2|uniprotkb:Q96D19|uniprotkb:Q96HZ5|uniprotkb:Q9NV02|uniprotkb:Q9NV94|uniprotkb:Q9Y4R9|uniprotkb:A8K0L2|uniprotkb:D3DNE6|uniprotkb:B7Z441|uniprotkb:B7Z453|uniprotkb:F5GWK4|ensembl:ENSP00000419413 psi-mi:pkp3_human(display_long)|uniprotkb:PKP3(gene name)|psi-mi:PKP3(display_short) psi-mi:armc8_human(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Gul et al. (2018) pubmed:30482882|imex:IM-26816 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21202365|imex:IM-26816-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000184363(gene)|ensembl:ENST00000331563(transcript)|go:"GO:0002159"(desmosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006417"(regulation of translation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0001533"(cornified envelope)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028434|interpro:IPR028435|mint:Q9Y446|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|refseq:NP_001289958.1|refseq:NP_009114.1 refseq:NP_054873.2|refseq:NP_056211.2|refseq:NP_998819.1|refseq:XP_011510934.1|refseq:XP_011510935.1|refseq:NP_001253970.1|refseq:NP_001253971.1|refseq:NP_001269271.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034657"(GID complex)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038739|mint:Q8IUR7|rcsb pdb:7NSC|reactome:R-HSA-6798695|ensembl:ENSG00000114098(gene)|ensembl:ENST00000469044(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|refseq:XP_006713627.1|refseq:XP_006713628.1|refseq:XP_006713629.1 - - - figure legend:Figure 6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-skco_15)|taxid:9606(Human SK-CO15 cell) - 2019/02/15 2019/02/19 rogid:zGNbdze5MA5Mnf8m9IWZsxAPjAQ9606 rogid:9QXdCIwU8zeZ94oQ7JJNDVD2NDk9606 rigid:80Mb3B+5lN8Wl1Hhj742HrPGRHs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y446 uniprotkb:Q8IUR7 intact:EBI-2880227|ensembl:ENSP00000331678|uniprotkb:F8J390|uniprotkb:Q53EX8 intact:EBI-1049469|uniprotkb:Q6PIL2|uniprotkb:Q96D19|uniprotkb:Q96HZ5|uniprotkb:Q9NV02|uniprotkb:Q9NV94|uniprotkb:Q9Y4R9|uniprotkb:A8K0L2|uniprotkb:D3DNE6|uniprotkb:B7Z441|uniprotkb:B7Z453|uniprotkb:F5GWK4|ensembl:ENSP00000419413 psi-mi:pkp3_human(display_long)|uniprotkb:PKP3(gene name)|psi-mi:PKP3(display_short) psi-mi:armc8_human(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0663"(confocal microscopy) Gul et al. (2018) pubmed:30482882|imex:IM-26816 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-21202379|imex:IM-26816-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000184363(gene)|ensembl:ENST00000331563(transcript)|go:"GO:0002159"(desmosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006417"(regulation of translation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0001533"(cornified envelope)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028434|interpro:IPR028435|mint:Q9Y446|reactome:R-HSA-6805567|reactome:R-HSA-6809371|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|refseq:NP_001289958.1|refseq:NP_009114.1 refseq:NP_054873.2|refseq:NP_056211.2|refseq:NP_998819.1|refseq:XP_011510934.1|refseq:XP_011510935.1|refseq:NP_001253970.1|refseq:NP_001253971.1|refseq:NP_001269271.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034657"(GID complex)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038739|mint:Q8IUR7|rcsb pdb:7NSC|reactome:R-HSA-6798695|ensembl:ENSG00000114098(gene)|ensembl:ENST00000469044(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|refseq:XP_006713627.1|refseq:XP_006713628.1|refseq:XP_006713629.1 - - - figure legend:Figure 6b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-skco_15)|taxid:9606(Human SK-CO15 cell) - 2019/02/15 2019/02/19 rogid:zGNbdze5MA5Mnf8m9IWZsxAPjAQ9606 rogid:9QXdCIwU8zeZ94oQ7JJNDVD2NDk9606 rigid:80Mb3B+5lN8Wl1Hhj742HrPGRHs false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)