#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BXU9	uniprotkb:P21554	intact:EBI-12187137|ensembl:ENSP00000378690|uniprotkb:J3KQA7	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:cabp8_human(display_long)|uniprotkb:CALN1(gene name)|psi-mi:CALN1(display_short)|uniprotkb:CABP8(gene name synonym)|uniprotkb:Calneuron I(gene name synonym)|uniprotkb:Calneuron-1(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Angelats et al. (2017)	imex:IM-27115|pubmed:30073165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21458285|imex:IM-27115-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183166(gene)|ensembl:ENST00000395275(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|refseq:NP_001017440.1|refseq:NP_113656.2|refseq:XP_011514897.1|refseq:XP_011514898.1|refseq:XP_011514899.1|refseq:XP_011514901.1|refseq:XP_016868164.1|refseq:XP_016868165.1|refseq:XP_016868167.1|refseq:XP_016868168.1|refseq:XP_016868169.1|refseq:XP_016868170.1|refseq:XP_016868171.1|refseq:XP_016868172.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2021/02/12	rogid:kaTrZ3CvG9/ME/MhBTstvz1fWUM9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:08pN0ZtHNfxEqHR8rNBWEfmnwlI	false	yellow fluorescent protein tag:c-c	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P62166	uniprotkb:P21554	intact:EBI-746987|uniprotkb:P36610|uniprotkb:Q9UK26|ensembl:ENSP00000361475|uniprotkb:E9PAY3	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:ncs1_human(display_long)|uniprotkb:Frequenin homolog(gene name synonym)|uniprotkb:Frequenin-like protein(gene name synonym)|uniprotkb:Frequenin-like ubiquitous protein(gene name synonym)|uniprotkb:NCS1(gene name)|psi-mi:NCS1(display_short)|uniprotkb:FLUP(gene name synonym)|uniprotkb:FREQ(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Angelats et al. (2017)	imex:IM-27115|pubmed:30073165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21458304|imex:IM-27115-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:P62166|rcsb pdb:1G8I|rcsb pdb:2LCP|rcsb pdb:4GUK|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|rcsb pdb:5O9S|rcsb pdb:6QI4|refseq:NP_001122298.1|refseq:NP_055101.2|ensembl:ENSG00000107130(gene)|ensembl:ENST00000372398(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031045"(dense core granule)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044305"(calyx of Held)|go:"GO:0045921"(positive regulation of exocytosis)	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Figure 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/06/25	rogid:5PSwZawiNKpqPVTCSgePkmcuU6k9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:7SoUek+AtHK0B75OoQKFuAuVozs	false	yellow fluorescent protein tag:c-c	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P62166	uniprotkb:P21554	intact:EBI-746987|uniprotkb:P36610|uniprotkb:Q9UK26|ensembl:ENSP00000361475|uniprotkb:E9PAY3	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:ncs1_human(display_long)|uniprotkb:Frequenin homolog(gene name synonym)|uniprotkb:Frequenin-like protein(gene name synonym)|uniprotkb:Frequenin-like ubiquitous protein(gene name synonym)|uniprotkb:NCS1(gene name)|psi-mi:NCS1(display_short)|uniprotkb:FLUP(gene name synonym)|uniprotkb:FREQ(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Angelats et al. (2017)	imex:IM-27115|pubmed:30073165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21458326|imex:IM-27115-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:P62166|rcsb pdb:1G8I|rcsb pdb:2LCP|rcsb pdb:4GUK|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|rcsb pdb:5O9S|rcsb pdb:6QI4|refseq:NP_001122298.1|refseq:NP_055101.2|ensembl:ENSG00000107130(gene)|ensembl:ENST00000372398(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031045"(dense core granule)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044305"(calyx of Held)|go:"GO:0045921"(positive regulation of exocytosis)	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:"Figure 1C, (2D), 3B"|comment:An N-terminal myristoylation-deficient NCS1 mutant of unknown species origin and sequence  reduced binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2019/06/25	rogid:5PSwZawiNKpqPVTCSgePkmcuU6k9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:7SoUek+AtHK0B75OoQKFuAuVozs	false	yellow fluorescent protein tag:c-c	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q9BXU9	uniprotkb:P21554	intact:EBI-12187137|ensembl:ENSP00000378690|uniprotkb:J3KQA7	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:cabp8_human(display_long)|uniprotkb:CALN1(gene name)|psi-mi:CALN1(display_short)|uniprotkb:CABP8(gene name synonym)|uniprotkb:Calneuron I(gene name synonym)|uniprotkb:Calneuron-1(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Angelats et al. (2017)	imex:IM-27115|pubmed:30073165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21458318|imex:IM-27115-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183166(gene)|ensembl:ENST00000395275(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|refseq:NP_001017440.1|refseq:NP_113656.2|refseq:XP_011514897.1|refseq:XP_011514898.1|refseq:XP_011514899.1|refseq:XP_011514901.1|refseq:XP_016868164.1|refseq:XP_016868165.1|refseq:XP_016868167.1|refseq:XP_016868168.1|refseq:XP_016868169.1|refseq:XP_016868170.1|refseq:XP_016868171.1|refseq:XP_016868172.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:"Figure 1B, (2A), 3A"|comment:A Calneuron-1 construct, truncated at the C terminus and of unknown species origin did not bind Cb1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2021/02/12	rogid:kaTrZ3CvG9/ME/MhBTstvz1fWUM9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:08pN0ZtHNfxEqHR8rNBWEfmnwlI	false	yellow fluorescent protein tag:c-c	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q9BXU9	uniprotkb:P21554	intact:EBI-12187137|ensembl:ENSP00000378690|uniprotkb:J3KQA7	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:cabp8_human(display_long)|uniprotkb:CALN1(gene name)|psi-mi:CALN1(display_short)|uniprotkb:CABP8(gene name synonym)|uniprotkb:Calneuron I(gene name synonym)|uniprotkb:Calneuron-1(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Angelats et al. (2017)	imex:IM-27115|pubmed:30073165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21458360|imex:IM-27115-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183166(gene)|ensembl:ENST00000395275(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|refseq:NP_001017440.1|refseq:NP_113656.2|refseq:XP_011514897.1|refseq:XP_011514898.1|refseq:XP_011514899.1|refseq:XP_011514901.1|refseq:XP_016868164.1|refseq:XP_016868165.1|refseq:XP_016868167.1|refseq:XP_016868168.1|refseq:XP_016868169.1|refseq:XP_016868170.1|refseq:XP_016868171.1|refseq:XP_016868172.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Figure 2B/C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2021/02/12	rogid:kaTrZ3CvG9/ME/MhBTstvz1fWUM9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:08pN0ZtHNfxEqHR8rNBWEfmnwlI	false	renilla luciferase protein tag:c-c	yellow fluorescent protein tag:c-c|sufficient binding region:1..1-432..432|mutation disrupting interaction strength:321-322	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q9BXU9	uniprotkb:P21554	intact:EBI-12187137|ensembl:ENSP00000378690|uniprotkb:J3KQA7	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:cabp8_human(display_long)|uniprotkb:CALN1(gene name)|psi-mi:CALN1(display_short)|uniprotkb:CABP8(gene name synonym)|uniprotkb:Calneuron I(gene name synonym)|uniprotkb:Calneuron-1(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Angelats et al. (2017)	imex:IM-27115|pubmed:30073165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21458640|imex:IM-27115-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183166(gene)|ensembl:ENST00000395275(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|refseq:NP_001017440.1|refseq:NP_113656.2|refseq:XP_011514897.1|refseq:XP_011514898.1|refseq:XP_011514899.1|refseq:XP_011514901.1|refseq:XP_016868164.1|refseq:XP_016868165.1|refseq:XP_016868167.1|refseq:XP_016868168.1|refseq:XP_016868169.1|refseq:XP_016868170.1|refseq:XP_016868171.1|refseq:XP_016868172.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Figure 3A|comment:Increasing intracellular Ca2+ concentrations reduced the competitive effect of of NCS1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2021/02/12	rogid:kaTrZ3CvG9/ME/MhBTstvz1fWUM9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:lxGbQd3G1ooek9XPdSjDiS88+tU	false	yellow fluorescent protein tag:c-c	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q9BXU9	uniprotkb:P62166	intact:EBI-12187137|ensembl:ENSP00000378690|uniprotkb:J3KQA7	intact:EBI-746987|uniprotkb:P36610|uniprotkb:Q9UK26|ensembl:ENSP00000361475|uniprotkb:E9PAY3	psi-mi:cabp8_human(display_long)|uniprotkb:CALN1(gene name)|psi-mi:CALN1(display_short)|uniprotkb:CABP8(gene name synonym)|uniprotkb:Calneuron I(gene name synonym)|uniprotkb:Calneuron-1(gene name synonym)	psi-mi:ncs1_human(display_long)|uniprotkb:Frequenin homolog(gene name synonym)|uniprotkb:Frequenin-like protein(gene name synonym)|uniprotkb:Frequenin-like ubiquitous protein(gene name synonym)|uniprotkb:NCS1(gene name)|psi-mi:NCS1(display_short)|uniprotkb:FLUP(gene name synonym)|uniprotkb:FREQ(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Angelats et al. (2017)	imex:IM-27115|pubmed:30073165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21458640|imex:IM-27115-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183166(gene)|ensembl:ENST00000395275(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|refseq:NP_001017440.1|refseq:NP_113656.2|refseq:XP_011514897.1|refseq:XP_011514898.1|refseq:XP_011514899.1|refseq:XP_011514901.1|refseq:XP_016868164.1|refseq:XP_016868165.1|refseq:XP_016868167.1|refseq:XP_016868168.1|refseq:XP_016868169.1|refseq:XP_016868170.1|refseq:XP_016868171.1|refseq:XP_016868172.1	go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:P62166|rcsb pdb:1G8I|rcsb pdb:2LCP|rcsb pdb:4GUK|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|rcsb pdb:5O9S|rcsb pdb:6QI4|refseq:NP_001122298.1|refseq:NP_055101.2|ensembl:ENSG00000107130(gene)|ensembl:ENST00000372398(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031045"(dense core granule)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044305"(calyx of Held)|go:"GO:0045921"(positive regulation of exocytosis)	-	-	-	figure legend:Figure 3A|comment:Increasing intracellular Ca2+ concentrations reduced the competitive effect of of NCS1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2021/02/12	rogid:kaTrZ3CvG9/ME/MhBTstvz1fWUM9606	rogid:5PSwZawiNKpqPVTCSgePkmcuU6k9606	rigid:lxGbQd3G1ooek9XPdSjDiS88+tU	false	yellow fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q9BXU9	uniprotkb:P21554	intact:EBI-12187137|ensembl:ENSP00000378690|uniprotkb:J3KQA7	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:cabp8_human(display_long)|uniprotkb:CALN1(gene name)|psi-mi:CALN1(display_short)|uniprotkb:CABP8(gene name synonym)|uniprotkb:Calneuron I(gene name synonym)|uniprotkb:Calneuron-1(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Angelats et al. (2017)	imex:IM-27115|pubmed:30073165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21458671|imex:IM-27115-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2334"(luminescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183166(gene)|ensembl:ENST00000395275(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|refseq:NP_001017440.1|refseq:NP_113656.2|refseq:XP_011514897.1|refseq:XP_011514898.1|refseq:XP_011514899.1|refseq:XP_011514901.1|refseq:XP_016868164.1|refseq:XP_016868165.1|refseq:XP_016868167.1|refseq:XP_016868168.1|refseq:XP_016868169.1|refseq:XP_016868170.1|refseq:XP_016868171.1|refseq:XP_016868172.1	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	-	-	-	figure legend:Figure 3B|comment:Increasing intracellular Ca2+ concentrations did not reduce the competitive effect of of calneuron-1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2021/02/12	rogid:kaTrZ3CvG9/ME/MhBTstvz1fWUM9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:lxGbQd3G1ooek9XPdSjDiS88+tU	false	-	renilla luciferase protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q9BXU9	uniprotkb:P62166	intact:EBI-12187137|ensembl:ENSP00000378690|uniprotkb:J3KQA7	intact:EBI-746987|uniprotkb:P36610|uniprotkb:Q9UK26|ensembl:ENSP00000361475|uniprotkb:E9PAY3	psi-mi:cabp8_human(display_long)|uniprotkb:CALN1(gene name)|psi-mi:CALN1(display_short)|uniprotkb:CABP8(gene name synonym)|uniprotkb:Calneuron I(gene name synonym)|uniprotkb:Calneuron-1(gene name synonym)	psi-mi:ncs1_human(display_long)|uniprotkb:Frequenin homolog(gene name synonym)|uniprotkb:Frequenin-like protein(gene name synonym)|uniprotkb:Frequenin-like ubiquitous protein(gene name synonym)|uniprotkb:NCS1(gene name)|psi-mi:NCS1(display_short)|uniprotkb:FLUP(gene name synonym)|uniprotkb:FREQ(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Angelats et al. (2017)	imex:IM-27115|pubmed:30073165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21458671|imex:IM-27115-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:2335"(luminescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183166(gene)|ensembl:ENST00000395275(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|refseq:NP_001017440.1|refseq:NP_113656.2|refseq:XP_011514897.1|refseq:XP_011514898.1|refseq:XP_011514899.1|refseq:XP_011514901.1|refseq:XP_016868164.1|refseq:XP_016868165.1|refseq:XP_016868167.1|refseq:XP_016868168.1|refseq:XP_016868169.1|refseq:XP_016868170.1|refseq:XP_016868171.1|refseq:XP_016868172.1	go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:P62166|rcsb pdb:1G8I|rcsb pdb:2LCP|rcsb pdb:4GUK|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|rcsb pdb:5O9S|rcsb pdb:6QI4|refseq:NP_001122298.1|refseq:NP_055101.2|ensembl:ENSG00000107130(gene)|ensembl:ENST00000372398(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031045"(dense core granule)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044305"(calyx of Held)|go:"GO:0045921"(positive regulation of exocytosis)	-	-	-	figure legend:Figure 3B|comment:Increasing intracellular Ca2+ concentrations did not reduce the competitive effect of of calneuron-1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/27	2021/02/12	rogid:kaTrZ3CvG9/ME/MhBTstvz1fWUM9606	rogid:5PSwZawiNKpqPVTCSgePkmcuU6k9606	rigid:lxGbQd3G1ooek9XPdSjDiS88+tU	false	-	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q9JJG7	uniprotkb:P47746	intact:EBI-21458695|ensembl:ENSMUSP00000083193|uniprotkb:F8WHE1	intact:EBI-21282107|ensembl:ENSMUSP00000055797|ensembl:ENSMUSP00000081787|uniprotkb:Q5SF33	psi-mi:cabp8_mouse(display_long)|uniprotkb:Calneuron I(gene name synonym)|uniprotkb:Calneuron-1(gene name synonym)|uniprotkb:MNCb-0849(orf name)|uniprotkb:Caln1(gene name)|psi-mi:Caln1(display_short)|uniprotkb:Cabp8(gene name synonym)	psi-mi:cnr1_mouse(display_long)|uniprotkb:Cnr1(gene name)|psi-mi:Cnr1(display_short)|uniprotkb:Brain-type cannabinoid receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Angelats et al. (2017)	imex:IM-27115|pubmed:30073165	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21458692|imex:IM-27115-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067346.1|refseq:NP_851388.1|refseq:XP_006504436.1|refseq:XP_006504437.1|ensembl:ENSMUSG00000060371(gene)|ensembl:ENSMUST00000086029(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|refseq:XP_006504435.1	go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098793"(presynapse)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|ensembl:ENSMUSG00000044288(gene)|ensembl:ENSMUST00000057188(transcript)|ensembl:ENSMUST00000084736(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0007611"(learning or memory)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-373076|reactome:R-MMU-418594|refseq:NP_031752.1|refseq:XP_006537654.1|refseq:XP_006537655.1|refseq:XP_006537656.1|refseq:XP_006537657.1|refseq:XP_006537658.1|refseq:XP_017175428.1	-	-	-	figure legend:Figure 4A|agonist:"Ionomycin -an ionophore  used  to raise the intracellular level of calcium (Ca2+)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuron)|taxid:10090(Mus musculus neuronal cell)	-	2019/05/27	2021/02/12	rogid:ky40x5lSrGpXXQo+vvE8bUkij/k10090	rogid:+0dCe91oDIcGgJ+nafOeTbD6e7k10090	rigid:7uFqTcdEH1JSopMb+PHKcJ7qdKY	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8BNY6	uniprotkb:P47746	intact:EBI-8327161|intact:MINT-4439526|uniprotkb:A2AJ84|ensembl:ENSMUSP00000000199	intact:EBI-21282107|ensembl:ENSMUSP00000055797|ensembl:ENSMUSP00000081787|uniprotkb:Q5SF33	psi-mi:ncs1_mouse(display_long)|uniprotkb:Ncs1(gene name)|psi-mi:Ncs1(display_short)|uniprotkb:Freq(gene name synonym)|uniprotkb:Frequenin homolog(gene name synonym)	psi-mi:cnr1_mouse(display_long)|uniprotkb:Cnr1(gene name)|psi-mi:Cnr1(display_short)|uniprotkb:Brain-type cannabinoid receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Angelats et al. (2017)	imex:IM-27115|pubmed:30073165	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21458724|imex:IM-27115-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062655.1|dip:DIP-61316N|ensembl:ENSMUSG00000062661(gene)|ensembl:ENSMUST00000000199(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031045"(dense core granule)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044305"(calyx of Held)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099626"(voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|mint:Q8BNY6	go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043271"(negative regulation of ion transport)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098793"(presynapse)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|ensembl:ENSMUSG00000044288(gene)|ensembl:ENSMUST00000057188(transcript)|ensembl:ENSMUST00000084736(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0007611"(learning or memory)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-373076|reactome:R-MMU-418594|refseq:NP_031752.1|refseq:XP_006537654.1|refseq:XP_006537655.1|refseq:XP_006537656.1|refseq:XP_006537657.1|refseq:XP_006537658.1|refseq:XP_017175428.1	-	function:"Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin"|comment:mint	-	figure legend:Figure 4B|antagonist:"Ionomycin -an ionophore  used  to raise the intracellular level of calcium (Ca2+)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neuron)|taxid:10090(Mus musculus neuronal cell)	-	2019/05/27	2019/06/26	rogid:5PSwZawiNKpqPVTCSgePkmcuU6k10090	rogid:+0dCe91oDIcGgJ+nafOeTbD6e7k10090	rigid:aePdcz5S0a/lykrmkzU/UfSODpc	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)