#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-21016712	intact:EBI-21199910	rnacentral:URS000075C431_10090	rnacentral:URS00004BCD9C_10090	psi-mi:lnc meg3_2(display_short)|psi-mi:EBI-21016712(display_long)	psi-mi:mmu-mir-16 5p(display_short)|psi-mi:EBI-21199910(display_long)	psi-mi:"MI:2285"(miRNA interference luciferase reporter assay)	Xu et al. (2016)	imex:IM-26818|pubmed:29255591	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21016264|imex:IM-26818-3	-	-	psi-mi:"MI:2275"(regulator target)	psi-mi:"MI:2274"(regulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:2190"(long non-coding ribonucleic acid)	psi-mi:"MI:2204"(micro rna)	-	-	-	-	-	figure legend:Fig 3 A C|causality statement:down-regulates quantity by destabilization|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/01/08	2019/02/15	-	-	-	false	luciferase tag:?-?|mutation decreasing interaction:452-457	-	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-21016268	intact:EBI-21199910	ensembl:ENSMUST00000026999.9	rnacentral:URS00004BCD9C_10090	psi-mi:mrna_smad7(display_short)|psi-mi:EBI-21016268(display_long)	psi-mi:mmu-mir-16 5p(display_short)|psi-mi:EBI-21199910(display_long)	psi-mi:"MI:2285"(miRNA interference luciferase reporter assay)	Xu et al. (2016)	imex:IM-26818|pubmed:29255591	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21016276|imex:IM-26818-5	-	-	psi-mi:"MI:2275"(regulator target)	psi-mi:"MI:2274"(regulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0324"(messenger rna)	psi-mi:"MI:2204"(micro rna)	refseq:NM_001042660.1(see-also)	-	go:"GO:1903231"(mRNA binding involved in posttranscriptional gene silencing)	-	-	figure legend:FIG 4 A, B|causality statement:down-regulates quantity by destabilization|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/01/08	2019/02/18	-	-	-	false	luciferase tag:?-?|mutation decreasing interaction:2941-2948	-	-	-	psi-mi:"MI:1220"(tag visualisation by luciferase assay)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9QZ81	intact:EBI-21201899	intact:EBI-9527129	-	psi-mi:ago2_rat(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Golgi ER protein 95 kDa(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:rat lnc meg3(display_short)|psi-mi:EBI-21201899(display_long)	psi-mi:"MI:1017"(rna immunoprecipitation)	Xu et al. (2016)	imex:IM-26818|pubmed:29255591	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21016186|imex:IM-26818-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:2190"(long non-coding ribonucleic acid)	mint:Q9QZ81|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|refseq:NP_067608.1|rgd:621255|interpro:IPR036085|interpro:IPR036397|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-RNO-203927|reactome:R-RNO-426486|reactome:R-RNO-426496|reactome:R-RNO-5578749	-	-	-	-	figure legend:Fig 3 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-chondrocyte)|taxid:10116(rat catilage)	-	2019/01/08	2019/02/18	rogid:VnRN9Tgow+tnUpODieHJ/WhbbSA10116	-	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:1196"(quantitative reverse transcription pcr)
uniprotkb:Q9QZ81	intact:EBI-21016203	intact:EBI-9527129	rnacentral:URS00004BCD9C_10116	psi-mi:ago2_rat(display_long)|uniprotkb:Ago2(gene name)|psi-mi:Ago2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:Eif2c2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:Golgi ER protein 95 kDa(gene name synonym)|uniprotkb:Protein slicer(gene name synonym)	psi-mi:rno-mir-16-5p(display_short)|psi-mi:EBI-21016203(display_long)	psi-mi:"MI:1017"(rna immunoprecipitation)	Xu et al. (2016)	imex:IM-26818|pubmed:29255591	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21016186|imex:IM-26818-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:2204"(micro rna)	mint:Q9QZ81|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|refseq:NP_067608.1|rgd:621255|interpro:IPR036085|interpro:IPR036397|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016442"(RISC complex)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-RNO-203927|reactome:R-RNO-426486|reactome:R-RNO-426496|reactome:R-RNO-5578749	-	-	-	-	figure legend:Fig 3 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-chondrocyte)|taxid:10116(rat catilage)	-	2019/01/08	2019/02/18	rogid:VnRN9Tgow+tnUpODieHJ/WhbbSA10116	-	-	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:1196"(quantitative reverse transcription pcr)