#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21246	uniprotkb:P11215	intact:EBI-473725|ensembl:ENSP00000341170|uniprotkb:Q5U0B0|uniprotkb:Q6ICQ5|uniprotkb:Q9UCC6	intact:EBI-2568251|uniprotkb:Q4VAK0|uniprotkb:Q4VAK2|ensembl:ENSP00000441691|uniprotkb:Q4VAK1	psi-mi:ptn_human(display_long)|uniprotkb:Heparin-binding growth-associated molecule(gene name synonym)|uniprotkb:Heparin-binding growth factor 8(gene name synonym)|uniprotkb:Osteoblast-specific factor 1(gene name synonym)|uniprotkb:Heparin-binding neurite outgrowth-promoting factor 1(gene name synonym)|uniprotkb:Heparin-binding brain mitogen(gene name synonym)|uniprotkb:PTN(gene name)|psi-mi:PTN(display_short)|uniprotkb:HBNF1(gene name synonym)|uniprotkb:NEGF1(gene name synonym)|uniprotkb:Heparin-binding neurite outgrowth-promoting factor(gene name synonym)	psi-mi:itam_human(display_long)|uniprotkb:ITGAM(gene name)|psi-mi:ITGAM(display_short)|uniprotkb:CD11B(gene name synonym)|uniprotkb:CR3A(gene name synonym)|uniprotkb:Cell surface glycoprotein MAC-1 subunit alpha(gene name synonym)|uniprotkb:CR-3 alpha chain(gene name synonym)|uniprotkb:Leukocyte adhesion receptor MO1(gene name synonym)|uniprotkb:Neutrophil adherence receptor(gene name synonym)|uniprotkb:CD11 antigen-like family member B(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Shen et al. (2017)	pubmed:28939773|imex:IM-27579	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21399938|imex:IM-27579-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105894(gene)|ensembl:ENST00000348225(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007185"(transmembrane receptor protein tyrosine phosphatase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007507"(heart development)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021794"(thalamus development)|go:"GO:0030282"(bone mineralization)|refseq:NP_002816.1|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904397"(negative regulation of neuromuscular junction development)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1990089"(response to nerve growth factor)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|interpro:IPR000762(PTN/MK heparin-binding protein)|interpro:IPR020089|interpro:IPR020090|interpro:IPR020091|interpro:IPR020092|interpro:IPR037122|interpro:IPR038130|rcsb pdb:2N6F|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0140059"(dendrite arborization)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1903706"(regulation of hemopoiesis)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904389"(rod bipolar cell differentiation)|go:"GO:1904391"(response to ciliary neurotrophic factor)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045545"(syndecan binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046697"(decidualization)|go:"GO:0030324"(lung development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031104"(dendrite regeneration)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035373"(chondroitin sulfate proteoglycan binding)|go:"GO:0048477"(oogenesis)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060221"(retinal rod cell differentiation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0044849"(estrous cycle)|refseq:NP_001308315.1|refseq:NP_001308316.1|dip:DIP-5953N	refseq:NP_000623.2|refseq:NP_001139280.1|ensembl:ENSG00000169896(gene)|ensembl:ENST00000544665(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|rcsb pdb:1A8X|rcsb pdb:1BHO|rcsb pdb:1BHQ|rcsb pdb:1IDN|rcsb pdb:1IDO|rcsb pdb:1JLM|rcsb pdb:1M1U|rcsb pdb:1MF7|rcsb pdb:1N9Z|rcsb pdb:1NA5|rcsb pdb:2LKE|rcsb pdb:2LKJ|rcsb pdb:3Q3G|rcsb pdb:3QA3|rcsb pdb:4M76|rcsb pdb:4XW2|rcsb pdb:6RHW|reactome:R-HSA-166016|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-6798695	-	-	-	figure legend:Fig. 5|comment:Altering how PTN bound to the chip had no effect on Kd value.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.2x10^-6(molar)	2019/05/08	2019/05/08	rogid:vBF/t/qNd5/5ylZx9o1LbqIyvZE9606	rogid:LdazC8w25LRfb+vgr/kGcKmIkYo9606	rigid:GFtPFqOk5inAIRlKfQrRbgD6BZg	false	his tag:n-n	sufficient binding region:139-331	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21246	uniprotkb:P11215	intact:EBI-473725|ensembl:ENSP00000341170|uniprotkb:Q5U0B0|uniprotkb:Q6ICQ5|uniprotkb:Q9UCC6	intact:EBI-2568251|uniprotkb:Q4VAK0|uniprotkb:Q4VAK2|ensembl:ENSP00000441691|uniprotkb:Q4VAK1	psi-mi:ptn_human(display_long)|uniprotkb:Heparin-binding growth-associated molecule(gene name synonym)|uniprotkb:Heparin-binding growth factor 8(gene name synonym)|uniprotkb:Osteoblast-specific factor 1(gene name synonym)|uniprotkb:Heparin-binding neurite outgrowth-promoting factor 1(gene name synonym)|uniprotkb:Heparin-binding brain mitogen(gene name synonym)|uniprotkb:PTN(gene name)|psi-mi:PTN(display_short)|uniprotkb:HBNF1(gene name synonym)|uniprotkb:NEGF1(gene name synonym)|uniprotkb:Heparin-binding neurite outgrowth-promoting factor(gene name synonym)	psi-mi:itam_human(display_long)|uniprotkb:ITGAM(gene name)|psi-mi:ITGAM(display_short)|uniprotkb:CD11B(gene name synonym)|uniprotkb:CR3A(gene name synonym)|uniprotkb:Cell surface glycoprotein MAC-1 subunit alpha(gene name synonym)|uniprotkb:CR-3 alpha chain(gene name synonym)|uniprotkb:Leukocyte adhesion receptor MO1(gene name synonym)|uniprotkb:Neutrophil adherence receptor(gene name synonym)|uniprotkb:CD11 antigen-like family member B(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Shen et al. (2017)	pubmed:28939773|imex:IM-27579	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21399973|imex:IM-27579-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105894(gene)|ensembl:ENST00000348225(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007185"(transmembrane receptor protein tyrosine phosphatase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007507"(heart development)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021794"(thalamus development)|go:"GO:0030282"(bone mineralization)|refseq:NP_002816.1|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904397"(negative regulation of neuromuscular junction development)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1990089"(response to nerve growth factor)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|interpro:IPR000762(PTN/MK heparin-binding protein)|interpro:IPR020089|interpro:IPR020090|interpro:IPR020091|interpro:IPR020092|interpro:IPR037122|interpro:IPR038130|rcsb pdb:2N6F|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0140059"(dendrite arborization)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1903706"(regulation of hemopoiesis)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904389"(rod bipolar cell differentiation)|go:"GO:1904391"(response to ciliary neurotrophic factor)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045545"(syndecan binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046697"(decidualization)|go:"GO:0030324"(lung development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031104"(dendrite regeneration)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035373"(chondroitin sulfate proteoglycan binding)|go:"GO:0048477"(oogenesis)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060221"(retinal rod cell differentiation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0044849"(estrous cycle)|refseq:NP_001308315.1|refseq:NP_001308316.1|dip:DIP-5953N	refseq:NP_000623.2|refseq:NP_001139280.1|ensembl:ENSG00000169896(gene)|ensembl:ENST00000544665(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|rcsb pdb:1A8X|rcsb pdb:1BHO|rcsb pdb:1BHQ|rcsb pdb:1IDN|rcsb pdb:1IDO|rcsb pdb:1JLM|rcsb pdb:1M1U|rcsb pdb:1MF7|rcsb pdb:1N9Z|rcsb pdb:1NA5|rcsb pdb:2LKE|rcsb pdb:2LKJ|rcsb pdb:3Q3G|rcsb pdb:3QA3|rcsb pdb:4M76|rcsb pdb:4XW2|rcsb pdb:6RHW|reactome:R-HSA-166016|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-6798695	-	-	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/08	2019/05/08	rogid:vBF/t/qNd5/5ylZx9o1LbqIyvZE9606	rogid:LdazC8w25LRfb+vgr/kGcKmIkYo9606	rigid:GFtPFqOk5inAIRlKfQrRbgD6BZg	false	his tag:n-n|15n label:?-?	sufficient binding region:139-331	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21246	uniprotkb:P11215	intact:EBI-473725|ensembl:ENSP00000341170|uniprotkb:Q5U0B0|uniprotkb:Q6ICQ5|uniprotkb:Q9UCC6	intact:EBI-2568251|uniprotkb:Q4VAK0|uniprotkb:Q4VAK2|ensembl:ENSP00000441691|uniprotkb:Q4VAK1	psi-mi:ptn_human(display_long)|uniprotkb:Heparin-binding growth-associated molecule(gene name synonym)|uniprotkb:Heparin-binding growth factor 8(gene name synonym)|uniprotkb:Osteoblast-specific factor 1(gene name synonym)|uniprotkb:Heparin-binding neurite outgrowth-promoting factor 1(gene name synonym)|uniprotkb:Heparin-binding brain mitogen(gene name synonym)|uniprotkb:PTN(gene name)|psi-mi:PTN(display_short)|uniprotkb:HBNF1(gene name synonym)|uniprotkb:NEGF1(gene name synonym)|uniprotkb:Heparin-binding neurite outgrowth-promoting factor(gene name synonym)	psi-mi:itam_human(display_long)|uniprotkb:ITGAM(gene name)|psi-mi:ITGAM(display_short)|uniprotkb:CD11B(gene name synonym)|uniprotkb:CR3A(gene name synonym)|uniprotkb:Cell surface glycoprotein MAC-1 subunit alpha(gene name synonym)|uniprotkb:CR-3 alpha chain(gene name synonym)|uniprotkb:Leukocyte adhesion receptor MO1(gene name synonym)|uniprotkb:Neutrophil adherence receptor(gene name synonym)|uniprotkb:CD11 antigen-like family member B(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Shen et al. (2017)	pubmed:28939773|imex:IM-27579	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21399995|imex:IM-27579-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105894(gene)|ensembl:ENST00000348225(transcript)|go:"GO:0001889"(liver development)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007185"(transmembrane receptor protein tyrosine phosphatase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007507"(heart development)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021549"(cerebellum development)|go:"GO:0021794"(thalamus development)|go:"GO:0030282"(bone mineralization)|refseq:NP_002816.1|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904397"(negative regulation of neuromuscular junction development)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1990089"(response to nerve growth factor)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|interpro:IPR000762(PTN/MK heparin-binding protein)|interpro:IPR020089|interpro:IPR020090|interpro:IPR020091|interpro:IPR020092|interpro:IPR037122|interpro:IPR038130|rcsb pdb:2N6F|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0140059"(dendrite arborization)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1903706"(regulation of hemopoiesis)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904389"(rod bipolar cell differentiation)|go:"GO:1904391"(response to ciliary neurotrophic factor)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045545"(syndecan binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046697"(decidualization)|go:"GO:0030324"(lung development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031104"(dendrite regeneration)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035373"(chondroitin sulfate proteoglycan binding)|go:"GO:0048477"(oogenesis)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060221"(retinal rod cell differentiation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0044849"(estrous cycle)|refseq:NP_001308315.1|refseq:NP_001308316.1|dip:DIP-5953N	refseq:NP_000623.2|refseq:NP_001139280.1|ensembl:ENSG00000169896(gene)|ensembl:ENST00000544665(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045087"(innate immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150064"(vertebrate eye-specific patterning)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:1905114"(cell surface receptor signaling pathway involved in cell-cell signaling)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|rcsb pdb:1A8X|rcsb pdb:1BHO|rcsb pdb:1BHQ|rcsb pdb:1IDN|rcsb pdb:1IDO|rcsb pdb:1JLM|rcsb pdb:1M1U|rcsb pdb:1MF7|rcsb pdb:1N9Z|rcsb pdb:1NA5|rcsb pdb:2LKE|rcsb pdb:2LKJ|rcsb pdb:3Q3G|rcsb pdb:3QA3|rcsb pdb:4M76|rcsb pdb:4XW2|rcsb pdb:6RHW|reactome:R-HSA-166016|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-6798695	-	-	-	figure legend:Fig. 7A, 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/05/08	2019/05/08	rogid:vBF/t/qNd5/5ylZx9o1LbqIyvZE9606	rogid:LdazC8w25LRfb+vgr/kGcKmIkYo9606	rigid:GFtPFqOk5inAIRlKfQrRbgD6BZg	false	sufficient binding region:77-100|sufficient binding region:32-46|sufficient binding region:113-130|sufficient binding region:137-163	sufficient binding region:139-331|125i radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)