#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14678	uniprotkb:Q9NUN5	intact:EBI-714396|ensembl:ENSP00000349396|uniprotkb:Q6IAQ0|uniprotkb:Q96E75|uniprotkb:A8K5L7	intact:EBI-2805231|uniprotkb:Q9NZD6|uniprotkb:Q86Y70|uniprotkb:Q96FW4|uniprotkb:Q9BY56|uniprotkb:A8K204|uniprotkb:Q5VUN6|uniprotkb:E1P531|ensembl:ENSP00000497690	psi-mi:abcd4_human(display_long)|uniprotkb:Peroxisomal membrane protein 69(gene name synonym)|uniprotkb:Peroxisomal membrane protein 1-like(gene name synonym)|uniprotkb:PMP70-related protein(gene name synonym)|uniprotkb:ABCD4(gene name)|psi-mi:ABCD4(display_short)|uniprotkb:PXMP1L(gene name synonym)|uniprotkb:ATP-binding cassette sub-family D member 4(gene name synonym)	psi-mi:lmbd1_human(display_long)|uniprotkb:C6orf209(gene name synonym)|uniprotkb:NESI(gene name synonym)|uniprotkb:HDAg-L-interacting protein NESI(gene name synonym)|uniprotkb:LMBR1 domain-containing protein 1(gene name synonym)|uniprotkb:Nuclear export signal-interacting protein(gene name synonym)|uniprotkb:BM-021(orf name)|uniprotkb:CD001(orf name)|uniprotkb:MSTP044(orf name)|uniprotkb:LMBRD1(gene name)|psi-mi:LMBRD1(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Fettelschoss et al. (2017)	imex:IM-27072|pubmed:28572511	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21450130|imex:IM-27072-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000119688(gene)|ensembl:ENST00000356924(transcript)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0015420"(ABC-type vitamin B12 transporter activity)|go:"GO:0015889"(cobalamin transport)|go:"GO:0015910"(long-chain fatty acid import into peroxisome)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0055085"(transmembrane transport)|go:"GO:0140359"(ABC-type transporter activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|rcsb pdb:6JBJ|reactome:R-HSA-196741|reactome:R-HSA-5683329|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|refseq:NP_005041.1	refseq:XP_011534243.1|refseq:NP_060838.3|ensembl:ENSG00000168216(gene)|ensembl:ENST00000649934(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007369"(gastrulation)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0015420"(ABC-type vitamin B12 transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072665"(protein localization to vacuole)|interpro:IPR006876(LMBR1-like conserved region)|reactome:R-HSA-196741|reactome:R-HSA-3359458|go:"GO:0038016"(insulin receptor internalization)	-	-	-	figure legend:Figure 3a, 4a, S8a|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0")	-	2019/06/07	2019/06/07	rogid:ojfuYsHtwnxPMTGv3j6UAHICYOI9606	rogid:Dw1UVIzcLg+gauw4KLA87WGuiKQ9606	rigid:V9z6QhvdpzOdSL9i31k1ibny50k	false	red fluorescent protein tag:c-c|mutation decreasing interaction strength:141-141|mutation decreasing interaction strength:432-432|mutation decreasing interaction strength:548-548|mutation disrupting interaction strength:426-427|mutation decreasing interaction strength:426-426|mutation decreasing interaction strength:427-427	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9NUN5	uniprotkb:O14678	intact:EBI-2805231|uniprotkb:Q9NZD6|uniprotkb:Q86Y70|uniprotkb:Q96FW4|uniprotkb:Q9BY56|uniprotkb:A8K204|uniprotkb:Q5VUN6|uniprotkb:E1P531|ensembl:ENSP00000497690	intact:EBI-714396|ensembl:ENSP00000349396|uniprotkb:Q6IAQ0|uniprotkb:Q96E75|uniprotkb:A8K5L7	psi-mi:lmbd1_human(display_long)|uniprotkb:C6orf209(gene name synonym)|uniprotkb:NESI(gene name synonym)|uniprotkb:HDAg-L-interacting protein NESI(gene name synonym)|uniprotkb:LMBR1 domain-containing protein 1(gene name synonym)|uniprotkb:Nuclear export signal-interacting protein(gene name synonym)|uniprotkb:BM-021(orf name)|uniprotkb:CD001(orf name)|uniprotkb:MSTP044(orf name)|uniprotkb:LMBRD1(gene name)|psi-mi:LMBRD1(display_short)	psi-mi:abcd4_human(display_long)|uniprotkb:Peroxisomal membrane protein 69(gene name synonym)|uniprotkb:Peroxisomal membrane protein 1-like(gene name synonym)|uniprotkb:PMP70-related protein(gene name synonym)|uniprotkb:ABCD4(gene name)|psi-mi:ABCD4(display_short)|uniprotkb:PXMP1L(gene name synonym)|uniprotkb:ATP-binding cassette sub-family D member 4(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Fettelschoss et al. (2017)	imex:IM-27072|pubmed:28572511	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21450192|imex:IM-27072-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534243.1|refseq:NP_060838.3|ensembl:ENSG00000168216(gene)|ensembl:ENST00000649934(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007369"(gastrulation)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0015420"(ABC-type vitamin B12 transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072665"(protein localization to vacuole)|interpro:IPR006876(LMBR1-like conserved region)|reactome:R-HSA-196741|reactome:R-HSA-3359458|go:"GO:0038016"(insulin receptor internalization)	ensembl:ENSG00000119688(gene)|ensembl:ENST00000356924(transcript)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0015420"(ABC-type vitamin B12 transporter activity)|go:"GO:0015889"(cobalamin transport)|go:"GO:0015910"(long-chain fatty acid import into peroxisome)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0055085"(transmembrane transport)|go:"GO:0140359"(ABC-type transporter activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|rcsb pdb:6JBJ|reactome:R-HSA-196741|reactome:R-HSA-5683329|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|refseq:NP_005041.1	go:"GO:0005764"(lysosome)	-	-	figure legend:Figure 4b, S8b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0")	-	2019/06/07	2019/06/07	rogid:Dw1UVIzcLg+gauw4KLA87WGuiKQ9606	rogid:ojfuYsHtwnxPMTGv3j6UAHICYOI9606	rigid:V9z6QhvdpzOdSL9i31k1ibny50k	false	green fluorescent protein tag:c-c	red fluorescent protein tag:c-c|mutation decreasing interaction strength:141-141|mutation decreasing interaction strength:432-432|mutation decreasing interaction strength:548-548|mutation decreasing interaction strength:426-427|mutation decreasing interaction strength:426-426|mutation decreasing interaction strength:427-427	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9NUN5	uniprotkb:O14678	intact:EBI-2805231|uniprotkb:Q9NZD6|uniprotkb:Q86Y70|uniprotkb:Q96FW4|uniprotkb:Q9BY56|uniprotkb:A8K204|uniprotkb:Q5VUN6|uniprotkb:E1P531|ensembl:ENSP00000497690	intact:EBI-714396|ensembl:ENSP00000349396|uniprotkb:Q6IAQ0|uniprotkb:Q96E75|uniprotkb:A8K5L7	psi-mi:lmbd1_human(display_long)|uniprotkb:C6orf209(gene name synonym)|uniprotkb:NESI(gene name synonym)|uniprotkb:HDAg-L-interacting protein NESI(gene name synonym)|uniprotkb:LMBR1 domain-containing protein 1(gene name synonym)|uniprotkb:Nuclear export signal-interacting protein(gene name synonym)|uniprotkb:BM-021(orf name)|uniprotkb:CD001(orf name)|uniprotkb:MSTP044(orf name)|uniprotkb:LMBRD1(gene name)|psi-mi:LMBRD1(display_short)	psi-mi:abcd4_human(display_long)|uniprotkb:Peroxisomal membrane protein 69(gene name synonym)|uniprotkb:Peroxisomal membrane protein 1-like(gene name synonym)|uniprotkb:PMP70-related protein(gene name synonym)|uniprotkb:ABCD4(gene name)|psi-mi:ABCD4(display_short)|uniprotkb:PXMP1L(gene name synonym)|uniprotkb:ATP-binding cassette sub-family D member 4(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Fettelschoss et al. (2017)	imex:IM-27072|pubmed:28572511	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21450417|imex:IM-27072-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011534243.1|refseq:NP_060838.3|ensembl:ENSG00000168216(gene)|ensembl:ENST00000649934(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007369"(gastrulation)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0015420"(ABC-type vitamin B12 transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072665"(protein localization to vacuole)|interpro:IPR006876(LMBR1-like conserved region)|reactome:R-HSA-196741|reactome:R-HSA-3359458|go:"GO:0038016"(insulin receptor internalization)	ensembl:ENSG00000119688(gene)|ensembl:ENST00000356924(transcript)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0015420"(ABC-type vitamin B12 transporter activity)|go:"GO:0015889"(cobalamin transport)|go:"GO:0015910"(long-chain fatty acid import into peroxisome)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0043190"("ATP-binding cassette (ABC) transporter complex")|go:"GO:0055085"(transmembrane transport)|go:"GO:0140359"(ABC-type transporter activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|rcsb pdb:6JBJ|reactome:R-HSA-196741|reactome:R-HSA-5683329|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|refseq:NP_005041.1	go:"GO:0005764"(lysosome)	-	-	figure legend:Figure S2|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/06/07	2019/09/20	rogid:Dw1UVIzcLg+gauw4KLA87WGuiKQ9606	rogid:ojfuYsHtwnxPMTGv3j6UAHICYOI9606	rigid:V9z6QhvdpzOdSL9i31k1ibny50k	false	green fluorescent protein tag:c-c|mutation decreasing interaction strength:232-232	mkate:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)