#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BQ15	uniprotkb:P54132	intact:EBI-2120336|uniprotkb:Q6XYC8|uniprotkb:A6NDF8|ensembl:ENSP00000267023|ensembl:ENSP00000368862|ensembl:ENSP00000369545	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	psi-mi:sosb1_human(display_long)|uniprotkb:NABP2(gene name)|psi-mi:NABP2(display_short)|uniprotkb:Nucleic acid-binding protein 2(gene name synonym)|uniprotkb:OBFC2B(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 2B(gene name synonym)|uniprotkb:SSB1(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit B1(gene name synonym)|uniprotkb:Sensor of ssDNA subunit B1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein 1(gene name synonym)|uniprotkb:LP3587(orf name)	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21139623|imex:IM-26827-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076973.1|refseq:XP_005269205.1|refseq:XP_005269206.1|ensembl:ENSG00000139579(gene)|ensembl:ENST00000267023(transcript)|ensembl:ENST00000341463(transcript)|ensembl:ENST00000380198(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0070876"(SOSS complex)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:5D8E|rcsb pdb:5D8F|reactome:R-HSA-6807505	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	-	-	-	figure legend:Fig. 1a, 1d|comment:Treatment with hydroxy urea did not affect the level of binding; but ionizing radiation exposure reduced interaction at initial stage and let to recovery after some time.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/29	rogid:6DsQucffddtyHikGkCiY7xaguaY9606	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rigid:S1guCBPGiRs2ea5yVrhwRb/BLmM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BQ15	uniprotkb:P54132	intact:EBI-2120336|uniprotkb:Q6XYC8|uniprotkb:A6NDF8|ensembl:ENSP00000267023|ensembl:ENSP00000368862|ensembl:ENSP00000369545	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	psi-mi:sosb1_human(display_long)|uniprotkb:NABP2(gene name)|psi-mi:NABP2(display_short)|uniprotkb:Nucleic acid-binding protein 2(gene name synonym)|uniprotkb:OBFC2B(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 2B(gene name synonym)|uniprotkb:SSB1(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit B1(gene name synonym)|uniprotkb:Sensor of ssDNA subunit B1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein 1(gene name synonym)|uniprotkb:LP3587(orf name)	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21145887|imex:IM-26827-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076973.1|refseq:XP_005269205.1|refseq:XP_005269206.1|ensembl:ENSG00000139579(gene)|ensembl:ENST00000267023(transcript)|ensembl:ENST00000341463(transcript)|ensembl:ENST00000380198(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0070876"(SOSS complex)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:5D8E|rcsb pdb:5D8F|reactome:R-HSA-6807505	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	-	-	-	figure legend:Fig. 1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/29	rogid:6DsQucffddtyHikGkCiY7xaguaY9606	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rigid:TxnXcfgoo9YNLI9cYTiEONc6ls0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BQ15	uniprotkb:Q68E01	intact:EBI-2120336|uniprotkb:Q6XYC8|uniprotkb:A6NDF8|ensembl:ENSP00000267023|ensembl:ENSP00000368862|ensembl:ENSP00000369545	intact:EBI-2680854|uniprotkb:Q8TB23|uniprotkb:Q6MZQ4|uniprotkb:Q9H6S9|uniprotkb:Q6AI57|uniprotkb:Q5VUQ6|uniprotkb:Q4G0E5|uniprotkb:B4DQC8|uniprotkb:B4E3U9|uniprotkb:A8K1W0|uniprotkb:Q8NC46|uniprotkb:Q68DJ1|uniprotkb:Q6DKG7|uniprotkb:Q5VUR1|uniprotkb:Q6MZZ9|uniprotkb:Q5VUQ5|uniprotkb:Q69YR5|uniprotkb:Q5VUR0|uniprotkb:D3DV57	psi-mi:sosb1_human(display_long)|uniprotkb:NABP2(gene name)|psi-mi:NABP2(display_short)|uniprotkb:Nucleic acid-binding protein 2(gene name synonym)|uniprotkb:OBFC2B(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 2B(gene name synonym)|uniprotkb:SSB1(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit B1(gene name synonym)|uniprotkb:Sensor of ssDNA subunit B1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein 1(gene name synonym)|uniprotkb:LP3587(orf name)	psi-mi:int3_human(display_long)|uniprotkb:INTS3(gene name)|psi-mi:INTS3(display_short)|uniprotkb:C1orf193(gene name synonym)|uniprotkb:C1orf60(gene name synonym)|uniprotkb:SOSS complex subunit A(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21145887|imex:IM-26827-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076973.1|refseq:XP_005269205.1|refseq:XP_005269206.1|ensembl:ENSG00000139579(gene)|ensembl:ENST00000267023(transcript)|ensembl:ENST00000341463(transcript)|ensembl:ENST00000380198(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0070876"(SOSS complex)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:5D8E|rcsb pdb:5D8F|reactome:R-HSA-6807505	refseq:NP_075391.3|interpro:IPR019333|refseq:XP_005245518.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070876"(SOSS complex)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:6WLG|reactome:R-HSA-6807505|refseq:NP_001311404.1|mint:Q68E01	-	-	-	figure legend:Fig. 1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/29	rogid:6DsQucffddtyHikGkCiY7xaguaY9606	rogid:GxQTTVSOwBdWifr7ZdM8Zbqxy5M9606	rigid:TxnXcfgoo9YNLI9cYTiEONc6ls0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54132	uniprotkb:P15927	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21146499|imex:IM-26827-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N	-	-	-	figure legend:Fig 1e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/29	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	rigid:pIJ/ye4LuEUT7s+XsiaZUgBZPCA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54132	uniprotkb:P49959	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	intact:EBI-396513|uniprotkb:O43475|uniprotkb:B3KTC7|ensembl:ENSP00000325863	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:mre11_human(display_long)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)|uniprotkb:Double-strand break repair protein MRE11A(gene name synonym)|uniprotkb:HNGS1(gene name synonym)|uniprotkb:MRE11A(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog 1(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21146499|imex:IM-26827-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	refseq:NP_005581.2|refseq:NP_005582.1|refseq:XP_011541139.1|refseq:XP_016873261.1|dip:DIP-33238N|ensembl:ENSG00000020922(gene)|ensembl:ENST00000323929(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016605"(PML body)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|go:"GO:0110025"(DNA strand resection involved in replication fork processing)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|mint:P49959|rcsb pdb:3T1I|reactome:R-HSA-1834949|reactome:R-HSA-2559586|reactome:R-HSA-3270619|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446	-	-	-	figure legend:Fig 1e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/29	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rogid:fgwgA0BcNZ9phGBaOSYjkldDgeI9606	rigid:pIJ/ye4LuEUT7s+XsiaZUgBZPCA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54132	uniprotkb:Q68E01	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	intact:EBI-2680854|uniprotkb:Q8TB23|uniprotkb:Q6MZQ4|uniprotkb:Q9H6S9|uniprotkb:Q6AI57|uniprotkb:Q5VUQ6|uniprotkb:Q4G0E5|uniprotkb:B4DQC8|uniprotkb:B4E3U9|uniprotkb:A8K1W0|uniprotkb:Q8NC46|uniprotkb:Q68DJ1|uniprotkb:Q6DKG7|uniprotkb:Q5VUR1|uniprotkb:Q6MZZ9|uniprotkb:Q5VUQ5|uniprotkb:Q69YR5|uniprotkb:Q5VUR0|uniprotkb:D3DV57	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:int3_human(display_long)|uniprotkb:INTS3(gene name)|psi-mi:INTS3(display_short)|uniprotkb:C1orf193(gene name synonym)|uniprotkb:C1orf60(gene name synonym)|uniprotkb:SOSS complex subunit A(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21146499|imex:IM-26827-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	refseq:NP_075391.3|interpro:IPR019333|refseq:XP_005245518.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070876"(SOSS complex)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:6WLG|reactome:R-HSA-6807505|refseq:NP_001311404.1|mint:Q68E01	-	-	-	figure legend:Fig 1e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/29	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rogid:GxQTTVSOwBdWifr7ZdM8Zbqxy5M9606	rigid:pIJ/ye4LuEUT7s+XsiaZUgBZPCA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54132	uniprotkb:Q9BQ15	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	intact:EBI-2120336|uniprotkb:Q6XYC8|uniprotkb:A6NDF8|ensembl:ENSP00000267023|ensembl:ENSP00000368862|ensembl:ENSP00000369545	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:sosb1_human(display_long)|uniprotkb:NABP2(gene name)|psi-mi:NABP2(display_short)|uniprotkb:Nucleic acid-binding protein 2(gene name synonym)|uniprotkb:OBFC2B(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 2B(gene name synonym)|uniprotkb:SSB1(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit B1(gene name synonym)|uniprotkb:Sensor of ssDNA subunit B1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein 1(gene name synonym)|uniprotkb:LP3587(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21146505|imex:IM-26827-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	refseq:NP_076973.1|refseq:XP_005269205.1|refseq:XP_005269206.1|ensembl:ENSG00000139579(gene)|ensembl:ENST00000267023(transcript)|ensembl:ENST00000341463(transcript)|ensembl:ENST00000380198(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0070876"(SOSS complex)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:5D8E|rcsb pdb:5D8F|reactome:R-HSA-6807505	-	-	-	figure legend:Fig 1e|comment:Presence of the p.Phe89Ala mutant version of hSSB1 / SOSB1 decreases the abundance of co-immunoprecipitated INTS3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/29	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rogid:6DsQucffddtyHikGkCiY7xaguaY9606	rigid:1H2c9WCX2UuglFWW/f3JmsDCHww	false	-	flag tag:n-n|mutation:98-98	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P54132	uniprotkb:P15927	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21146505|imex:IM-26827-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N	-	-	-	figure legend:Fig 1e|comment:Presence of the p.Phe89Ala mutant version of hSSB1 / SOSB1 decreases the abundance of co-immunoprecipitated INTS3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/29	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	rigid:1H2c9WCX2UuglFWW/f3JmsDCHww	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54132	uniprotkb:P49959	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	intact:EBI-396513|uniprotkb:O43475|uniprotkb:B3KTC7|ensembl:ENSP00000325863	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:mre11_human(display_long)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)|uniprotkb:Double-strand break repair protein MRE11A(gene name synonym)|uniprotkb:HNGS1(gene name synonym)|uniprotkb:MRE11A(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog 1(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21146505|imex:IM-26827-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	refseq:NP_005581.2|refseq:NP_005582.1|refseq:XP_011541139.1|refseq:XP_016873261.1|dip:DIP-33238N|ensembl:ENSG00000020922(gene)|ensembl:ENST00000323929(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016605"(PML body)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|go:"GO:0110025"(DNA strand resection involved in replication fork processing)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|mint:P49959|rcsb pdb:3T1I|reactome:R-HSA-1834949|reactome:R-HSA-2559586|reactome:R-HSA-3270619|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446	-	-	-	figure legend:Fig 1e|comment:Presence of the p.Phe89Ala mutant version of hSSB1 / SOSB1 decreases the abundance of co-immunoprecipitated INTS3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/29	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rogid:fgwgA0BcNZ9phGBaOSYjkldDgeI9606	rigid:1H2c9WCX2UuglFWW/f3JmsDCHww	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54132	uniprotkb:Q68E01	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	intact:EBI-2680854|uniprotkb:Q8TB23|uniprotkb:Q6MZQ4|uniprotkb:Q9H6S9|uniprotkb:Q6AI57|uniprotkb:Q5VUQ6|uniprotkb:Q4G0E5|uniprotkb:B4DQC8|uniprotkb:B4E3U9|uniprotkb:A8K1W0|uniprotkb:Q8NC46|uniprotkb:Q68DJ1|uniprotkb:Q6DKG7|uniprotkb:Q5VUR1|uniprotkb:Q6MZZ9|uniprotkb:Q5VUQ5|uniprotkb:Q69YR5|uniprotkb:Q5VUR0|uniprotkb:D3DV57	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:int3_human(display_long)|uniprotkb:INTS3(gene name)|psi-mi:INTS3(display_short)|uniprotkb:C1orf193(gene name synonym)|uniprotkb:C1orf60(gene name synonym)|uniprotkb:SOSS complex subunit A(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21146505|imex:IM-26827-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	refseq:NP_075391.3|interpro:IPR019333|refseq:XP_005245518.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070876"(SOSS complex)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:6WLG|reactome:R-HSA-6807505|refseq:NP_001311404.1|mint:Q68E01	-	-	-	figure legend:Fig 1e|comment:Presence of the p.Phe89Ala mutant version of hSSB1 / SOSB1 decreases the abundance of co-immunoprecipitated INTS3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/29	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rogid:GxQTTVSOwBdWifr7ZdM8Zbqxy5M9606	rigid:1H2c9WCX2UuglFWW/f3JmsDCHww	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54132	uniprotkb:Q9BQ15	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	intact:EBI-2120336|uniprotkb:Q6XYC8|uniprotkb:A6NDF8|ensembl:ENSP00000267023|ensembl:ENSP00000368862|ensembl:ENSP00000369545	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:sosb1_human(display_long)|uniprotkb:NABP2(gene name)|psi-mi:NABP2(display_short)|uniprotkb:Nucleic acid-binding protein 2(gene name synonym)|uniprotkb:OBFC2B(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 2B(gene name synonym)|uniprotkb:SSB1(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit B1(gene name synonym)|uniprotkb:Sensor of ssDNA subunit B1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein 1(gene name synonym)|uniprotkb:LP3587(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21174619|imex:IM-26827-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	refseq:NP_076973.1|refseq:XP_005269205.1|refseq:XP_005269206.1|ensembl:ENSG00000139579(gene)|ensembl:ENST00000267023(transcript)|ensembl:ENST00000341463(transcript)|ensembl:ENST00000380198(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0070876"(SOSS complex)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:5D8E|rcsb pdb:5D8F|reactome:R-HSA-6807505	-	-	-	figure legend:Fig 1e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/31	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rogid:6DsQucffddtyHikGkCiY7xaguaY9606	rigid:1H2c9WCX2UuglFWW/f3JmsDCHww	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P54132	uniprotkb:P15927	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21174619|imex:IM-26827-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N	-	-	-	figure legend:Fig 1e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/31	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	rigid:1H2c9WCX2UuglFWW/f3JmsDCHww	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54132	uniprotkb:P49959	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	intact:EBI-396513|uniprotkb:O43475|uniprotkb:B3KTC7|ensembl:ENSP00000325863	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:mre11_human(display_long)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)|uniprotkb:Double-strand break repair protein MRE11A(gene name synonym)|uniprotkb:HNGS1(gene name synonym)|uniprotkb:MRE11A(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog 1(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21174619|imex:IM-26827-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	refseq:NP_005581.2|refseq:NP_005582.1|refseq:XP_011541139.1|refseq:XP_016873261.1|dip:DIP-33238N|ensembl:ENSG00000020922(gene)|ensembl:ENST00000323929(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016605"(PML body)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|go:"GO:0110025"(DNA strand resection involved in replication fork processing)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|mint:P49959|rcsb pdb:3T1I|reactome:R-HSA-1834949|reactome:R-HSA-2559586|reactome:R-HSA-3270619|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446	-	-	-	figure legend:Fig 1e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/31	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rogid:fgwgA0BcNZ9phGBaOSYjkldDgeI9606	rigid:1H2c9WCX2UuglFWW/f3JmsDCHww	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54132	uniprotkb:Q68E01	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	intact:EBI-2680854|uniprotkb:Q8TB23|uniprotkb:Q6MZQ4|uniprotkb:Q9H6S9|uniprotkb:Q6AI57|uniprotkb:Q5VUQ6|uniprotkb:Q4G0E5|uniprotkb:B4DQC8|uniprotkb:B4E3U9|uniprotkb:A8K1W0|uniprotkb:Q8NC46|uniprotkb:Q68DJ1|uniprotkb:Q6DKG7|uniprotkb:Q5VUR1|uniprotkb:Q6MZZ9|uniprotkb:Q5VUQ5|uniprotkb:Q69YR5|uniprotkb:Q5VUR0|uniprotkb:D3DV57	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:int3_human(display_long)|uniprotkb:INTS3(gene name)|psi-mi:INTS3(display_short)|uniprotkb:C1orf193(gene name synonym)|uniprotkb:C1orf60(gene name synonym)|uniprotkb:SOSS complex subunit A(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21174619|imex:IM-26827-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	refseq:NP_075391.3|interpro:IPR019333|refseq:XP_005245518.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070876"(SOSS complex)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:6WLG|reactome:R-HSA-6807505|refseq:NP_001311404.1|mint:Q68E01	-	-	-	figure legend:Fig 1e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/01/29	2019/01/31	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rogid:GxQTTVSOwBdWifr7ZdM8Zbqxy5M9606	rigid:1H2c9WCX2UuglFWW/f3JmsDCHww	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54132	uniprotkb:Q9BQ15	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	intact:EBI-2120336|uniprotkb:Q6XYC8|uniprotkb:A6NDF8|ensembl:ENSP00000267023|ensembl:ENSP00000368862|ensembl:ENSP00000369545	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:sosb1_human(display_long)|uniprotkb:NABP2(gene name)|psi-mi:NABP2(display_short)|uniprotkb:Nucleic acid-binding protein 2(gene name synonym)|uniprotkb:OBFC2B(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 2B(gene name synonym)|uniprotkb:SSB1(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit B1(gene name synonym)|uniprotkb:Sensor of ssDNA subunit B1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein 1(gene name synonym)|uniprotkb:LP3587(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21146376|imex:IM-26827-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	refseq:NP_076973.1|refseq:XP_005269205.1|refseq:XP_005269206.1|ensembl:ENSG00000139579(gene)|ensembl:ENST00000267023(transcript)|ensembl:ENST00000341463(transcript)|ensembl:ENST00000380198(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0070876"(SOSS complex)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:5D8E|rcsb pdb:5D8F|reactome:R-HSA-6807505|go:"GO:0005634"(nucleus)	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig 2a, Fig 2b|comment:On exposure to ioinising radiation, staining for both the proteins were significantly increased at 1 hour and 3 hour; peak increase was observed post 3 hours of exposure. When cells were exposed to hydroxy urea, increased staining was observed at 4 hour and 20 hours after treatment|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/01/29	2019/01/30	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rogid:6DsQucffddtyHikGkCiY7xaguaY9606	rigid:S1guCBPGiRs2ea5yVrhwRb/BLmM	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9BQ15	uniprotkb:P54132	intact:EBI-2120336|uniprotkb:Q6XYC8|uniprotkb:A6NDF8|ensembl:ENSP00000267023|ensembl:ENSP00000368862|ensembl:ENSP00000369545	intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96	psi-mi:sosb1_human(display_long)|uniprotkb:NABP2(gene name)|psi-mi:NABP2(display_short)|uniprotkb:Nucleic acid-binding protein 2(gene name synonym)|uniprotkb:OBFC2B(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 2B(gene name synonym)|uniprotkb:SSB1(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit B1(gene name synonym)|uniprotkb:Sensor of ssDNA subunit B1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein 1(gene name synonym)|uniprotkb:LP3587(orf name)	psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21147374|imex:IM-26827-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076973.1|refseq:XP_005269205.1|refseq:XP_005269206.1|ensembl:ENSG00000139579(gene)|ensembl:ENST00000267023(transcript)|ensembl:ENST00000341463(transcript)|ensembl:ENST00000380198(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0070876"(SOSS complex)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:5D8E|rcsb pdb:5D8F|reactome:R-HSA-6807505	go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N	-	-	-	figure legend:Suppl. Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/01/29	2019/01/30	rogid:6DsQucffddtyHikGkCiY7xaguaY9606	rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606	rigid:S1guCBPGiRs2ea5yVrhwRb/BLmM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BQ15	uniprotkb:Q68E01	intact:EBI-2120336|uniprotkb:Q6XYC8|uniprotkb:A6NDF8|ensembl:ENSP00000267023|ensembl:ENSP00000368862|ensembl:ENSP00000369545	intact:EBI-2680854|uniprotkb:Q8TB23|uniprotkb:Q6MZQ4|uniprotkb:Q9H6S9|uniprotkb:Q6AI57|uniprotkb:Q5VUQ6|uniprotkb:Q4G0E5|uniprotkb:B4DQC8|uniprotkb:B4E3U9|uniprotkb:A8K1W0|uniprotkb:Q8NC46|uniprotkb:Q68DJ1|uniprotkb:Q6DKG7|uniprotkb:Q5VUR1|uniprotkb:Q6MZZ9|uniprotkb:Q5VUQ5|uniprotkb:Q69YR5|uniprotkb:Q5VUR0|uniprotkb:D3DV57	psi-mi:sosb1_human(display_long)|uniprotkb:NABP2(gene name)|psi-mi:NABP2(display_short)|uniprotkb:Nucleic acid-binding protein 2(gene name synonym)|uniprotkb:OBFC2B(gene name synonym)|uniprotkb:Oligonucleotide/oligosaccharide-binding fold-containing protein 2B(gene name synonym)|uniprotkb:SSB1(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit B1(gene name synonym)|uniprotkb:Sensor of ssDNA subunit B1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein 1(gene name synonym)|uniprotkb:LP3587(orf name)	psi-mi:int3_human(display_long)|uniprotkb:INTS3(gene name)|psi-mi:INTS3(display_short)|uniprotkb:C1orf193(gene name synonym)|uniprotkb:C1orf60(gene name synonym)|uniprotkb:SOSS complex subunit A(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Croft et al. (2017)	pubmed:28506294|imex:IM-26827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21147379|imex:IM-26827-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076973.1|refseq:XP_005269205.1|refseq:XP_005269206.1|ensembl:ENSG00000139579(gene)|ensembl:ENST00000267023(transcript)|ensembl:ENST00000341463(transcript)|ensembl:ENST00000380198(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0070876"(SOSS complex)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:5D8E|rcsb pdb:5D8F|reactome:R-HSA-6807505	refseq:NP_075391.3|interpro:IPR019333|refseq:XP_005245518.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070876"(SOSS complex)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:6WLG|reactome:R-HSA-6807505|refseq:NP_001311404.1|mint:Q68E01	-	-	-	figure legend:Suppl. Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/01/29	2019/01/30	rogid:6DsQucffddtyHikGkCiY7xaguaY9606	rogid:GxQTTVSOwBdWifr7ZdM8Zbqxy5M9606	rigid:Z/lRA7bQrB17ROazZCJ0aRXHM8w	false	mutation disrupting interaction strength:98-98|flag tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)