#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92878	uniprotkb:Q92878	intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100	intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100	psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)	psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)	psi-mi:"MI:0826"(x ray scattering)	Park et al. (2017)	pubmed:28134932|imex:IM-27165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21350384|wwpdb:5GOX|imex:IM-27165-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50)	refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50)	-	-	-	figure legend:Figure 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/27	2019/04/27	rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606	rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606	rigid:X5EDzFRyGdxSre7ukRU+MJeR4KQ	false	binding-associated region:351-532|his tag:n-n	binding-associated region:351-532|his tag:n-n	2	0	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q92878	uniprotkb:Q92878	intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100	intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100	psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)	psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Park et al. (2017)	pubmed:28134932|imex:IM-27165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21453591|wwpdb:5GOX|imex:IM-27165-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50)	refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50)	-	-	-	figure legend:Figure 1a,b, Table 1, Supplementary Fig. 1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/27	2019/06/16	rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606	rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606	rigid:X5EDzFRyGdxSre7ukRU+MJeR4KQ	false	binding-associated region:585-766|his tag:n-n	binding-associated region:585-766|his tag:n-n	2	0	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q92878	uniprotkb:Q92878	intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100	intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100	psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)	psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)	psi-mi:"MI:0030"(cross-linking study)	Park et al. (2017)	pubmed:28134932|imex:IM-27165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21453625|imex:IM-27165-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50)	refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50)	-	-	-	figure legend:Figure 4h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/01/27	2019/06/16	rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606	rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606	rigid:X5EDzFRyGdxSre7ukRU+MJeR4KQ	false	binding-associated region:585-766|his tag:n-n	binding-associated region:585-766|his tag:n-n	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92878	uniprotkb:Q92878	intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100	intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100	psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)	psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)	psi-mi:"MI:0030"(cross-linking study)	Park et al. (2017)	pubmed:28134932|imex:IM-27165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21454620|imex:IM-27165-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50)	refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50)	-	-	-	figure legend:Figure 4j|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2019/01/27	2019/06/19	rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606	rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606	rigid:9irhqbRZ0ud+2ZFZLUTV3xajaHc	false	binding-associated region:585-766|mutation:738-738|his tag:n-n	binding-associated region:585-766|mutation:599-599|his tag:n-n	2	2	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92878	uniprotkb:Q92878	intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100	intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100	psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)	psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Park et al. (2017)	pubmed:28134932|imex:IM-27165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21453620|imex:IM-27165-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50)	refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50)	-	-	-	figure legend:Figure 4f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/27	2019/07/11	rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606	rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606	rigid:9irhqbRZ0ud+2ZFZLUTV3xajaHc	false	binding-associated region:651-722|fluorescent dye label:?-?	binding-associated region:651-722|fluorescent dye label:?-?	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32829	uniprotkb:P33301	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-20599|uniprotkb:D6VT00|ensemblfungi:YDR369C	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:xrs2_yeast(display_long)|uniprotkb:XRS2(gene name)|psi-mi:XRS2(display_short)|uniprotkb:D9481.13(orf name)|uniprotkb:YDR369C(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Park et al. (2017)	pubmed:28134932|imex:IM-27165	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21454368|imex:IM-27165-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	sgd:S000002777|refseq:NP_010657.3|ensemblfungi:YDR369C(gene)|ensemblfungi:YDR369C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|dip:DIP-2420N|mint:P33301	-	crc64:D58433E32E852B73	crc64:833DAD6D20F6693E	figure legend:Supplementary Figure 2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2019/01/27	2019/07/11	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:o505mxGL67ZY1mBUls7e15A4JTY559292	rigid:yZf89qyO97mr7yLmN2GqNxx5Xm4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32829	uniprotkb:P12753	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-14700|uniprotkb:D6W0U3|ensemblfungi:YNL250W	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:rad50_yeast(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)|uniprotkb:YNL250W(locus name)|uniprotkb:N0872(orf name)|uniprotkb:153 kDa protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Park et al. (2017)	pubmed:28134932|imex:IM-27165	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21454368|imex:IM-27165-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	refseq:NP_014149.1|sgd:S000005194|ensemblfungi:YNL250W(gene)|ensemblfungi:YNL250W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0032078"(negative regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR004584(Recombination/repair protein Rad50)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|reactome:R-SCE-5693548|go:"GO:0007129"(homologous chromosome pairing at meiosis)|dip:DIP-2419N|mint:P12753	-	crc64:D58433E32E852B73	crc64:58A0AA173AC5677E	figure legend:Supplementary Figure 2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2019/01/27	2019/07/11	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:5Fc4FL8mWNa6ZVO7CVaEwv5ccuk559292	rigid:yZf89qyO97mr7yLmN2GqNxx5Xm4	false	-	mutation:639-639|mutation:641-641|mutation:644-644	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32829	uniprotkb:Q92878	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Park et al. (2017)	pubmed:28134932|imex:IM-27165	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21454567|imex:IM-27165-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50)	-	crc64:D58433E32E852B73	-	figure legend:Figure 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2019/01/27	2019/07/11	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606	rigid:aKzvpV+OCuKK77WDKb3PQIwl3cU	false	-	mutation decreasing interaction:682-682|binding-associated region:751-766,669-701,585-613|mutation decreasing interaction:679-679|his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32829	uniprotkb:P33301	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-20599|uniprotkb:D6VT00|ensemblfungi:YDR369C	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:xrs2_yeast(display_long)|uniprotkb:XRS2(gene name)|psi-mi:XRS2(display_short)|uniprotkb:D9481.13(orf name)|uniprotkb:YDR369C(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Park et al. (2017)	pubmed:28134932|imex:IM-27165	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-21454567|imex:IM-27165-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	sgd:S000002777|refseq:NP_010657.3|ensemblfungi:YDR369C(gene)|ensemblfungi:YDR369C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|dip:DIP-2420N|mint:P33301	-	crc64:D58433E32E852B73	crc64:833DAD6D20F6693E	figure legend:Figure 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2019/01/27	2019/07/11	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:o505mxGL67ZY1mBUls7e15A4JTY559292	rigid:aKzvpV+OCuKK77WDKb3PQIwl3cU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)