#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A0A0B4L3F2	uniprotkb:O11875	intact:EBI-22275764	intact:EBI-22275701	psi-mi:a0a0b4l3f2_9flav(display_long)|uniprotkb:Envelope protein E(gene name synonym)|uniprotkb:Flavivirin protease NS2B regulatory subunit(gene name synonym)|uniprotkb:Flavivirin protease NS3 catalytic subunit(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Matrix protein(gene name synonym)|uniprotkb:Non-structural protein 1(gene name synonym)|uniprotkb:Non-structural protein 2A(gene name synonym)|uniprotkb:Non-structural protein 2B(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Peptide 2k(gene name synonym)|uniprotkb:Peptide pr(gene name synonym)|uniprotkb:Protein prM(gene name synonym)|uniprotkb:RNA-directed RNA polymerase NS5(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:Serine protease subunit NS2B(gene name synonym)|uniprotkb:Small envelope protein M(gene name synonym)|uniprotkb:Non-structural protein 5(gene name synonym)	psi-mi:o11875_9flav(display_long)|uniprotkb:Envelope protein E(gene name synonym)|uniprotkb:Flavivirin protease NS2B regulatory subunit(gene name synonym)|uniprotkb:Flavivirin protease NS3 catalytic subunit(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Matrix protein(gene name synonym)|uniprotkb:Non-structural protein 1(gene name synonym)|uniprotkb:Non-structural protein 2A(gene name synonym)|uniprotkb:Non-structural protein 2B(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Peptide 2k(gene name synonym)|uniprotkb:Peptide pr(gene name synonym)|uniprotkb:Protein prM(gene name synonym)|uniprotkb:RNA-directed RNA polymerase NS5(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:Serine protease subunit NS2B(gene name synonym)|uniprotkb:Small envelope protein M(gene name synonym)|uniprotkb:Non-structural protein 5(gene name synonym)	psi-mi:"MI:0410"(3D electron microscopy)	Prasad et al. (2017)	imex:IM-27594|pubmed:28067914	taxid:11060(dengue virus 2)|taxid:11060(Dengue virus 2)	taxid:11060(dengue virus 2)|taxid:11060(Dengue virus 2)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22275699|imex:IM-27594-1|wwpdb:5U4W|emdb:EMD-8508	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0055036"(virion membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:5U4W|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR038302|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR037172|interpro:IPR026470|interpro:IPR038345|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR038688|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR036253|interpro:IPR038055|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027287|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026490|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|interpro:IPR043502|interpro:IPR043504	go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0055036"(virion membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:3C6E|rcsb pdb:3J42|rcsb pdb:5U4W|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR038302|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR037172|interpro:IPR027287|interpro:IPR026470|interpro:IPR038345|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR038688|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR036253|interpro:IPR038055|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026490|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|rcsb pdb:6ZQU|interpro:IPR043502|interpro:IPR043504	-	-	-	figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/10	2020/03/25	rogid:O3Yg0poa4QUBJr9bR/eZlSNv49I11060	rogid:f73whiRfWkU71s/2ALy6TiSs5bQ11060	rigid:ckNaOhaKsC5gpqiHhht+Ue1ISqc	false	binding-associated region:115-195	binding-associated region:281-674	3	3	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A0B4L3F2	uniprotkb:A0A024B7W1	intact:EBI-22275764	intact:EBI-22275825	psi-mi:a0a0b4l3f2_9flav(display_long)|uniprotkb:Envelope protein E(gene name synonym)|uniprotkb:Flavivirin protease NS2B regulatory subunit(gene name synonym)|uniprotkb:Flavivirin protease NS3 catalytic subunit(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Matrix protein(gene name synonym)|uniprotkb:Non-structural protein 1(gene name synonym)|uniprotkb:Non-structural protein 2A(gene name synonym)|uniprotkb:Non-structural protein 2B(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Peptide 2k(gene name synonym)|uniprotkb:Peptide pr(gene name synonym)|uniprotkb:Protein prM(gene name synonym)|uniprotkb:RNA-directed RNA polymerase NS5(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:Serine protease subunit NS2B(gene name synonym)|uniprotkb:Small envelope protein M(gene name synonym)|uniprotkb:Non-structural protein 5(gene name synonym)	psi-mi:polg_zikvf(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Prasad et al. (2017)	imex:IM-27594|pubmed:28067914	taxid:11060(dengue virus 2)|taxid:11060(Dengue virus 2)	taxid:2043570(isolate ZIKV/Human/French Polynesia/10087PF/2013)|taxid:2043570(Zika virus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22275699|imex:IM-27594-1|wwpdb:5U4W|emdb:EMD-8508	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0055036"(virion membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:5U4W|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR038302|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR037172|interpro:IPR026470|interpro:IPR038345|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR038688|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR036253|interpro:IPR038055|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027287|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026490|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|interpro:IPR043502|interpro:IPR043504	go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140272"(exogenous protein binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR038688|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR036253|interpro:IPR038055|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026490|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|rcsb pdb:5GOZ|rcsb pdb:5GP1|rcsb pdb:5H30|rcsb pdb:5H32|rcsb pdb:5H37|rcsb pdb:5IRE|rcsb pdb:5IZ7|rcsb pdb:5JMT|rcsb pdb:5KQR|rcsb pdb:5KQS|rcsb pdb:5KVE|rcsb pdb:5LBS|rcsb pdb:5LBV|rcsb pdb:5LCV|rcsb pdb:5M5B|rcsb pdb:5MRK|rcsb pdb:5NJU|rcsb pdb:5NJV|rcsb pdb:5U4W|rcsb pdb:5UHY|rcsb pdb:5ULP|rcsb pdb:5Y0A|rcsb pdb:5Y6M|rcsb pdb:5Y6N|rcsb pdb:6CO8|rcsb pdb:6I7P|rcsb pdb:6JFI|rcsb pdb:6JFH|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR038302|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR037172|interpro:IPR027287|interpro:IPR026470|interpro:IPR038345|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|rcsb pdb:6RWZ|rcsb pdb:6S0J|rcsb pdb:7BSD|rcsb pdb:6NIP|rcsb pdb:6NIU|interpro:IPR043502|rcsb pdb:6PLK|rcsb pdb:7BU8|rcsb pdb:7BUA|rcsb pdb:6LD1|rcsb pdb:6LD2|rcsb pdb:6LD3|rcsb pdb:6LD4|rcsb pdb:6LD5|rcsb pdb:6UM3	-	-	-	figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/10	2020/03/25	rogid:O3Yg0poa4QUBJr9bR/eZlSNv49I11060	rogid:fKC1IID5xJenf+J2o0+x/1KVACA2043570	rigid:ckNaOhaKsC5gpqiHhht+Ue1ISqc	false	binding-associated region:115-195	binding-associated region:238-290	3	3	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:A0A0B4L3F2	uniprotkb:A0A024B7W1	intact:EBI-22275764	intact:EBI-22275825	psi-mi:a0a0b4l3f2_9flav(display_long)|uniprotkb:Envelope protein E(gene name synonym)|uniprotkb:Flavivirin protease NS2B regulatory subunit(gene name synonym)|uniprotkb:Flavivirin protease NS3 catalytic subunit(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:Matrix protein(gene name synonym)|uniprotkb:Non-structural protein 1(gene name synonym)|uniprotkb:Non-structural protein 2A(gene name synonym)|uniprotkb:Non-structural protein 2B(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Peptide 2k(gene name synonym)|uniprotkb:Peptide pr(gene name synonym)|uniprotkb:Protein prM(gene name synonym)|uniprotkb:RNA-directed RNA polymerase NS5(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:Serine protease subunit NS2B(gene name synonym)|uniprotkb:Small envelope protein M(gene name synonym)|uniprotkb:Non-structural protein 5(gene name synonym)	psi-mi:polg_zikvf(display_long)	psi-mi:"MI:0410"(3D electron microscopy)	Prasad et al. (2017)	imex:IM-27594|pubmed:28067914	taxid:11060(dengue virus 2)|taxid:11060(Dengue virus 2)	taxid:2043570(isolate ZIKV/Human/French Polynesia/10087PF/2013)|taxid:2043570(Zika virus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-22275699|imex:IM-27594-1|wwpdb:5U4W|emdb:EMD-8508	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0055036"(virion membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:5U4W|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR038302|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR037172|interpro:IPR026470|interpro:IPR038345|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR038688|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR036253|interpro:IPR038055|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027287|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026490|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|interpro:IPR043502|interpro:IPR043504	go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140272"(exogenous protein binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR038688|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR036253|interpro:IPR038055|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026490|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|rcsb pdb:5GOZ|rcsb pdb:5GP1|rcsb pdb:5H30|rcsb pdb:5H32|rcsb pdb:5H37|rcsb pdb:5IRE|rcsb pdb:5IZ7|rcsb pdb:5JMT|rcsb pdb:5KQR|rcsb pdb:5KQS|rcsb pdb:5KVE|rcsb pdb:5LBS|rcsb pdb:5LBV|rcsb pdb:5LCV|rcsb pdb:5M5B|rcsb pdb:5MRK|rcsb pdb:5NJU|rcsb pdb:5NJV|rcsb pdb:5U4W|rcsb pdb:5UHY|rcsb pdb:5ULP|rcsb pdb:5Y0A|rcsb pdb:5Y6M|rcsb pdb:5Y6N|rcsb pdb:6CO8|rcsb pdb:6I7P|rcsb pdb:6JFI|rcsb pdb:6JFH|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR038302|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR037172|interpro:IPR027287|interpro:IPR026470|interpro:IPR038345|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|rcsb pdb:6RWZ|rcsb pdb:6S0J|rcsb pdb:7BSD|rcsb pdb:6NIP|rcsb pdb:6NIU|interpro:IPR043502|rcsb pdb:6PLK|rcsb pdb:7BU8|rcsb pdb:7BUA|rcsb pdb:6LD1|rcsb pdb:6LD2|rcsb pdb:6LD3|rcsb pdb:6LD4|rcsb pdb:6LD5|rcsb pdb:6UM3	-	-	-	figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/12/10	2020/03/25	rogid:O3Yg0poa4QUBJr9bR/eZlSNv49I11060	rogid:fKC1IID5xJenf+J2o0+x/1KVACA2043570	rigid:ckNaOhaKsC5gpqiHhht+Ue1ISqc	false	binding-associated region:115-195	binding-associated region:726-791	3	3	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)