#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96A47	uniprotkb:Q969G2	intact:EBI-18560216|uniprotkb:B3KM37|ensembl:ENSP00000290759	intact:EBI-2865388|uniprotkb:Q8NHM1|uniprotkb:Q969W2|uniprotkb:Q8TCJ1|uniprotkb:Q8NHE0|uniprotkb:Q8WWX2|ensembl:ENSP00000263726	psi-mi:isl2_human(display_long)|uniprotkb:ISL2(gene name)|psi-mi:ISL2(display_short)	psi-mi:lhx4_human(display_long)|uniprotkb:LHX4(gene name)|psi-mi:LHX4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cohen et al. (2017)	pubmed:27820671|imex:IM-26998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21402064|imex:IM-26998-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_665804.1|ensembl:ENSG00000159556(gene)|ensembl:ENST00000290759(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007409"(axonogenesis)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048666"(neuron development)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q96A47|go:"GO:0045665"(negative regulation of neuron differentiation)	refseq:NP_203129.1|dip:DIP-29454N|ensembl:ENSG00000121454(gene)|ensembl:ENST00000263726(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q969G2|rcsb pdb:5HOD|reactome:R-HSA-9010553	-	-	crc64:6499F38E78B79FD1	figure legend:Figure 5e|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/08	2019/05/10	rogid:TuRrmmyJy7Dk+0fn1BDmkcmUf1A9606	rogid:dCB3WgIBMdi0nNvaCFaioh+F9sw9606	rigid:LTzNW0Cq1fb5sTXgTJ7HmgzYzf8	false	flag tag:n-n	ha tag:n-n|mutation with no effect:65-65|mutation decreasing interaction strength:29-80|mutation decreasing interaction strength:57-57,60-60|necessary binding region:88-143	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UBR4	uniprotkb:Q969G2	intact:EBI-12541594|ensembl:ENSP00000360813|uniprotkb:Q5TB39|uniprotkb:Q5TB40|uniprotkb:Q9NZB5|uniprotkb:Q9P0I8|uniprotkb:Q9P0I9	intact:EBI-2865388|uniprotkb:Q8NHM1|uniprotkb:Q969W2|uniprotkb:Q8TCJ1|uniprotkb:Q8NHE0|uniprotkb:Q8WWX2|ensembl:ENSP00000263726	psi-mi:lhx3_human(display_long)|uniprotkb:LHX3(gene name)|psi-mi:LHX3(display_short)	psi-mi:lhx4_human(display_long)|uniprotkb:LHX4(gene name)|psi-mi:LHX4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cohen et al. (2017)	pubmed:27820671|imex:IM-26998	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21402081|imex:IM-26998-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000107187(gene)|ensembl:ENST00000371748(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|reactome:R-HSA-9010553|refseq:NP_055379.1|refseq:NP_835258.1	refseq:NP_203129.1|dip:DIP-29454N|ensembl:ENSG00000121454(gene)|ensembl:ENST00000263726(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q969G2|rcsb pdb:5HOD|reactome:R-HSA-9010553	-	-	crc64:6499F38E78B79FD1	figure legend:Figure 5f|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/08	2019/05/10	rogid:8P8tXvMgf1EZfv1DSEN0e2zaSHw9606	rogid:dCB3WgIBMdi0nNvaCFaioh+F9sw9606	rigid:f5wSJm1R32NlhS5UBNKISe8LPHU	false	flag tag:?-?	ha tag:n-n|mutation with no effect:65-65|mutation decreasing interaction strength:29-80|mutation decreasing interaction strength:57-57,60-60|necessary binding region:88-143	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)