#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9HB75	uniprotkb:P78560	intact:EBI-520427|ensembl:ENSP00000337797|uniprotkb:Q59FD1|uniprotkb:Q59H10|uniprotkb:Q59HC7|uniprotkb:Q7Z4P8|uniprotkb:Q8NC89|uniprotkb:Q8NDL2|uniprotkb:Q96C25|uniprotkb:Q9NRE6	intact:EBI-520375|uniprotkb:B7Z2Q5|ensembl:ENSP00000327647|ensembl:ENSP00000439068	psi-mi:pidd1_human(display_long)|uniprotkb:PIDD1(gene name)|psi-mi:PIDD1(display_short)|uniprotkb:LRDD(gene name synonym)|uniprotkb:Leucine-rich repeat and death domain-containing protein(gene name synonym)|uniprotkb:PIDD(gene name synonym)	psi-mi:cradd_human(display_long)|uniprotkb:Caspase and RIP adapter with death domain(gene name synonym)|uniprotkb:RIP-associated protein with a death domain(gene name synonym)|uniprotkb:CRADD(gene name)|psi-mi:CRADD(display_short)|uniprotkb:RAIDD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Di et al. (2016)	imex:IM-27134|pubmed:27773430	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461044|imex:IM-27134-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_665893.2|refseq:NP_665894.2|ensembl:ENSG00000177595(gene)|ensembl:ENST00000347755(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|refseq:XP_011518512.1|refseq:XP_011518513.1|refseq:XP_016873482.1|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR000488(Death)|interpro:IPR000906(ZU5)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011029(DEATH-like)|interpro:IPR019502|interpro:IPR032675|mint:Q9HB75|rcsb pdb:2OF5|reactome:R-HSA-6803207	refseq:NP_003796.1|refseq:NP_001307029.1|refseq:NP_001307030.1|refseq:NP_001307028.1|refseq:XP_016875633.1|ensembl:ENSG00000169372(gene)|ensembl:ENST00000332896(transcript)|ensembl:ENST00000542893(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0070513"(death domain binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR037926|interpro:IPR037939|interpro:IPR042148|mint:P78560|rcsb pdb:2O71|rcsb pdb:2OF5|rcsb pdb:3CRD|reactome:R-HSA-6803207|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)	-	-	-	figure legend:Figure 2d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/07/01	2019/07/01	rogid:n0LSBUZQ057RjeGw0h+yCoXgi0w9606	rogid:koYvv+L+23G4lMEFIFmYYBNaNkk9606	rigid:zbnLpmFlPQmERiXAv0wQzHch1b8	false	v5 tag:n-n	flag tag:n-n|mutation disrupting interaction strength:128-128|mutation decreasing interaction strength:170-170|mutation decreasing interaction strength:170-170|mutation with no effect:164-164	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P55215	uniprotkb:P78560	intact:EBI-15732853|ensembl:ENSRNOP00000022672|uniprotkb:O35398|uniprotkb:O55194|uniprotkb:Q9WUI6	intact:EBI-520375|uniprotkb:B7Z2Q5|ensembl:ENSP00000327647|ensembl:ENSP00000439068	psi-mi:casp2_rat(display_long)|uniprotkb:Casp2(gene name)|psi-mi:Casp2(display_short)|uniprotkb:Ich1(gene name synonym)|uniprotkb:Protease ICH-1(gene name synonym)	psi-mi:cradd_human(display_long)|uniprotkb:Caspase and RIP adapter with death domain(gene name synonym)|uniprotkb:RIP-associated protein with a death domain(gene name synonym)|uniprotkb:CRADD(gene name)|psi-mi:CRADD(display_short)|uniprotkb:RAIDD(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Di et al. (2016)	imex:IM-27134|pubmed:27773430	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21461092|imex:IM-27134-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016707(gene)|ensembl:ENSRNOT00000022672(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0003407"(neural retina development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR035702|reactome:R-RNO-168638|reactome:R-RNO-205025|reactome:R-RNO-6803207|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rgd:69274|refseq:NP_071967.2|dip:DIP-48602N	refseq:NP_003796.1|refseq:NP_001307029.1|refseq:NP_001307030.1|refseq:NP_001307028.1|refseq:XP_016875633.1|ensembl:ENSG00000169372(gene)|ensembl:ENST00000332896(transcript)|ensembl:ENST00000542893(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0070513"(death domain binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR037926|interpro:IPR037939|interpro:IPR042148|mint:P78560|rcsb pdb:2O71|rcsb pdb:2OF5|rcsb pdb:3CRD|reactome:R-HSA-6803207|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)	-	-	-	figure legend:Figure 2e|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2019/07/01	2019/07/04	rogid:ZNIUFaw1pJ8CgILlXc7yNn0aOZA10116	rogid:koYvv+L+23G4lMEFIFmYYBNaNkk9606	rigid:w4bykpKicNBcGxhDmZcmtIgoy/c	false	-	mutation decreasing interaction strength:128-128|mutation decreasing interaction strength:170-170|mutation decreasing interaction strength:170-170|penetrating tag:?-?|mutation with no effect:164-164	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)