#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6UWE0	uniprotkb:P11499	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-492813|uniprotkb:O89078|uniprotkb:Q3UIQ7|ensembl:ENSMUSP00000024739	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:hs90b_mouse(display_long)|uniprotkb:Heat shock 84 kDa(gene name synonym)|uniprotkb:Tumor-specific transplantation 84 kDa antigen(gene name synonym)|uniprotkb:Hsp90ab1(gene name)|psi-mi:Hsp90ab1(display_short)|uniprotkb:Hsp84(gene name synonym)|uniprotkb:Hsp84-1(gene name synonym)|uniprotkb:Hspcb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_032328.2|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P11499|reactome:R-MMU-168928|reactome:R-MMU-2029482|reactome:R-MMU-3371497|reactome:R-MMU-3371511|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-399954|reactome:R-MMU-6798695|reactome:R-MMU-844456|reactome:R-MMU-8852276|reactome:R-MMU-8937144|reactome:R-MMU-8939211|reactome:R-MMU-9013418|reactome:R-MMU-9018519|ensembl:ENSMUSG00000023944(gene)|ensembl:ENSMUST00000024739(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|dip:DIP-461N	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:5/MXDESVXdwuWna0s87Ap19aLMA10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q99K48	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-607499|ensembl:ENSMUSP00000033673|uniprotkb:Q63887|uniprotkb:Q9CYQ4|uniprotkb:Q9DBP2	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:nono_mouse(display_long)|uniprotkb:Nono(gene name)|psi-mi:Nono(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000031311(gene)|ensembl:ENSMUST00000033673(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034552|interpro:IPR035979|mint:Q99K48|rcsb pdb:2CPJ|rcsb pdb:2RS8|refseq:NP_075633.2|refseq:NP_001239447.1|dip:DIP-34308N	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:78ly3/4yzdfLjl9d/cV6Ob/SFG810090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q8CH25	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-8314778|ensembl:ENSMUSP00000049112|uniprotkb:Q8BR40|uniprotkb:Q9CS57|uniprotkb:Q8VCF4|uniprotkb:Q3UYE5|intact:MINT-4115860|uniprotkb:Q8BP76	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:sltm_mouse(display_long)|uniprotkb:Sltm(gene name)|psi-mi:Sltm(display_short)|uniprotkb:Met(gene name synonym)|uniprotkb:Modulator of estrogen-induced transcription(gene name synonym)|uniprotkb:SAF-like transcription modulator(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000032212(gene)|ensembl:ENSMUST00000049263(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0016604"(nuclear body)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0050684"(regulation of mRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034780|interpro:IPR035979|interpro:IPR036361|mint:Q8CH25|refseq:NP_080613.1|refseq:NP_079966.2	-	-	comment:mint	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:MmIaktCmPhynmaBFQARrYE6oGfQ10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:O70305	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-8006253|uniprotkb:P97421|intact:MINT-1865582	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:atx2_mouse(display_long)|uniprotkb:Atxn2(gene name)|psi-mi:Atxn2(display_short)|uniprotkb:Atx2(gene name synonym)|uniprotkb:Sca2(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 2 protein homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	interpro:IPR033093|refseq:NP_033151.2|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR025852|mint:O70305|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050905"(neuromuscular process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)	-	-	comment:mint	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:SbI0yjYObe6jYhmgokZb1LLJlP810090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:P35550	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-7817407|ensembl:ENSMUSP00000037613|intact:MINT-1854224|uniprotkb:Q99L58	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:fbrl_mouse(display_long)|uniprotkb:Fbl(gene name)|psi-mi:Fbl(display_short)|uniprotkb:Nucleolar protein 1(gene name synonym)|uniprotkb:Histone-glutamine methyltransferase(gene name synonym)|uniprotkb:U6 snRNA 2'-O-methyltransferase fibrillarin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008649"(rRNA methyltransferase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0016074"("sno(s)RNA metabolic process")|go:"GO:0031167"(rRNA methylation)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:1990258"(histone glutamine methylation)|go:"GO:1990259"(histone-glutamine methyltransferase activity)|interpro:IPR000692(Fibrillarin)|interpro:IPR020813|interpro:IPR029063|mint:P35550|reactome:R-MMU-6791226|go:"GO:0001652"(granular component)|ensembl:ENSMUSG00000046865(gene)|ensembl:ENSMUST00000042405(transcript)|go:"GO:0000494"(box C/D RNA 3'-end processing)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|refseq:NP_032017.2	-	-	function:Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA|comment:mint|comment:homomint	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:+sPcLBU2pW5qt05z4awAKpVQryY10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q3TJZ6	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-8318357|intact:MINT-1858128|uniprotkb:Q99KJ2|ensembl:ENSMUSP00000108126	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:fa98a_mouse(display_long)|uniprotkb:Fam98a(gene name)|psi-mi:Fam98a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_598508.2|ensembl:ENSMUSG00000002017(gene)|ensembl:ENSMUST00000112507(transcript)|go:"GO:0006479"(protein methylation)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032418"(lysosome localization)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR018797|mint:Q3TJZ6	-	-	comment:mint	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:ZvcKhnXQtXNW4jEx2X8IvALCfZU10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q61584	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-8350418|uniprotkb:Q9WUA8|intact:MINT-257148|uniprotkb:Q9R1E3|uniprotkb:Q8VCU4|uniprotkb:Q9R1E4|uniprotkb:Q9R1E2|uniprotkb:Q9WUA9|uniprotkb:Q9R1E5|uniprotkb:Q9WUA7|ensembl:ENSMUSP00000001620	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:fxr1_mouse(display_long)|uniprotkb:Fxr1(gene name)|psi-mi:Fxr1(display_short)|uniprotkb:Fxr1h(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_032079.1|refseq:NP_001106659.1|refseq:NP_001106660.1|refseq:XP_006535463.1|refseq:XP_006535464.1|refseq:XP_006535465.1|ensembl:ENSMUSG00000027680(gene)|ensembl:ENSMUST00000001620(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0007517"(muscle organ development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060538"(skeletal muscle organ development)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR032177|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:Q61584|go:"GO:0005829"(cytosol)	-	-	comment:mint|function:RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:llAsLdKtqlUDX3mK8DOwdYvnfw810090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:P97379	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-8319813|intact:MINT-1858459|uniprotkb:Q9R1B8|uniprotkb:Q3UL55|ensembl:ENSMUSP00000128244|ensembl:ENSMUSP00000128353|ensembl:ENSMUSP00000144456	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:g3bp2_mouse(display_long)|uniprotkb:G3bp2(gene name)|psi-mi:G3bp2(display_short)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_035946.2|refseq:NP_001074263.1|refseq:NP_001074266.1|refseq:XP_006534990.1|refseq:XP_006534991.1|ensembl:ENSMUSG00000029405(gene)|ensembl:ENSMUST00000164378(transcript)|ensembl:ENSMUST00000169094(transcript)|ensembl:ENSMUST00000202258(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:P97379	-	-	function:Probable scaffold protein that may be involved in mRNA transport|comment:mint	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:1MhDKzi09if4Beb23/9+ZTB0xKM10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q9CXK9	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-21994184|uniprotkb:Q3U5Z3|uniprotkb:Q8C5J6|ensembl:ENSMUSP00000062449	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:rbm33_mouse(display_long)|uniprotkb:Proline-rich protein 8(gene name synonym)|uniprotkb:RNA-binding motif protein 33(gene name synonym)|uniprotkb:Rbm33(gene name)|psi-mi:Rbm33(display_short)|uniprotkb:Prr8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_082510.1|ensembl:ENSMUSG00000048271(gene)|ensembl:ENSMUST00000059644(transcript)|go:"GO:0003676"(nucleic acid binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR039878	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:1IwmGJyRTcDTJYwc1V0fwT6egmg10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:P68033	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-352284|uniprotkb:P04270|ensembl:ENSMUSP00000087736	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:actc_mouse(display_long)|uniprotkb:Actc1(gene name)|psi-mi:Actc1(display_short)|uniprotkb:Actc(gene name synonym)|uniprotkb:Alpha-cardiac actin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_033738.1|ensembl:ENSMUSG00000068614(gene)|ensembl:ENSMUST00000090269(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005869"(dynactin complex)|go:"GO:0005884"(actin filament)|go:"GO:0007015"(actin filament organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030175"(filopodium)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0033275"(actin-myosin filament sliding)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070252"(actin-mediated cell contraction)|go:"GO:0090131"(mesenchyme migration)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P68033|reactome:R-MMU-390522|reactome:R-MMU-8980692|reactome:R-MMU-9013026	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:U/lKYqWUWMSC3fBHFaAcgzfk+3w10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:P35700	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-444948|uniprotkb:Q3UBV4|uniprotkb:Q9CWI2|ensembl:ENSMUSP00000102078|ensembl:ENSMUSP00000114159	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:prdx1_mouse(display_long)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Osteoblast-specific factor 3(gene name synonym)|uniprotkb:Macrophage 23 kDa stress protein(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Prdx1(gene name)|psi-mi:Prdx1(display_short)|uniprotkb:Msp23(gene name synonym)|uniprotkb:Paga(gene name synonym)|uniprotkb:Tdpx2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_035164.1|ensembl:ENSMUST00000135573(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000791"(euchromatin)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:P35700|reactome:R-MMU-3299685|reactome:R-MMU-5628897|ensembl:ENSMUST00000106470(transcript)|ensembl:ENSMUSG00000028691(gene)	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:xOppWev1GtpILoJ1rY+tSPoymVU10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q6ZQ58	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-6908968|ensembl:ENSMUSP00000136673|intact:EBI-9030511|uniprotkb:A2AFQ8|uniprotkb:J3QNB1|uniprotkb:Q7TSF7	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:larp1_mouse(display_long)|uniprotkb:Larp1(gene name)|psi-mi:Larp1(display_short)|uniprotkb:Kiaa0731(gene name synonym)|uniprotkb:La ribonucleoprotein domain family member 1(gene name synonym)|uniprotkb:Larp(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000037331(gene)|ensembl:ENSMUST00000178636(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008494"(translation activator activity)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031929"(TOR signaling)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR006607(Protein of unknown function DM15)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR036388|interpro:IPR036390|refseq:NP_082727.1	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:DgxWWF7aiKBOUyGXmibtu8Wh+DU10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:P62751	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-4286547|uniprotkb:P29316|uniprotkb:P39024|uniprotkb:Q92774|ensembl:ENSMUSP00000099541	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:rl23a_mouse(display_long)|uniprotkb:Rpl23a(gene name)|psi-mi:Rpl23a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_997406.1|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:1904841"(TORC2 complex binding)|interpro:IPR001014(Ribosomal protein L23, conserved site)|interpro:IPR005633(Ribosomal protein L23/L25, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR013025(Ribosomal protein L25/L23)|interpro:IPR019985|mint:P62751|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|ensembl:ENSMUSG00000058546(gene)|ensembl:ENSMUST00000102483(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|dip:DIP-59973N	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:lA1ubRFO9/Tl54Z1dKUzoCKvpAo10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:D3YXK2	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-539539|ensembl:ENSMUSP00000092849	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:safb1_mouse(display_long)|uniprotkb:Safb(gene name)|psi-mi:Safb(display_short)|uniprotkb:Safb1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_001156772.1|ensembl:ENSMUST00000095224(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030496"(midbody)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0040008"(regulation of growth)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050684"(regulation of mRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034781|interpro:IPR035979|interpro:IPR036361|mint:D3YXK2|ensembl:ENSMUSG00000071054(gene)|reactome:R-MMU-3899300	-	-	comment:Author screened murine library then identified protein by homology to rat. Currently no murine sequence in database.	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:wGs3hvKUEDoWR83eBl9+qv4JWzs10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q7TMK9	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-2735641|uniprotkb:O88991|uniprotkb:Q2YDV8|uniprotkb:Q68ED6|uniprotkb:Q80YV6|uniprotkb:Q8BGP1|uniprotkb:Q8C5K6|uniprotkb:Q8CGC2|uniprotkb:Q91ZR0|uniprotkb:Q99KU9|uniprotkb:Q9QYF4|ensembl:ENSMUSP00000133649	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:hnrpq_mouse(display_long)|uniprotkb:Syncrip(gene name)|psi-mi:Syncrip(display_short)|uniprotkb:Hnrpq(gene name synonym)|uniprotkb:Nsap1(gene name synonym)|uniprotkb:Nsap1l(gene name synonym)|uniprotkb:Synaptotagmin-binding, cytoplasmic RNA-interacting protein(gene name synonym)|uniprotkb:Glycine- and tyrosine-rich RNA-binding protein(gene name synonym)|uniprotkb:NS1-associated protein 1(gene name synonym)|uniprotkb:pp68(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_001271257.1|refseq:NP_062640.2|refseq:NP_062770.1|refseq:NP_001298042.1|ensembl:ENSMUSG00000032423(gene)|ensembl:ENSMUST00000173801(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006397"(mRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006535(HnRNP R and Q splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034544|interpro:IPR034548|interpro:IPR035979|interpro:IPR041337|mint:Q7TMK9	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:Ljuz8koebOL7L9jFBaevQYHinzw10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q80ZI6	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-647658|ensembl:ENSMUSP00000028132|ensembl:ENSMUSP00000108825	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:lrsm1_mouse(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:Lrsam1(gene name)|psi-mi:Lrsam1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_955006.1|refseq:XP_006498032.1|refseq:XP_006498033.1|refseq:XP_006498034.1|refseq:XP_006498035.1|ensembl:ENSMUSG00000026792(gene)|ensembl:ENSMUST00000028132(transcript)|ensembl:ENSMUST00000113200(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|reactome:R-MMU-983168	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:f3uhrAhkyTZPnMxktnsg0zqdWAU10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q91VM5	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-647431|uniprotkb:O35479|ensembl:ENSMUSP00000048153|ensembl:ENSMUSP00000147384	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:rmxl1_mouse(display_long)|uniprotkb:Rbmxl1(gene name)|psi-mi:Rbmxl1(display_short)|uniprotkb:Heterogeneous nuclear ribonucleoprotein G-like 1(gene name synonym)|uniprotkb:RNA binding motif protein, X chromosome retrogene(gene name synonym)|uniprotkb:Rbmxrt(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:XP_006530838.1|refseq:XP_006530839.1|refseq:NP_001239018.1|refseq:NP_033059.2|ensembl:ENSMUSG00000037070(gene)|ensembl:ENSMUST00000049245(transcript)|ensembl:ENSMUST00000211719(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012604(RBM1CTR)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q91VM5	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:1aPRrfU5gcmzCimlfwuz07A4gyA10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:O88532	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-645485|uniprotkb:Q3TY30|uniprotkb:Q8BS85|uniprotkb:Q8CGG5|uniprotkb:Q91VZ0|uniprotkb:Q9CT34|ensembl:ENSMUSP00000118911	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:zfr_mouse(display_long)|uniprotkb:Zfr(gene name)|psi-mi:Zfr(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_035897.2|ensembl:ENSMUSG00000022201(gene)|ensembl:ENSMUST00000122941(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:O88532	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:ncNwFUEUk0r2XotuXm/9Tt4iB5w10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:P99024	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-350896|uniprotkb:P05218|uniprotkb:Q3TFB6|uniprotkb:Q3THH9|uniprotkb:Q3TIL1|uniprotkb:Q3UAV4|uniprotkb:Q3UF52|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|uniprotkb:B1B178|ensembl:ENSMUSP00000001566	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:tbb5_mouse(display_long)|uniprotkb:Tubb5(gene name)|psi-mi:Tubb5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_035785.1|interpro:IPR023123|interpro:IPR036525|interpro:IPR018316|interpro:IPR037103|mint:P99024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-6798695|reactome:R-MMU-8854518|ensembl:ENSMUSG00000001525(gene)|ensembl:ENSMUST00000001566(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045298"(tubulin complex)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051225"(spindle assembly)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:B6pmb1dvCroZXGd/1Zazi+s72GA10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:O35737	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-299747|ensembl:ENSMUSP00000070503|ensembl:ENSMUSP00000104770	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:hnrh1_mouse(display_long)|uniprotkb:Hnrnph1(gene name)|psi-mi:Hnrnph1(display_short)|uniprotkb:Hnrph(gene name synonym)|uniprotkb:Hnrph1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000007850(gene)|ensembl:ENSMUST00000069304(transcript)|ensembl:ENSMUST00000109142(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:O35737|reactome:R-MMU-6803529|reactome:R-MMU-72163|reactome:R-MMU-72203|refseq:NP_067485.1|refseq:XP_017170179.1|refseq:XP_017170180.1	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:nBSCiXDDfkwqslFAXPXlDzC+5e410090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:E9QNN1	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-11517564|ensembl:ENSMUSP00000038135	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:e9qnn1_mouse(display_long)|uniprotkb:Dhx9(gene name)|psi-mi:Dhx9(display_short)|uniprotkb:Nuclear DNA helicase II(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:XP_011246220.1|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR044445|interpro:IPR044446|interpro:IPR044447|go:"GO:1990841"(promoter-specific chromatin binding)|ensembl:ENSMUSG00000042699(gene)|ensembl:ENSMUST00000042141(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001069"(regulatory region RNA binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005813"(centrosome)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016442"(RISC complex)|go:"GO:0016604"(nuclear body)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033679"(3'-5' DNA/RNA helicase activity)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0035197"(siRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045142"(triplex DNA binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070922"(small RNA loading onto RISC)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904973"(positive regulation of viral translation)|go:"GO:1905172"(RISC complex binding)|go:"GO:1905538"(polysome binding)|go:"GO:1905698"(positive regulation of polysome binding)|go:"GO:1990518"(single-stranded 3'-5' DNA helicase activity)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:NWMysITLxBQL819Vxx4yPFZBuRg10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q5F2E7	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-11567759|uniprotkb:Q80TF1|uniprotkb:Q3V195|uniprotkb:Q3TCE2|ensembl:ENSMUSP00000098365	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:nufp2_mouse(display_long)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:Kiaa1321(gene name synonym)|uniprotkb:Nufip2(gene name)|psi-mi:Nufip2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_001019376.1|refseq:XP_006534125.1|ensembl:ENSMUSG00000037857(gene)|ensembl:ENSMUST00000100802(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q5F2E7	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:rckz1rTUY3/RppScoXLaw1Z9ipU10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q61656	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-643076|uniprotkb:E9Q105	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:ddx5_mouse(display_long)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD1(gene name synonym)|uniprotkb:Ddx5(gene name)|psi-mi:Ddx5(display_short)|uniprotkb:Tnz2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|reactome:R-MMU-3899300|reactome:R-MMU-72163|reactome:R-MMU-9018519|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009299"(mRNA transcription)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|dip:DIP-32293N|mint:Q61656	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:X5OQN/Gdq852njTrHnlDliAjrQY10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q80X50	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-11664310|uniprotkb:Q8BIT6|uniprotkb:Q8BIW4|uniprotkb:Q8BJ01|uniprotkb:Q8CIG7|uniprotkb:Q8K102|uniprotkb:Q9CRT6|ensembl:ENSMUSP00000143459	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:ubp2l_mouse(display_long)|uniprotkb:Ubap2l(gene name)|psi-mi:Ubap2l(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_001159455.1|refseq:NP_001159456.1|refseq:NP_001159457.1|refseq:NP_001159458.1|refseq:NP_082751.1|refseq:XP_006502235.1|ensembl:ENSMUSG00000042520(gene)|ensembl:ENSMUST00000196843(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|mint:Q80X50|rcsb pdb:1WJ7	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:ucHEy1MXF7PTEdwLChr6zAOqtcM10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q8R326	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-309927|uniprotkb:Q3TUK2|uniprotkb:Q9CYH1|uniprotkb:Q9D0M8|ensembl:ENSMUSP00000022507	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:pspc1_mouse(display_long)|uniprotkb:Pspc1(gene name)|psi-mi:Pspc1(display_short)|uniprotkb:Psp1(gene name synonym)|uniprotkb:Paraspeckle protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_079958.3|ensembl:ENSMUSG00000021938(gene)|ensembl:ENSMUST00000022507(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034522|interpro:IPR034523|interpro:IPR035979|mint:Q8R326	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:ytx7HwtwAo7SxG0MsNz1YR1dKiQ10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q7TSC1	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-645425|uniprotkb:Q923A9|uniprotkb:Q9Z1R1|ensembl:ENSMUSP00000025253	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:prc2a_mouse(display_long)|uniprotkb:HLA-B-associated transcript 2(gene name synonym)|uniprotkb:Prrc2a(gene name)|psi-mi:Prrc2a(display_short)|uniprotkb:Bat2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_001185973.1|refseq:NP_064411.2|refseq:XP_006524683.1|dip:DIP-49629N|ensembl:ENSMUSG00000024393(gene)|ensembl:ENSMUST00000025253(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q7TSC1	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:ktwyGkClOoaD4rZap/xJb/aKj4s10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:P61979	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-299907|ensembl:ENSMUSP00000039269|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q60577|uniprotkb:Q8BGQ8|uniprotkb:Q922Y7|uniprotkb:Q96J62	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:hnrpk_mouse(display_long)|uniprotkb:Hnrnpk(gene name)|psi-mi:Hnrnpk(display_short)|uniprotkb:Hnrpk(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUST00000043269(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0002102"(podosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|ensembl:ENSMUSG00000021546(gene)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1990715"(mRNA CDS binding)|go:"GO:1990829"(C-rich single-stranded DNA binding)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000173"(negative regulation of branching morphogenesis of a nerve)|interpro:IPR004087(K Homology)|go:"GO:0051117"(ATPase binding)|go:"GO:0060999"(positive regulation of dendritic spine development)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61979|reactome:R-MMU-4570464|reactome:R-MMU-72163|reactome:R-MMU-72203|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904322"(cellular response to forskolin)|refseq:NP_001288269.1|refseq:NP_001288270.1|refseq:NP_001288272.1|refseq:NP_001288273.1|refseq:NP_001288274.1|refseq:XP_017170884.1|refseq:XP_017170885.1|refseq:NP_079555.1|refseq:XP_006517166.1|refseq:XP_006517167.1	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q62167	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-773173|uniprotkb:O09060|uniprotkb:O09143|ensembl:ENSMUSP00000000804	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:ddx3x_mouse(display_long)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD3(gene name synonym)|uniprotkb:Embryonic RNA helicase(gene name synonym)|uniprotkb:D1Pas1-related sequence 2(gene name synonym)|uniprotkb:Ddx3x(gene name)|psi-mi:Ddx3x(display_short)|uniprotkb:D1Pas1-rs2(gene name synonym)|uniprotkb:Ddx3(gene name synonym)|uniprotkb:Dead3(gene name synonym)|uniprotkb:Erh(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_034158.1|ensembl:ENSMUSG00000000787(gene)|ensembl:ENSMUST00000000804(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q62167|reactome:R-MMU-6798695	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:K7PtRsPpXHni4TU8uzOsr6QaVxA10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:P35922	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-645094	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:P63017	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-433443|uniprotkb:P08109|uniprotkb:P12225|uniprotkb:Q3U6R0|uniprotkb:Q3U764|uniprotkb:Q3U7D7|uniprotkb:Q3U7E2|uniprotkb:Q3U9B4|uniprotkb:Q3U9G0|uniprotkb:Q3UGM0|uniprotkb:Q5FWJ6|uniprotkb:Q62373|uniprotkb:Q62374|uniprotkb:Q62375|uniprotkb:Q6NZD0|ensembl:ENSMUSP00000015800	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:hsp7c_mouse(display_long)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Hspa8(gene name)|psi-mi:Hspa8(display_short)|uniprotkb:Hsc70(gene name synonym)|uniprotkb:Hsc73(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_112442.2|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031686"(A1 adenosine receptor binding)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043531"(ADP binding)|go:"GO:0043624"|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044309"(neuron spine)|go:"GO:0044788"(modulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0030425"(dendrite)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904592"(positive regulation of protein refolding)|go:"GO:1904593"(prostaglandin binding)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005681"(spliceosomal complex)|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-450408|reactome:R-MMU-6798695|reactome:R-MMU-72163|reactome:R-MMU-8856828|reactome:R-MMU-8876725|reactome:R-MMU-888590|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990836"(lysosomal matrix)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P63017|rcsb pdb:3CQX|reactome:R-MMU-3371453|reactome:R-MMU-3371497|ensembl:ENSMUSG00000015656(gene)|ensembl:ENSMUST00000015800(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|dip:DIP-32353N	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:WDnUczLfoe3ODQbiEITN3DfQnFA10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:P62317	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-6665916|ensembl:ENSMUSP00000037597|uniprotkb:P43330	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:smd2_mouse(display_long)|uniprotkb:Snrpd2(gene name)|psi-mi:Snrpd2(display_short)|uniprotkb:snRNP core protein D2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000040824(gene)|ensembl:ENSMUST00000049294(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005685"(U1 snRNP)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990446"(U1 snRNP binding)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027248|mint:P62317|reactome:R-MMU-191859|reactome:R-MMU-72163|reactome:R-MMU-72165|refseq:NP_081219.1	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:4OshNPT6N4dOcWMVXrF5Fm8dcnI10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q7TQH0	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-6908203|ensembl:ENSMUSP00000035415|uniprotkb:Q80XN9|uniprotkb:Q8K059	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:atx2l_mouse(display_long)|uniprotkb:Atxn2l(gene name)|psi-mi:Atxn2l(display_short)|uniprotkb:A2lp(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:XP_006507788.1|ensembl:ENSMUSG00000032637(gene)|ensembl:ENSMUST00000040202(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|mint:Q7TQH0|refseq:NP_898841.1	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:7v7iuPRti2err2QrmJIGoWqEM3U10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:P97855	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-6666067|ensembl:ENSMUSP00000018727	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:g3bp1_mouse(display_long)|uniprotkb:G3bp1(gene name)|psi-mi:G3bp1(display_short)|uniprotkb:G3bp(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym)|uniprotkb:HDH-VIII(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000018583(gene)|ensembl:ENSMUST00000018727(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:P97855|refseq:NP_038744.1	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:Xxq1G7S8hxbGPvterifIOxpri6U10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q9CY58	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-6393149|ensembl:ENSMUSP00000039110|uniprotkb:Q8BHS2|uniprotkb:Q8BHU0|uniprotkb:Q91WP3|uniprotkb:Q9CSN0|uniprotkb:Q9DBY6	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:pairb_mouse(display_long)|uniprotkb:Serbp1(gene name)|psi-mi:Serbp1(display_short)|uniprotkb:Pairbp1(gene name synonym)|uniprotkb:PAI1 RNA-binding protein 1(gene name synonym)|uniprotkb:SERPINE1 mRNA-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000036371(gene)|ensembl:ENSMUST00000042990(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030578"(PML body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR006861(Hyaluronan/mRNA binding protein)|interpro:IPR027205|interpro:IPR032381|interpro:IPR039764|mint:Q9CY58|refseq:NP_001107037.1|refseq:NP_001107038.1|refseq:NP_080090.2	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:SXRlAj8j23iy2v1N+Cx7gT7g4lM10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q9CY57	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-6393116|ensembl:ENSMUSP00000061800|uniprotkb:Q8C5N4|uniprotkb:Q9D7T3|uniprotkb:Q9DB03|uniprotkb:Q9DC54|uniprotkb:Q9JJ95|uniprotkb:Q0VBG3|uniprotkb:Q3U7V6|uniprotkb:Q3UF43|uniprotkb:Q3V105|uniprotkb:Q5XJG9	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:chtop_mouse(display_long)|uniprotkb:Chtop(gene name)|psi-mi:Chtop(display_short)|uniprotkb:Fop(gene name synonym)|uniprotkb:Friend of PRMT1 protein(gene name synonym)|uniprotkb:Small arginine- and glycine-rich protein(gene name synonym)|uniprotkb:MNCb-1706(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000001017(gene)|ensembl:ENSMUST00000049937(transcript)|go:"GO:0000346"(transcription export complex)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0051096"(positive regulation of helicase activity)|interpro:IPR025715|mint:Q9CY57|reactome:R-MMU-159236|reactome:R-MMU-72187|reactome:R-MMU-73856|refseq:NP_075704.2|refseq:NP_001280705.1|refseq:NP_001280706.1|refseq:NP_001280707.1|refseq:NP_001280708.1|refseq:NP_001280710.1|refseq:NP_001280711.1	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:tbiD3N+cZ5sPCgf8oao5CrHEwtE10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q3UH59	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-4281695|ensembl:ENSMUSP00000090661	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:q3uh59_mouse(display_long)|uniprotkb:Myh10(gene name)|psi-mi:Myh10(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000020900(gene)|ensembl:ENSMUST00000092984(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001725"(stress fiber)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005938"(cell cortex)|go:"GO:0016460"(myosin II complex)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0097513"(myosin II filament)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|refseq:NP_780469.1	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:gODdELEKYILlc9W4X84k/RV05tU10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q8K2F8	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-2554251|uniprotkb:Q9CTG8|ensembl:ENSMUSP00000082723	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:ls14a_mouse(display_long)|uniprotkb:Fam61a(gene name synonym)|uniprotkb:Rap55a(gene name synonym)|uniprotkb:Protein FAM61A(gene name synonym)|uniprotkb:RNA-associated protein 55A(gene name synonym)|uniprotkb:Lsm14a(gene name)|psi-mi:Lsm14a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_080224.1|ensembl:ENSMUSG00000066568(gene)|ensembl:ENSMUST00000085585(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025761|interpro:IPR025762|interpro:IPR025768|mint:Q8K2F8	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:ukJG23hyWin24AD3ZzrcPCeQ6Wg10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q569Z6	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-2536252|ensembl:ENSMUSP00000079722	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:tr150_mouse(display_long)|uniprotkb:Thrap3(gene name)|psi-mi:Thrap3(display_short)|uniprotkb:Trap150(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 150 kDa component(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000043962(gene)|ensembl:ENSMUST00000080919(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR026667|interpro:IPR029199|go:"GO:0008380"(RNA splicing)|refseq:XP_011238805.1|refseq:NP_666265.3|refseq:XP_006503104.1	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:Cb0vHuEX3Ew27z2gvfC/36tdeYE10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:O08583	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-6464301|ensembl:ENSMUSP00000026125|uniprotkb:Q0VBL5|uniprotkb:Q8CBM4|uniprotkb:Q9JJW7	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:thoc4_mouse(display_long)|uniprotkb:Alyref(gene name)|psi-mi:Alyref(display_short)|uniprotkb:Aly(gene name synonym)|uniprotkb:Ref1(gene name synonym)|uniprotkb:Refbp1(gene name synonym)|uniprotkb:THOC4(gene name synonym)|uniprotkb:Ally of AML-1 and LEF-1(gene name synonym)|uniprotkb:Aly/REF export factor(gene name synonym)|uniprotkb:REF1-I(gene name synonym)|uniprotkb:RNA and export factor-binding protein 1(gene name synonym)|uniprotkb:Transcriptional coactivator Aly/REF(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000025134(gene)|ensembl:ENSMUST00000026125(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0051028"(mRNA transport)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR025715|interpro:IPR035979|mint:O08583|rcsb pdb:1NO8|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|refseq:NP_035698.1|dip:DIP-59977N	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:DZAvcQrp7S1uipKsc/Wpxgb+gJI10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q8K019	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-2536273|uniprotkb:Q8C2E9|uniprotkb:Q9CSW5|uniprotkb:Q8BNZ0|ensembl:ENSMUSP00000043583	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:bclf1_mouse(display_long)|uniprotkb:Bclaf1(gene name)|psi-mi:Bclaf1(display_short)|uniprotkb:Btf(gene name synonym)|uniprotkb:Kiaa0164(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000037608(gene)|ensembl:ENSMUST00000043881(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR026668|interpro:IPR029199|mint:Q8K019|refseq:NP_001020563.1|refseq:NP_722482.1	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:+9NQPsUgV77P3yH9iK0ZRDIOioM10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q60865	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-647767|uniprotkb:Q6IMN3|uniprotkb:Q7TT26|uniprotkb:Q60758|uniprotkb:Q61620|ensembl:ENSMUSP00000028607|ensembl:ENSMUSP00000106777	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:capr1_mouse(display_long)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:Caprin1(gene name)|psi-mi:Caprin1(display_short)|uniprotkb:Gpiap(gene name synonym)|uniprotkb:Gpiap1(gene name synonym)|uniprotkb:Gpip137(gene name synonym)|uniprotkb:M11s1(gene name synonym)|uniprotkb:G5E5(orf name)|uniprotkb:Rng105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_001104759.1|refseq:NP_001104760.1|refseq:NP_001104761.1|refseq:NP_001104762.1|refseq:NP_058019.2|ensembl:ENSMUSG00000027184(gene)|ensembl:ENSMUST00000028607(transcript)|ensembl:ENSMUST00000111147(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q60865	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:e+Dcb+82jx+CoLhlGBbdSG62dPU10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q99LF4	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-6261036|ensembl:ENSMUSP00000001834|uniprotkb:Q3UDW6|uniprotkb:Q3TI25|uniprotkb:Q3TA04	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:rtcb_mouse(display_long)|uniprotkb:Rtcb(gene name)|psi-mi:Rtcb(display_short)|uniprotkb:D10Wsu52e(gene name synonym)|uniprotkb:Focal adhesion-associated protein(gene name synonym)|uniprotkb:3'-phosphate/5'-hydroxy nucleic acid ligase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000001783(gene)|go:"GO:0000971"(tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001890"(placenta development)|go:"GO:0003972"("RNA ligase (ATP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0017166"(vinculin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0072669"(tRNA-splicing ligase complex)|interpro:IPR001233(Protein of unknown function UPF0027)|interpro:IPR027513|interpro:IPR036025|mint:Q99LF4|ensembl:ENSMUST00000001834(transcript)|refseq:NP_663397.1	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:ISQNiLQA7DCcgBkTueMDhUHrkFQ10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q60749	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:P56959	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-400452|ensembl:ENSMUSP00000101858	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:fus_mouse(display_long)|uniprotkb:Fus(gene name)|psi-mi:Fus(display_short)|uniprotkb:Protein pigpen(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_631888.1|ensembl:ENSMUSG00000030795(gene)|ensembl:ENSMUST00000106251(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030425"(dendrite)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P56959|reactome:R-MMU-72163	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:Vwv/0vlM50l49XaUOHCtEWt/b2A10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:P29341	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-773902|uniprotkb:Q99L36|ensembl:ENSMUSP00000001809	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:pabp1_mouse(display_long)|uniprotkb:Pabpc1(gene name)|psi-mi:Pabpc1(display_short)|uniprotkb:Pabp1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	dip:DIP-32127N|refseq:NP_032800.2|refseq:XP_011243641.1|ensembl:ENSMUSG00000022283(gene)|ensembl:ENSMUST00000001809(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031252"(cell leading edge)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045202"(synapse)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000623"(negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006515(Polyadenylate binding protein, human types 1, 2, 3, 4)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036053|mint:P29341|reactome:R-MMU-156827|reactome:R-MMU-429947|reactome:R-MMU-450408|reactome:R-MMU-72649|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:jvlQW6kphF2tkZwK72DtAXDPHvs10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q91VR5	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-773164|uniprotkb:Q3TU41|ensembl:ENSMUSP00000065987	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:ddx1_mouse(display_long)|uniprotkb:DEAD box protein 1(gene name synonym)|uniprotkb:Ddx1(gene name)|psi-mi:Ddx1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_598801.1|ensembl:ENSMUSG00000037149(gene)|ensembl:ENSMUST00000071103(transcript)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006397"(mRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071920"(cleavage body)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR043136|mint:Q91VR5	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:NXUFdXIf8H/od5xV+OXhcO+51aY10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q62189	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-6665678|ensembl:ENSMUSP00000079228|ensembl:ENSMUSP00000113678|ensembl:ENSMUSP00000131897|uniprotkb:Q52LA2	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:snrpa_mouse(display_long)|uniprotkb:Snrpa(gene name)|psi-mi:Snrpa(display_short)|uniprotkb:Rnu1a-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_001272754.1|ensembl:ENSMUSG00000061479(gene)|ensembl:ENSMUST00000080356(transcript)|ensembl:ENSMUST00000122202(transcript)|ensembl:ENSMUST00000163311(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005685"(U1 snRNP)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:1900363"(regulation of mRNA polyadenylation)|go:"GO:1990446"(U1 snRNP binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034407|interpro:IPR034409|interpro:IPR035979|mint:Q62189|reactome:R-MMU-72163|refseq:NP_001040102.1|refseq:NP_056597.3	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:WqP6iBe+63wvTgHfNq60p+cFF9Y10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q8VDD5	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-400906|intact:EBI-777674|uniprotkb:Q3UHT9|uniprotkb:Q3UHU4|uniprotkb:Q6KAN6|uniprotkb:Q811I2|ensembl:ENSMUSP00000016771	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:myh9_mouse(display_long)|uniprotkb:Myh9(gene name)|psi-mi:Myh9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_071855.2|ensembl:ENSMUSG00000022443(gene)|ensembl:ENSMUST00000016771(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0097513"(myosin II filament)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903919"(negative regulation of actin filament severing)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q8VDD5|reactome:R-MMU-2029482|reactome:R-MMU-5627123|dip:DIP-29546N	-	-	caution:This sequence has been withdrawn from Uniprot.|crc64:AAAC0E83A0A4F24A	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:qYfcGuWOF9npzsKD3zXTuLeP9iE10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q8VEK3	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-529674|uniprotkb:Q9R205|uniprotkb:G3XA10|ensembl:ENSMUSP00000047571	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:hnrpu_mouse(display_long)|uniprotkb:Hnrpu(gene name synonym)|uniprotkb:Hnrnpu(gene name)|psi-mi:Hnrnpu(display_short)|uniprotkb:Scaffold-attachment factor A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:XP_017177162.1|refseq:XP_017177163.1|refseq:NP_058085.2|refseq:XP_017177161.1|dip:DIP-34257N|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q8VEK3|reactome:R-MMU-72163|reactome:R-MMU-72203|ensembl:ENSMUSG00000039630(gene)|ensembl:ENSMUST00000037748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:ONBrFPHIT3aP6XnUgJMf4qiu8VQ10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:Q6UWE0	uniprotkb:Q8VIJ6	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-6094576|uniprotkb:A2A7U6|uniprotkb:Q9ERW2|ensembl:ENSMUSP00000030623	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:sfpq_mouse(display_long)|uniprotkb:Sfpq(gene name)|psi-mi:Sfpq(display_short)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:Psf(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22050272|imex:IM-27330-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_076092.1|ensembl:ENSMUSG00000028820(gene)|ensembl:ENSMUST00000030623(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:Q8VIJ6|reactome:R-MMU-8849468	-	-	-	figure legend:Fig. 5b|comment:"Preys of wild-type and mutant LRSAM1 were indistinguishable:- the top 50 proteins only were identified based on their relative abundance, regardless whether the candidate proteins were from the wild-type cells or mutant cells."|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/24	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:9mciNgfKrEvyAv7kjs55FHlUtRY10090	rigid:NM3WX6NWM2FRolukZdNF4mbUBRI	false	mutation with complex effect:694-694|enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0658"(multidimensional protein identification technology)	psi-mi:"MI:0658"(multidimensional protein identification technology)
uniprotkb:P35637	uniprotkb:Q13148	intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108	intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203	psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym)	psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22013984|imex:IM-27330-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N	refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)	-	-	figure legend:Figure 6a|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0")	-	2019/09/02	2019/09/04	rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606	rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606	rigid:xHL5i3F0iEI6XwmD6B/H+Moi9ps	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35637	uniprotkb:Q6UWE0	intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym)	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22013984|imex:IM-27330-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)	-	-	figure legend:Figure 6a|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0")	-	2019/09/02	2019/09/04	rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rigid:xHL5i3F0iEI6XwmD6B/H+Moi9ps	false	-	mutation disrupting interaction strength:694-694	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13283	uniprotkb:Q6UWE0	intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym)	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22014003|imex:IM-27330-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)	-	-	figure legend:Figure 6b|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0")	-	2019/09/02	2019/09/04	rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rigid:0ST5IHuFYEYbAvIkX8eNqur/IPg	false	-	mutation disrupting interaction strength:694-694	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13148	uniprotkb:P35637	intact:EBI-372899|uniprotkb:Q6FI92|uniprotkb:E2PU12|uniprotkb:Q96DJ0|intact:EBI-2821405|uniprotkb:A4GUK4|uniprotkb:A4GUK5|uniprotkb:A4GUK6|uniprotkb:B2R629|uniprotkb:Q53H27|uniprotkb:B4DJ45|ensembl:ENSP00000240185|ensembl:ENSP00000491203	intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108	psi-mi:tadbp_human(display_long)|uniprotkb:TARDBP(gene name)|psi-mi:TARDBP(display_short)|uniprotkb:TDP43(gene name synonym)	psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22014135|imex:IM-27330-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031401.1|ensembl:ENSG00000120948(gene)|ensembl:ENST00000240185(transcript)|ensembl:ENST00000639083(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071765"(nuclear inner membrane organization)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR041105|mint:Q13148|rcsb pdb:1WF0|rcsb pdb:2CQG|rcsb pdb:2N2C|rcsb pdb:2N3X|rcsb pdb:2N4G|rcsb pdb:2N4H|rcsb pdb:2N4P|rcsb pdb:4BS2|rcsb pdb:4IUF|rcsb pdb:4Y00|rcsb pdb:4Y0F|rcsb pdb:5MDI|rcsb pdb:5MRG|rcsb pdb:5W50|rcsb pdb:5W52|rcsb pdb:5W7V|rcsb pdb:5WHN|rcsb pdb:5WHP|rcsb pdb:5WIA|rcsb pdb:5WIQ|rcsb pdb:5WKB|rcsb pdb:5WKD|rcsb pdb:5X4F|rcsb pdb:6B1G|rcsb pdb:6CF4|rcsb pdb:6CFH|rcsb pdb:6N37|rcsb pdb:6N3A|rcsb pdb:6N3B|rcsb pdb:6N3C|rcsb pdb:6T4B|rcsb pdb:7KWZ|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|refseq:XP_016856352.1|refseq:XP_016856353.1|refseq:XP_016856354.1|refseq:XP_016856355.1|refseq:XP_016856356.1|refseq:XP_016856357.1|dip:DIP-31167N	refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N	go:"GO:0005634"(nucleus)	-	-	figure legend:Figure 6d|comment:There was a decrease of FUS immunoreactivity in the nuclei of Cys694Arg fibroblasts, compared with those in normal fibroblasts. LRSAM1 was not added as an interactor as it was not detected in fluorescence microscopy.|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0")	-	2019/09/02	2019/09/25	rogid:KG5C6KnWiKeFQLYbHcfr9a11Ro49606	rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606	rigid:K6lyt5Bcqd/Qmp5ZogacR8ZV/28	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P56959	uniprotkb:Q6UWE0	intact:EBI-400452|ensembl:ENSMUSP00000101858	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	psi-mi:fus_mouse(display_long)|uniprotkb:Fus(gene name)|psi-mi:Fus(display_short)|uniprotkb:Protein pigpen(gene name synonym)	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hu et al. (2016)	pubmed:27615052|imex:IM-27330	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22014305|imex:IM-27330-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_631888.1|ensembl:ENSMUSG00000030795(gene)|ensembl:ENSMUST00000106251(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030425"(dendrite)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P56959|reactome:R-MMU-72163	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	go:"GO:0005634"(nucleus)	-	-	figure legend:Figure 6g|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nsc34)|taxid:10090(Mouse neuroblastomaspinal cord cell nsc-34)	-	2019/09/02	2019/09/04	rogid:Vwv/0vlM50l49XaUOHCtEWt/b2A10090	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rigid:4D5CHIddtzjA5g+/GpDcnjuiQZE	false	-	enhanced green fluorescent protein tag:?-?|mutation disrupting interaction strength:694-694	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)