#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q92847-2 uniprotkb:Q92847-1 intact:EBI-21459245|ensembl:ENSP00000395344 intact:EBI-21459171|ensembl:ENSP00000241256 psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:0663"(confocal microscopy) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-21915447|imex:IM-27383-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) - - - figure legend:Figure 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8 false renilla luciferase protein tag:c-c yellow fluorescent protein tag:c-c - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92847-1 uniprotkb:Q92847-1 intact:EBI-21459171|ensembl:ENSP00000241256 intact:EBI-21459171|ensembl:ENSP00000241256 psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-21915467|imex:IM-27383-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:2334"(luminescence donor) psi-mi:"MI:2335"(luminescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) - - - figure legend:Figure 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rigid:UAoWDNfVt15rAy/p/fK9AqsX+ig false renilla luciferase protein tag:c-c green fluorescent protein tag:c-c - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q92847-2 uniprotkb:Q92847-2 intact:EBI-21459245|ensembl:ENSP00000395344 intact:EBI-21459245|ensembl:ENSP00000395344 psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-21915475|imex:IM-27383-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:2334"(luminescence donor) psi-mi:"MI:2335"(luminescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript) - - - figure legend:Figure 6B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606 rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606 rigid:AIKgpg4BZgUFZSb07UabdN0YFWU false renilla luciferase protein tag:c-c green fluorescent protein tag:c-c - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P21728 uniprotkb:Q92847-1 intact:EBI-6624459|intact:EBI-28969432|ensembl:ENSP00000377353|uniprotkb:B2RA44|uniprotkb:Q4QRJ0 intact:EBI-21459171|ensembl:ENSP00000241256 psi-mi:drd1_human(display_long)|uniprotkb:DRD1(gene name)|psi-mi:DRD1(display_short)|uniprotkb:Dopamine D1 receptor(gene name synonym) psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-21915571|imex:IM-27383-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:2334"(luminescence donor) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000377353|ensembl:ENST00000393752(transcript)|go:"GO:0001588"(dopamine neurotransmitter receptor activity, coupled via Gs)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|ensembl:ENSG00000184845(gene)|go:"GO:0007617"(mating behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035240"(dopamine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001413(Dopamine 1A receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1OZ5|rcsb pdb:7CKW|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CRH|rcsb pdb:7JOZ|go:"GO:0060170"(ciliary membrane)|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7LJC|go:"GO:0071870"(cellular response to catecholamine stimulus)|rcsb pdb:7LJD|reactome:R-HSA-390651|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903351"(cellular response to dopamine)|refseq:NP_000785.1 intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) - - - figure legend:Figure 11E|comment:In the absence of GHS-R1a cDNA only a non-specific interaction was observed.|agonist:ghrelin|agonist:"ghrelin plus SKF81297 (a D1R agonist)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:AFtjhLTHlY7MiBUIYqC5/3tHHxg9606 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rigid:iyw5AiIfgavpHYZ+oJkR10TcDW0 false renilla luciferase protein tag:c-c - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P21728 uniprotkb:Q92847-2 intact:EBI-6624459|intact:EBI-28969432|ensembl:ENSP00000377353|uniprotkb:B2RA44|uniprotkb:Q4QRJ0 intact:EBI-21459245|ensembl:ENSP00000395344 psi-mi:drd1_human(display_long)|uniprotkb:DRD1(gene name)|psi-mi:DRD1(display_short)|uniprotkb:Dopamine D1 receptor(gene name synonym) psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-21915571|imex:IM-27383-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:2334"(luminescence donor) psi-mi:"MI:2335"(luminescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000377353|ensembl:ENST00000393752(transcript)|go:"GO:0001588"(dopamine neurotransmitter receptor activity, coupled via Gs)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|ensembl:ENSG00000184845(gene)|go:"GO:0007617"(mating behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035240"(dopamine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001413(Dopamine 1A receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1OZ5|rcsb pdb:7CKW|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CRH|rcsb pdb:7JOZ|go:"GO:0060170"(ciliary membrane)|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7LJC|go:"GO:0071870"(cellular response to catecholamine stimulus)|rcsb pdb:7LJD|reactome:R-HSA-390651|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903351"(cellular response to dopamine)|refseq:NP_000785.1 intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript) - - - figure legend:Figure 11E|comment:In the absence of GHS-R1a cDNA only a non-specific interaction was observed.|agonist:ghrelin|agonist:"ghrelin plus SKF81297 (a D1R agonist)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:AFtjhLTHlY7MiBUIYqC5/3tHHxg9606 rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606 rigid:iyw5AiIfgavpHYZ+oJkR10TcDW0 false renilla luciferase protein tag:c-c yellow fluorescent protein tag:c-c - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P21728 uniprotkb:Q92847-1 intact:EBI-6624459|intact:EBI-28969432|ensembl:ENSP00000377353|uniprotkb:B2RA44|uniprotkb:Q4QRJ0 intact:EBI-21459171|ensembl:ENSP00000241256 psi-mi:drd1_human(display_long)|uniprotkb:DRD1(gene name)|psi-mi:DRD1(display_short)|uniprotkb:Dopamine D1 receptor(gene name synonym) psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-21915595|imex:IM-27383-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:2334"(luminescence donor) psi-mi:"MI:2335"(luminescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000377353|ensembl:ENST00000393752(transcript)|go:"GO:0001588"(dopamine neurotransmitter receptor activity, coupled via Gs)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|ensembl:ENSG00000184845(gene)|go:"GO:0007617"(mating behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035240"(dopamine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001413(Dopamine 1A receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1OZ5|rcsb pdb:7CKW|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CRH|rcsb pdb:7JOZ|go:"GO:0060170"(ciliary membrane)|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7LJC|go:"GO:0071870"(cellular response to catecholamine stimulus)|rcsb pdb:7LJD|reactome:R-HSA-390651|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903351"(cellular response to dopamine)|refseq:NP_000785.1 intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) - - - figure legend:Figure 11F|comment:In the absence of GHS-R1b cDNA only a non-specific interaction was observed.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:AFtjhLTHlY7MiBUIYqC5/3tHHxg9606 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rigid:iyw5AiIfgavpHYZ+oJkR10TcDW0 false renilla luciferase protein tag:c-c yellow fluorescent protein tag:c-c - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:P21728 uniprotkb:Q92847-2 intact:EBI-6624459|intact:EBI-28969432|ensembl:ENSP00000377353|uniprotkb:B2RA44|uniprotkb:Q4QRJ0 intact:EBI-21459245|ensembl:ENSP00000395344 psi-mi:drd1_human(display_long)|uniprotkb:DRD1(gene name)|psi-mi:DRD1(display_short)|uniprotkb:Dopamine D1 receptor(gene name synonym) psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-21915595|imex:IM-27383-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:2334"(luminescence donor) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000377353|ensembl:ENST00000393752(transcript)|go:"GO:0001588"(dopamine neurotransmitter receptor activity, coupled via Gs)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007416"(synapse assembly)|ensembl:ENSG00000184845(gene)|go:"GO:0007617"(mating behavior)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008542"(visual learning)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035240"(dopamine binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042493"|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR001413(Dopamine 1A receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1OZ5|rcsb pdb:7CKW|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CRH|rcsb pdb:7JOZ|go:"GO:0060170"(ciliary membrane)|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7LJC|go:"GO:0071870"(cellular response to catecholamine stimulus)|rcsb pdb:7LJD|reactome:R-HSA-390651|reactome:R-HSA-418555|reactome:R-HSA-9660821|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903351"(cellular response to dopamine)|refseq:NP_000785.1 intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript) - - - figure legend:Figure 11F|comment:In the absence of GHS-R1b cDNA only a non-specific interaction was observed.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:AFtjhLTHlY7MiBUIYqC5/3tHHxg9606 rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606 rigid:iyw5AiIfgavpHYZ+oJkR10TcDW0 false renilla luciferase protein tag:c-c - - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q92847-1 uniprotkb:Q92847-2 intact:EBI-21459171|ensembl:ENSP00000241256 intact:EBI-21459245|ensembl:ENSP00000395344 psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:0051"(fluorescence technology) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21915494|imex:IM-27383-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:2341"(luminescence transmitter) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript) - - - figure legend:Figure 6C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606 rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8 false green fluorescent protein tag:c-c yellow fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92847-1 uniprotkb:Q92847-2 intact:EBI-21459171|ensembl:ENSP00000241256 intact:EBI-21459245|ensembl:ENSP00000395344 psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:0051"(fluorescence technology) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21915494|imex:IM-27383-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:2341"(luminescence transmitter) psi-mi:"MI:2334"(luminescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript) - - - figure legend:Figure 6C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606 rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8 false green fluorescent protein tag:c-c renilla luciferase protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92847-1 uniprotkb:Q92847-1 intact:EBI-21459171|ensembl:ENSP00000241256 intact:EBI-21459171|ensembl:ENSP00000241256 psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:0051"(fluorescence technology) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21915505|imex:IM-27383-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:2341"(luminescence transmitter) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) - - - figure legend:Figure 6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8 false yellow fluorescent protein tag:c-c green fluorescent protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92847-1 uniprotkb:Q92847-2 intact:EBI-21459171|ensembl:ENSP00000241256 intact:EBI-21459245|ensembl:ENSP00000395344 psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:0051"(fluorescence technology) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21915505|imex:IM-27383-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:2334"(luminescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript) - - - figure legend:Figure 6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606 rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8 false yellow fluorescent protein tag:c-c renilla luciferase protein tag:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92847-1 uniprotkb:Q92847-1 intact:EBI-21459171|ensembl:ENSP00000241256 intact:EBI-21459171|ensembl:ENSP00000241256 psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:2171"(complemented donor-acceptor resonance energy transfer) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21915528|imex:IM-27383-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:2335"(luminescence acceptor) psi-mi:"MI:2334"(luminescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) - - - figure legend:Figure 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8 false cYFP:c-c renilla-c:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92847-1 uniprotkb:Q92847-2 intact:EBI-21459171|ensembl:ENSP00000241256 intact:EBI-21459245|ensembl:ENSP00000395344 psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:2171"(complemented donor-acceptor resonance energy transfer) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21915528|imex:IM-27383-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:2335"(luminescence acceptor) psi-mi:"MI:2335"(luminescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript) - - - figure legend:Figure 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606 rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8 false cYFP:c-c nYFP:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q92847-1 uniprotkb:Q92847-2 intact:EBI-21459171|ensembl:ENSP00000241256 intact:EBI-21459245|ensembl:ENSP00000395344 psi-mi:q92847-1(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:q92847-2(display_long)|uniprotkb:GH-releasing peptide receptor(gene name synonym)|uniprotkb:Ghrelin receptor(gene name synonym)|uniprotkb:GHSR(gene name)|psi-mi:GHSR(display_short) psi-mi:"MI:2171"(complemented donor-acceptor resonance energy transfer) Navarro et al. (2016) pubmed:27129257|imex:IM-27383 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-21915528|imex:IM-27383-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:2335"(luminescence acceptor) psi-mi:"MI:2334"(luminescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000241256(transcript) intact:EBI-21495682(isoform-parent)|ensembl:ENSG00000121853(gene)|ensembl:ENST00000427970(transcript) - - - figure legend:Figure 6E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2019/05/27 2019/07/15 rogid:G0sX69hZa1BC//6+Zg6QHxzcTHg9606 rogid:RXvP4HYT1JKe683ZQO+LbSh9mRs9606 rigid:x3hpCLAsAztJCiqlm1IfNM9BvH8 false cYFP:c-c renilla-n:c-c - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)