#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
wwpdb:4a5w	uniprotkb:P07360-PRO_0000017881	intact:EBI-12513275|wwpdb:4e0s|reactome:R-HSA-173711	intact:EBI-22117447	psi-mi:co5-co6_human(display_short)|psi-mi:4a5w(display_long)|intact:C5bC6 complex(complex synonym)|intact:C5b-6 complex(complex synonym)|intact:C5b6 complement complex(complex recommended name)|intact:"C5:C6"(complex systematic name)|intact:C5b-C6 complex(complex synonym)	psi-mi:p07360-pro_0000017881(display_long)|uniprotkb:C8G(gene name)|psi-mi:C8G(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Serna et al. (2016)	pubmed:26841837|imex:IM-27446	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22117444|emdb:EMD-3135|emdb:EMD-3134|imex:IM-27446-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	complex portal:CPX-677(complex-primary)|go:"GO:0006956"(complement activation)|pubmed:22832194(see-also)|evidence ontology:"ECO:0000353"	intact:EBI-9021652(chain-parent)	-	curated-complex:"Involved in the complement system. The complement system is a part of the innate immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism. The complex is formed after C5 cleavage by C5 convertase into C5a and C5b. C5b has a transient binding site for C6. Without C6 binding, C5b will irreversibly decay to a state incapable of binding C6. The complex initiates pore formation via the sequential recruitment of homologous proteins: C7, C8, and 12-18 copies of C9, each of which comprises a central MAC-perforin domain flanked by auxiliary domains. Activation of the complement system results in formation of membrane attack complexes (MACs), pores that disrupt lipid bilayers and lyse bacteria and other pathogens."|complex-assembly:Heterotrimer|complex-properties:Bimolecular complex of Mr = 300,000. C5b grabs the top of C6 like a pair of pincers. The C-terminal region of C6 forms the major interface with C5b. The C5b-C6  interface buries 3100 A2 of solvent accessible surface area.	chain-seq-start:21|chain-seq-end:202	figure legend:1, Supplementary Table 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/09/04	2019/10/23	-	rogid:iBihg+hMlo1Lr3Nrbh75/JWj/Ls9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
wwpdb:4a5w	uniprotkb:P10643-PRO_0000023583	intact:EBI-12513275|wwpdb:4e0s|reactome:R-HSA-173711	intact:EBI-22117452	psi-mi:co5-co6_human(display_short)|psi-mi:4a5w(display_long)|intact:C5bC6 complex(complex synonym)|intact:C5b-6 complex(complex synonym)|intact:C5b6 complement complex(complex recommended name)|intact:"C5:C6"(complex systematic name)|intact:C5b-C6 complex(complex synonym)	psi-mi:pro_0000023583(display_long)|uniprotkb:C7(gene name)|psi-mi:C7(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Serna et al. (2016)	pubmed:26841837|imex:IM-27446	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22117444|emdb:EMD-3135|emdb:EMD-3134|imex:IM-27446-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	complex portal:CPX-677(complex-primary)|go:"GO:0006956"(complement activation)|pubmed:22832194(see-also)|evidence ontology:"ECO:0000353"	uniprotkb:P10643(chain-parent)	-	curated-complex:"Involved in the complement system. The complement system is a part of the innate immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism. The complex is formed after C5 cleavage by C5 convertase into C5a and C5b. C5b has a transient binding site for C6. Without C6 binding, C5b will irreversibly decay to a state incapable of binding C6. The complex initiates pore formation via the sequential recruitment of homologous proteins: C7, C8, and 12-18 copies of C9, each of which comprises a central MAC-perforin domain flanked by auxiliary domains. Activation of the complement system results in formation of membrane attack complexes (MACs), pores that disrupt lipid bilayers and lyse bacteria and other pathogens."|complex-assembly:Heterotrimer|complex-properties:Bimolecular complex of Mr = 300,000. C5b grabs the top of C6 like a pair of pincers. The C-terminal region of C6 forms the major interface with C5b. The C5b-C6  interface buries 3100 A2 of solvent accessible surface area.	-	figure legend:1, Supplementary Table 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/09/04	2019/10/23	-	rogid:B+8pwSMN1ZaqaBSdNMN+CUOQUl09606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
wwpdb:4a5w	uniprotkb:P07357-PRO_0000023586	intact:EBI-12513275|wwpdb:4e0s|reactome:R-HSA-173711	intact:EBI-22117457	psi-mi:co5-co6_human(display_short)|psi-mi:4a5w(display_long)|intact:C5bC6 complex(complex synonym)|intact:C5b-6 complex(complex synonym)|intact:C5b6 complement complex(complex recommended name)|intact:"C5:C6"(complex systematic name)|intact:C5b-C6 complex(complex synonym)	psi-mi:pro_0000023586(display_long)|uniprotkb:C8A(gene name)|psi-mi:C8A(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Serna et al. (2016)	pubmed:26841837|imex:IM-27446	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22117444|emdb:EMD-3135|emdb:EMD-3134|imex:IM-27446-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	complex portal:CPX-677(complex-primary)|go:"GO:0006956"(complement activation)|pubmed:22832194(see-also)|evidence ontology:"ECO:0000353"	uniprotkb:P07357(chain-parent)	-	curated-complex:"Involved in the complement system. The complement system is a part of the innate immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism. The complex is formed after C5 cleavage by C5 convertase into C5a and C5b. C5b has a transient binding site for C6. Without C6 binding, C5b will irreversibly decay to a state incapable of binding C6. The complex initiates pore formation via the sequential recruitment of homologous proteins: C7, C8, and 12-18 copies of C9, each of which comprises a central MAC-perforin domain flanked by auxiliary domains. Activation of the complement system results in formation of membrane attack complexes (MACs), pores that disrupt lipid bilayers and lyse bacteria and other pathogens."|complex-assembly:Heterotrimer|complex-properties:Bimolecular complex of Mr = 300,000. C5b grabs the top of C6 like a pair of pincers. The C-terminal region of C6 forms the major interface with C5b. The C5b-C6  interface buries 3100 A2 of solvent accessible surface area.	-	figure legend:1, Supplementary Table 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/09/04	2019/10/23	-	rogid:+QmfCGzvxxZALBw6xtZuY8i0Jcw9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
wwpdb:4a5w	uniprotkb:P07358-PRO_0000023592	intact:EBI-12513275|wwpdb:4e0s|reactome:R-HSA-173711	intact:EBI-22117462	psi-mi:co5-co6_human(display_short)|psi-mi:4a5w(display_long)|intact:C5bC6 complex(complex synonym)|intact:C5b-6 complex(complex synonym)|intact:C5b6 complement complex(complex recommended name)|intact:"C5:C6"(complex systematic name)|intact:C5b-C6 complex(complex synonym)	psi-mi:pro_0000023592(display_long)|uniprotkb:C8B(gene name)|psi-mi:C8B(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Serna et al. (2016)	pubmed:26841837|imex:IM-27446	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22117444|emdb:EMD-3135|emdb:EMD-3134|imex:IM-27446-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	complex portal:CPX-677(complex-primary)|go:"GO:0006956"(complement activation)|pubmed:22832194(see-also)|evidence ontology:"ECO:0000353"	uniprotkb:P07358(chain-parent)	-	curated-complex:"Involved in the complement system. The complement system is a part of the innate immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism. The complex is formed after C5 cleavage by C5 convertase into C5a and C5b. C5b has a transient binding site for C6. Without C6 binding, C5b will irreversibly decay to a state incapable of binding C6. The complex initiates pore formation via the sequential recruitment of homologous proteins: C7, C8, and 12-18 copies of C9, each of which comprises a central MAC-perforin domain flanked by auxiliary domains. Activation of the complement system results in formation of membrane attack complexes (MACs), pores that disrupt lipid bilayers and lyse bacteria and other pathogens."|complex-assembly:Heterotrimer|complex-properties:Bimolecular complex of Mr = 300,000. C5b grabs the top of C6 like a pair of pincers. The C-terminal region of C6 forms the major interface with C5b. The C5b-C6  interface buries 3100 A2 of solvent accessible surface area.	-	figure legend:1, Supplementary Table 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/09/04	2019/10/23	-	rogid:CjQqNgToQdh3rmjrxXd4hRb2eoE9606	-	false	-	-	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
wwpdb:4a5w	uniprotkb:P02748-PRO_0000023602	intact:EBI-12513275|wwpdb:4e0s|reactome:R-HSA-173711	intact:EBI-22117467	psi-mi:co5-co6_human(display_short)|psi-mi:4a5w(display_long)|intact:C5bC6 complex(complex synonym)|intact:C5b-6 complex(complex synonym)|intact:C5b6 complement complex(complex recommended name)|intact:"C5:C6"(complex systematic name)|intact:C5b-C6 complex(complex synonym)	psi-mi:pro_0000023602(display_long)|uniprotkb:C9(gene name)|psi-mi:C9(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Serna et al. (2016)	pubmed:26841837|imex:IM-27446	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22117444|emdb:EMD-3135|emdb:EMD-3134|imex:IM-27446-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	complex portal:CPX-677(complex-primary)|go:"GO:0006956"(complement activation)|pubmed:22832194(see-also)|evidence ontology:"ECO:0000353"	uniprotkb:P02748(chain-parent)	-	curated-complex:"Involved in the complement system. The complement system is a part of the innate immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism. The complex is formed after C5 cleavage by C5 convertase into C5a and C5b. C5b has a transient binding site for C6. Without C6 binding, C5b will irreversibly decay to a state incapable of binding C6. The complex initiates pore formation via the sequential recruitment of homologous proteins: C7, C8, and 12-18 copies of C9, each of which comprises a central MAC-perforin domain flanked by auxiliary domains. Activation of the complement system results in formation of membrane attack complexes (MACs), pores that disrupt lipid bilayers and lyse bacteria and other pathogens."|complex-assembly:Heterotrimer|complex-properties:Bimolecular complex of Mr = 300,000. C5b grabs the top of C6 like a pair of pincers. The C-terminal region of C6 forms the major interface with C5b. The C5b-C6  interface buries 3100 A2 of solvent accessible surface area.	-	figure legend:1, Supplementary Table 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/09/04	2019/10/23	-	rogid:5JjlLCrqklp8PuzXlORpI7vGEfY9606	-	false	-	-	1	18	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:P01031	uniprotkb:P13671	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	intact:EBI-1753221|ensembl:ENSP00000263413|ensembl:ENSP00000338861	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:co6_human(display_long)|uniprotkb:C6(gene name)|psi-mi:C6(display_short)	psi-mi:"MI:0943"(detection by mass spectrometry)	Serna et al. (2016)	pubmed:26841837|imex:IM-27446	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22117486|imex:IM-27446-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	refseq:NP_000056.2|refseq:NP_001108603.2|ensembl:ENSG00000039537(gene)|ensembl:ENST00000263413(transcript)|ensembl:ENST00000337836(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR035976|interpro:IPR036055|interpro:IPR036383|rcsb pdb:3T5O|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	-	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	-	figure legend:Supplementary table 2|caution:"Supplementary table 2 gives the same Uniprot  identifier for Component C9 and C8  (P07357); it has been assumed that P02748 should be entered for Component C9."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/09/04	2019/12/20	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	rogid:GfycGXFpIoDx8sLZwxVYVMaJp4g9606	rigid:EL0T0wunQn9Io6uVfijTxe1V88U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01031	uniprotkb:P10643	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	intact:EBI-2872846|uniprotkb:A8K2T4|uniprotkb:Q92489|uniprotkb:Q6P3T5|ensembl:ENSP00000322061	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:co7_human(display_long)|uniprotkb:C7(gene name)|psi-mi:C7(display_short)	psi-mi:"MI:0943"(detection by mass spectrometry)	Serna et al. (2016)	pubmed:26841837|imex:IM-27446	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22117486|imex:IM-27446-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	refseq:NP_000578.2|ensembl:ENSG00000112936(gene)|ensembl:ENST00000313164(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR035976|interpro:IPR036055|interpro:IPR036383|interpro:IPR037564|interpro:IPR040729|rcsb pdb:2WCY|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	-	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	-	figure legend:Supplementary table 2|caution:"Supplementary table 2 gives the same Uniprot  identifier for Component C9 and C8  (P07357); it has been assumed that P02748 should be entered for Component C9."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/09/04	2019/12/20	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	rogid:RJDxSLqEzP1N71ZWcSspzpBI8+k9606	rigid:EL0T0wunQn9Io6uVfijTxe1V88U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01031	uniprotkb:P07357	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	intact:EBI-9021639|uniprotkb:Q9H130|uniprotkb:A2RUI4|uniprotkb:Q13668|uniprotkb:A2RUI5|ensembl:ENSP00000354458	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:co8a_human(display_long)|uniprotkb:C8A(gene name)|psi-mi:C8A(display_short)|uniprotkb:Complement component 8 subunit alpha(gene name synonym)	psi-mi:"MI:0943"(detection by mass spectrometry)	Serna et al. (2016)	pubmed:26841837|imex:IM-27446	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22117486|imex:IM-27446-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	refseq:NP_000553.1|dip:DIP-1125N|ensembl:ENSG00000157131(gene)|ensembl:ENST00000361249(transcript)|go:"GO:0001848"(complement binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0016020"(membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR036055|interpro:IPR036383|interpro:IPR037565|rcsb pdb:2QOS|rcsb pdb:2QQH|rcsb pdb:2RD7|rcsb pdb:3OJY|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	-	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	-	figure legend:Supplementary table 2|caution:"Supplementary table 2 gives the same Uniprot  identifier for Component C9 and C8  (P07357); it has been assumed that P02748 should be entered for Component C9."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/09/04	2019/12/20	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	rogid:yxjkH/5pI3e1Sq3z4cycR2D7BqA9606	rigid:EL0T0wunQn9Io6uVfijTxe1V88U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01031	uniprotkb:P07358	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	intact:EBI-12523855|uniprotkb:A1L4K7|ensembl:ENSP00000360281	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:co8b_human(display_long)|uniprotkb:C8B(gene name)|psi-mi:C8B(display_short)|uniprotkb:Complement component 8 subunit beta(gene name synonym)	psi-mi:"MI:0943"(detection by mass spectrometry)	Serna et al. (2016)	pubmed:26841837|imex:IM-27446	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22117486|imex:IM-27446-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	refseq:NP_000057.2|refseq:XP_016857724.1|ensembl:ENSG00000021852(gene)|ensembl:ENST00000371237(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006955"(immune response)|go:"GO:0006956"(complement activation)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0016020"(membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR036055|interpro:IPR036383|interpro:IPR037566|rcsb pdb:3OJY|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	-	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	-	figure legend:Supplementary table 2|caution:"Supplementary table 2 gives the same Uniprot  identifier for Component C9 and C8  (P07357); it has been assumed that P02748 should be entered for Component C9."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/09/04	2019/12/20	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	rogid:jevm2nY8n6750D+nkigfM5lmoYI9606	rigid:EL0T0wunQn9Io6uVfijTxe1V88U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01031	uniprotkb:P07360	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	intact:EBI-9021652|uniprotkb:Q5SQ07|uniprotkb:Q14CT8|uniprotkb:Q14CU0|ensembl:ENSP00000360697	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:co8g_human(display_long)|uniprotkb:C8G(gene name)|psi-mi:C8G(display_short)	psi-mi:"MI:0943"(detection by mass spectrometry)	Serna et al. (2016)	pubmed:26841837|imex:IM-27446	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22117486|imex:IM-27446-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	refseq:NP_000597.2|ensembl:ENSG00000176919(gene)|ensembl:ENST00000371634(transcript)|go:"GO:0001848"(complement binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0019841"(retinol binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|interpro:IPR022272|interpro:IPR043245|rcsb pdb:1IW2|rcsb pdb:1LF7|rcsb pdb:2OVA|rcsb pdb:2OVD|rcsb pdb:2OVE|rcsb pdb:2QOS|rcsb pdb:2RD7|rcsb pdb:3OJY|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606|interpro:IPR002968(Alpha-1-microglobulin)	-	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	-	figure legend:Supplementary table 2|caution:"Supplementary table 2 gives the same Uniprot  identifier for Component C9 and C8  (P07357); it has been assumed that P02748 should be entered for Component C9."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/09/04	2019/12/20	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	rogid:YU8/KH6FgbBJ00DBO2oEOWZqT0w9606	rigid:EL0T0wunQn9Io6uVfijTxe1V88U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01031	uniprotkb:P02748	intact:EBI-8558308|intact:UNK-5392818|uniprotkb:Q27I61|intact:UNK-5368655|uniprotkb:Q14CJ0|intact:UNK-5396112|ensembl:ENSP00000223642	intact:EBI-6677628|ensembl:ENSP00000263408	psi-mi:co5_human(display_long)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4(gene name synonym)|uniprotkb:CPAMD4(gene name synonym)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)	psi-mi:co9_human(display_long)|uniprotkb:C9(gene name)|psi-mi:C9(display_short)	psi-mi:"MI:0943"(detection by mass spectrometry)	Serna et al. (2016)	pubmed:26841837|imex:IM-27446	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22117486|imex:IM-27446-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304092.1|refseq:NP_001726.2|ensembl:ENSG00000106804(gene)|ensembl:ENST00000223642(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:1CFA|rcsb pdb:1KJS|rcsb pdb:1XWE|rcsb pdb:3CU7|rcsb pdb:3HQA|rcsb pdb:3HQB|rcsb pdb:3KLS|rcsb pdb:3KM9|rcsb pdb:3PRX|rcsb pdb:3PVM|rcsb pdb:4A5W|rcsb pdb:4E0S|rcsb pdb:4P39|rcsb pdb:4UU9|rcsb pdb:5B4P|rcsb pdb:5B71|rcsb pdb:5HCC|rcsb pdb:5HCD|rcsb pdb:5HCE|rcsb pdb:5I5K|rcsb pdb:6H03|rcsb pdb:6H04|rcsb pdb:6RPT|rcsb pdb:7AD6|rcsb pdb:7AD7|reactome:R-HSA-166665|reactome:R-HSA-174577|reactome:R-HSA-375276|reactome:R-HSA-418594|reactome:R-HSA-977606	refseq:NP_001728.1|dip:DIP-1124N|ensembl:ENSG00000113600(gene)|ensembl:ENST00000263408(transcript)|go:"GO:0001906"(cell killing)|go:"GO:0005576"(extracellular region)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0019835"(cytolysis)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001862(Membrane attack complex component/perforin/complement C9)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR020863|interpro:IPR020864|interpro:IPR023415|interpro:IPR036055|interpro:IPR036383|interpro:IPR037567|rcsb pdb:5FMW|rcsb pdb:6DLW|rcsb pdb:6H03|rcsb pdb:6H04|reactome:R-HSA-166665|reactome:R-HSA-977606	-	function:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled|comment:mint|function:"Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis)"|function:"Defects in C5 are the cause of complement C5 deficiency [MIM:609536]. Patients with dysfunction of C5 display a propensity for severe recurrent infections"|function:"Genetic variation in C5 can be associated with susceptibility to liver fibrosis [MIM:120900]. Liver fibrosis is a common consequence of all chronic liver diseases, irrespective of etiology. Common C5 variants can influence the progression and severity of fibrogenesis"	-	figure legend:Supplementary table 2|caution:"Supplementary table 2 gives the same Uniprot  identifier for Component C9 and C8  (P07357); it has been assumed that P02748 should be entered for Component C9."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/09/04	2019/12/20	rogid:EpfpW2TQ68YvIqNRfr6uIyA6MUU9606	rogid:XzPZJ9OUi00H+87so48Q/n+GXds9606	rigid:EL0T0wunQn9Io6uVfijTxe1V88U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)