#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15923	uniprotkb:Q9BRJ9	intact:EBI-769630|uniprotkb:Q2TB40|uniprotkb:P15883|uniprotkb:Q14208|uniprotkb:Q14635|uniprotkb:Q14636|uniprotkb:Q9UPI9|uniprotkb:Q2TB39|intact:EBI-11119608|ensembl:ENSP00000262965	intact:EBI-21944954|uniprotkb:Q9NSF1|uniprotkb:Q9NSF2|intact:EBI-28972745|ensembl:ENSP00000300057	psi-mi:tfe2_human(display_long)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 1(gene name synonym)|uniprotkb:Transcription factor ITF-1(gene name synonym)|uniprotkb:Kappa-E2-binding factor(gene name synonym)|uniprotkb:TCF3(gene name)|psi-mi:TCF3(display_short)|uniprotkb:E2A(gene name synonym)|uniprotkb:ITF1(gene name synonym)|uniprotkb:BHLHB21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 21(gene name synonym)	psi-mi:mesp1_human(display_long)|uniprotkb:Class C basic helix-loop-helix protein 5(gene name synonym)|uniprotkb:MESP1(gene name)|psi-mi:MESP1(display_short)|uniprotkb:BHLHC5(gene name synonym)	psi-mi:"MI:0728"(gal4 vp16 complementation)	Werner et al. (2016)	pubmed:26694203|imex:IM-27209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21945010|imex:IM-27209-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129611.1|refseq:NP_003191.1|refseq:XP_016882669.1|refseq:XP_016882670.1|refseq:XP_016882671.1|dip:DIP-74N|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000071564(gene)|ensembl:ENST00000262965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2YPA|rcsb pdb:2YPB|rcsb pdb:3U5V|rcsb pdb:6MGN|reactome:R-HSA-525793|reactome:R-HSA-8939236|rcsb pdb:2MH0|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1HLH	ensembl:ENSP00000300057|refseq:NP_061140.1|ensembl:ENSG00000166823(gene)|ensembl:ENST00000300057(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003236"(sinus venosus morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003259"(cardioblast anterior-lateral migration)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0010467"(gene expression)|go:"GO:0022008"(neurogenesis)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0035481"(positive regulation of Notch signaling pathway involved in heart induction)|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060921"(sinoatrial node cell differentiation)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060975"(cardioblast migration to the midline involved in heart field formation)|go:"GO:0070368"(positive regulation of hepatocyte differentiation)|go:"GO:0090082"(positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR040259	-	-	-	figure legend:Figure 3|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/08/01	2019/08/01	rogid:EybpTkEZM4cIWyf25UVHfaOaP3Y9606	rogid:DF8ScCTeO984+eC2uZpqE0HKKt09606	rigid:qnThtMBywxbx8NHRmEKKjg7z97Y	false	-	gal4 dna binding domain:?-?|mutation with no effect:70-70|mutation with no effect:27-29|mutation with no effect:268-268|mutation decreasing interaction strength:168-168|mutation decreasing interaction strength:104-104|mutation decreasing interaction strength:120-120|mutation disrupting interaction strength:147-268	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)