#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B chebi:"CHEBI:16856" chebi:"CHEBI:28115" intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-21945572|chebi:"CHEBI:48831"|chebi:"CHEBI:6869"|chebi:"CHEBI:25291" psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:methylcobalamin(display_short)|psi-mi:"CHEBI:28115"(display_long)|intact:CO-METHYLCOBALAMIN(synonym)|intact:MeCbl(synonym)|intact:mecobalamin(synonym)|intact:"methylcob(III)alamin"(synonym)|intact:Methylcobalamin(synonym)|intact:methylcobalamin(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-methylcobamide"(iupac name) psi-mi:"MI:0071"(molecular sieving) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21945552|imex:IM-27214-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - - - - figure legend:Figure 1d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/02 - - - false - - - - psi-mi:"MI:0815"(confirmation by molecular weight) psi-mi:"MI:0815"(confirmation by molecular weight) chebi:"CHEBI:16856" uniprotkb:Q9Y4U1 intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-9775184|uniprotkb:Q5T157|uniprotkb:Q9BRQ7|ensembl:ENSP00000383840 psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:mmac_human(display_long)|uniprotkb:MMACHC(gene name)|psi-mi:MMACHC(display_short)|uniprotkb:CblC(gene name synonym)|uniprotkb:"Cyanocobalamin reductase (cyanide-eliminating)"(gene name synonym)|uniprotkb:"Alkylcobalamin:glutathione S-alkyltransferase"(gene name synonym)|uniprotkb:Methylmalonic aciduria and homocystinuria type C protein(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21945552|imex:IM-27214-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_056321.2|refseq:NP_001317469.1|ensembl:ENSG00000132763(gene)|ensembl:ENST00000401061(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016740"(transferase activity)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032451"(demethylase activity)|go:"GO:0033787"("cyanocobalamin reductase (cyanide-eliminating) activity")|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043295"(glutathione binding)|go:"GO:0070988"(demethylation)|go:"GO:0071949"(FAD binding)|interpro:IPR032037|rcsb pdb:3SBY|rcsb pdb:3SBZ|rcsb pdb:3SC0|rcsb pdb:3SOM|rcsb pdb:5UOS|reactome:R-HSA-196741|reactome:R-HSA-3359473|reactome:R-HSA-3359474 - - - figure legend:Figure 1d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/02 - rogid:HLpV70pJ6XpjFsQ6SehGTXMRuDQ9606 - false - sufficient binding region:1-235 - - psi-mi:"MI:0815"(confirmation by molecular weight) psi-mi:"MI:0815"(confirmation by molecular weight) chebi:"CHEBI:16856" uniprotkb:Q99LS1 intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-11600752|ensembl:ENSMUSP00000099830 psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:mmad_mouse(display_long)|uniprotkb:Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial(gene name synonym)|uniprotkb:Mmadhc(gene name)|psi-mi:Mmadhc(display_short)|uniprotkb:CblD(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21945552|imex:IM-27214-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_598600.1|refseq:XP_006497661.1|ensembl:ENSMUSG00000026766(gene)|ensembl:ENSMUST00000102769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0009235"(cobalamin metabolic process)|interpro:IPR019362|rcsb pdb:5A4R|reactome:R-MMU-196741 - - - figure legend:Figure 1d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/02 - rogid:Lusq0MN+gikEe2ej72XRmfrMzqU10090 - false - sufficient binding region:129-296|his tag:n-n - - psi-mi:"MI:0815"(confirmation by molecular weight) psi-mi:"MI:0815"(confirmation by molecular weight) chebi:"CHEBI:16856" chebi:"CHEBI:28115" intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-21945572|chebi:"CHEBI:48831"|chebi:"CHEBI:6869"|chebi:"CHEBI:25291" psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:methylcobalamin(display_short)|psi-mi:"CHEBI:28115"(display_long)|intact:CO-METHYLCOBALAMIN(synonym)|intact:MeCbl(synonym)|intact:mecobalamin(synonym)|intact:"methylcob(III)alamin"(synonym)|intact:Methylcobalamin(synonym)|intact:methylcobalamin(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-methylcobamide"(iupac name) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21945598|imex:IM-27214-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - - - - figure legend:Figure 1g|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/02 - - - false - - - - psi-mi:"MI:0815"(confirmation by molecular weight) psi-mi:"MI:0815"(confirmation by molecular weight) chebi:"CHEBI:16856" uniprotkb:Q9Y4U1 intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-9775184|uniprotkb:Q5T157|uniprotkb:Q9BRQ7|ensembl:ENSP00000383840 psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:mmac_human(display_long)|uniprotkb:MMACHC(gene name)|psi-mi:MMACHC(display_short)|uniprotkb:CblC(gene name synonym)|uniprotkb:"Cyanocobalamin reductase (cyanide-eliminating)"(gene name synonym)|uniprotkb:"Alkylcobalamin:glutathione S-alkyltransferase"(gene name synonym)|uniprotkb:Methylmalonic aciduria and homocystinuria type C protein(gene name synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21945598|imex:IM-27214-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_056321.2|refseq:NP_001317469.1|ensembl:ENSG00000132763(gene)|ensembl:ENST00000401061(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016740"(transferase activity)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032451"(demethylase activity)|go:"GO:0033787"("cyanocobalamin reductase (cyanide-eliminating) activity")|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043295"(glutathione binding)|go:"GO:0070988"(demethylation)|go:"GO:0071949"(FAD binding)|interpro:IPR032037|rcsb pdb:3SBY|rcsb pdb:3SBZ|rcsb pdb:3SC0|rcsb pdb:3SOM|rcsb pdb:5UOS|reactome:R-HSA-196741|reactome:R-HSA-3359473|reactome:R-HSA-3359474 - - - figure legend:Figure 1g|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/02 - rogid:HLpV70pJ6XpjFsQ6SehGTXMRuDQ9606 - false - - - 1 psi-mi:"MI:0815"(confirmation by molecular weight) psi-mi:"MI:0815"(confirmation by molecular weight) chebi:"CHEBI:16856" uniprotkb:Q9H3L0 intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-11111575|uniprotkb:B2R895|uniprotkb:O95891|uniprotkb:D3DP91|ensembl:ENSP00000301920|ensembl:ENSP00000389060 psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:mmad_human(display_long)|uniprotkb:Methylmalonic aciduria and homocystinuria type D protein, mitochondrial(gene name synonym)|uniprotkb:HSPC161(orf name)|uniprotkb:My011(orf name)|uniprotkb:MMADHC(gene name)|psi-mi:MMADHC(display_short)|uniprotkb:C2orf25(gene name synonym)|uniprotkb:CL25022(gene name synonym)|uniprotkb:CblD(gene name synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21945598|imex:IM-27214-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_056517.1|ensembl:ENSG00000168288(gene)|ensembl:ENST00000303319(transcript)|ensembl:ENST00000428879(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009235"(cobalamin metabolic process)|interpro:IPR019362|rcsb pdb:5CUZ|rcsb pdb:5CV0|rcsb pdb:6X8Z|reactome:R-HSA-196741|reactome:R-HSA-3359473 - - - figure legend:Figure 1g|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/02 - rogid:au3sO2FnulvG7w034Mf++ijEm9Q9606 - false - sufficient binding region:124-296|his tag:n-n - 1 psi-mi:"MI:0815"(confirmation by molecular weight) psi-mi:"MI:0815"(confirmation by molecular weight) chebi:"CHEBI:16856" chebi:"CHEBI:28115" intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-21945572|chebi:"CHEBI:48831"|chebi:"CHEBI:6869"|chebi:"CHEBI:25291" psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:methylcobalamin(display_short)|psi-mi:"CHEBI:28115"(display_long)|intact:CO-METHYLCOBALAMIN(synonym)|intact:MeCbl(synonym)|intact:mecobalamin(synonym)|intact:"methylcob(III)alamin"(synonym)|intact:Methylcobalamin(synonym)|intact:methylcobalamin(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-methylcobamide"(iupac name) psi-mi:"MI:0276"(blue native page) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21945658|imex:IM-27214-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - - - - figure legend:Figure 5d, 1a, 1b, 1c, 1d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/02 - - - false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) chebi:"CHEBI:16856" uniprotkb:Q9Y4U1 intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-9775184|uniprotkb:Q5T157|uniprotkb:Q9BRQ7|ensembl:ENSP00000383840 psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:mmac_human(display_long)|uniprotkb:MMACHC(gene name)|psi-mi:MMACHC(display_short)|uniprotkb:CblC(gene name synonym)|uniprotkb:"Cyanocobalamin reductase (cyanide-eliminating)"(gene name synonym)|uniprotkb:"Alkylcobalamin:glutathione S-alkyltransferase"(gene name synonym)|uniprotkb:Methylmalonic aciduria and homocystinuria type C protein(gene name synonym) psi-mi:"MI:0276"(blue native page) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21945658|imex:IM-27214-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_056321.2|refseq:NP_001317469.1|ensembl:ENSG00000132763(gene)|ensembl:ENST00000401061(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016740"(transferase activity)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032451"(demethylase activity)|go:"GO:0033787"("cyanocobalamin reductase (cyanide-eliminating) activity")|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043295"(glutathione binding)|go:"GO:0070988"(demethylation)|go:"GO:0071949"(FAD binding)|interpro:IPR032037|rcsb pdb:3SBY|rcsb pdb:3SBZ|rcsb pdb:3SC0|rcsb pdb:3SOM|rcsb pdb:5UOS|reactome:R-HSA-196741|reactome:R-HSA-3359473|reactome:R-HSA-3359474 - - - figure legend:Figure 5d, 1a, 1b, 1c, 1d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/02 - rogid:HLpV70pJ6XpjFsQ6SehGTXMRuDQ9606 - false - mutation decreasing interaction strength:161-161|mutation disrupting interaction strength:109-111 - 1 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) chebi:"CHEBI:16856" uniprotkb:Q9H3L0 intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-11111575|uniprotkb:B2R895|uniprotkb:O95891|uniprotkb:D3DP91|ensembl:ENSP00000301920|ensembl:ENSP00000389060 psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:mmad_human(display_long)|uniprotkb:Methylmalonic aciduria and homocystinuria type D protein, mitochondrial(gene name synonym)|uniprotkb:HSPC161(orf name)|uniprotkb:My011(orf name)|uniprotkb:MMADHC(gene name)|psi-mi:MMADHC(display_short)|uniprotkb:C2orf25(gene name synonym)|uniprotkb:CL25022(gene name synonym)|uniprotkb:CblD(gene name synonym) psi-mi:"MI:0276"(blue native page) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21945658|imex:IM-27214-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_056517.1|ensembl:ENSG00000168288(gene)|ensembl:ENST00000303319(transcript)|ensembl:ENST00000428879(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009235"(cobalamin metabolic process)|interpro:IPR019362|rcsb pdb:5CUZ|rcsb pdb:5CV0|rcsb pdb:6X8Z|reactome:R-HSA-196741|reactome:R-HSA-3359473 - - - figure legend:Figure 5d, 1a, 1b, 1c, 1d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/02 - rogid:au3sO2FnulvG7w034Mf++ijEm9Q9606 - false - sufficient binding region:124-296|mutation decreasing interaction strength:182-182|mutation with no effect:186-186|mutation decreasing interaction strength:189-189|mutation with no effect:226-226|mutation with no effect:259-259|his tag:n-n - 1 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) chebi:"CHEBI:16856" chebi:"CHEBI:28115" intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-21945572|chebi:"CHEBI:48831"|chebi:"CHEBI:6869"|chebi:"CHEBI:25291" psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:methylcobalamin(display_short)|psi-mi:"CHEBI:28115"(display_long)|intact:CO-METHYLCOBALAMIN(synonym)|intact:MeCbl(synonym)|intact:mecobalamin(synonym)|intact:"methylcob(III)alamin"(synonym)|intact:Methylcobalamin(synonym)|intact:methylcobalamin(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-methylcobamide"(iupac name) psi-mi:"MI:0276"(blue native page) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21986471|imex:IM-27214-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - - - - figure legend:Figure 1f|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/15 - - - false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) chebi:"CHEBI:16856" uniprotkb:Q9Y4U1 intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-9775184|uniprotkb:Q5T157|uniprotkb:Q9BRQ7|ensembl:ENSP00000383840 psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:mmac_human(display_long)|uniprotkb:MMACHC(gene name)|psi-mi:MMACHC(display_short)|uniprotkb:CblC(gene name synonym)|uniprotkb:"Cyanocobalamin reductase (cyanide-eliminating)"(gene name synonym)|uniprotkb:"Alkylcobalamin:glutathione S-alkyltransferase"(gene name synonym)|uniprotkb:Methylmalonic aciduria and homocystinuria type C protein(gene name synonym) psi-mi:"MI:0276"(blue native page) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21986471|imex:IM-27214-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_056321.2|refseq:NP_001317469.1|ensembl:ENSG00000132763(gene)|ensembl:ENST00000401061(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016740"(transferase activity)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032451"(demethylase activity)|go:"GO:0033787"("cyanocobalamin reductase (cyanide-eliminating) activity")|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043295"(glutathione binding)|go:"GO:0070988"(demethylation)|go:"GO:0071949"(FAD binding)|interpro:IPR032037|rcsb pdb:3SBY|rcsb pdb:3SBZ|rcsb pdb:3SC0|rcsb pdb:3SOM|rcsb pdb:5UOS|reactome:R-HSA-196741|reactome:R-HSA-3359473|reactome:R-HSA-3359474 - - - figure legend:Figure 1f|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/15 - rogid:HLpV70pJ6XpjFsQ6SehGTXMRuDQ9606 - false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) chebi:"CHEBI:16856" uniprotkb:Q99LS1 intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-11600752|ensembl:ENSMUSP00000099830 psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:mmad_mouse(display_long)|uniprotkb:Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial(gene name synonym)|uniprotkb:Mmadhc(gene name)|psi-mi:Mmadhc(display_short)|uniprotkb:CblD(gene name synonym) psi-mi:"MI:0276"(blue native page) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21986471|imex:IM-27214-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_598600.1|refseq:XP_006497661.1|ensembl:ENSMUSG00000026766(gene)|ensembl:ENSMUST00000102769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0009235"(cobalamin metabolic process)|interpro:IPR019362|rcsb pdb:5A4R|reactome:R-MMU-196741 - - - figure legend:Figure 1f|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/15 - rogid:Lusq0MN+gikEe2ej72XRmfrMzqU10090 - false - sufficient binding region:129-296|his tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) chebi:"CHEBI:16856" chebi:"CHEBI:28115" intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-21945572|chebi:"CHEBI:48831"|chebi:"CHEBI:6869"|chebi:"CHEBI:25291" psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:methylcobalamin(display_short)|psi-mi:"CHEBI:28115"(display_long)|intact:CO-METHYLCOBALAMIN(synonym)|intact:MeCbl(synonym)|intact:mecobalamin(synonym)|intact:"methylcob(III)alamin"(synonym)|intact:Methylcobalamin(synonym)|intact:methylcobalamin(synonym)|intact:"Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-methylcobamide"(iupac name) psi-mi:"MI:0826"(x ray scattering) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21981648|imex:IM-27214-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) - - - - - figure legend:Figure 6a, 6b, 6c|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/12 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16856" uniprotkb:Q9Y4U1 intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-9775184|uniprotkb:Q5T157|uniprotkb:Q9BRQ7|ensembl:ENSP00000383840 psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:mmac_human(display_long)|uniprotkb:MMACHC(gene name)|psi-mi:MMACHC(display_short)|uniprotkb:CblC(gene name synonym)|uniprotkb:"Cyanocobalamin reductase (cyanide-eliminating)"(gene name synonym)|uniprotkb:"Alkylcobalamin:glutathione S-alkyltransferase"(gene name synonym)|uniprotkb:Methylmalonic aciduria and homocystinuria type C protein(gene name synonym) psi-mi:"MI:0826"(x ray scattering) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21981648|imex:IM-27214-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_056321.2|refseq:NP_001317469.1|ensembl:ENSG00000132763(gene)|ensembl:ENST00000401061(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009235"(cobalamin metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016740"(transferase activity)|go:"GO:0031419"(cobalamin binding)|go:"GO:0032451"(demethylase activity)|go:"GO:0033787"("cyanocobalamin reductase (cyanide-eliminating) activity")|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043295"(glutathione binding)|go:"GO:0070988"(demethylation)|go:"GO:0071949"(FAD binding)|interpro:IPR032037|rcsb pdb:3SBY|rcsb pdb:3SBZ|rcsb pdb:3SC0|rcsb pdb:3SOM|rcsb pdb:5UOS|reactome:R-HSA-196741|reactome:R-HSA-3359473|reactome:R-HSA-3359474 - - - figure legend:Figure 6a, 6b, 6c|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/12 - rogid:HLpV70pJ6XpjFsQ6SehGTXMRuDQ9606 - false - sufficient binding region:1-235 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:16856" uniprotkb:Q99LS1 intact:EBI-10824516|chebi:"CHEBI:42873"|chebi:"CHEBI:43049"|chebi:"CHEBI:5437"|chebi:"CHEBI:12402"|chebi:"CHEBI:14327"|chebi:"CHEBI:24334" intact:EBI-11600752|ensembl:ENSMUSP00000099830 psi-mi:glutathione(display_short)|psi-mi:"CHEBI:16856"(display_long)|intact:gamma-L-Glutamyl-L-cysteinyl-glycine(synonym)|intact:5-L-Glutamyl-L-cysteinylglycine(synonym)|intact:Glutathione(synonym)|intact:Glutathione-SH(synonym)|intact:GSH(synonym)|intact:"N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine"(synonym)|intact:Reduced glutathione(synonym)|intact:L-gamma-glutamyl-L-cysteinylglycine(iupac name) psi-mi:mmad_mouse(display_long)|uniprotkb:Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial(gene name synonym)|uniprotkb:Mmadhc(gene name)|psi-mi:Mmadhc(display_short)|uniprotkb:CblD(gene name synonym) psi-mi:"MI:0826"(x ray scattering) Froese et al. (2015) pubmed:26483544|imex:IM-27214 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-21981648|imex:IM-27214-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0682"(cofactor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_598600.1|refseq:XP_006497661.1|ensembl:ENSMUSG00000026766(gene)|ensembl:ENSMUST00000102769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0009235"(cobalamin metabolic process)|interpro:IPR019362|rcsb pdb:5A4R|reactome:R-MMU-196741 - - - figure legend:Figure 6a, 6b, 6c|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2019/08/02 2019/08/12 - rogid:Lusq0MN+gikEe2ej72XRmfrMzqU10090 - false - sufficient binding region:129-296 - 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)