#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UIK5	uniprotkb:P05067-PRO_0000000088	intact:EBI-11423693|ensembl:ENSP00000272771|uniprotkb:Q53H90|uniprotkb:Q4ZFW4|uniprotkb:Q2FA44|uniprotkb:Q9UK65|uniprotkb:Q9NR15|uniprotkb:Q53RE1|uniprotkb:Q8N2R5|uniprotkb:Q9P2Y9|uniprotkb:Q9NSS5	intact:EBI-21194778	psi-mi:teff2_human(display_long)|uniprotkb:TMEFF2(gene name)|psi-mi:TMEFF2(display_short)|uniprotkb:HPP1(gene name synonym)|uniprotkb:Hyperplastic polyposis protein 1(gene name synonym)|uniprotkb:TENB2(gene name synonym)|uniprotkb:TPEF(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and two follistatin-like domains(gene name synonym)|uniprotkb:UNQ178/PRO204(orf name)	psi-mi:p05067-pro_0000000088(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:AD1(gene name synonym)|uniprotkb:A4(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hong et al. (2014)	pubmed:26402097|imex:IM-27224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21194785|imex:IM-27224-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000144339(gene)|ensembl:ENST00000272771(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR036058|rcsb pdb:2FMW|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|refseq:NP_001292063.1|refseq:NP_001292074.1|refseq:NP_057276.2	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:18|chain-seq-end:770	figure legend:na|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mc65)|taxid:9606(Human neuroblastoma cell MC65)	-	2019/02/06	2019/02/06	rogid:cjznO3tchWAGUCRwK+0QEyj1cgA9606	rogid:9eSh/xetaVpIKr921pcLotBd/Ks9606	rigid:e4ngixLb6l7INuZsHNw6qpeBq1A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9UIK5	uniprotkb:P05067-PRO_0000000090	intact:EBI-11423693|ensembl:ENSP00000272771|uniprotkb:Q53H90|uniprotkb:Q4ZFW4|uniprotkb:Q2FA44|uniprotkb:Q9UK65|uniprotkb:Q9NR15|uniprotkb:Q53RE1|uniprotkb:Q8N2R5|uniprotkb:Q9P2Y9|uniprotkb:Q9NSS5	intact:EBI-21194918	psi-mi:teff2_human(display_long)|uniprotkb:TMEFF2(gene name)|psi-mi:TMEFF2(display_short)|uniprotkb:HPP1(gene name synonym)|uniprotkb:Hyperplastic polyposis protein 1(gene name synonym)|uniprotkb:TENB2(gene name synonym)|uniprotkb:TPEF(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and two follistatin-like domains(gene name synonym)|uniprotkb:UNQ178/PRO204(orf name)	psi-mi:p05067-pro_0000000090(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hong et al. (2014)	pubmed:26402097|imex:IM-27224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21194914|imex:IM-27224-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000144339(gene)|ensembl:ENST00000272771(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR036058|rcsb pdb:2FMW|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|refseq:NP_001292063.1|refseq:NP_001292074.1|refseq:NP_057276.2	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:18|chain-seq-end:671	figure legend:Fig. 2A|comment:Amyloid beta tetramers may also have been present but their identification was masked by the bait protein.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mc65)|taxid:9606(Human neuroblastoma cell MC65)	-	2019/02/06	2019/02/07	rogid:cjznO3tchWAGUCRwK+0QEyj1cgA9606	rogid:3ApqSWtuylGp/VO52cjjYt/m/BM9606	rigid:5ZvL5w9aOWpS/JkvFrO/BUDoXgQ	false	-	-	-	3	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UIK5	uniprotkb:P05067-PRO_0000000090	intact:EBI-11423693|ensembl:ENSP00000272771|uniprotkb:Q53H90|uniprotkb:Q4ZFW4|uniprotkb:Q2FA44|uniprotkb:Q9UK65|uniprotkb:Q9NR15|uniprotkb:Q53RE1|uniprotkb:Q8N2R5|uniprotkb:Q9P2Y9|uniprotkb:Q9NSS5	intact:EBI-21194918	psi-mi:teff2_human(display_long)|uniprotkb:TMEFF2(gene name)|psi-mi:TMEFF2(display_short)|uniprotkb:HPP1(gene name synonym)|uniprotkb:Hyperplastic polyposis protein 1(gene name synonym)|uniprotkb:TENB2(gene name synonym)|uniprotkb:TPEF(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and two follistatin-like domains(gene name synonym)|uniprotkb:UNQ178/PRO204(orf name)	psi-mi:p05067-pro_0000000090(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hong et al. (2014)	pubmed:26402097|imex:IM-27224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21194914|imex:IM-27224-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000144339(gene)|ensembl:ENST00000272771(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR036058|rcsb pdb:2FMW|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|refseq:NP_001292063.1|refseq:NP_001292074.1|refseq:NP_057276.2	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:18|chain-seq-end:671	figure legend:Fig. 2A|comment:Amyloid beta tetramers may also have been present but their identification was masked by the bait protein.|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mc65)|taxid:9606(Human neuroblastoma cell MC65)	-	2019/02/06	2019/02/07	rogid:cjznO3tchWAGUCRwK+0QEyj1cgA9606	rogid:3ApqSWtuylGp/VO52cjjYt/m/BM9606	rigid:5ZvL5w9aOWpS/JkvFrO/BUDoXgQ	false	-	-	-	2	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UIK5	uniprotkb:P05067-PRO_0000000093	intact:EBI-11423693|ensembl:ENSP00000272771|uniprotkb:Q53H90|uniprotkb:Q4ZFW4|uniprotkb:Q2FA44|uniprotkb:Q9UK65|uniprotkb:Q9NR15|uniprotkb:Q53RE1|uniprotkb:Q8N2R5|uniprotkb:Q9P2Y9|uniprotkb:Q9NSS5	intact:EBI-2431589|intact:EBI-20772365	psi-mi:teff2_human(display_long)|uniprotkb:TMEFF2(gene name)|psi-mi:TMEFF2(display_short)|uniprotkb:HPP1(gene name synonym)|uniprotkb:Hyperplastic polyposis protein 1(gene name synonym)|uniprotkb:TENB2(gene name synonym)|uniprotkb:TPEF(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and two follistatin-like domains(gene name synonym)|uniprotkb:UNQ178/PRO204(orf name)	psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Hong et al. (2014)	pubmed:26402097|imex:IM-27224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21194942|imex:IM-27224-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000144339(gene)|ensembl:ENST00000272771(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR036058|rcsb pdb:2FMW|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|refseq:NP_001292063.1|refseq:NP_001292074.1|refseq:NP_057276.2	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:711	antagonist:"Tetracyclin (CHEBI:27902)"|figure legend:Fig. 2B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mc65)|taxid:9606(Human neuroblastoma cell MC65)	-	2019/02/06	2019/02/06	rogid:cjznO3tchWAGUCRwK+0QEyj1cgA9606	rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606	rigid:eGJ3j/+DJKYOJ1EQNJ55+6KjuSs	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)
uniprotkb:Q9UIK5	uniprotkb:P05067-PRO_0000000092	intact:EBI-11423693|ensembl:ENSP00000272771|uniprotkb:Q53H90|uniprotkb:Q4ZFW4|uniprotkb:Q2FA44|uniprotkb:Q9UK65|uniprotkb:Q9NR15|uniprotkb:Q53RE1|uniprotkb:Q8N2R5|uniprotkb:Q9P2Y9|uniprotkb:Q9NSS5	intact:EBI-821758	psi-mi:teff2_human(display_long)|uniprotkb:TMEFF2(gene name)|psi-mi:TMEFF2(display_short)|uniprotkb:HPP1(gene name synonym)|uniprotkb:Hyperplastic polyposis protein 1(gene name synonym)|uniprotkb:TENB2(gene name synonym)|uniprotkb:TPEF(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and two follistatin-like domains(gene name synonym)|uniprotkb:UNQ178/PRO204(orf name)	psi-mi:p05067-pro_0000000092(display_long)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hong et al. (2014)	pubmed:26402097|imex:IM-27224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21194955|imex:IM-27224-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000144339(gene)|ensembl:ENST00000272771(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR036058|rcsb pdb:2FMW|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|refseq:NP_001292063.1|refseq:NP_001292074.1|refseq:NP_057276.2	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:672|chain-seq-end:713	figure legend:Fig. 2A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/06	2019/02/06	rogid:cjznO3tchWAGUCRwK+0QEyj1cgA9606	rogid:EBSGluIZCNVA1aC0Wdg7MlDdGxk9606	rigid:avtZXMCM1oIsxMhIkCxvhKcMrXI	false	v5 tag:c-c|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UIK5	intact:EBI-14348029	intact:EBI-11423693|ensembl:ENSP00000272771|uniprotkb:Q53H90|uniprotkb:Q4ZFW4|uniprotkb:Q2FA44|uniprotkb:Q9UK65|uniprotkb:Q9NR15|uniprotkb:Q53RE1|uniprotkb:Q8N2R5|uniprotkb:Q9P2Y9|uniprotkb:Q9NSS5	-	psi-mi:teff2_human(display_long)|uniprotkb:TMEFF2(gene name)|psi-mi:TMEFF2(display_short)|uniprotkb:HPP1(gene name synonym)|uniprotkb:Hyperplastic polyposis protein 1(gene name synonym)|uniprotkb:TENB2(gene name synonym)|uniprotkb:TPEF(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and two follistatin-like domains(gene name synonym)|uniprotkb:UNQ178/PRO204(orf name)	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hong et al. (2014)	pubmed:26402097|imex:IM-27224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21195190|imex:IM-27224-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000144339(gene)|ensembl:ENST00000272771(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR036058|rcsb pdb:2FMW|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|refseq:NP_001292063.1|refseq:NP_001292074.1|refseq:NP_057276.2	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	-	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	figure legend:Fig. 4|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.7x10^-8(molar)	2019/02/06	2019/02/07	rogid:cjznO3tchWAGUCRwK+0QEyj1cgA9606	-	-	false	sufficient binding region:40-301|his tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02649	intact:EBI-14348029	intact:EBI-1222467|uniprotkb:C0JYY5|uniprotkb:Q9P2S4|uniprotkb:B2RC15|ensembl:ENSP00000252486	-	psi-mi:apoe_human(display_long)|uniprotkb:APOE(gene name)|psi-mi:APOE(display_short)	psi-mi:abeta-42-oligomer_human(display_short)|psi-mi:EBI-14348029(display_long)|intact:pre-fibrillar amyloid-beta oligomer(complex synonym)|intact:prefibrillar amyloid-beta oligomer(complex synonym)|intact:Type 2 amyloid-beta oligomer(complex synonym)|intact:fibrillar amyloid-beta oligomer(complex synonym)|intact:Annular protofibril complex(complex synonym)|intact:Amyloid-beta fibrils(complex synonym)|intact:beta-amyloid protein 42 heterooligomer(complex synonym)|intact:beta-amyloid protein 42 complex(complex synonym)|intact:beta-amyloid-42 complex(complex synonym)|intact:beta amyloid protein 42 complex(complex synonym)|intact:amyloid-beta-42 complex(complex synonym)|intact:amyloid beta protein 42 complex(complex synonym)|intact:amyloid-beta protein 42 heterooligomer(complex synonym)|intact:amyloid-beta-42 heterooligomer(complex synonym)|intact:amyloid beta protein 42 heterooligomer(complex synonym)|intact:beta-amyloid-42 heterooligomer(complex synonym)|intact:beta amyloid protein 42 heterooligomer(complex synonym)|intact:Abeta protein 42 complex(complex synonym)|intact:Amyloid-beta protein 42 oligomeric complex(complex recommended name)|intact:APP oligomer(complex systematic name)|intact:Type 1 amyloid-beta oligomer(complex synonym)|intact:ADDL complex(complex synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hong et al. (2014)	pubmed:26402097|imex:IM-27224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21195355|imex:IM-27224-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_000032.1|refseq:NP_001289617.1|refseq:NP_001289618.1|refseq:NP_001289619.1|refseq:NP_001289620.1|dip:DIP-1120N|ensembl:ENSG00000130203(gene)|ensembl:ENST00000252486(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010467"(gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046907"(intracellular transport)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072562"(blood microparticle)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901627"(negative regulation of postsynaptic membrane organization)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1902999"(negative regulation of phospholipid efflux)|go:"GO:1903001"(negative regulation of lipid transport across blood-brain barrier)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P02649|rcsb pdb:1B68|rcsb pdb:1BZ4|rcsb pdb:1EA8|rcsb pdb:1GS9|rcsb pdb:1H7I|rcsb pdb:1LE2|rcsb pdb:1LE4|rcsb pdb:1LPE|rcsb pdb:1NFN|rcsb pdb:1NFO|rcsb pdb:1OEF|rcsb pdb:1OEG|rcsb pdb:1OR2|rcsb pdb:1OR3|rcsb pdb:2KC3|rcsb pdb:2KNY|rcsb pdb:2L7B|rcsb pdb:6IWB|rcsb pdb:6NCN|rcsb pdb:6NCO|reactome:R-HSA-1251985|reactome:R-HSA-3000480|reactome:R-HSA-381426|reactome:R-HSA-8864260|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-8963901|reactome:R-HSA-8964026|reactome:R-HSA-8964058|reactome:R-HSA-9029569|reactome:R-HSA-975634|reactome:R-HSA-977225	pubmed:23106396(see-also)|go:"GO:0046872"(metal ion binding)|pubmed:26719327(see-also)|pubmed:26898943(see-also)|wwpdb:2mgt(subset)|go:"GO:0106003"(amyloid-beta complex)|pubmed:18568035(see-also)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|pubmed:28197076(see-also)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|pubmed:21593310(see-also)|pubmed:22820466(see-also)|pubmed:19242475(see-also)|pubmed:18216187(see-also)|wwpdb:2y3k(subset)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|efo:"EFO:0000249"(see-also)|evidence ontology:"ECO:0005546"|pubmed:15190117(see-also)|go:"GO:0045666"(positive regulation of neuron differentiation)|complex portal:CPX-1070(inferred-from)|complex portal:CPX-1134(complex-primary)	-	-	curated-complex:"Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. This oligomer of protein 42 only has positive neurogenetic effects by activating synaptic protein kinases. May have a role in depressing synaptic activity thus preventing excitotoxicity. Influences synaptic plasticity through various receptors, including NMDAR, mGluR and alpha7 nicotinic acetylcholine receptors (CPX-236). Mediates dendritic spine loss leading to decreased synapse density, inhibition of long-term potentiation (LTP), enhancement of long-term depression (LTD), excessive calcium influx, mitochondrial impairment, endoplasmic reticulum stress and activation of apoptotic processes. May bind plasma membrane lipids affecting their stability and leading to cytotoxicity. May affect metal ion homeostasis by chelating synaptic copper, zinc or iron ions. Mostly found in the extracellular space with a small proportion occurring as membrane-bound species. Dimers (CPX-1062) and oligomers of soluble amyloid-beta peptides are the main pathogenic species linked to Alzheimer's disease. Cellular prion protein (PrPC/PRNP, P04156) binds amyloid-beta oligomers mediating their synaptic dysfunction. Insoluble fibrils and plaques form during the latter stages of the disease. Chaperones, such as alphaB-crystallins or clusterin (P10909), bind to misfolded oligomeric species and form long-lived complexes, thereby preventing both their further growth into fibrils and their dissociation into synaptotoxic dimers.     Amyloid-beta peptide may act as transcription factor for its own precursor protein APP and its cleavage enzyme BACE1 (P56817) initiating a positive feedback mechanism that ultimately leads to amyloidogenesis and Alzheimer's disease."|complex-assembly:Heterooligomer|disease:"Alzheimers disease [EFO:0000249]: a progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language, starting in late middle age or in old age. Marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid."|complex-properties:"Many forms of amyloid-beta oligomers exist in a dynamic equilibrium: from low-n amyloid-beta oligomer complexes such as dimers and trimers to high-n amyloid-beta oligomer complexes, such as pre-fibrilar and fibrilar oligomers to inactive fibrils. Pre-fibrilar oligomers form random coils and beta-turns and fibrils and oligomeric fibrils form anti-parallel beta-sheets. The oligomers are inherently thermodynamically more stable than the dimers."|curation request:Barbara Kramarz, ARUK-UCL	figure legend:Fig. 4|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.3x10^-8(molar)	2019/02/06	2019/02/07	rogid:vnCU03+HdGblqtALKeOTZRx5/3E9606	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UIK5	uniprotkb:P05067-PRO_0000000090	intact:EBI-11423693|ensembl:ENSP00000272771|uniprotkb:Q53H90|uniprotkb:Q4ZFW4|uniprotkb:Q2FA44|uniprotkb:Q9UK65|uniprotkb:Q9NR15|uniprotkb:Q53RE1|uniprotkb:Q8N2R5|uniprotkb:Q9P2Y9|uniprotkb:Q9NSS5	intact:EBI-21194918	psi-mi:teff2_human(display_long)|uniprotkb:TMEFF2(gene name)|psi-mi:TMEFF2(display_short)|uniprotkb:HPP1(gene name synonym)|uniprotkb:Hyperplastic polyposis protein 1(gene name synonym)|uniprotkb:TENB2(gene name synonym)|uniprotkb:TPEF(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and two follistatin-like domains(gene name synonym)|uniprotkb:UNQ178/PRO204(orf name)	psi-mi:p05067-pro_0000000090(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0042"(electron paramagnetic resonance)	Hong et al. (2014)	pubmed:26402097|imex:IM-27224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21195376|imex:IM-27224-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000144339(gene)|ensembl:ENST00000272771(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR036058|rcsb pdb:2FMW|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|refseq:NP_001292063.1|refseq:NP_001292074.1|refseq:NP_057276.2	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:18|chain-seq-end:671	figure legend:Fig. 4|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.7x10^-8(molar)	2019/02/06	2019/02/07	rogid:cjznO3tchWAGUCRwK+0QEyj1cgA9606	rogid:3ApqSWtuylGp/VO52cjjYt/m/BM9606	rigid:5ZvL5w9aOWpS/JkvFrO/BUDoXgQ	false	his tag:?-?|sufficient binding region:40-301	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UIK5	uniprotkb:P05067-4	intact:EBI-11423693|ensembl:ENSP00000272771|uniprotkb:Q53H90|uniprotkb:Q4ZFW4|uniprotkb:Q2FA44|uniprotkb:Q9UK65|uniprotkb:Q9NR15|uniprotkb:Q53RE1|uniprotkb:Q8N2R5|uniprotkb:Q9P2Y9|uniprotkb:Q9NSS5	intact:EBI-302641|ensembl:ENSP00000345463|intact:EBI-8513344|intact:MINT-150885|intact:EBI-8513450|intact:EBI-8513789|intact:EBI-7458081|intact:EBI-7458225|intact:EBI-8513738|intact:EBI-8513677|intact:EBI-8513407|intact:EBI-7457926	psi-mi:teff2_human(display_long)|uniprotkb:TMEFF2(gene name)|psi-mi:TMEFF2(display_short)|uniprotkb:HPP1(gene name synonym)|uniprotkb:Hyperplastic polyposis protein 1(gene name synonym)|uniprotkb:TENB2(gene name synonym)|uniprotkb:TPEF(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and two follistatin-like domains(gene name synonym)|uniprotkb:UNQ178/PRO204(orf name)	psi-mi:p05067-4(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:PreA4 695(isoform synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hong et al. (2014)	pubmed:26402097|imex:IM-27224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21195407|imex:IM-27224-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000144339(gene)|ensembl:ENST00000272771(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR036058|rcsb pdb:2FMW|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|refseq:NP_001292063.1|refseq:NP_001292074.1|refseq:NP_057276.2	intact:EBI-77613(a4_human)|ensembl:ENSG00000142192(gene)|ensembl:ENST00000348990(transcript)	-	-	isoform-comment:A major isoform.	figure legend:Fig. 6A|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2019/02/06	2019/02/07	rogid:cjznO3tchWAGUCRwK+0QEyj1cgA9606	rogid:g3lIuSzu8RGEONgITBEVFyMpfqk9606	rigid:ho1b+d48ZYHDSExamR7dqqnku78	false	v5 tag:c-c|his tag:c-c	mutation:595-596	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UIK5	uniprotkb:P05067-PRO_0000000090	intact:EBI-11423693|ensembl:ENSP00000272771|uniprotkb:Q53H90|uniprotkb:Q4ZFW4|uniprotkb:Q2FA44|uniprotkb:Q9UK65|uniprotkb:Q9NR15|uniprotkb:Q53RE1|uniprotkb:Q8N2R5|uniprotkb:Q9P2Y9|uniprotkb:Q9NSS5	intact:EBI-21194918	psi-mi:teff2_human(display_long)|uniprotkb:TMEFF2(gene name)|psi-mi:TMEFF2(display_short)|uniprotkb:HPP1(gene name synonym)|uniprotkb:Hyperplastic polyposis protein 1(gene name synonym)|uniprotkb:TENB2(gene name synonym)|uniprotkb:TPEF(gene name synonym)|uniprotkb:Transmembrane protein with EGF-like and two follistatin-like domains(gene name synonym)|uniprotkb:UNQ178/PRO204(orf name)	psi-mi:p05067-pro_0000000090(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hong et al. (2014)	pubmed:26402097|imex:IM-27224	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21195455|imex:IM-27224-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000144339(gene)|ensembl:ENST00000272771(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0051497"(negative regulation of stress fiber assembly)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR036058|rcsb pdb:2FMW|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|refseq:NP_001292063.1|refseq:NP_001292074.1|refseq:NP_057276.2	intact:EBI-77613(chain-parent)	-	-	chain-seq-start:18|chain-seq-end:671	figure legend:Fig. 6B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/02/06	2019/02/07	rogid:cjznO3tchWAGUCRwK+0QEyj1cgA9606	rogid:3ApqSWtuylGp/VO52cjjYt/m/BM9606	rigid:5ZvL5w9aOWpS/JkvFrO/BUDoXgQ	false	v5 tag:c-c|his tag:c-c|sufficient binding region:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)