#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P28799	uniprotkb:P38646	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P08670	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-353844|uniprotkb:Q15867|uniprotkb:Q15868|uniprotkb:Q15869|uniprotkb:Q548L2|uniprotkb:Q6LER9|uniprotkb:Q8N850|uniprotkb:Q96ML2|uniprotkb:Q9NTM3|uniprotkb:B0YJC2|intact:EBI-3442369|uniprotkb:D3DRU4|ensembl:ENSP00000224237|ensembl:ENSP00000446007	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:vime_human(display_long)|uniprotkb:VIM(gene name)|psi-mi:VIM(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_003371.2|ensembl:ENSG00000026025(gene)|ensembl:ENST00000224237(transcript)|ensembl:ENST00000544301(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|mint:P08670|rcsb pdb:1GK4|rcsb pdb:1GK6|rcsb pdb:1GK7|rcsb pdb:3G1E|rcsb pdb:3KLT|rcsb pdb:3S4R|rcsb pdb:3SSU|rcsb pdb:3SWK|rcsb pdb:3TRT|rcsb pdb:3UF1|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4YPC|rcsb pdb:4YV3|rcsb pdb:5WHF|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6BIR|rcsb pdb:6YXK|reactome:R-HSA-264870|reactome:R-HSA-390522|reactome:R-HSA-6785807|reactome:R-HSA-9013422|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:XP_006717563.1|dip:DIP-32507N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:GhAhVuXMNxi6P5J0CfNi5l9bjRk9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P00973	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-3932815|uniprotkb:F8VXY3|uniprotkb:Q6IPC6|uniprotkb:Q6A1Z3|uniprotkb:Q6P7N9|uniprotkb:P78485|uniprotkb:Q16700|uniprotkb:Q53GC5|uniprotkb:A8K4N8|uniprotkb:Q16701|uniprotkb:Q53YA4|uniprotkb:Q96J61|uniprotkb:Q1PG42|uniprotkb:Q3ZM01|uniprotkb:P78486|uniprotkb:P29080|uniprotkb:P29081|uniprotkb:P04820|ensembl:ENSP00000202917|ensembl:ENSP00000505482|ensembl:ENSP00000505572	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:oas1_human(display_long)|uniprotkb:OAS1(gene name)|psi-mi:OAS1(display_short)|uniprotkb:OIAS(gene name synonym)|uniprotkb:E18/E16(gene name synonym)|uniprotkb:p46/p42 OAS(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_001307080.1|ensembl:ENSG00000089127(gene)|ensembl:ENST00000202917(transcript)|ensembl:ENST00000680189(transcript)|ensembl:ENST00000681934(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0060700"(regulation of ribonuclease activity)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071659"(negative regulation of IP-10 production)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR002934(Nucleotidyltransferase)|interpro:IPR006116(2-5-oligoadenylate synthetase, ubiquitin-like region)|interpro:IPR006117(2-5-oligoadenylate synthetase, conserved site)|interpro:IPR018952|interpro:IPR026774|interpro:IPR043518|interpro:IPR043519|mint:P00973|rcsb pdb:4IG8|reactome:R-HSA-877300|reactome:R-HSA-8983711|reactome:R-HSA-909733|go:"GO:0001730"(2'-5'-oligoadenylate synthetase activity)|refseq:NP_001027581.1|refseq:NP_002525.2|refseq:NP_058132.2	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:Ge7bhYV3xhGulZW601pZQ8WNY8Q9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:Q06830	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-353193|ensembl:ENSP00000262746|ensembl:ENSP00000361152|ensembl:ENSP00000389047|ensembl:ENSP00000407034|ensembl:ENSP00000503140|uniprotkb:P35703|uniprotkb:Q2V576|uniprotkb:Q5T154|uniprotkb:Q5T155|uniprotkb:B5BU26|uniprotkb:D3DPZ8	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:prdx1_human(display_long)|uniprotkb:PRDX1(gene name)|psi-mi:PRDX1(display_short)|uniprotkb:PAGA(gene name synonym)|uniprotkb:PAGB(gene name synonym)|uniprotkb:TDPX2(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Proliferation-associated gene protein(gene name synonym)|uniprotkb:Natural killer cell-enhancing factor A(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	ensembl:ENSG00000117450(gene)|ensembl:ENST00000262746(transcript)|ensembl:ENST00000319248(transcript)|ensembl:ENST00000424390(transcript)|ensembl:ENST00000447184(transcript)|ensembl:ENST00000676549(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042470"(melanosome)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q06830|rcsb pdb:2RII|rcsb pdb:3HY2|rcsb pdb:4XCS|reactome:R-HSA-3299685|reactome:R-HSA-5628897|reactome:R-HSA-8862803|refseq:NP_001189360.1|refseq:NP_002565.1|refseq:NP_859047.1|refseq:NP_859048.1|dip:DIP-33152N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:ZM5ZXF900izH81QVqgd2+opwMrs9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:Q92945	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-1049099|uniprotkb:O00301|uniprotkb:Q59EZ9|uniprotkb:Q5U4P6|uniprotkb:Q9UNT5|uniprotkb:Q9UQH5|intact:EBI-5455671|ensembl:ENSP00000381216	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:fubp2_human(display_long)|uniprotkb:KH type-splicing regulatory protein(gene name synonym)|uniprotkb:p75(gene name synonym)|uniprotkb:KHSRP(gene name)|psi-mi:KHSRP(display_short)|uniprotkb:FUBP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_003676.2|ensembl:ENSG00000088247(gene)|ensembl:ENST00000398148(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0051028"(mRNA transport)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR015096(Region of unknown function DUF1897)|interpro:IPR036612|mint:Q92945|rcsb pdb:2HH2|rcsb pdb:2HH3|rcsb pdb:2JVZ|rcsb pdb:2OPU|rcsb pdb:2OPV|rcsb pdb:4B8T|reactome:R-HSA-380994|reactome:R-HSA-450604|dip:DIP-48484N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:hlybJllTqSgPgtwwz3kc12zDYh49606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:Q13162	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-2211957|uniprotkb:Q6FHT3|ensembl:ENSP00000368646	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:prdx4_human(display_long)|uniprotkb:PRDX4(gene name)|psi-mi:PRDX4(display_short)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_006397.1|ensembl:ENSG00000123131(gene)|ensembl:ENST00000379341(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:Q13162|rcsb pdb:2PN8|rcsb pdb:3TJB|rcsb pdb:3TJF|rcsb pdb:3TJG|rcsb pdb:3TJJ|rcsb pdb:3TJK|rcsb pdb:3TKP|rcsb pdb:3TKQ|rcsb pdb:3TKR|rcsb pdb:3TKS|rcsb pdb:4RQX|rcsb pdb:5HQP|reactome:R-HSA-6798695	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:5KWl3YuUpRDrSUxWlJS6sP7CLAs9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P11142	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P46109	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:Q15365	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P42224	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P49589	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-2691328|uniprotkb:Q53XI8|uniprotkb:Q9HD24|uniprotkb:Q9HD25|uniprotkb:Q5HYE4|ensembl:ENSP00000380300|ensembl:ENSP00000488657	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:sycc_human(display_long)|uniprotkb:CARS1(gene name)|psi-mi:CARS1(display_short)|uniprotkb:CARS(gene name synonym)|uniprotkb:Cysteinyl-tRNA synthetase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_001742.1|refseq:NP_644802.1|refseq:NP_001014437.1|ensembl:ENSG00000110619(gene)|ensembl:ENSG00000278191(gene)|ensembl:ENST00000397111(transcript)|ensembl:ENST00000633248(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004817"(cysteine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006423"(cysteinyl-tRNA aminoacylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR015803(Cysteinyl-tRNA synthetase, class Ia, N-terminal)|interpro:IPR024909|interpro:IPR032678|reactome:R-HSA-379716	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:x6XOxU90AlAudm/b3atmp4xahZE9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P33316	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-353224|uniprotkb:O14785|uniprotkb:Q16708|uniprotkb:Q16860|uniprotkb:Q96Q81|uniprotkb:A8K650|uniprotkb:B4DPR5|uniprotkb:Q6FHN1|uniprotkb:Q6NSA3|ensembl:ENSP00000370376	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:dut_human(display_long)|uniprotkb:DUT(gene name)|psi-mi:DUT(display_short)|uniprotkb:dUTP pyrophosphatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_001020419.1|refseq:NP_001020420.1|refseq:NP_001939.1|rcsb pdb:1Q5U|rcsb pdb:2HQU|rcsb pdb:3ARA|rcsb pdb:3ARN|rcsb pdb:3EHW|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:5H4J|reactome:R-HSA-499943|ensembl:ENSG00000128951(gene)|ensembl:ENST00000331200(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004170"(dUTP diphosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006226"(dUMP biosynthetic process)|go:"GO:0006260"(DNA replication)|go:"GO:0046081"(dUTP catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008181(DeoxyUTP pyrophosphatase subfamily 1)|interpro:IPR029054|interpro:IPR033704|interpro:IPR036157|rcsb pdb:1Q5H|refseq:NP_001317215.1	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:lHET9Z1Rre4xbVStybz65KJ8QLk9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P49327	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-356658|uniprotkb:Q4LE83|uniprotkb:Q13479|uniprotkb:Q16702|uniprotkb:Q6P4U5|uniprotkb:Q6SS02|uniprotkb:Q969R1|uniprotkb:Q96C68|uniprotkb:Q96IT0|ensembl:ENSP00000304592	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:fas_human(display_long)|uniprotkb:FASN(gene name)|psi-mi:FASN(display_short)|uniprotkb:FAS(gene name synonym)|uniprotkb:Type I fatty acid synthase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_004095.4|ensembl:ENSG00000169710(gene)|ensembl:ENST00000306749(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003723"(RNA binding)|go:"GO:0004313"([acyl-carrier-protein] S-acetyltransferase activity)|go:"GO:0004314"([acyl-carrier-protein] S-malonyltransferase activity)|go:"GO:0004315"(3-oxoacyl-[acyl-carrier-protein] synthase activity)|go:"GO:0004316"("3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity")|go:"GO:0004317"(3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0004320"(oleoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0008611"(ether lipid biosynthetic process)|go:"GO:0008659"("(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity")|go:"GO:0008693"(3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0016020"(membrane)|go:"GO:0016295"(myristoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0016296"(palmitoyl-[acyl-carrier-protein] hydrolase activity)|go:"GO:0030223"(neutrophil differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031177"(phosphopantetheine binding)|go:"GO:0042470"(melanosome)|go:"GO:0042587"(glycogen granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0047451"(3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0102131"(obsolete 3-oxo-glutaryl-[acp] methyl ester reductase activity)|go:"GO:0102132"(obsolete 3-oxo-pimeloyl-[acp] methyl ester reductase activity)|interpro:IPR001031(Thioesterase)|interpro:IPR001227(Acyl transferase region)|interpro:IPR006162(Phosphopantetheine attachment site)|interpro:IPR009081(Acyl carrier protein-like)|interpro:IPR011032(GroES-like)|interpro:IPR013149(Alcohol dehydrogenase, zinc-binding)|interpro:IPR013217(Methyltransferase type 12)|interpro:IPR013968(Polyketide synthase, KR)|interpro:IPR014030(Beta-ketoacyl synthase, N-terminal)|interpro:IPR014031(Beta-ketoacyl synthase, C-terminal)|interpro:IPR014043(Acyl transferase)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR016036(Malonyl-CoA ACP transacylase, ACP-binding)|interpro:IPR016039(Thiolase-like)|interpro:IPR018201|interpro:IPR020806|interpro:IPR020807|interpro:IPR020841|interpro:IPR020843|interpro:IPR029058|interpro:IPR029063|interpro:IPR032821|interpro:IPR036291|interpro:IPR036736|interpro:IPR042104|mint:P49327|rcsb pdb:1XKT|rcsb pdb:2CG5|rcsb pdb:2JFD|rcsb pdb:2JFK|rcsb pdb:2PX6|rcsb pdb:3HHD|rcsb pdb:3TJM|rcsb pdb:4PIV|rcsb pdb:4W82|rcsb pdb:4W9N|rcsb pdb:4Z49|rcsb pdb:5C37|rcsb pdb:6NNA|reactome:R-HSA-163765|reactome:R-HSA-199220|reactome:R-HSA-2426168|reactome:R-HSA-75105|reactome:R-HSA-9029558|go:"GO:0047117"("enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity")|refseq:XP_011521840.1|dip:DIP-33681N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:bQYEH/uQ6l+SPzLBDNCV5yP+yzs9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P25205	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P14618	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-353408|uniprotkb:A6NFK3|uniprotkb:P14786|uniprotkb:Q53GK4|uniprotkb:Q96E76|uniprotkb:Q9BWB5|uniprotkb:Q9UPF2|uniprotkb:B2R5N8|uniprotkb:B3KRY0|uniprotkb:B4DFX8|uniprotkb:Q9UCV6|intact:EBI-2555890|uniprotkb:B4DUU6|ensembl:ENSP00000334983	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:kpym_human(display_long)|uniprotkb:PKM(gene name)|psi-mi:PKM(display_short)|uniprotkb:Cytosolic thyroid hormone-binding protein(gene name synonym)|uniprotkb:OIP3(gene name synonym)|uniprotkb:Opa-interacting protein 3(gene name synonym)|uniprotkb:PK2(gene name synonym)|uniprotkb:PK3(gene name synonym)|uniprotkb:PKM2(gene name synonym)|uniprotkb:Pyruvate kinase 2/3(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:Thyroid hormone-binding protein 1(gene name synonym)|uniprotkb:Tumor M2-PK(gene name synonym)|uniprotkb:p58(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_001193725.1|refseq:NP_001193727.1|refseq:NP_001193728.1|refseq:NP_002645.3|refseq:NP_872270.1|refseq:NP_872271.1|refseq:NP_001193726.1|refseq:NP_001303247.1|refseq:XP_005254502.1|dip:DIP-31273N|ensembl:ENSG00000067225(gene)|ensembl:ENST00000335181(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006096"(glycolytic process)|go:"GO:0012501"(programmed cell death)|go:"GO:0016301"(kinase activity)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045296"(cadherin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000767"(positive regulation of cytoplasmic translation)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|mint:P14618|rcsb pdb:1T5A|rcsb pdb:1ZJH|rcsb pdb:3BJF|rcsb pdb:3BJT|rcsb pdb:3G2G|rcsb pdb:3GQY|rcsb pdb:3GR4|rcsb pdb:3H6O|rcsb pdb:3ME3|rcsb pdb:3SRD|rcsb pdb:3SRF|rcsb pdb:3U2Z|rcsb pdb:4B2D|rcsb pdb:4FXF|rcsb pdb:4FXJ|rcsb pdb:4G1N|rcsb pdb:4JPG|rcsb pdb:4QG6|rcsb pdb:4QG8|rcsb pdb:4QG9|rcsb pdb:4QGC|rcsb pdb:4RPP|rcsb pdb:4WJ8|rcsb pdb:4YJ5|rcsb pdb:5X0I|rcsb pdb:5X1V|rcsb pdb:5X1W|rcsb pdb:6B6U|rcsb pdb:6GG3|rcsb pdb:6GG4|rcsb pdb:6GG5|rcsb pdb:6GG6|rcsb pdb:6JFB|rcsb pdb:6NU1|rcsb pdb:6NU5|rcsb pdb:6NUB|rcsb pdb:6TTF|rcsb pdb:6TTH|rcsb pdb:6TTI|rcsb pdb:6TTQ|rcsb pdb:6V74|rcsb pdb:3SRH|rcsb pdb:6V75|rcsb pdb:6V76|rcsb pdb:6WP3|rcsb pdb:6WP4|rcsb pdb:6WP5|rcsb pdb:6WP6|reactome:R-HSA-6798695|reactome:R-HSA-70171|refseq:XP_016877802.1	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:dDaoXCaqd0x6qFSElvngHusttuk9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P17812	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-1042983|uniprotkb:Q5VW67|uniprotkb:Q96GK6|ensembl:ENSP00000361699|ensembl:ENSP00000497602|ensembl:ENSP00000497744|uniprotkb:D3DPW1|uniprotkb:B4DR64	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:pyrg1_human(display_long)|uniprotkb:CTPS1(gene name)|psi-mi:CTPS1(display_short)|uniprotkb:CTP synthetase 1(gene name synonym)|uniprotkb:CTPS(gene name synonym)|uniprotkb:UTP--ammonia ligase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	ensembl:ENSG00000171793(gene)|ensembl:ENST00000372616(transcript)|ensembl:ENST00000649124(transcript)|ensembl:ENST00000650070(transcript)|go:"GO:0003883"(CTP synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019856"(pyrimidine nucleobase biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044210"('de novo' CTP biosynthetic process)|go:"GO:0097268"(cytoophidium)|interpro:IPR004468(CTP synthase)|interpro:IPR017456(CTP synthase, N-terminal)|interpro:IPR017926|interpro:IPR027417|interpro:IPR029062|interpro:IPR033828|mint:P17812|rcsb pdb:2VO1|rcsb pdb:5U03|reactome:R-HSA-499943|refseq:NP_001288166.1|refseq:NP_001896.2	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:0QkxA3YRejXU0X7dk7zf1XeAMt89606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P21333	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P29590	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-295890|ensembl:ENSP00000268058|uniprotkb:P29591|uniprotkb:P29592|uniprotkb:P29593|uniprotkb:Q00755|uniprotkb:Q96S41|intact:EBI-779712|intact:EBI-1210702|intact:EBI-870812|uniprotkb:Q15959|uniprotkb:Q59FP9|uniprotkb:Q8WUA0|uniprotkb:Q9BPW2|uniprotkb:Q9BWP7|uniprotkb:Q9BZX6|uniprotkb:Q9BZX7|uniprotkb:Q9BZX8|uniprotkb:Q9BZX9|uniprotkb:Q9BZY0|uniprotkb:Q9BZY2|uniprotkb:Q9BZY3|uniprotkb:E9PBR7	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:pml_human(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	ensembl:ENST00000268058(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000140464(gene)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006605"(protein targeting)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009411"(response to UV)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010522"(regulation of calcium ion transport into cytosol)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016605"(PML body)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030578"(PML body organization)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032183"(SUMO binding)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0034097"(response to cytokine)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032938"(negative regulation of translation in response to oxidative stress)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046332"(SMAD binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0050821"(protein stabilization)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090398"(cellular senescence)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:1902187"|go:"GO:1904816"(positive regulation of protein localization to chromosome, telomeric region)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|rcsb pdb:2MWX|rcsb pdb:4WJN|rcsb pdb:4WJO|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|rcsb pdb:5YUF|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000315(Zinc finger, B-box)|rcsb pdb:6IMQ|rcsb pdb:6UYO|rcsb pdb:6UYP|interpro:IPR001841(Zinc finger, RING-type)|rcsb pdb:6UYQ|rcsb pdb:6UYR|rcsb pdb:6UYS|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:6UYT|rcsb pdb:6UYU|rcsb pdb:6UYV|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-6804758|reactome:R-HSA-877300|reactome:R-HSA-8934593|reactome:R-HSA-8948747|reactome:R-HSA-9609690|reactome:R-HSA-9616222|interpro:IPR021978|mint:P29590|rcsb pdb:1BOR|rcsb pdb:2MVW|refseq:NP_002666.1|refseq:NP_150241.2|refseq:NP_150242.1|refseq:NP_150243.2|refseq:NP_150247.2|refseq:NP_150249.1|refseq:NP_150250.2|refseq:NP_150252.1|refseq:NP_150253.2|dip:DIP-33053N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:FdAh5Rbyu37luTScMzCopbbwXvk9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P12111	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-2465936|ensembl:ENSP00000295550|uniprotkb:Q53QF4|uniprotkb:Q53QF6|uniprotkb:Q16501|uniprotkb:B4E3U5|uniprotkb:E9PGQ9|uniprotkb:A8MT30|uniprotkb:B7ZMJ7|uniprotkb:E9PFQ6	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:co6a3_human(display_long)|uniprotkb:COL6A3(gene name)|psi-mi:COL6A3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0007517"(muscle organ development)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042383"(sarcolemma)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008160(Collagen triple helix repeat)|go:"GO:0005615"(extracellular space)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR020901|interpro:IPR036116|interpro:IPR036465|interpro:IPR036880|interpro:IPR041900|rcsb pdb:1KNT|rcsb pdb:1KTH|rcsb pdb:1KUN|rcsb pdb:2KNT|rcsb pdb:6SNK|reactome:R-HSA-1442490|reactome:R-HSA-1650814|reactome:R-HSA-186797|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-3000178|reactome:R-HSA-419037|reactome:R-HSA-8948216|mint:P12111|ensembl:ENSG00000163359(gene)|ensembl:ENST00000295550(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005589"(collagen type VI trimer)|refseq:NP_476506.3|refseq:NP_004360.2|refseq:NP_476508.2|refseq:NP_476505.3|refseq:NP_476507.3|refseq:XP_016858792.1	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:7xGWLmEvMdbEeoy4MT+iheiQkB09606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:Q14195	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-1104726|uniprotkb:Q93012|ensembl:ENSP00000381526|uniprotkb:B3SXQ8	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:dpyl3_human(display_long)|uniprotkb:DPYSL3(gene name)|psi-mi:DPYSL3(display_short)|uniprotkb:CRMP4(gene name synonym)|uniprotkb:DRP3(gene name synonym)|uniprotkb:ULIP(gene name synonym)|uniprotkb:ULIP1(gene name synonym)|uniprotkb:Collapsin response mediator protein 4(gene name synonym)|uniprotkb:Unc-33-like phosphoprotein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	ensembl:ENSG00000113657(gene)|ensembl:ENST00000398514(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031005"(filamin binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0048666"(neuron development)|go:"GO:0048678"(response to axon injury)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030628|interpro:IPR032466|rcsb pdb:4BKN|rcsb pdb:4CNS|rcsb pdb:4CNT|rcsb pdb:4CNU|reactome:R-HSA-399956|refseq:NP_001184223.1|refseq:NP_001378.1	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:L+A3ff3KuMbKlfygxHUu+M749MI9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:O60313	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P68104	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-352162|uniprotkb:P04719|uniprotkb:P04720|intact:EBI-2834776|intact:EBI-8011754|intact:MINT-4903558|uniprotkb:Q6IQ15|ensembl:ENSP00000330054|ensembl:ENSP00000339053|ensembl:ENSP00000339063|ensembl:ENSP00000348651|ensembl:ENSP00000392366|ensembl:ENSP00000479055|ensembl:ENSP00000503192|ensembl:ENSP00000503249|ensembl:ENSP00000503823|ensembl:ENSP00000504335|intact:EBI-16423274	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:ef1a1_human(display_long)|uniprotkb:EEF1A1(gene name)|psi-mi:EEF1A1(display_short)|uniprotkb:EEF1A(gene name synonym)|uniprotkb:EF1A(gene name synonym)|uniprotkb:LENG7(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Leukocyte receptor cluster member 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:XP_011533816.1|ensembl:ENSG00000156508(gene)|ensembl:ENST00000309268(transcript)|ensembl:ENST00000316292(transcript)|ensembl:ENST00000331523(transcript)|ensembl:ENST00000356303(transcript)|ensembl:ENST00000455918(transcript)|ensembl:ENST00000615060(transcript)|ensembl:ENST00000676710(transcript)|ensembl:ENST00000677236(transcript)|ensembl:ENST00000678508(transcript)|ensembl:ENST00000678702(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P68104|rcsb pdb:1SYW|rcsb pdb:3C5J|rcsb pdb:6ZMO|reactome:R-HSA-156842|reactome:R-HSA-156902|reactome:R-HSA-3371511|reactome:R-HSA-6798695|reactome:R-HSA-8876725|reactome:R-HSA-9613829|dip:DIP-31277N|refseq:NP_001393.1	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:d3REF87FDKboAjyvlJJEXtqhrcw9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:Q9NSD9	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-353803|uniprotkb:B4DFM0|uniprotkb:O95708|uniprotkb:Q9NZZ6|uniprotkb:Q4ZFX1|uniprotkb:Q57ZJ5|ensembl:ENSP00000281828	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:syfb_human(display_long)|uniprotkb:FARSB(gene name)|psi-mi:FARSB(display_short)|uniprotkb:FARSLB(gene name synonym)|uniprotkb:FRSB(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase beta subunit(gene name synonym)|uniprotkb:HSPC173(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_005678.3|refseq:XP_006712232.1|refseq:XP_011508768.1|ensembl:ENSG00000116120(gene)|ensembl:ENST00000281828(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0009328"(phenylalanine-tRNA ligase complex)|go:"GO:0016020"(membrane)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR004531(Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR005147(tRNA synthetase, B5)|interpro:IPR009061(Putative DNA binding)|interpro:IPR020825|interpro:IPR040659|interpro:IPR041616|rcsb pdb:3L4G|reactome:R-HSA-379716|refseq:XP_016858599.1|dip:DIP-32869N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:YgMUMEiw+jAUaDK5KomMWi66vn09606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P07355	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-352622|uniprotkb:Q567R4|uniprotkb:Q96DD5|intact:EBI-2211824|uniprotkb:Q6N0B3|uniprotkb:Q8TBV2|uniprotkb:Q9UDH8|ensembl:ENSP00000379342|ensembl:ENSP00000387545|ensembl:ENSP00000411352|ensembl:ENSP00000452858|ensembl:ENSP00000452895|ensembl:ENSP00000452981|ensembl:ENSP00000453694|ensembl:ENSP00000453859|ensembl:ENSP00000503447|ensembl:ENSP00000503757|ensembl:ENSP00000503855|ensembl:ENSP00000504035|ensembl:ENSP00000504164	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:anxa2_human(display_long)|uniprotkb:ANXA2(gene name)|psi-mi:ANXA2(display_short)|uniprotkb:ANX2(gene name synonym)|uniprotkb:ANX2L4(gene name synonym)|uniprotkb:CAL1H(gene name synonym)|uniprotkb:LPC2D(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_001002857.1|refseq:NP_001002858.1|refseq:NP_001129487.1|refseq:NP_004030.1|refseq:XP_016877579.1|refseq:XP_016877580.1|ensembl:ENSG00000182718(gene)|ensembl:ENST00000396024(transcript)|ensembl:ENST00000421017(transcript)|ensembl:ENST00000451270(transcript)|ensembl:ENST00000557906(transcript)|ensembl:ENST00000558558(transcript)|ensembl:ENST00000559818(transcript)|ensembl:ENST00000559956(transcript)|ensembl:ENST00000560468(transcript)|ensembl:ENST00000677968(transcript)|ensembl:ENST00000678061(transcript)|ensembl:ENST00000678450(transcript)|ensembl:ENST00000678870(transcript)|ensembl:ENST00000679109(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0005509"(calcium ion binding)|rcsb pdb:2HYU|rcsb pdb:2HYV|rcsb pdb:2HYW|rcsb pdb:4DRW|rcsb pdb:4FTG|rcsb pdb:4HRH|rcsb pdb:5LPU|rcsb pdb:5LPX|rcsb pdb:5LQ0|rcsb pdb:5LQ2|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:6TWQ|rcsb pdb:6TWU|rcsb pdb:6TWX|rcsb pdb:6TWY|reactome:R-HSA-445355|reactome:R-HSA-6798695|reactome:R-HSA-75205|reactome:R-HSA-8950505|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07355|rcsb pdb:1W7B|rcsb pdb:1XJL|go:"GO:0097066"(response to thyroid hormone)	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:jcB4Dt0LFv8YaBUnC2BSTCshveg9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:Q8WX93	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-2803991|uniprotkb:Q9Y2J6|uniprotkb:Q9UQF5|uniprotkb:Q8N1M2|uniprotkb:Q7Z3W0|uniprotkb:Q86WE8|uniprotkb:B5MD56|uniprotkb:Q7L3E0|uniprotkb:Q9UGA0|uniprotkb:Q9Y3E9|uniprotkb:B7ZMM5|uniprotkb:B3KTG2	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:palld_human(display_long)|uniprotkb:KIAA0992(gene name synonym)|uniprotkb:SIH002(gene name synonym)|uniprotkb:Sarcoma antigen NY-SAR-77(gene name synonym)|uniprotkb:CGI-151(orf name)|uniprotkb:PALLD(gene name)|psi-mi:PALLD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	interpro:IPR033017|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0098632"(cell-cell adhesion mediator activity)|rcsb pdb:2DM2|rcsb pdb:2DM3|go:"GO:0016477"(cell migration)|refseq:NP_001159580.1|refseq:NP_001159581.1|refseq:NP_001159582.1|refseq:NP_057165.3|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR036179|mint:Q8WX93	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:0GUVyoDYzf03b+bZXUa1n/fnP/Y9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P10599	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-594644|uniprotkb:B1ALW1|uniprotkb:O60744|uniprotkb:Q53X69|uniprotkb:Q96KI3|uniprotkb:Q9UDG5|intact:EBI-1042712|ensembl:ENSP00000363641	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:thio_human(display_long)|uniprotkb:ATL-derived factor(gene name synonym)|uniprotkb:Surface-associated sulphydryl protein(gene name synonym)|uniprotkb:TXN(gene name)|psi-mi:TXN(display_short)|uniprotkb:TRDX(gene name synonym)|uniprotkb:TRX(gene name synonym)|uniprotkb:TRX1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_003320.2|refseq:NP_001231867.1|dip:DIP-6129N|ensembl:ENSG00000136810(gene)|ensembl:ENST00000374517(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0004791"(thioredoxin-disulfide reductase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006662"(glycerol ether metabolic process)|go:"GO:0009314"(response to radiation)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0047134"("protein-disulfide reductase (NAD(P)) activity")|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071731"(response to nitric oxide)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:2000170"(positive regulation of peptidyl-cysteine S-nitrosylation)|interpro:IPR005746(Thioredoxin)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P10599|rcsb pdb:1AIU|rcsb pdb:1AUC|rcsb pdb:1CQG|rcsb pdb:1CQH|rcsb pdb:1ERT|rcsb pdb:1ERU|rcsb pdb:1ERV|rcsb pdb:1ERW|rcsb pdb:1M7T|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1TRS|rcsb pdb:1TRU|rcsb pdb:1TRV|rcsb pdb:1TRW|rcsb pdb:1W1C|rcsb pdb:1W1E|rcsb pdb:2HSH|rcsb pdb:2HXK|rcsb pdb:2IFQ|rcsb pdb:2IIY|rcsb pdb:3E3E|rcsb pdb:3KD0|rcsb pdb:3M9J|rcsb pdb:3M9K|rcsb pdb:3QFA|rcsb pdb:3QFB|rcsb pdb:3TRX|rcsb pdb:4LL1|rcsb pdb:4LL4|rcsb pdb:4OO4|rcsb pdb:4OO5|rcsb pdb:4POK|rcsb pdb:4POL|rcsb pdb:4POM|rcsb pdb:4PUF|rcsb pdb:4TRX|rcsb pdb:5DQY|reactome:R-HSA-2559580|reactome:R-HSA-3299685|reactome:R-HSA-499943|reactome:R-HSA-5628897|reactome:R-HSA-5676934|reactome:R-HSA-844456|reactome:R-HSA-9617629|reactome:R-HSA-9660826	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:5u+iJJtwAwAKXljKHnpY8h5uRkQ9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:Q9ULA0	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-748356|uniprotkb:Q9BW44|uniprotkb:Q9NUV5|uniprotkb:Q9NV55|ensembl:ENSP00000273075	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:dnpep_human(display_long)|uniprotkb:ASPEP(gene name synonym)|uniprotkb:DAP(gene name synonym)|uniprotkb:DNPEP(gene name)|psi-mi:DNPEP(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_001306049.1|refseq:NP_036232.2|ensembl:ENSG00000123992(gene)|ensembl:ENST00000273075(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0072562"(blood microparticle)|interpro:IPR001948(Peptidase M18, aminopeptidase I)|interpro:IPR023358|rcsb pdb:4DYO	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:xG06vZosglPmA5ktZd8A8EH9h0g9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P35080	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-473138|uniprotkb:Q8WVF9|uniprotkb:Q9HBK2|uniprotkb:B2R4C8|uniprotkb:Q4VBQ4|uniprotkb:D3DNI4|ensembl:ENSP00000239940	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:prof2_human(display_long)|uniprotkb:PFN2(gene name)|psi-mi:PFN2(display_short)|uniprotkb:Profilin II(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_002619.1|refseq:NP_444252.1|ensembl:ENSG00000070087(gene)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0010633"(negative regulation of epithelial cell migration)|ensembl:ENST00000239940(transcript)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900028"(negative regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029891|interpro:IPR036140|mint:P35080|rcsb pdb:1D1J|reactome:R-HSA-376176|reactome:R-HSA-5663220	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:064T9afVEb7WrgJPLVbKByJDUXc9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P47756	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-353595|uniprotkb:Q5U0L4|uniprotkb:Q8TB49|uniprotkb:Q9NUC4|uniprotkb:Q32Q68|ensembl:ENSP00000364284|ensembl:ENSP00000501528	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:capzb_human(display_long)|uniprotkb:CAPZB(gene name)|psi-mi:CAPZB(display_short)|uniprotkb:CapZ beta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_001193469.1|refseq:NP_004921.1|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071203"(WASH complex)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|interpro:IPR001698(F-actin capping protein, beta subunit)|interpro:IPR019771|interpro:IPR037282|interpro:IPR042276|interpro:IPR043175|mint:P47756|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-9013405|reactome:R-HSA-9035034|reactome:R-HSA-9662360|reactome:R-HSA-983231|ensembl:ENSG00000077549(gene)|ensembl:ENST00000375142(transcript)|ensembl:ENST00000674432(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005903"(brush border)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030863"(cortical cytoskeleton)|refseq:NP_001269091.1	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:qRXsrB2fLT1DMVIVRWKFYe4Aln49606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P22102	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-356297|ensembl:ENSP00000371236|ensembl:ENSP00000371253|ensembl:ENSP00000371261|ensembl:ENSP00000459391|ensembl:ENSP00000459532|ensembl:ENSP00000461700|uniprotkb:D3DSF3|uniprotkb:D3DSF4|uniprotkb:O14659|uniprotkb:A8KA32|uniprotkb:A8K945|uniprotkb:Q52M77	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:pur2_human(display_long)|uniprotkb:GART(gene name)|psi-mi:GART(display_short)|uniprotkb:PRGS(gene name synonym)|uniprotkb:PGFT(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0021549"(cerebellum development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0046084"(adenine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000115(Phosphoribosylglycinamide synthetase)|interpro:IPR001555(Phosphoribosylglycinamide formyltransferase, active site)|interpro:IPR002376(Formyl transferase, N-terminal)|interpro:IPR004607(Phosphoribosylglycinamide formyltransferase)|interpro:IPR004733(Phosphoribosylformylglycinamidine cyclo-ligase)|interpro:IPR010918(AIR synthase related protein, C-terminal)|ensembl:ENST00000571089(transcript)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|ensembl:ENST00000573055(transcript)|ensembl:ENST00000575273(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0004637"(phosphoribosylamine-glycine ligase activity)|go:"GO:0004641"(phosphoribosylformylglycinamidine cyclo-ligase activity)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|go:"GO:0004644"(phosphoribosylglycinamide formyltransferase activity)|interpro:IPR016185(PreATP-grasp-like fold)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR016188(PurM, N-terminal-like)|ensembl:ENSG00000159131(gene)|ensembl:ENSG00000262473(gene)|ensembl:ENST00000381815(transcript)|ensembl:ENST00000381831(transcript)|ensembl:ENST00000381839(transcript)|interpro:IPR020560|interpro:IPR020561|interpro:IPR020562|interpro:IPR036477|interpro:IPR036676|interpro:IPR036921|interpro:IPR037123|mint:P22102|rcsb pdb:1MEJ|rcsb pdb:1MEN|rcsb pdb:1MEO|rcsb pdb:1NJS|rcsb pdb:1RBM|rcsb pdb:1RBQ|rcsb pdb:1RBY|rcsb pdb:1RBZ|rcsb pdb:1RC0|rcsb pdb:1RC1|rcsb pdb:1ZLX|rcsb pdb:1ZLY|rcsb pdb:2QK4|rcsb pdb:2V9Y|rcsb pdb:4EW1|rcsb pdb:4EW2|rcsb pdb:4EW3|rcsb pdb:4ZYT|interpro:IPR020559|rcsb pdb:4ZYU|rcsb pdb:4ZYV|rcsb pdb:4ZYW|rcsb pdb:4ZYX|rcsb pdb:4ZYY|rcsb pdb:4ZYZ|rcsb pdb:4ZZ0|rcsb pdb:4ZZ1|rcsb pdb:4ZZ2|rcsb pdb:5J9F|rcsb pdb:7JG0|rcsb pdb:4ZZ3|refseq:NP_000810.1|refseq:NP_001129477.1|refseq:NP_001129478.1|refseq:NP_780294.1|rcsb pdb:7JG4|reactome:R-HSA-73817|rcsb pdb:7JG3|refseq:XP_011527828.1|refseq:XP_006724052.1|refseq:XP_006724053.1|refseq:XP_005260998.1	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:7Iy33CtBsB8LHZFDP5mZ3eRX8pU9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P07437	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-350864|uniprotkb:P05218|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|ensembl:ENSP00000339001|ensembl:ENSP00000373058|ensembl:ENSP00000399155|ensembl:ENSP00000400663|ensembl:ENSP00000401317|ensembl:ENSP00000406811|ensembl:ENSP00000410071|ensembl:ENSP00000410829	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:tbb5_human(display_long)|uniprotkb:TUBB(gene name)|psi-mi:TUBB(display_short)|uniprotkb:Tubulin beta-5 chain(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:OK/SW-cl.56(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_821133.1|refseq:NP_001280141.1|refseq:NP_001280142.1|refseq:NP_001280143.1|refseq:NP_001280144.1|refseq:NP_001280145.1|ensembl:ENSG00000183311(gene)|ensembl:ENSG00000196230(gene)|ensembl:ENSG00000224156(gene)|ensembl:ENSG00000227739(gene)|ensembl:ENSG00000229684(gene)|ensembl:ENSG00000232421(gene)|ensembl:ENSG00000232575(gene)|ensembl:ENSG00000235067(gene)|ensembl:ENST00000327892(transcript)|ensembl:ENST00000383564(transcript)|ensembl:ENST00000419792(transcript)|ensembl:ENST00000421473(transcript)|ensembl:ENST00000422650(transcript)|ensembl:ENST00000422674(transcript)|ensembl:ENST00000432462(transcript)|ensembl:ENST00000436628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P07437|rcsb pdb:3QNZ|rcsb pdb:3QO0|rcsb pdb:5N5N|rcsb pdb:6I2I|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|reactome:R-HSA-2565942|go:"GO:0050807"(regulation of synapse organization)|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518|reactome:R-HSA-9679191|reactome:R-HSA-380320|dip:DIP-32772N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:B6pmb1dvCroZXGd/1Zazi+s72GA9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P52907	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-355586|uniprotkb:Q53FQ6|uniprotkb:Q6FHD5|ensembl:ENSP00000263168	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:caza1_human(display_long)|uniprotkb:CAPZA1(gene name)|psi-mi:CAPZA1(display_short)|uniprotkb:CapZ alpha-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_006126.1|ensembl:ENSG00000116489(gene)|ensembl:ENST00000263168(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071203"(WASH complex)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P52907|rcsb pdb:1MQ1|rcsb pdb:1MWN|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-879415|reactome:R-HSA-8950505|reactome:R-HSA-9662360|reactome:R-HSA-983231	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:97S4WPtjgt4MDLoptRhQ2yH8UNE9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P47755	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-762451|uniprotkb:B4DG50|ensembl:ENSP00000354947	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:caza2_human(display_long)|uniprotkb:CapZ alpha-2(gene name synonym)|uniprotkb:CAPZA2(gene name)|psi-mi:CAPZA2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_006127.1|ensembl:ENSG00000198898(gene)|ensembl:ENST00000361183(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P47755|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-879415|reactome:R-HSA-9662360|reactome:R-HSA-983231|go:"GO:0016020"(membrane)	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:7+0w8fJ0OowIwAC7/tdNqiGSepc9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P00390	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-720325|uniprotkb:C8KIM0|uniprotkb:C8KIL8|uniprotkb:C8KIL9|ensembl:ENSP00000221130|uniprotkb:Q7Z5C9|uniprotkb:Q9NP63|uniprotkb:D3DSV3	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:gshr_human(display_long)|uniprotkb:GLUR(gene name synonym)|uniprotkb:GRD1(gene name synonym)|uniprotkb:GSR(gene name)|psi-mi:GSR(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	ensembl:ENSG00000104687(gene)|ensembl:ENST00000221130(transcript)|go:"GO:0004362"("glutathione-disulfide reductase (NADPH) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|refseq:NP_000628.2|interpro:IPR023753|interpro:IPR006322(Glutathione reductase, animal and bacterial)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR036188|rcsb pdb:1ALG|rcsb pdb:1BWC|rcsb pdb:1DNC|rcsb pdb:1GRA|rcsb pdb:1GRB|rcsb pdb:1GRE|rcsb pdb:1GRF|rcsb pdb:1GRG|rcsb pdb:1GRH|rcsb pdb:1GRT|rcsb pdb:1GSN|rcsb pdb:1K4Q|rcsb pdb:1XAN|rcsb pdb:2AAQ|rcsb pdb:2GH5|rcsb pdb:2GRT|rcsb pdb:3DJG|rcsb pdb:3DJJ|rcsb pdb:3DK4|rcsb pdb:3DK8|rcsb pdb:3DK9|rcsb pdb:3GRS|rcsb pdb:3GRT|rcsb pdb:3SQP|rcsb pdb:4GR1|rcsb pdb:4GRT|rcsb pdb:5GRT|reactome:R-HSA-2408550|reactome:R-HSA-3299685|reactome:R-HSA-499943|reactome:R-HSA-5628897|refseq:NP_001182031.1|refseq:NP_001182032.1|refseq:NP_001182033.1	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:7vVXBCpDFlu835Jcm+ZeGReIA+Q9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P11413	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-4289891|uniprotkb:Q8IU88|uniprotkb:D3DWX9|uniprotkb:Q16000|uniprotkb:Q16765|uniprotkb:Q8IUA6|uniprotkb:Q8IU70|uniprotkb:Q96PQ2|ensembl:ENSP00000377192|ensembl:ENSP00000377194	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:g6pd_human(display_long)|uniprotkb:G6PD(gene name)|psi-mi:G6PD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_000393.4|refseq:NP_001035810.1|ensembl:ENSG00000160211(gene)|ensembl:ENST00000393562(transcript)|ensembl:ENST00000393564(transcript)|go:"GO:0004345"(glucose-6-phosphate dehydrogenase activity)|go:"GO:0005536"(glucose binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006740"(NADPH regeneration)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010734"(negative regulation of protein glutathionylation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0019322"(pentose biosynthetic process)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032094"(response to food)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046390"(ribose phosphate biosynthetic process)|go:"GO:0050661"(NADP binding)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001282(Glucose-6-phosphate dehydrogenase)|interpro:IPR019796|interpro:IPR022674|interpro:IPR022675|interpro:IPR036291|rcsb pdb:1QKI|rcsb pdb:2BH9|rcsb pdb:2BHL|rcsb pdb:5UKW|rcsb pdb:6E07|rcsb pdb:6E08|rcsb pdb:6JYU|rcsb pdb:6VA0|rcsb pdb:6VA7|rcsb pdb:6VA8|rcsb pdb:6VA9|rcsb pdb:6VAQ|reactome:R-HSA-5628897|reactome:R-HSA-71336	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:qW8uk6xBGtrxlsosIH6gEG1ZfWA9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:Q15084	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-1043087|uniprotkb:Q6ZSH5|ensembl:ENSP00000272227|uniprotkb:B3KY95|uniprotkb:B5MCQ5|uniprotkb:B7Z4M8|uniprotkb:F8WA83|uniprotkb:B7Z254|uniprotkb:Q99778|uniprotkb:Q53RC7	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:pdia6_human(display_long)|uniprotkb:PDIA6(gene name)|psi-mi:PDIA6(display_short)|uniprotkb:TXNDC7(gene name synonym)|uniprotkb:Protein disulfide isomerase P5(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 7(gene name synonym)|uniprotkb:ERP5(gene name synonym)|uniprotkb:P5(gene name synonym)|uniprotkb:Endoplasmic reticulum protein 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_001269633.1|refseq:NP_001269634.1|refseq:NP_001269635.1|refseq:NP_001269636.1|interpro:IPR036249|interpro:IPR044569|mint:Q15084|rcsb pdb:1X5D|rcsb pdb:3VWW|rcsb pdb:3W8J|rcsb pdb:4EF0|rcsb pdb:4GWR|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-8957275|interpro:IPR017937|ensembl:ENSG00000143870(gene)|ensembl:ENST00000272227(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005733.1	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:411bo7TdfeCtMvUqyBb7bofi5To9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:Q8IXB1	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-2949763|ensembl:ENSP00000264065|uniprotkb:Q53QT7|uniprotkb:Q6UWZ6|uniprotkb:Q96K44|uniprotkb:Q8NC82|uniprotkb:Q86T61|uniprotkb:Q9NSY6|uniprotkb:Q17RJ6|uniprotkb:Q8TD87|uniprotkb:Q96K54|uniprotkb:Q96K38|uniprotkb:Q4ZG06|uniprotkb:Q3B7W8	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:djc10_human(display_long)|uniprotkb:DNAJC10(gene name)|psi-mi:DNAJC10(display_short)|uniprotkb:ERDJ5(gene name synonym)|uniprotkb:Macrothioredoxin(gene name synonym)|uniprotkb:UNQ495/PRO1012(orf name)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	ensembl:ENSG00000077232(gene)|ensembl:ENST00000264065(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0016020"(membrane)|go:"GO:0016671"(oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR021170|interpro:IPR035673|interpro:IPR035674|interpro:IPR036249|interpro:IPR036869|mint:Q8IXB1|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|refseq:NP_061854.1|refseq:NP_001258510.1|dip:DIP-48947N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:sD/pp49jws0LrBjwCxQmZqzfR9U9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P11021	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P07237	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-395883|uniprotkb:P30037|uniprotkb:P32079|uniprotkb:Q15205|uniprotkb:Q6LDE5|uniprotkb:B2RDQ2|ensembl:ENSP00000327801	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:pdia1_human(display_long)|uniprotkb:P4HB(gene name)|psi-mi:P4HB(display_short)|uniprotkb:PDI(gene name synonym)|uniprotkb:PDIA1(gene name synonym)|uniprotkb:PO4DB(gene name synonym)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:ERBA2L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_000909.2|ensembl:ENSG00000185624(gene)|ensembl:ENST00000331483(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042470"(melanosome)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P07237|rcsb pdb:1BJX|rcsb pdb:1MEK|rcsb pdb:1X5C|rcsb pdb:2BJX|rcsb pdb:2K18|rcsb pdb:3BJ5|rcsb pdb:3UEM|rcsb pdb:4EKZ|rcsb pdb:4EL1|rcsb pdb:4JU5|rcsb pdb:6I7S|reactome:R-HSA-1650814|reactome:R-HSA-3299685|reactome:R-HSA-381426|reactome:R-HSA-5358346|reactome:R-HSA-8866423|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-32979N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:rh0B38TSfTX+lvU5OyBwEbVndFA9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P30101	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P13667	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28799	uniprotkb:P07602	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21335826|imex:IM-27556-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	-	-	-	figure legend:Fig. 1, Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t98g)|taxid:9606(Human caucasian glioblastoma line T98G)	-	2019/04/18	2020/10/21	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rigid:dzWjBfnskE20dX3Tpes3r9wz10k	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P28799	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347654|imex:IM-27556-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	-	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/04/18	2019/04/23	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rigid:Yp1tPRjxpBNcFkv6jhXTEuOx6yA	false	v5 tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P28798	uniprotkb:Q61207	intact:EBI-2365205|ensembl:ENSMUSP00000159379	intact:EBI-645756|uniprotkb:Q60861|uniprotkb:Q64006|uniprotkb:Q64219|ensembl:ENSMUSP00000137476	psi-mi:grn_mouse(display_long)|uniprotkb:Grn(gene name)|psi-mi:Grn(display_short)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin/granulin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)	psi-mi:sap_mouse(display_long)|uniprotkb:Psap(gene name)|psi-mi:Psap(display_short)|uniprotkb:Sgp1(gene name synonym)|uniprotkb:Sulfated glycoprotein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347669|imex:IM-27556-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032201.2|ensembl:ENSMUSG00000034708(gene)|ensembl:ENSMUST00000239431(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007566"(embryo implantation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060179"(male mating behavior)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098793"(presynapse)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905671"(regulation of lysosome organization)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28798|reactome:R-MMU-6798695	refseq:NP_001139592.1|refseq:NP_001139593.1|refseq:NP_001139594.1|refseq:NP_001139595.1|refseq:NP_001139596.1|refseq:NP_035309.3|go:"GO:0003335"(corneocyte development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0006643"(membrane lipid metabolic process)|go:"GO:0006664"(glycolipid metabolic process)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006678"(glucosylceramide metabolic process)|go:"GO:0006683"(galactosylceramide catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0002020"(protease binding)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENSMUSG00000004207(gene)|ensembl:ENSMUST00000179238(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0010467"(gene expression)|go:"GO:0016235"(aggresome)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0030882"(lipid antigen binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048589"(developmental growth)|go:"GO:0050877"(nervous system process)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0060073"(micturition)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0009306"(protein secretion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0090102"(cochlea development)|go:"GO:0090659"(walking behavior)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903575"(cornified envelope assembly)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|go:"GO:1905575"(ganglioside GM3 binding)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|mint:Q61207|rcsb pdb:5NXB|rcsb pdb:5U85|reactome:R-MMU-114608|reactome:R-MMU-1660662|reactome:R-MMU-375276|reactome:R-MMU-418594|reactome:R-MMU-6798695|go:"GO:0070841"(inclusion body assembly)	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/23	rogid:2nKMRNqLyZN/IXAvz1zMzDCpDmg10090	rogid:IOmtR34fe4aSy6aqmQvkB2xvuwU10090	rigid:etetOSR2Pfvd1NVicUbcMaWvS5A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P28798	uniprotkb:Q61207	intact:EBI-2365205|ensembl:ENSMUSP00000159379	intact:EBI-645756|uniprotkb:Q60861|uniprotkb:Q64006|uniprotkb:Q64219|ensembl:ENSMUSP00000137476	psi-mi:grn_mouse(display_long)|uniprotkb:Grn(gene name)|psi-mi:Grn(display_short)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin/granulin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)	psi-mi:sap_mouse(display_long)|uniprotkb:Psap(gene name)|psi-mi:Psap(display_short)|uniprotkb:Sgp1(gene name synonym)|uniprotkb:Sulfated glycoprotein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347673|imex:IM-27556-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032201.2|ensembl:ENSMUSG00000034708(gene)|ensembl:ENSMUST00000239431(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007566"(embryo implantation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060179"(male mating behavior)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098793"(presynapse)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905671"(regulation of lysosome organization)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28798|reactome:R-MMU-6798695	refseq:NP_001139592.1|refseq:NP_001139593.1|refseq:NP_001139594.1|refseq:NP_001139595.1|refseq:NP_001139596.1|refseq:NP_035309.3|go:"GO:0003335"(corneocyte development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0006643"(membrane lipid metabolic process)|go:"GO:0006664"(glycolipid metabolic process)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006678"(glucosylceramide metabolic process)|go:"GO:0006683"(galactosylceramide catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0002020"(protease binding)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENSMUSG00000004207(gene)|ensembl:ENSMUST00000179238(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0010467"(gene expression)|go:"GO:0016235"(aggresome)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0030882"(lipid antigen binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048589"(developmental growth)|go:"GO:0050877"(nervous system process)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0060073"(micturition)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0009306"(protein secretion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0090102"(cochlea development)|go:"GO:0090659"(walking behavior)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903575"(cornified envelope assembly)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|go:"GO:1905575"(ganglioside GM3 binding)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|mint:Q61207|rcsb pdb:5NXB|rcsb pdb:5U85|reactome:R-MMU-114608|reactome:R-MMU-1660662|reactome:R-MMU-375276|reactome:R-MMU-418594|reactome:R-MMU-6798695|go:"GO:0070841"(inclusion body assembly)	-	-	-	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/23	rogid:2nKMRNqLyZN/IXAvz1zMzDCpDmg10090	rogid:IOmtR34fe4aSy6aqmQvkB2xvuwU10090	rigid:etetOSR2Pfvd1NVicUbcMaWvS5A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07602	uniprotkb:P28799	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347683|imex:IM-27556-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	-	-	-	figure legend:Fig. 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/04/18	2019/12/12	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rigid:Yp1tPRjxpBNcFkv6jhXTEuOx6yA	false	his tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P28798	uniprotkb:Q61207	intact:EBI-2365205|ensembl:ENSMUSP00000159379	intact:EBI-645756|uniprotkb:Q60861|uniprotkb:Q64006|uniprotkb:Q64219|ensembl:ENSMUSP00000137476	psi-mi:grn_mouse(display_long)|uniprotkb:Grn(gene name)|psi-mi:Grn(display_short)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin/granulin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)	psi-mi:sap_mouse(display_long)|uniprotkb:Psap(gene name)|psi-mi:Psap(display_short)|uniprotkb:Sgp1(gene name synonym)|uniprotkb:Sulfated glycoprotein 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347699|imex:IM-27556-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032201.2|ensembl:ENSMUSG00000034708(gene)|ensembl:ENSMUST00000239431(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007566"(embryo implantation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060179"(male mating behavior)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098793"(presynapse)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905671"(regulation of lysosome organization)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28798|reactome:R-MMU-6798695	refseq:NP_001139592.1|refseq:NP_001139593.1|refseq:NP_001139594.1|refseq:NP_001139595.1|refseq:NP_001139596.1|refseq:NP_035309.3|go:"GO:0003335"(corneocyte development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0006643"(membrane lipid metabolic process)|go:"GO:0006664"(glycolipid metabolic process)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006678"(glucosylceramide metabolic process)|go:"GO:0006683"(galactosylceramide catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0002020"(protease binding)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENSMUSG00000004207(gene)|ensembl:ENSMUST00000179238(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0010467"(gene expression)|go:"GO:0016235"(aggresome)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0030882"(lipid antigen binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048589"(developmental growth)|go:"GO:0050877"(nervous system process)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0060073"(micturition)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0009306"(protein secretion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0090102"(cochlea development)|go:"GO:0090659"(walking behavior)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903575"(cornified envelope assembly)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|go:"GO:1905575"(ganglioside GM3 binding)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|mint:Q61207|rcsb pdb:5NXB|rcsb pdb:5U85|reactome:R-MMU-114608|reactome:R-MMU-1660662|reactome:R-MMU-375276|reactome:R-MMU-418594|reactome:R-MMU-6798695|go:"GO:0070841"(inclusion body assembly)	go:"GO:0005764"(lysosome)	-	-	figure legend:Fig. 3A, 6B, Supp. Fig. 2, 3A|comment:Loss of lysosomal PGRN signal is accompanied by increased secretion of PGRN to the extracellular space.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/23	rogid:2nKMRNqLyZN/IXAvz1zMzDCpDmg10090	rogid:IOmtR34fe4aSy6aqmQvkB2xvuwU10090	rigid:etetOSR2Pfvd1NVicUbcMaWvS5A	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P07602	uniprotkb:P28799	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347718|imex:IM-27556-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	-	-	-	figure legend:Fig. 5A|comment:Purified proteins are delivered to the lysosome, the mechanism for this is not given.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/23	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rigid:Yp1tPRjxpBNcFkv6jhXTEuOx6yA	false	his tag:n-n	his tag:c-c|flag tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P07602	uniprotkb:Q99K48	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-607499|ensembl:ENSMUSP00000033673|uniprotkb:Q63887|uniprotkb:Q9CYQ4|uniprotkb:Q9DBP2	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:nono_mouse(display_long)|uniprotkb:Nono(gene name)|psi-mi:Nono(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000031311(gene)|ensembl:ENSMUST00000033673(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034552|interpro:IPR035979|mint:Q99K48|rcsb pdb:2CPJ|rcsb pdb:2RS8|refseq:NP_075633.2|refseq:NP_001239447.1|dip:DIP-34308N	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:78ly3/4yzdfLjl9d/cV6Ob/SFG810090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P54823	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-3647041|ensembl:ENSMUSP00000128421|ensembl:ENSMUSP00000149620|uniprotkb:O54979|uniprotkb:Q3UFI3|uniprotkb:Q8BW68	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ddx6_mouse(display_long)|uniprotkb:Ddx6(gene name)|psi-mi:Ddx6(display_short)|uniprotkb:Hlr2(gene name synonym)|uniprotkb:Rck(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:Oncogene RCK homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|mint:P54823|reactome:R-MMU-430039|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|ensembl:ENSMUSG00000032097(gene)|ensembl:ENSMUST00000170489(transcript)|ensembl:ENSMUST00000217034(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_001104296.1|refseq:NP_031867.1|refseq:NP_851841.2|refseq:XP_011240693.1|refseq:XP_011240694.1|refseq:XP_017168613.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:Q80hxmsbz9kQgOP9Gflto87Sp/M10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P19221	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-8375972|intact:MINT-4137721|ensembl:ENSMUSP00000028681	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:thrb_mouse(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Cf2(gene name synonym)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_034298.1|dip:DIP-60968N|ensembl:ENSMUSG00000027249(gene)|ensembl:ENSMUST00000028681(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|interpro:IPR035972|interpro:IPR037111|interpro:IPR038178|interpro:IPR043504|mint:P19221|rcsb pdb:2OCV|rcsb pdb:2PUX|rcsb pdb:2PV9|rcsb pdb:3EDX|rcsb pdb:3HK3|rcsb pdb:3HK6|rcsb pdb:3HKI|reactome:R-MMU-140837|reactome:R-MMU-140875|reactome:R-MMU-159740|reactome:R-MMU-159763|reactome:R-MMU-159782|reactome:R-MMU-202733|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-456926|reactome:R-MMU-76009|reactome:R-MMU-977606	-	-	comment:mint|function:Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:amZ+Pl0pNliSHuykYcjQLfqb1vw10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P01868	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-7139648|intact:MINT-138391	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ighg1_mouse(display_long)|uniprotkb:Ighg1(gene name)|psi-mi:Ighg1(display_short)|uniprotkb:Igh-4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	go:"GO:0001798"(positive regulation of type IIa hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003823"(antigen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0001788"(antibody-dependent cellular cytotoxicity)|rcsb pdb:1AHW|rcsb pdb:1DBJ|rcsb pdb:1AI1|rcsb pdb:2DBL|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2ATY|rcsb pdb:1KEL|rcsb pdb:1FBI|rcsb pdb:1OPG|rcsb pdb:1DBA|rcsb pdb:1CLO|rcsb pdb:3ZO0|rcsb pdb:1DBM|rcsb pdb:2B2X|rcsb pdb:1SEQ|rcsb pdb:1DBB|rcsb pdb:1DBK|rcsb pdb:1YED|rcsb pdb:1KEM|rcsb pdb:1NTL|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|rcsb pdb:1BM3|rcsb pdb:1CT8|rcsb pdb:1EMT|rcsb pdb:1FDL|rcsb pdb:1FNS|rcsb pdb:1GPO|rcsb pdb:1K4D|rcsb pdb:1MF2|rcsb pdb:1MLC|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1OAK|rcsb pdb:1P2C|rcsb pdb:1P7K|rcsb pdb:1R0A|rcsb pdb:1R3I|rcsb pdb:1R3J|rcsb pdb:1R3K|rcsb pdb:1R3L|rcsb pdb:1RIH|interpro:IPR036179	-	-	comment:mint	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:kYhqFpXxc0zklNhrHHDNsZSLuYY10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q9JJ28	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-7996161|uniprotkb:Q8K095|uniprotkb:Q8VI44|intact:MINT-4095146|ensembl:ENSMUSP00000002889	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:flii_mouse(display_long)|uniprotkb:Flii(gene name)|psi-mi:Flii(display_short)|uniprotkb:Fli1(gene name synonym)|uniprotkb:Fliih(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_071292.1|dip:DIP-47641N|ensembl:ENSMUSG00000002812(gene)|ensembl:ENSMUST00000002889(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030239"(myofibril assembly)|go:"GO:0034451"(centriolar satellite)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR025875|interpro:IPR029006|interpro:IPR029919|interpro:IPR032675|interpro:IPR036180|mint:Q9JJ28	-	-	comment:mint|function:"May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling (By similarity). Essential for early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration"	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:wCG18Ps+gmkZd+I52mICu1O1SdQ10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8BTI8	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-8328602|uniprotkb:E9QNB0|uniprotkb:Q3TBY5|uniprotkb:Q569P9|uniprotkb:Q80U37|intact:MINT-4112373|uniprotkb:Q8K383|ensembl:ENSMUSP00000139842	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:srrm2_mouse(display_long)|uniprotkb:Srrm2(gene name)|psi-mi:Srrm2(display_short)|uniprotkb:Kiaa0324(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_780438.2|refseq:XP_006525139.1|refseq:XP_006525140.1|ensembl:ENSMUSG00000039218(gene)|ensembl:ENSMUST00000190686(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|interpro:IPR013170(mRNA splicing factor, Cwf21)|interpro:IPR024945|mint:Q8BTI8|reactome:R-MMU-72163	-	-	function:Part of pre- and post-splicing multiprotein mRNP complexes. May be involved in pre-mRNA processing events. Binds to RNA|comment:mint	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:PTLJsCjqGftaxq5deG19BhEASWo10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8BGD9	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-8175971|uniprotkb:Q3TD64|intact:MINT-1954873|ensembl:ENSMUSP00000127774	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:if4b_mouse(display_long)|uniprotkb:Eif4b(gene name)|psi-mi:Eif4b(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_663600.2|ensembl:ENSMUSG00000058655(gene)|ensembl:ENSMUST00000169681(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0030425"(dendrite)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034057"(RNA strand-exchange activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0097010"(eukaryotic translation initiation factor 4F complex assembly)|go:"GO:0098794"(postsynapse)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033107|interpro:IPR035979|mint:Q8BGD9|reactome:R-MMU-156827|reactome:R-MMU-166208|reactome:R-MMU-429947|reactome:R-MMU-72649|reactome:R-MMU-72662|reactome:R-MMU-72702|reactome:R-MMU-72706	-	-	comment:mint|function:Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:BpntysITPv8NbtpvHATfgCjI/i810090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q91WK0	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-7996195|uniprotkb:Q9CU89|uniprotkb:Q8BVD1|intact:MINT-5102469	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:lrrf2_mouse(display_long)|uniprotkb:Lrrfip2(gene name)|psi-mi:Lrrfip2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	interpro:IPR019139|refseq:NP_082018.1|refseq:NP_001158310.1|mint:Q91WK0|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035660"(MyD88-dependent toll-like receptor 4 signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)	-	-	comment:mint|function:May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:oDgIYHLW2PlrYk0pvnqMRhdnG1U10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q6Y7W8	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-8652170|uniprotkb:Q8K0R0|uniprotkb:Q3UNS2|intact:MINT-266607|uniprotkb:Q8R0A3|uniprotkb:Q0VGQ7|uniprotkb:Q63ZU9|uniprotkb:Q80TV1|ensembl:ENSMUSP00000027475|ensembl:ENSMUSP00000133327	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ggyf2_mouse(display_long)|uniprotkb:Kiaa0642(gene name synonym)|uniprotkb:Perq2(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 15 protein(gene name synonym)|uniprotkb:Gigyf2(gene name)|psi-mi:Gigyf2(display_short)|uniprotkb:Tnrc15(gene name synonym)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_001103682.1|refseq:NP_666224.3|refseq:XP_006529527.1|refseq:XP_006529528.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007631"(feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070064"(proline-rich region binding)|go:"GO:1990635"(proximal dendrite)|interpro:IPR003169(GYF)|interpro:IPR035445|ensembl:ENSMUSG00000048000(gene)|ensembl:ENSMUST00000027475(transcript)|ensembl:ENSMUST00000174501(transcript)	-	-	comment:mint|function:May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:XjYRWxaHyi+oSBy+5fX2jnJKU7I10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8CG76	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-8322524|uniprotkb:Q8JZQ8|uniprotkb:Q8CG77|intact:MINT-1869477|uniprotkb:Q3UPU2|uniprotkb:A2AMV3|uniprotkb:Q9D157|ensembl:ENSMUSP00000073459	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ark72_mouse(display_long)|uniprotkb:Akr7a2(gene name)|psi-mi:Akr7a2(display_short)|uniprotkb:Afar(gene name synonym)|uniprotkb:Akr7a5(gene name synonym)|uniprotkb:Succinic semialdehyde reductase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_079613.3|ensembl:ENSMUSG00000028743(gene)|ensembl:ENSMUST00000073787(transcript)|go:"GO:0004032"("alditol:NADP+ 1-oxidoreductase activity")|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0019119"(phenanthrene-9,10-epoxide hydrolase activity)|go:"GO:0044597"(daunorubicin metabolic process)|go:"GO:0044598"(doxorubicin metabolic process)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|interpro:IPR023210|interpro:IPR036812|mint:Q8CG76|rcsb pdb:2C91|reactome:R-MMU-5423646	-	-	function:"Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen"|comment:mint	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:4FHXTY2OHX2EsE2Dpi5DuDO17Ro10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q62426	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-8320940|intact:MINT-4092754|uniprotkb:Q3UAW2|ensembl:ENSMUSP00000005185	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:cytb_mouse(display_long)|uniprotkb:Cstb(gene name)|psi-mi:Cstb(display_short)|uniprotkb:Cst6(gene name synonym)|uniprotkb:Stfb(gene name synonym)|uniprotkb:Stefin-B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_031819.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR001713(Proteinase inhibitor I25A, stefin A)|interpro:IPR018073|mint:Q62426|reactome:R-MMU-6798695|go:"GO:0005730"(nucleolus)|ensembl:ENSMUSG00000005054(gene)|ensembl:ENSMUST00000005185(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)	-	-	function:This is an intracellular thiol proteinase inhibitor|comment:mint	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:cJ8kEKV//q18yhym1BQGZO8hGu010090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8BP67	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-7914360|uniprotkb:P38663|uniprotkb:Q58EA4|intact:MINT-1857981|ensembl:ENSMUSP00000023269	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rl24_mouse(display_long)|uniprotkb:Rpl24(gene name)|psi-mi:Rpl24(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_077180.1|ensembl:ENSMUSG00000098274(gene)|ensembl:ENSMUST00000023269(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0010458"(exit from mitosis)|go:"GO:0021554"(optic nerve development)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:1902626"(assembly of large subunit precursor of preribosome)|interpro:IPR000988(Ribosomal protein L24e)|interpro:IPR011017(TRASH)|interpro:IPR023442|interpro:IPR038630|mint:Q8BP67|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|reactome:R-MMU-6791226	-	-	comment:mint	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:+Ah+YGgcjqOsk5ZS1HZUMQA/Of810090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q60759	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-8346707|uniprotkb:Q6P8N6|intact:MINT-1861107|ensembl:ENSMUSP00000105367	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:gcdh_mouse(display_long)|uniprotkb:Gcdh(gene name)|psi-mi:Gcdh(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_032123.3|ensembl:ENSMUSG00000003809(gene)|ensembl:ENSMUST00000109745(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0004361"(glutaryl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006568"(tryptophan metabolic process)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|mint:Q60759|reactome:R-MMU-71064	-	-	comment:mint|function:"Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor"	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:9Eqsf+BV433ivsm8Ht159P8ucKA10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q64282	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-8407973|intact:MINT-4124109|uniprotkb:Q99L77|ensembl:ENSMUSP00000099888	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ifit1_mouse(display_long)|uniprotkb:Ifit1(gene name)|psi-mi:Ifit1(display_short)|uniprotkb:Garg16(gene name synonym)|uniprotkb:Glucocorticoid-attenuated response gene 16 protein(gene name synonym)|uniprotkb:Ifi56(gene name synonym)|uniprotkb:Interferon-induced 56 kDa protein(gene name synonym)|uniprotkb:Isg56(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_032357.2|ensembl:ENSMUSG00000034459(gene)|ensembl:ENSMUST00000102824(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q64282	-	-	comment:mint	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:JkhvoGmwqpo/NNj0zpx5vScjgro10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q80VD1	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-8312352|ensembl:ENSMUSP00000028825|intact:MINT-4125185|uniprotkb:A2ATZ4|uniprotkb:Q9CS37|uniprotkb:Q9CS28	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:fa98b_mouse(display_long)|uniprotkb:Fam98b(gene name)|psi-mi:Fam98b(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000027349(gene)|ensembl:ENSMUST00000028825(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|mint:Q80VD1|go:"GO:0006479"(protein methylation)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0072669"(tRNA-splicing ligase complex)|interpro:IPR018797|refseq:NP_080896.2	-	-	comment:mint	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:RhwdW3SPEJ+fy34p2EuYxovNQno10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q91YR9	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-8391101|uniprotkb:Q3TKT6|intact:MINT-4122050|uniprotkb:Q9CPS1|ensembl:ENSMUSP00000030069	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ptgr1_mouse(display_long)|uniprotkb:Dithiolethione-inducible gene 1 protein(gene name synonym)|uniprotkb:Leukotriene B4 12-hydroxydehydrogenase(gene name synonym)|uniprotkb:"NAD(P)H-dependent alkenal/one oxidoreductase"(gene name synonym)|uniprotkb:Ptgr1(gene name)|psi-mi:Ptgr1(display_short)|uniprotkb:Ltb4dh(gene name synonym)|uniprotkb:15-oxoprostaglandin 13-reductase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_080244.1|ensembl:ENSMUSG00000028378(gene)|ensembl:ENSMUST00000030069(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0035798"("2-alkenal reductase (NADP+) activity")|go:"GO:0036102"(leukotriene B4 metabolic process)|go:"GO:0036132"(13-prostaglandin reductase activity)|go:"GO:0036185"(13-lipoxin reductase activity)|go:"GO:0047522"(15-oxoprostaglandin 13-oxidase activity)|go:"GO:0097257"(leukotriene B4 12-hydroxy dehydrogenase activity)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:2001302"(lipoxin A4 metabolic process)|interpro:IPR011032(GroES-like)|interpro:IPR013149(Alcohol dehydrogenase, zinc-binding)|interpro:IPR014190(Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase)|interpro:IPR020843|interpro:IPR036291|interpro:IPR041694|mint:Q91YR9	-	-	comment:mint|function:Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:SVT+Yycfdhm7XpA112geNdD/GWQ10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q99J09	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2940098|ensembl:ENSMUSP00000010278|uniprotkb:Q3TFJ1|uniprotkb:Q8BSH8|uniprotkb:Q9CZY5	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:mep50_mouse(display_long)|uniprotkb:Wdr77(gene name)|psi-mi:Wdr77(display_short)|uniprotkb:Mep50(gene name synonym)|uniprotkb:WD repeat-containing protein 77(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000000561(gene)|ensembl:ENSMUST00000010278(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007315"(pole plasm assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0034709"(methylosome)|go:"GO:0045495"(pole plasm)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:Q99J09|reactome:R-MMU-191859|reactome:R-MMU-3214858|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|refseq:NP_081708.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:JFY7nRR7e+fM7CD6/0A/oqvC1xU10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q9WV32	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2693804|uniprotkb:Q9CRC4|ensembl:ENSMUSP00000082822	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:arc1b_mouse(display_long)|uniprotkb:Arpc1b(gene name)|psi-mi:Arpc1b(display_short)|uniprotkb:Arp2/3 complex 41 kDa subunit(gene name synonym)|uniprotkb:p41-ARC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_075631.2|ensembl:ENSMUSG00000029622(gene)|ensembl:ENSMUST00000085679(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0036284"(tubulobulbar complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017383(Actin-related protein 2/3 complex, subunit 1)|interpro:IPR030141|interpro:IPR036322|mint:Q9WV32|rcsb pdb:7AQK|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-5663213	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:hAHGie5VAy2Jp+WBsA9kQQqJZfs10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8CIG8	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2527009|uniprotkb:Q3TNN1|uniprotkb:Q9QZS9	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:anm5_mouse(display_long)|uniprotkb:Prmt5(gene name)|psi-mi:Prmt5(display_short)|uniprotkb:Jbp1(gene name synonym)|uniprotkb:Skb1(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT5(gene name synonym)|uniprotkb:Shk1 kinase-binding protein 1 homolog(gene name synonym)|uniprotkb:Jak-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	interpro:IPR035075|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000785"(chromatin)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006479"(protein methylation)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034709"(methylosome)|go:"GO:0034969"(histone arginine methylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035243"(protein-arginine omega-N symmetric methyltransferase activity)|go:"GO:0035246"(peptidyl-arginine N-methylation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904992"(positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway)|reactome:R-MMU-191859|reactome:R-MMU-3214858|reactome:R-MMU-6804760|refseq:NP_038796.2|interpro:IPR007857(Skb1 methyltransferase)|interpro:IPR029063|refseq:NP_001300835.1|refseq:NP_001300836.1|interpro:IPR025799|interpro:IPR035247|interpro:IPR035248|mint:Q8CIG8	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:xMQdLXo5TNQQFK9XjxjH+5/ZwNA10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q3UZ39	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2270972|uniprotkb:O70323|uniprotkb:Q3TS94|ensembl:ENSMUSP00000095254	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:lrrf1_mouse(display_long)|uniprotkb:H186 FLAP(gene name synonym)|uniprotkb:FLI-LRR-associated protein 1(gene name synonym)|uniprotkb:Lrrfip1(gene name)|psi-mi:Lrrfip1(display_short)|uniprotkb:Flap(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_001104781.1|refseq:NP_001104782.1|refseq:NP_032541.1|ensembl:ENSMUSG00000026305(gene)|ensembl:ENSMUST00000097649(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR019139|mint:Q3UZ39	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:LL6ZrfCorNlWgE0W5E5+LVfsqWo10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q6PDM2	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2550360|ensembl:ENSMUSP00000120595|uniprotkb:B2KGJ5|uniprotkb:Q3UCH2|uniprotkb:Q5SXC5|uniprotkb:Q8BJV3|uniprotkb:Q8C1H9	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:srsf1_mouse(display_long)|uniprotkb:Sfrs1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)|uniprotkb:Srsf1(gene name)|psi-mi:Srsf1(display_short)|uniprotkb:ASF/SF2(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SRp30a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000018379(gene)|ensembl:ENSMUST00000139129(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0050733"(RS domain binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q6PDM2|rcsb pdb:1X4C|go:"GO:0005654"(nucleoplasm)|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|reactome:R-MMU-72165|refseq:NP_001071635.1|refseq:NP_775550.2|dip:DIP-48723N	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:B2RRE7	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-16728605|ensembl:ENSMUSP00000133939|uniprotkb:B7ZNI5|uniprotkb:Q80TL3|uniprotkb:Q9CUN2	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:otud4_mouse(display_long)|uniprotkb:Otud4(gene name)|psi-mi:Otud4(display_short)|uniprotkb:Kiaa1046(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000036990(gene)|ensembl:ENSMUST00000173078(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|mint:B2RRE7|refseq:NP_001074633.1|refseq:NP_001242962.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:hvTooCUd0wIF+PvtoaDsmYWo4/s10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P13020	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-445180|uniprotkb:Q3UPB1|uniprotkb:Q8R590|intact:EBI-4281654|ensembl:ENSMUSP00000028239	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:gels_mouse(display_long)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Brevin(gene name synonym)|uniprotkb:Gsn(gene name)|psi-mi:Gsn(display_short)|uniprotkb:Gsb(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_666232.2|ensembl:ENSMUSG00000026879(gene)|ensembl:ENSMUST00000028239(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030478"(actin cap)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036313"(phosphatidylinositol 3-kinase catalytic subunit binding)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043209"(myelin sheath)|go:"GO:0045010"(actin nucleation)|go:"GO:0045159"(myosin II binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0051593"(response to folic acid)|go:"GO:0051693"(actin filament capping)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060271"(cilium assembly)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0097017"(renal protein absorption)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1903903"(regulation of establishment of T cell polarity)|go:"GO:1903906"(regulation of plasma membrane raft polarization)|go:"GO:1903909"(regulation of receptor clustering)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR030004|mint:P13020|rcsb pdb:1NPH|rcsb pdb:4CBU|rcsb pdb:4CBW|rcsb pdb:4CBX|rcsb pdb:5MVV|rcsb pdb:6I4D|rcsb pdb:6I4E|rcsb pdb:6I4F|rcsb pdb:6I4G|rcsb pdb:6I4H|rcsb pdb:6I4I|rcsb pdb:6I4J|rcsb pdb:6I4K|rcsb pdb:6I4L|rcsb pdb:6I4M|reactome:R-MMU-264870|reactome:R-MMU-6798695|dip:DIP-31941N	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:vByKB6qbsPzebkkufeXoP6n0SUI10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q91VJ4	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2527046|ensembl:ENSMUSP00000009138|ensembl:ENSMUSP00000113657|ensembl:ENSMUSP00000156711	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:stk38_mouse(display_long)|uniprotkb:Stk38(gene name)|psi-mi:Stk38(display_short)|uniprotkb:Ndr1(gene name synonym)|uniprotkb:NDR1 protein kinase(gene name synonym)|uniprotkb:Nuclear Dbf2-related kinase 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:Q91VJ4|reactome:R-MMU-9013418|reactome:R-MMU-9013422|interpro:IPR008271(Serine/threonine protein kinase, active site)|ensembl:ENSMUSG00000024006(gene)|ensembl:ENSMUST00000009138(transcript)|ensembl:ENSMUST00000119274(transcript)|ensembl:ENSMUST00000232836(transcript)|refseq:NP_598876.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:TvwVb4eUVw+H1smxX4+Z3LjcAUw10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P46735	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-400887|uniprotkb:P70244|uniprotkb:Q80VD8|ensembl:ENSMUSP00000040447	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:myo1b_mouse(display_long)|uniprotkb:Myo1b(gene name)|psi-mi:Myo1b(display_short)|uniprotkb:Myosin I alpha(gene name synonym)|uniprotkb:MIH-L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_034993.2|ensembl:ENSMUSG00000018417(gene)|ensembl:ENSMUST00000046390(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030175"(filopodium)|go:"GO:0031982"(vesicle)|go:"GO:0033572"(transferrin transport)|go:"GO:0045177"(apical part of cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0071944"(cell periphery)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|interpro:IPR036961|mint:P46735	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:GStJH3DUQORwMi1ow0mHcBAf4io10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q99JY9	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-773994|uniprotkb:Q9DC56|ensembl:ENSMUSP00000027579|ensembl:ENSMUSP00000137503	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:arp3_mouse(display_long)|uniprotkb:Actin-like protein 3(gene name synonym)|uniprotkb:Actr3(gene name)|psi-mi:Actr3(display_short)|uniprotkb:Arp3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_001192314.1|refseq:NP_001192315.1|refseq:NP_076224.1|ensembl:ENSMUSG00000026341(gene)|ensembl:ENSMUST00000027579(transcript)|ensembl:ENSMUST00000178474(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0030027"(lamellipodium)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043519"(regulation of myosin II filament organization)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060271"(cilium assembly)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061825"(podosome core)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0061832"(basal ectoplasmic specialization)|go:"GO:0061851"(leading edge of lamellipodium)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904171"(negative regulation of bleb assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|mint:Q99JY9|rcsb pdb:7AQK|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-5663213|reactome:R-MMU-8856828	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:FBCctn7WChHon0MhVlJUO4ctinE10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P60710	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-353957|ensembl:ENSMUSP00000098066|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q3TI89|uniprotkb:Q3TVP6|uniprotkb:Q64316|uniprotkb:Q6ZWM3	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:actb_mouse(display_long)|uniprotkb:Actb(gene name)|psi-mi:Actb(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000029580(gene)|ensembl:ENSMUST00000100497(transcript)|refseq:NP_031419.1|go:"GO:0002102"(podosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60710|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5250924|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-5689603|reactome:R-MMU-5696394|reactome:R-MMU-8856828|reactome:R-MMU-9035034|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0070160"(tight junction)|go:"GO:0001725"(stress fiber)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|dip:DIP-31574N	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P52332	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-646320|uniprotkb:Q62126	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:jak1_mouse(display_long)|uniprotkb:Janus kinase 1(gene name synonym)|uniprotkb:Jak1(gene name)|psi-mi:Jak1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	dip:DIP-41965N|mint:P52332|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR020776|interpro:IPR035963|interpro:IPR036860|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|reactome:R-MMU-1059683|reactome:R-MMU-110056|reactome:R-MMU-112411|reactome:R-MMU-1169408|reactome:R-MMU-1266695|reactome:R-MMU-5673001|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-6788467|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020591|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912526|reactome:R-MMU-912694|reactome:R-MMU-9674555|reactome:R-MMU-9705462	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:UIkyfJs6ggPxf4nXciyTLPqerSA10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q91YE6	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-529907|uniprotkb:Q924M3|uniprotkb:Q924M4	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ipo9_mouse(display_long)|uniprotkb:Importin-9a(gene name synonym)|uniprotkb:Importin-9b(gene name synonym)|uniprotkb:Ran-binding protein 9(gene name synonym)|uniprotkb:Ipo9(gene name)|psi-mi:Ipo9(display_short)|uniprotkb:Imp9(gene name synonym)|uniprotkb:Ranbp9(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	dip:DIP-34268N|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042393"(histone binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:pLLwywwG94FG4WvewQvoebF1HP410090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q9JHJ0	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2693841|uniprotkb:Q3TIT1|ensembl:ENSMUSP00000072087	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:tmod3_mouse(display_long)|uniprotkb:Tmod3(gene name)|psi-mi:Tmod3(display_short)|uniprotkb:Ubiquitous tropomodulin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_058659.1|ensembl:ENSMUSG00000058587(gene)|ensembl:ENSMUST00000072232(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0030016"(myofibril)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030239"(myofibril assembly)|go:"GO:0031941"(filamentous actin)|go:"GO:0048821"(erythrocyte development)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR004934(Tropomodulin)|interpro:IPR030133|interpro:IPR032675|mint:Q9JHJ0|reactome:R-MMU-390522|reactome:R-MMU-9013418|reactome:R-MMU-9696264	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:AzOWOiNC5rtaYG6tcsRez8dzDpI10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8VDD5	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-400906|intact:EBI-777674|uniprotkb:Q3UHT9|uniprotkb:Q3UHU4|uniprotkb:Q6KAN6|uniprotkb:Q811I2|ensembl:ENSMUSP00000016771	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:myh9_mouse(display_long)|uniprotkb:Myh9(gene name)|psi-mi:Myh9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_071855.2|ensembl:ENSMUSG00000022443(gene)|ensembl:ENSMUST00000016771(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0097513"(myosin II filament)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1903919"(negative regulation of actin filament severing)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q8VDD5|reactome:R-MMU-2029482|reactome:R-MMU-5627123|dip:DIP-29546N	-	-	caution:This sequence has been withdrawn from Uniprot.|crc64:AAAC0E83A0A4F24A	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:qYfcGuWOF9npzsKD3zXTuLeP9iE10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q9WTI7	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-777558|ensembl:ENSMUSP00000099563|uniprotkb:Q3TBQ4|uniprotkb:Q3U231|uniprotkb:Q5ND46|uniprotkb:Q5ND48|uniprotkb:Q5ND49|uniprotkb:Q9ERB6|uniprotkb:O08571|uniprotkb:O08834|uniprotkb:Q9QW54	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:myo1c_mouse(display_long)|uniprotkb:Myosin I beta(gene name synonym)|uniprotkb:Myo1c(gene name)|psi-mi:Myo1c(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000017774(gene)|ensembl:ENSMUST00000102505(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0006605"(protein targeting)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007015"(actin filament organization)|mint:Q9WTI7|rcsb pdb:4R8G|reactome:R-MMU-2029482|reactome:R-MMU-5250924|interpro:IPR036961|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016604"(nuclear body)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032421"(stereocilium bundle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0060171"(stereocilium membrane)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1900748"(positive regulation of vascular endothelial growth factor signaling pathway)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|refseq:NP_001074243.1|refseq:NP_001074244.1|refseq:NP_032685.1|refseq:XP_006532492.1|dip:DIP-35498N	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:E25nufEJATQnH9pvQlkmAdEOAd810090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P61161	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-773987|uniprotkb:O15142|uniprotkb:Q6PI31|ensembl:ENSMUSP00000000137	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:arp2_mouse(display_long)|uniprotkb:Actin-like protein 2(gene name synonym)|uniprotkb:Actr2(gene name)|psi-mi:Actr2(display_short)|uniprotkb:Arp2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_666355.1|ensembl:ENSMUSG00000020152(gene)|ensembl:ENSMUST00000000137(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005938"(cell cortex)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008306"(associative learning)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0016482"(cytosolic transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030478"(actin cap)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051015"(actin filament binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0060271"(cilium assembly)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061825"(podosome core)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0098794"(postsynapse)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129|mint:P61161|rcsb pdb:7AQK|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-5663213|reactome:R-MMU-6798695|reactome:R-MMU-8856828	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:URQsZpIsMtsFZAnpLYDDvgKcPqA10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q9CQE8	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-912160|ensembl:ENSMUSP00000022341	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rtraf_mouse(display_long)|uniprotkb:RTRAF(gene name)|psi-mi:RTRAF(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_080804.1|ensembl:ENSMUSG00000021807(gene)|ensembl:ENSMUST00000022341(transcript)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0072686"(mitotic spindle)|interpro:IPR019265|mint:Q9CQE8	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:AP73IJnWMs4jwKTGnIC+q1GcBRc10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P62482	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-771096|uniprotkb:P97381|uniprotkb:Q60942|uniprotkb:Q64284|ensembl:ENSMUSP00000101273|ensembl:ENSMUSP00000125058	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:kcab2_mouse(display_long)|uniprotkb:"K(+) channel subunit beta-2"(gene name synonym)|uniprotkb:Kv-beta-2(gene name synonym)|uniprotkb:Neuroimmune protein F5(gene name synonym)|uniprotkb:Kcnab2(gene name)|psi-mi:Kcnab2(display_short)|uniprotkb:Ckbeta2(gene name synonym)|uniprotkb:I2rf5(gene name synonym)|uniprotkb:Kcnb3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_034728.2|refseq:XP_017175485.1|refseq:NP_001239585.1|ensembl:ENSMUSG00000028931(gene)|ensembl:ENSMUST00000105648(transcript)|ensembl:ENSMUST00000160884(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004033"("aldo-keto reductase (NADP) activity")|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0030424"(axon)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034705"(potassium channel complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0047834"(D-threo-aldose 1-dehydrogenase activity)|go:"GO:0050905"(neuromuscular process)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0098900"(regulation of action potential)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1990031"(pinceau fiber)|go:"GO:2000008"(regulation of protein localization to cell surface)|interpro:IPR005399(Potassium channel, voltage-dependent, beta subunit, KCNAB-related)|interpro:IPR005401(Potassium channel, voltage-dependent, beta subunit, KCNAB2)|interpro:IPR005983(Potassium channel, voltage-dependent, beta subunit, KCNAB)|interpro:IPR023210|interpro:IPR036812|mint:P62482|reactome:R-MMU-1296072|reactome:R-MMU-6798695	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:ZWu/Ez0ginUniSAUbIGXgod3iqg10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q62167	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-773173|uniprotkb:O09060|uniprotkb:O09143|ensembl:ENSMUSP00000000804	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ddx3x_mouse(display_long)|uniprotkb:DEAD box protein 3, X-chromosomal(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD3(gene name synonym)|uniprotkb:Embryonic RNA helicase(gene name synonym)|uniprotkb:D1Pas1-related sequence 2(gene name synonym)|uniprotkb:Ddx3x(gene name)|psi-mi:Ddx3x(display_short)|uniprotkb:D1Pas1-rs2(gene name synonym)|uniprotkb:Ddx3(gene name synonym)|uniprotkb:Dead3(gene name synonym)|uniprotkb:Erh(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_034158.1|ensembl:ENSMUSG00000000787(gene)|ensembl:ENSMUST00000000804(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006413"(translational initiation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007276"(gamete generation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034161"(positive regulation of toll-like receptor 8 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043273"(CTPase activity)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q62167|reactome:R-MMU-6798695	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:K7PtRsPpXHni4TU8uzOsr6QaVxA10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P20029	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-772325|uniprotkb:Q3UFF2|uniprotkb:O35642|uniprotkb:Q61630|intact:EBI-4280750|ensembl:ENSMUSP00000028222|ensembl:ENSMUSP00000097747	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:bip_mouse(display_long)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:Hspa5(gene name)|psi-mi:Hspa5(display_short)|uniprotkb:Grp78(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_001156906.1|refseq:NP_071705.3|dip:DIP-32341N|ensembl:ENSMUSG00000026864(gene)|ensembl:ENSMUST00000028222(transcript)|ensembl:ENSMUST00000100171(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P20029|reactome:R-MMU-3371453|reactome:R-MMU-983170	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:AyJwwnH8IAQqF/cbTn336A79MOY10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P38647	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-772469|uniprotkb:Q9CQ05|intact:EBI-4282065|uniprotkb:Q3TW93|uniprotkb:Q3UVN1|uniprotkb:Q3V015|intact:EBI-1635058|uniprotkb:Q7TSZ0|ensembl:ENSMUSP00000025217	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:grp75_mouse(display_long)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:p66 MOT(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:Hspa9(gene name)|psi-mi:Hspa9(display_short)|uniprotkb:Grp75(gene name synonym)|uniprotkb:Hsp74(gene name synonym)|uniprotkb:Hspa9a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_034611.2|ensembl:ENSMUSG00000024359(gene)|ensembl:ENSMUST00000025217(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P38647|reactome:R-MMU-3371453	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:HyohIe5BGD5mW3UO0OekqUKOhbU10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q07113	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2891155|ensembl:ENSMUSP00000024599|uniprotkb:Q61822|uniprotkb:Q6LED1	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:mpri_mouse(display_long)|uniprotkb:Igf2r(gene name)|psi-mi:Igf2r(display_short)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:Q07113|reactome:R-MMU-432722|reactome:R-MMU-6798695|reactome:R-MMU-6811440|reactome:R-MMU-8856825|reactome:R-MMU-8856828|ensembl:ENSMUSG00000023830(gene)|ensembl:ENSMUST00000024599(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001889"(liver development)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|refseq:NP_034645.2	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:sqdDRrqMg68UCTjHNnqZACflsEs10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P18242	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-738562|ensembl:ENSMUSP00000121203	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:catd_mouse(display_long)|uniprotkb:Ctsd(gene name)|psi-mi:Ctsd(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_034113.1|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070001"(aspartic-type peptidase activity)|go:"GO:0070201"(regulation of establishment of protein localization)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR012848(Propeptide, peptidase A1)|go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033144|mint:P18242|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|reactome:R-MMU-1442490|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|reactome:R-MMU-2022377|reactome:R-MMU-2132295|reactome:R-MMU-6798695|go:"GO:0010008"(endosome membrane)|go:"GO:0016787"(hydrolase activity)|ensembl:ENSMUSG00000007891(gene)|ensembl:ENSMUST00000151120(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0004175"(endopeptidase activity)	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:PrpcvWCAFSmTF9ECBCB/zMV6d9M10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P10605	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2924871|ensembl:ENSMUSP00000006235|uniprotkb:Q3UDW7	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:catb_mouse(display_long)|uniprotkb:Ctsb(gene name)|psi-mi:Ctsb(display_short)|uniprotkb:Cathepsin B1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000021939(gene)|ensembl:ENSMUST00000006235(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0006508"(proteolysis)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0030984"(kininogen binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043621"(protein self-association)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046697"(decidualization)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR012599(Peptidase C1A, propeptide)|interpro:IPR025660|interpro:IPR025661|go:"GO:0030855"(epithelial cell differentiation)|mint:P10605|reactome:R-MMU-1442490|reactome:R-MMU-1679131|reactome:R-MMU-2022090|reactome:R-MMU-2132295|reactome:R-MMU-6798695|interpro:IPR038765|refseq:NP_031824.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:iaXeLGV1ftr7OnUqbeLPZGpJ7NI10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P28798	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2365205|ensembl:ENSMUSP00000159379	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:grn_mouse(display_long)|uniprotkb:Grn(gene name)|psi-mi:Grn(display_short)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin/granulin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_032201.2|ensembl:ENSMUSG00000034708(gene)|ensembl:ENSMUST00000239431(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007566"(embryo implantation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060179"(male mating behavior)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098793"(presynapse)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905671"(regulation of lysosome organization)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28798|reactome:R-MMU-6798695	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:2nKMRNqLyZN/IXAvz1zMzDCpDmg10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P21460	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-642162|uniprotkb:Q544Y0|ensembl:ENSMUSP00000028938	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:cytc_mouse(display_long)|uniprotkb:Cystatin-3(gene name synonym)|uniprotkb:Cst3(gene name)|psi-mi:Cst3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_034106.2|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0042493"|go:"GO:0042747"(circadian sleep/wake cycle, REM sleep)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043292"(contractile fiber)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060311"(negative regulation of elastin catabolic process)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097435"(supramolecular fiber organization)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR018073|mint:P21460|reactome:R-MMU-381426|reactome:R-MMU-6798695|reactome:R-MMU-8957275|go:"GO:0031965"(nuclear membrane)|ensembl:ENSMUSG00000027447(gene)|ensembl:ENSMUST00000028938(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001654"(eye development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007420"(brain development)|go:"GO:0007431"(salivary gland development)|go:"GO:0007566"(embryo implantation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030424"(axon)|go:"GO:0031667"(response to nutrient levels)	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:QukDaHiP8DQMaHOqRQkMHU3LrMU10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8K183	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-1634920|uniprotkb:Q3TM83|uniprotkb:Q8BJQ5|ensembl:ENSMUSP00000038540	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:pdxk_mouse(display_long)|uniprotkb:Pdxk(gene name)|psi-mi:Pdxk(display_short)|uniprotkb:Pkh(gene name synonym)|uniprotkb:Pyridoxine kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_742146.1|ensembl:ENSMUSG00000032788(gene)|ensembl:ENSMUST00000041616(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008478"(pyridoxal kinase activity)|go:"GO:0009443"(pyridoxal 5'-phosphate salvage)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031403"(lithium ion binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042823"(pyridoxal phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070280"(pyridoxal binding)|interpro:IPR004625("Pyridoxal phosphate (active vitamin B6) biosynthesis, pyridoxal kinase")|interpro:IPR013749(Phosphomethylpyrimidine kinase type-1)|interpro:IPR029056|mint:Q8K183|rcsb pdb:6YK0|rcsb pdb:6YK1|reactome:R-MMU-6798695|reactome:R-MMU-964975	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:z+mCly2nHtdLZ6dlMOMpWgUi+1s10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q61545	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-1606991|uniprotkb:Q9D2P0|ensembl:ENSMUSP00000078867	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ews_mouse(display_long)|uniprotkb:Ewsr1(gene name)|psi-mi:Ewsr1(display_short)|uniprotkb:Ews(gene name synonym)|uniprotkb:Ewsh(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_031994.2|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033109|interpro:IPR034869|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:Q61545|ensembl:ENSMUSG00000009079(gene)|ensembl:ENSMUST00000079949(transcript)	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:bvajg+ZT71/K+6hwdHFdOewgvrw10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P62702	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-354261|uniprotkb:P12631|uniprotkb:P12750|uniprotkb:P27576|uniprotkb:Q9CXN0|uniprotkb:P55831|uniprotkb:Q14727|ensembl:ENSMUSP00000033683	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rs4x_mouse(display_long)|uniprotkb:Rps4(gene name synonym)|uniprotkb:Rps4x(gene name)|psi-mi:Rps4x(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_033120.1|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|ensembl:ENSMUSG00000031320(gene)|ensembl:ENSMUST00000033683(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0019843"(rRNA binding)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000876(Ribosomal protein S4e)|interpro:IPR002942(RNA-binding S4)|interpro:IPR005824(KOW)|interpro:IPR013843(Ribosomal protein S4e, N-terminal)|interpro:IPR013845(Ribosomal protein S4e, central)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR018199|interpro:IPR032277|interpro:IPR036986|interpro:IPR038237|interpro:IPR041982|mint:P62702|reactome:R-MMU-156827|go:"GO:0003723"(RNA binding)	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:2ZuLXqBSDkK0CtN3mnIDoFAR8yI10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q62193	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-15756041	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rfa2_mouse(display_long)|uniprotkb:Rpa2(gene name)|psi-mi:Rpa2(display_short)|uniprotkb:Rpa34(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0035861"(site of double-strand break)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|go:"GO:0005634"(nucleus)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|reactome:R-MMU-110312|reactome:R-MMU-110314|reactome:R-MMU-110320|reactome:R-MMU-174437|reactome:R-MMU-176187|reactome:R-MMU-3371453|reactome:R-MMU-5358565|reactome:R-MMU-5358606|reactome:R-MMU-5651801|reactome:R-MMU-5655862|reactome:R-MMU-5656121|reactome:R-MMU-5656169|reactome:R-MMU-5685938|reactome:R-MMU-5685942|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-5696395|reactome:R-MMU-5696397|reactome:R-MMU-5696400|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6783310|reactome:R-MMU-68962|reactome:R-MMU-69166|dip:DIP-48715N|reactome:R-MMU-6804756|reactome:R-MMU-69473	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:hgOIMP5+ZKbWfWY2txTlqhBu2k810090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P97351	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-773982|ensembl:ENSMUSP00000029722	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rs3a_mouse(display_long)|uniprotkb:Rps3a(gene name)|psi-mi:Rps3a(display_short)|uniprotkb:Protein TU-11(gene name synonym)|uniprotkb:Rps3a1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_058655.3|ensembl:ENSMUSG00000028081(gene)|ensembl:ENSMUST00000029722(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001593(Ribosomal protein S3Ae)|interpro:IPR018281|interpro:IPR027500|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:pi623FvaPjjNAiN44zPHjtep4gs10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q9CR57	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-773925|uniprotkb:Q9D8Q1|ensembl:ENSMUSP00000131489	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rl14_mouse(display_long)|uniprotkb:Rpl14(gene name)|psi-mi:Rpl14(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_080250.1|ensembl:ENSMUSG00000025794(gene)|ensembl:ENSMUST00000165532(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|interpro:IPR002784(Ribosomal protein L14)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR039660|interpro:IPR041985|mint:Q9CR57|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:Z9bOUoDfmZzjfVXr5d6nHXMv6qA10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8CG19	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-643893|uniprotkb:O88349|uniprotkb:Q8BNW7|uniprotkb:Q8C7F5|uniprotkb:Q8CIR0|uniprotkb:B1B1D9|uniprotkb:B1B1E1|uniprotkb:Q505C9|uniprotkb:Q8CG18|ensembl:ENSMUSP00000001927	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ltbp1_mouse(display_long)|uniprotkb:Transforming growth factor beta-1-binding protein 1(gene name synonym)|uniprotkb:Ltbp1(gene name)|psi-mi:Ltbp1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_064303.2|refseq:NP_996841.1|ensembl:ENSMUST00000001927(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0035904"(aorta development)|go:"GO:0038045"(large latent transforming growth factor-beta complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050436"(microfibril binding)|ensembl:ENSMUSG00000001870(gene)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|reactome:R-MMU-2129379|reactome:R-MMU-381426|reactome:R-MMU-8957275|refseq:NP_001318166.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:6UWbo7DbOLmgtGoQ0zgAicqdBts10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P51881	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-445370|uniprotkb:Q61311|ensembl:ENSMUSP00000016463	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:adt2_mouse(display_long)|uniprotkb:Adenine nucleotide translocator 2(gene name synonym)|uniprotkb:ADP,ATP carrier protein 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 5(gene name synonym)|uniprotkb:Slc25a5(gene name)|psi-mi:Slc25a5(display_short)|uniprotkb:Ant2(gene name synonym)|uniprotkb:Aac2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_031477.1|dip:DIP-31399N|ensembl:ENSMUSG00000016319(gene)|ensembl:ENSMUST00000016463(transcript)|go:"GO:0000295"(adenine nucleotide transmembrane transporter activity)|go:"GO:0005471"("ATP:ADP antiporter activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0017077"(oxidative phosphorylation uncoupler activity)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0051503"(adenine nucleotide transport)|go:"GO:0071817"(MMXD complex)|go:"GO:0140021"(mitochondrial ADP transmembrane transport)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1990544"(mitochondrial ATP transmembrane transport)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR002113(Adenine nucleotide translocator 1)|interpro:IPR018108|interpro:IPR023395|mint:P51881|reactome:R-MMU-83936|go:"GO:0031625"(ubiquitin protein ligase binding)	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:146+I0bORlUf6z9chvmdXwUCtOs10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P09405	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-641864|uniprotkb:Q548M9|uniprotkb:Q61991|uniprotkb:Q8BQD8|uniprotkb:Q99K50|ensembl:ENSMUSP00000027438	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:nucl_mouse(display_long)|uniprotkb:Protein C23(gene name synonym)|uniprotkb:Ncl(gene name)|psi-mi:Ncl(display_short)|uniprotkb:Nuc(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_035010.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990631"(ErbB-4 class receptor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P09405|reactome:R-MMU-6791226|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000026234(gene)|ensembl:ENSMUST00000027438(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:NkPifysnX6CafgtN+Ko/p4aBqGE10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P14869	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-529949|uniprotkb:Q99L54|ensembl:ENSMUSP00000083705	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rla0_mouse(display_long)|uniprotkb:60S ribosomal protein L10E(gene name synonym)|uniprotkb:Rplp0(gene name)|psi-mi:Rplp0(display_short)|uniprotkb:Arbp(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_031501.1|ensembl:ENSMUSG00000067274(gene)|ensembl:ENSMUST00000086519(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0030425"(dendrite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042277"(peptide binding)|go:"GO:0045202"(synapse)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0098794"(postsynapse)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001790(Ribosomal protein L10)|interpro:IPR030670|interpro:IPR040637|interpro:IPR043141|interpro:IPR043164|mint:P14869|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:WHl41TZwjtqRSeIExT3vyjrZsJs10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P62908	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-299793|ensembl:ENSMUSP00000032998|uniprotkb:P17073|uniprotkb:P47933	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rs3_mouse(display_long)|uniprotkb:Rps3(gene name)|psi-mi:Rps3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000030744(gene)|ensembl:ENSMUST00000032998(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030425"(dendrite)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0032357"(oxidized purine DNA binding)|go:"GO:0032358"(oxidized pyrimidine DNA binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045738"(negative regulation of DNA repair)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051225"(spindle assembly)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0051301"(cell division)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061481"(response to TNF agonist)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071159"(NF-kappaB complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902546"(positive regulation of DNA N-glycosylase activity)|go:"GO:1905053"(positive regulation of base-excision repair)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001351(Ribosomal protein S3, C-terminal)|interpro:IPR004044(K Homology, type 2)|interpro:IPR005703(Ribosomal protein S3, eukaryotic/archaeal)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|interpro:IPR018280|interpro:IPR036419|mint:P62908|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|refseq:NP_036182.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:f4Vh6HESE+lKZinjkJ883IG3wiY10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8VEE4	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-3043955|ensembl:ENSMUSP00000090585|uniprotkb:Q3TEJ8	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rfa1_mouse(display_long)|uniprotkb:Rpa1(gene name)|psi-mi:Rpa1(display_short)|uniprotkb:Replication factor A protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000000751(gene)|ensembl:ENSMUST00000092907(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016605"(PML body)|go:"GO:0030097"(hemopoiesis)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051276"(chromosome organization)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0090734"(site of DNA damage)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|reactome:R-MMU-110312|reactome:R-MMU-110314|reactome:R-MMU-110320|reactome:R-MMU-174437|reactome:R-MMU-176187|reactome:R-MMU-3108214|reactome:R-MMU-3371453|reactome:R-MMU-5358565|reactome:R-MMU-5358606|reactome:R-MMU-5651801|reactome:R-MMU-5655862|reactome:R-MMU-5656121|reactome:R-MMU-5656169|reactome:R-MMU-5685938|reactome:R-MMU-5685942|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-5696395|reactome:R-MMU-5696397|reactome:R-MMU-5696400|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6783310|reactome:R-MMU-6804756|reactome:R-MMU-68962|reactome:R-MMU-69166|reactome:R-MMU-69473|refseq:NP_001157695.1|refseq:NP_080929.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:OMM1BI6PIp9gBtLB1XtcsIwVWR810090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q9CQ71	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-3043958|ensembl:ENSMUSP00000012627	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rfa3_mouse(display_long)|uniprotkb:Rpa3(gene name)|psi-mi:Rpa3(display_short)|uniprotkb:Replication factor A protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000012483(gene)|ensembl:ENSMUST00000012627(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013970(Replication factor A protein 3)|reactome:R-MMU-110312|reactome:R-MMU-110314|reactome:R-MMU-110320|reactome:R-MMU-174437|reactome:R-MMU-176187|reactome:R-MMU-3371453|reactome:R-MMU-5358565|reactome:R-MMU-5358606|reactome:R-MMU-5651801|reactome:R-MMU-5655862|reactome:R-MMU-5656121|reactome:R-MMU-5656169|reactome:R-MMU-5685938|reactome:R-MMU-5685942|reactome:R-MMU-5693607|reactome:R-MMU-5693616|reactome:R-MMU-5696395|reactome:R-MMU-5696397|reactome:R-MMU-5696400|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6783310|reactome:R-MMU-6804756|reactome:R-MMU-68962|reactome:R-MMU-69166|reactome:R-MMU-69473|refseq:NP_080908.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:vKHzYwRnC8SqPLSMsx0WgQowtms10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P97461	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-21348476|uniprotkb:O08607	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rs5_mouse(display_long)|uniprotkb:Rps5(gene name)|psi-mi:Rps5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:1990904"(ribonucleoprotein complex)|refseq:NP_033121.2|interpro:IPR000235(Ribosomal protein S7)|interpro:IPR005716(Ribosomal protein S7, eukaryotic/archaeal)|interpro:IPR020606|interpro:IPR023798|interpro:IPR036823	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:2AUGVdZjI7WKNLH/VcgidUGDB1410090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P62082	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-354350|uniprotkb:P24818|uniprotkb:P23821|ensembl:ENSMUSP00000073880|ensembl:ENSMUSP00000152456	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rs7_mouse(display_long)|uniprotkb:Rps7(gene name)|psi-mi:Rps7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_035430.1|ensembl:ENSMUSG00000061477(gene)|ensembl:ENSMUST00000074267(transcript)|ensembl:ENSMUST00000221871(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000554(Ribosomal protein S7e)|mint:P62082|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|go:"GO:0032040"(small-subunit processome)	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:l4aG6I34lmzYhNapbdv2CAAwRwg10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:O08583	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-6464301|ensembl:ENSMUSP00000026125|uniprotkb:Q0VBL5|uniprotkb:Q8CBM4|uniprotkb:Q9JJW7	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:thoc4_mouse(display_long)|uniprotkb:Alyref(gene name)|psi-mi:Alyref(display_short)|uniprotkb:Aly(gene name synonym)|uniprotkb:Ref1(gene name synonym)|uniprotkb:Refbp1(gene name synonym)|uniprotkb:THOC4(gene name synonym)|uniprotkb:Ally of AML-1 and LEF-1(gene name synonym)|uniprotkb:Aly/REF export factor(gene name synonym)|uniprotkb:REF1-I(gene name synonym)|uniprotkb:RNA and export factor-binding protein 1(gene name synonym)|uniprotkb:Transcriptional coactivator Aly/REF(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000025134(gene)|ensembl:ENSMUST00000026125(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0051028"(mRNA transport)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR025715|interpro:IPR035979|mint:O08583|rcsb pdb:1NO8|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|refseq:NP_035698.1|dip:DIP-59977N	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:DZAvcQrp7S1uipKsc/Wpxgb+gJI10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P14131	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-4286141|uniprotkb:Q3THM9|ensembl:ENSMUSP00000103940	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rs16_mouse(display_long)|uniprotkb:Rps16(gene name)|psi-mi:Rps16(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_038675.2|ensembl:ENSMUSG00000037563(gene)|ensembl:ENSMUST00000082134(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0097421"(liver regeneration)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000754(Ribosomal protein S9)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR020574|mint:P14131|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|reactome:R-MMU-72649	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:OrKriR6HsATLaO+drdUa2w3Gpd010090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q9CZX8	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-522873|uniprotkb:Q5M9J4|ensembl:ENSMUSP00000104067|ensembl:ENSMUSP00000104068	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rs19_mouse(display_long)|uniprotkb:Rps19(gene name)|psi-mi:Rps19(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_075622.1|ensembl:ENSMUSG00000040952(gene)|ensembl:ENSMUST00000108429(transcript)|ensembl:ENSMUST00000108430(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0007000"(nucleolus organization)|reactome:R-MMU-975956|reactome:R-MMU-975957|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0060265"(positive regulation of respiratory burst involved in inflammatory response)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001266(Ribosomal protein S19e)|interpro:IPR018277|interpro:IPR036388|interpro:IPR036390|mint:Q9CZX8|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|refseq:XP_006539743.1|refseq:XP_006539744.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:D3A6ULv7RIjBdw3qPwrdoWZ+F4U10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8K019	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2536273|uniprotkb:Q8C2E9|uniprotkb:Q9CSW5|uniprotkb:Q8BNZ0|ensembl:ENSMUSP00000043583	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:bclf1_mouse(display_long)|uniprotkb:Bclaf1(gene name)|psi-mi:Bclaf1(display_short)|uniprotkb:Btf(gene name synonym)|uniprotkb:Kiaa0164(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000037608(gene)|ensembl:ENSMUST00000043881(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR026668|interpro:IPR029199|mint:Q8K019|refseq:NP_001020563.1|refseq:NP_722482.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:+9NQPsUgV77P3yH9iK0ZRDIOioM10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q569Z6	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2536252|ensembl:ENSMUSP00000079722	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:tr150_mouse(display_long)|uniprotkb:Thrap3(gene name)|psi-mi:Thrap3(display_short)|uniprotkb:Trap150(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 150 kDa component(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000043962(gene)|ensembl:ENSMUST00000080919(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR026667|interpro:IPR029199|go:"GO:0008380"(RNA splicing)|refseq:XP_011238805.1|refseq:NP_666265.3|refseq:XP_006503104.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:Cb0vHuEX3Ew27z2gvfC/36tdeYE10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P99027	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-6261122|ensembl:ENSMUSP00000101625|ensembl:ENSMUSP00000101626|ensembl:ENSMUSP00000081474|uniprotkb:Q9CQ99|uniprotkb:Q9CZJ8|uniprotkb:Q3TKY3	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rla2_mouse(display_long)|uniprotkb:Rplp2(gene name)|psi-mi:Rplp2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUST00000084434(transcript)|ensembl:ENSMUST00000106003(transcript)|ensembl:ENSMUST00000106004(transcript)|go:"GO:0002182"(cytoplasmic translational elongation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0045202"(synapse)|interpro:IPR027534|interpro:IPR038716|interpro:IPR044076|mint:P99027|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|ensembl:ENSMUSG00000025508(gene)|refseq:XP_006536292.1|refseq:NP_080296.3	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:GYHP8hzpsOXoDDDnyOOBTMeIozg10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P20152	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-299269|ensembl:ENSMUSP00000028062|uniprotkb:O08704|uniprotkb:Q8CCH1	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:vime_mouse(display_long)|uniprotkb:Vim(gene name)|psi-mi:Vim(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000026728(gene)|ensembl:ENSMUST00000028062(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1900147"(regulation of Schwann cell migration)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031252"(cell leading edge)|interpro:IPR027699|interpro:IPR039008|mint:P20152|reactome:R-MMU-264870|reactome:R-MMU-390522|reactome:R-MMU-9013422|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|reactome:R-MMU-9646399|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044297"(cell body)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045103"(intermediate filament-based process)|refseq:NP_035831.2|dip:DIP-188N	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid://GDvGAXOR4hUXNtVpnZefex5v410090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P62960	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-529779|uniprotkb:P22568|uniprotkb:P27817|uniprotkb:P43482|ensembl:ENSMUSP00000078589	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ybox1_mouse(display_long)|uniprotkb:Y-box transcription factor(gene name synonym)|uniprotkb:CCAAT-binding transcription factor I subunit A(gene name synonym)|uniprotkb:Enhancer factor I subunit A(gene name synonym)|uniprotkb:DNA-binding protein B(gene name synonym)|uniprotkb:Ybx1(gene name)|psi-mi:Ybx1(display_short)|uniprotkb:Msy1(gene name synonym)|uniprotkb:Msy-1(gene name synonym)|uniprotkb:Yb1(gene name synonym)|uniprotkb:Nsep1(gene name synonym)|uniprotkb:Nuclease-sensitive element-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_035862.2|dip:DIP-34256N|ensembl:ENSMUSG00000028639(gene)|ensembl:ENSMUST00000079644(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002039"(p53 binding)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008380"(RNA splicing)|go:"GO:0008544"(epidermis development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030425"(dendrite)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035198"(miRNA binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050658"(RNA transport)|go:"GO:0051020"(GTPase binding)|go:"GO:0051031"(tRNA transport)|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0062153"(C5-methylcytidine-containing RNA binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990428"(miRNA transport)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR019844|mint:P62960|reactome:R-MMU-72163|reactome:R-MMU-72165|reactome:R-MMU-9017802|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:imkViHICtFj/0wQ8IDprza1b43010090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:O50061	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-21348424|ensemblplants:AT1G07320.1|uniprotkb:Q8LF27|uniprotkb:Q8VZS1|uniprotkb:Q9LNV1	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rk4_arath(display_long)|uniprotkb:RPL4(gene name)|psi-mi:RPL4(display_short)|uniprotkb:CL4(gene name synonym)|uniprotkb:R-protein L4(gene name synonym)|uniprotkb:F22G5.34(orf name)|uniprotkb:F22G5_28(orf name)|uniprotkb:At1g07320(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensemblplants:AT1G07320(gene)|ensemblplants:AT1G07320.1(transcript)|go:"GO:0000311"(plastid large ribosomal subunit)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0006412"(translation)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0009507"(chloroplast)|go:"GO:0009535"(chloroplast thylakoid membrane)|go:"GO:0009570"(chloroplast stroma)|go:"GO:0009579"(thylakoid)|go:"GO:0019843"(rRNA binding)|go:"GO:0022626"(cytosolic ribosome)|refseq:NP_001030985.1|refseq:NP_001030986.1|refseq:NP_563786.1|interpro:IPR002136(Ribosomal protein L4/L1e)|interpro:IPR023574|interpro:IPR013005(Ribosomal protein L4/L1e, bacterial-type)	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:itNUY/uqCnOGF/FSCVL/TZ0Wqro3702	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8VIJ6	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-6094576|uniprotkb:A2A7U6|uniprotkb:Q9ERW2|ensembl:ENSMUSP00000030623	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:sfpq_mouse(display_long)|uniprotkb:Sfpq(gene name)|psi-mi:Sfpq(display_short)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:Psf(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_076092.1|ensembl:ENSMUSG00000028820(gene)|ensembl:ENSMUST00000030623(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051276"(chromosome organization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:Q8VIJ6|reactome:R-MMU-8849468	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:9mciNgfKrEvyAv7kjs55FHlUtRY10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8VEK3	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-529674|uniprotkb:Q9R205|uniprotkb:G3XA10|ensembl:ENSMUSP00000047571	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:hnrpu_mouse(display_long)|uniprotkb:Hnrpu(gene name synonym)|uniprotkb:Hnrnpu(gene name)|psi-mi:Hnrnpu(display_short)|uniprotkb:Scaffold-attachment factor A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:XP_017177162.1|refseq:XP_017177163.1|refseq:NP_058085.2|refseq:XP_017177161.1|dip:DIP-34257N|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005813"(centrosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017069"(snRNA binding)|go:"GO:0017130"("poly(C) RNA binding")|go:"GO:0030496"(midbody)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070934"(CRD-mediated mRNA stabilization)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098577"(inactive sex chromosome)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990280"(RNA localization to chromatin)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003034(DNA-binding SAP)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR026745|interpro:IPR027417|interpro:IPR035778|interpro:IPR036361|interpro:IPR043136|mint:Q8VEK3|reactome:R-MMU-72163|reactome:R-MMU-72203|ensembl:ENSMUSG00000039630(gene)|ensembl:ENSMUST00000037748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001097"(TFIIH-class transcription factor complex binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:ONBrFPHIT3aP6XnUgJMf4qiu8VQ10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8BMK4	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-689057|uniprotkb:Q8BTK8|uniprotkb:Q8R3F2|uniprotkb:B2RRB4|ensembl:ENSMUSP00000050336|ensembl:ENSMUSP00000130304	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ckap4_mouse(display_long)|uniprotkb:Ckap4(gene name)|psi-mi:Ckap4(display_short)|uniprotkb:63-kDa cytoskeleton-linking membrane protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_780660.1|ensembl:ENSMUSG00000046841(gene)|ensembl:ENSMUST00000053871(transcript)|ensembl:ENSMUST00000167671(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR028428|mint:Q8BMK4|reactome:R-MMU-381426|reactome:R-MMU-5683826|reactome:R-MMU-6798695|reactome:R-MMU-8957275|reactome:R-MMU-9696264|reactome:R-MMU-9696270	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:mmjhipfUChfmrPP+NpygwvlH2Zc10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q9CYR0	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-9989649|ensembl:ENSMUSP00000031971	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ssbp_mouse(display_long)|uniprotkb:Ssbp1(gene name)|psi-mi:Ssbp1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_082634.1|refseq:NP_997633.1|refseq:XP_006506392.1|refseq:XP_017177153.1|ensembl:ENSMUSG00000029911(gene)|ensembl:ENSMUST00000031971(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009295"(nucleoid)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1905776"(positive regulation of DNA helicase activity)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q9CYR0	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:mPiUWKFQ/gJufRp4aggO3UUJdG810090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q99LF4	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-6261036|ensembl:ENSMUSP00000001834|uniprotkb:Q3UDW6|uniprotkb:Q3TI25|uniprotkb:Q3TA04	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rtcb_mouse(display_long)|uniprotkb:Rtcb(gene name)|psi-mi:Rtcb(display_short)|uniprotkb:D10Wsu52e(gene name synonym)|uniprotkb:Focal adhesion-associated protein(gene name synonym)|uniprotkb:3'-phosphate/5'-hydroxy nucleic acid ligase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	ensembl:ENSMUSG00000001783(gene)|go:"GO:0000971"(tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001890"(placenta development)|go:"GO:0003972"("RNA ligase (ATP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0017166"(vinculin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0072669"(tRNA-splicing ligase complex)|interpro:IPR001233(Protein of unknown function UPF0027)|interpro:IPR027513|interpro:IPR036025|mint:Q99LF4|ensembl:ENSMUST00000001834(transcript)|refseq:NP_663397.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:ISQNiLQA7DCcgBkTueMDhUHrkFQ10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q9ESZ8	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-6876774|ensembl:ENSMUSP00000049625|ensembl:ENSMUSP00000133566|uniprotkb:O54700|uniprotkb:O55030|uniprotkb:O55031|uniprotkb:Q8VHD1|uniprotkb:Q8VHD2|uniprotkb:Q8VHD3|uniprotkb:Q8VHD4|uniprotkb:Q9CSB5|uniprotkb:Q9D9K9	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:gtf2i_mouse(display_long)|uniprotkb:Gtf2i(gene name)|psi-mi:Gtf2i(display_short)|uniprotkb:Bap135(gene name synonym)|uniprotkb:Diws1t(gene name synonym)|uniprotkb:Bruton tyrosine kinase-associated protein 135(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:XP_017176169.1|refseq:XP_017176170.1|ensembl:ENSMUSG00000060261(gene)|ensembl:ENSMUST00000059042(transcript)|ensembl:ENSMUST00000174155(transcript)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0100026"(positive regulation of DNA repair by transcription from RNA polymerase II promoter)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR016659(Transcription factor II-I)|interpro:IPR036647|mint:Q9ESZ8|rcsb pdb:1Q60|refseq:NP_001074215.1|refseq:NP_001074216.1|refseq:NP_001074217.1|refseq:NP_034495.2	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:OT63xMPsr6JrPGl2oNXnwQqe2do10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P47911	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-773947|uniprotkb:Q6P5I2|uniprotkb:Q925C3|ensembl:ENSMUSP00000031617	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rl6_mouse(display_long)|uniprotkb:TAX-responsive enhancer element-binding protein 107(gene name synonym)|uniprotkb:Rpl6(gene name)|psi-mi:Rpl6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_035420.2|refseq:XP_006530290.1|ensembl:ENSMUSG00000029614(gene)|ensembl:ENSMUST00000031617(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000049"(tRNA binding)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031672"(A band)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR000915(Ribosomal protein L6E)|interpro:IPR005568(Ribosomal protein L6, N-terminal)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041997|mint:P47911|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:rm/g3X/3zoauNoUW6K4M43n8e4810090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q99LB2	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-773532|uniprotkb:Q9EQU4|uniprotkb:G3X8V7|ensembl:ENSMUSP00000022821	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:dhrs4_mouse(display_long)|uniprotkb:NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase(gene name synonym)|uniprotkb:Peroxisomal short-chain alcohol dehydrogenase(gene name synonym)|uniprotkb:NADPH-dependent retinol dehydrogenase/reductase(gene name synonym)|uniprotkb:Dhrs4(gene name)|psi-mi:Dhrs4(display_short)|uniprotkb:D14Ucla2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_001033027.2|ensembl:ENSMUSG00000022210(gene)|ensembl:ENSMUST00000022821(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0001758"(retinal dehydrogenase activity)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0006066"(alcohol metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0018455"("alcohol dehydrogenase [NAD(P)+] activity")|go:"GO:0042180"(cellular ketone metabolic process)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR029511|interpro:IPR036291|mint:Q99LB2|reactome:R-MMU-5365859|reactome:R-MMU-9033241	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:sCdPaEzxYGDptr0aZXGOVvDUzHA10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q9D0L8	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-21348388|ensembl:ENSMUSP00000009679|uniprotkb:Q3V3U9|uniprotkb:Q6ZQC6|uniprotkb:Q9D5F1	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:mces_mouse(display_long)|uniprotkb:Rnmt(gene name)|psi-mi:Rnmt(display_short)|uniprotkb:Kiaa0398(gene name synonym)|uniprotkb:RG7MT1(gene name synonym)|uniprotkb:mRNA cap methyltransferase(gene name synonym)|uniprotkb:"mRNA (guanine-N(7))-methyltransferase"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	interpro:IPR016899("mRNA (guanine-N(7))-methyltransferase")|interpro:IPR029063|interpro:IPR039753|reactome:R-MMU-72086|reactome:R-MMU-77075|interpro:IPR004971(mRNA capping enzyme, large subunit)|ensembl:ENSMUSG00000009535(gene)|ensembl:ENSMUST00000009679(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031533"(mRNA cap methyltransferase complex)|go:"GO:0043235"(receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|refseq:NP_001164424.1|refseq:NP_080716.1|refseq:XP_006526256.1|refseq:XP_006526257.1|refseq:XP_006526259.1|refseq:XP_006526260.1|refseq:XP_011245293.1	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:+IYakatODIfUC8SBL2BmX8tdHss10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:O89086	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-645649|ensembl:ENSMUSP00000111277|ensembl:ENSMUSP00000111282|ensembl:ENSMUSP00000111284	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rbm3_mouse(display_long)|uniprotkb:RNA-binding motif protein 3(gene name synonym)|uniprotkb:Rbm3(gene name)|psi-mi:Rbm3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_001159882.1|refseq:NP_001159883.1|ensembl:ENSMUSG00000031167(gene)|ensembl:ENSMUST00000115615(transcript)|ensembl:ENSMUST00000115619(transcript)|ensembl:ENSMUST00000115621(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0009409"(response to cold)|go:"GO:0030425"(dendrite)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034278|interpro:IPR035979|mint:O89086	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:loZc/KXvfUWniBvL99ZXgx7d9hQ10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P19253	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-445023|ensembl:ENSMUSP00000115722	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:rl13a_mouse(display_long)|uniprotkb:Transplantation antigen P198(gene name synonym)|uniprotkb:Tum-P198 antigen(gene name synonym)|uniprotkb:Rpl13a(gene name)|psi-mi:Rpl13a(display_short)|uniprotkb:P198(gene name synonym)|uniprotkb:Tstap198-7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_033464.2|ensembl:ENSMUSG00000074129(gene)|ensembl:ENSMUST00000150350(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042592"(homeostatic process)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:1901194"(negative regulation of formation of translation preinitiation complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005755(Ribosomal protein L13, eukaryotic/archaeal)|interpro:IPR005822(Ribosomal protein L13)|interpro:IPR023563|interpro:IPR036899|mint:P19253|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|rcsb pdb:6SWA	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:OHHQbay1m62ZSGYnKANekTh+C5Q10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:P56959	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-400452|ensembl:ENSMUSP00000101858	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:fus_mouse(display_long)|uniprotkb:Fus(gene name)|psi-mi:Fus(display_short)|uniprotkb:Protein pigpen(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_631888.1|ensembl:ENSMUSG00000030795(gene)|ensembl:ENSMUST00000106251(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030425"(dendrite)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P56959|reactome:R-MMU-72163	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:Vwv/0vlM50l49XaUOHCtEWt/b2A10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q91VR5	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-773164|uniprotkb:Q3TU41|ensembl:ENSMUSP00000065987	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ddx1_mouse(display_long)|uniprotkb:DEAD box protein 1(gene name synonym)|uniprotkb:Ddx1(gene name)|psi-mi:Ddx1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_598801.1|ensembl:ENSMUSG00000037149(gene)|ensembl:ENSMUST00000071103(transcript)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004518"(nuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006388"(tRNA splicing, via endonucleolytic cleavage and ligation)|go:"GO:0006397"(mRNA processing)|go:"GO:0008143"("poly(A) binding")|go:"GO:0009615"(response to virus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071920"(cleavage body)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR043136|mint:Q91VR5	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:NXUFdXIf8H/od5xV+OXhcO+51aY10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8BJS4	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-646914|uniprotkb:Q3TBU0|uniprotkb:Q3U160|uniprotkb:Q6B4H2|ensembl:ENSMUSP00000047864	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:sun2_mouse(display_long)|uniprotkb:Sad1/unc-84 protein-like 2(gene name synonym)|uniprotkb:Sun2(gene name)|psi-mi:Sun2(display_short)|uniprotkb:Unc84b(gene name synonym)|uniprotkb:Protein unc-84 homolog B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_001192274.1|refseq:NP_001192275.1|refseq:NP_919323.2|dip:DIP-49694N|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051642"(centrosome localization)|go:"GO:0090292"(nuclear matrix anchoring at nuclear membrane)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|interpro:IPR012919(Sad1/UNC-like, C-terminal)|interpro:IPR030272|interpro:IPR040994|rcsb pdb:5ED8|rcsb pdb:5ED9|ensembl:ENSMUSG00000042524(gene)|ensembl:ENSMUST00000046259(transcript)|go:"GO:0000781"(chromosome, telomeric region)	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:F+gOC6NhX2BXG3iU0TI2DNxYWYQ10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q62191	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-6840982	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ro52_mouse(display_long)|uniprotkb:Trim21(gene name)|psi-mi:Trim21(display_short)|uniprotkb:Ro52(gene name synonym)|uniprotkb:Ssa1(gene name synonym)|uniprotkb:52 kDa Ro protein(gene name synonym)|uniprotkb:52 kDa ribonucleoprotein autoantigen Ro/SS-A(gene name synonym)|uniprotkb:"Ro(SS-A)"(gene name synonym)|uniprotkb:Sjoegren syndrome type A antigen(gene name synonym)|uniprotkb:Tripartite motif-containing protein 21(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM21(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR020457|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:2VOK|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000932"(P-body)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031648"(protein destabilization)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090086"(negative regulation of protein deubiquitination)|go:"GO:1902187"|rcsb pdb:3ZO0|interpro:IPR018957|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035831|reactome:R-MMU-3134975|reactome:R-MMU-983168|interpro:IPR043136	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:4Q3+XUHMvlLeLLws2XCjd66AwOI10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P07602	uniprotkb:Q8K2F8	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	intact:EBI-2554251|uniprotkb:Q9CTG8|ensembl:ENSMUSP00000082723	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:ls14a_mouse(display_long)|uniprotkb:Fam61a(gene name synonym)|uniprotkb:Rap55a(gene name synonym)|uniprotkb:Protein FAM61A(gene name synonym)|uniprotkb:RNA-associated protein 55A(gene name synonym)|uniprotkb:Lsm14a(gene name)|psi-mi:Lsm14a(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21347829|imex:IM-27556-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	refseq:NP_080224.1|ensembl:ENSMUSG00000066568(gene)|ensembl:ENSMUST00000085585(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025761|interpro:IPR025762|interpro:IPR025768|mint:Q8K2F8	-	-	-	figure legend:Fig. 7. Supp Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-fibroblast)|taxid:10090(Mus musculus)	-	2019/04/18	2019/04/24	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rogid:ukJG23hyWin24AD3ZzrcPCeQ6Wg10090	rigid:ZlqWK60gkhO/KPyVX6sCiED/DFw	false	flag tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P28798	uniprotkb:Q61207	intact:EBI-2365205|ensembl:ENSMUSP00000159379	intact:EBI-645756|uniprotkb:Q60861|uniprotkb:Q64006|uniprotkb:Q64219|ensembl:ENSMUSP00000137476	psi-mi:grn_mouse(display_long)|uniprotkb:Grn(gene name)|psi-mi:Grn(display_short)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin/granulin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)	psi-mi:sap_mouse(display_long)|uniprotkb:Psap(gene name)|psi-mi:Psap(display_short)|uniprotkb:Sgp1(gene name synonym)|uniprotkb:Sulfated glycoprotein 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21348560|imex:IM-27556-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032201.2|ensembl:ENSMUSG00000034708(gene)|ensembl:ENSMUST00000239431(transcript)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007566"(embryo implantation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060179"(male mating behavior)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0098793"(presynapse)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905671"(regulation of lysosome organization)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28798|reactome:R-MMU-6798695	refseq:NP_001139592.1|refseq:NP_001139593.1|refseq:NP_001139594.1|refseq:NP_001139595.1|refseq:NP_001139596.1|refseq:NP_035309.3|go:"GO:0003335"(corneocyte development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0006643"(membrane lipid metabolic process)|go:"GO:0006664"(glycolipid metabolic process)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006678"(glucosylceramide metabolic process)|go:"GO:0006683"(galactosylceramide catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0002020"(protease binding)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENSMUSG00000004207(gene)|ensembl:ENSMUST00000179238(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0010467"(gene expression)|go:"GO:0016235"(aggresome)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0030882"(lipid antigen binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048589"(developmental growth)|go:"GO:0050877"(nervous system process)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0060073"(micturition)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0009306"(protein secretion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0090102"(cochlea development)|go:"GO:0090659"(walking behavior)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903575"(cornified envelope assembly)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|go:"GO:1905575"(ganglioside GM3 binding)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|mint:Q61207|rcsb pdb:5NXB|rcsb pdb:5U85|reactome:R-MMU-114608|reactome:R-MMU-1660662|reactome:R-MMU-375276|reactome:R-MMU-418594|reactome:R-MMU-6798695|go:"GO:0070841"(inclusion body assembly)	go:"GO:0005764"(lysosome)	-	-	figure legend:Fig.9|comment:Loss of lysosomal PGRN signal is accompanied by increased secretion of PGRN to the extracellular space.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cerebral_cortical_neuron)|taxid:10090(Mouse cerebral cortical neuron)	-	2019/04/18	2019/04/24	rogid:2nKMRNqLyZN/IXAvz1zMzDCpDmg10090	rogid:IOmtR34fe4aSy6aqmQvkB2xvuwU10090	rigid:etetOSR2Pfvd1NVicUbcMaWvS5A	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P28799	uniprotkb:P07602	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	intact:EBI-716699|uniprotkb:Q53Y86|uniprotkb:P07292|uniprotkb:P15793|uniprotkb:P78538|uniprotkb:P78541|uniprotkb:P78546|uniprotkb:P78547|uniprotkb:P78558|uniprotkb:Q6IBQ6|uniprotkb:Q92739|uniprotkb:Q92740|uniprotkb:Q92741|uniprotkb:Q92742|ensembl:ENSP00000378394	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:sap_human(display_long)|uniprotkb:PSAP(gene name)|psi-mi:PSAP(display_short)|uniprotkb:GLBA(gene name synonym)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Proactivator polypeptide(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Zhou et al. (2015)	pubmed:26370502|imex:IM-27556	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21348574|imex:IM-27556-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	refseq:NP_001035930.1|refseq:NP_001035931.1|refseq:NP_002769.1|ensembl:ENSG00000197746(gene)|ensembl:ENST00000394936(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0007041"(lysosomal transport)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|rcsb pdb:1M12|rcsb pdb:1N69|rcsb pdb:1SN6|rcsb pdb:2DOB|rcsb pdb:2GTG|rcsb pdb:2QYP|rcsb pdb:2R0R|rcsb pdb:2R1Q|rcsb pdb:2RB3|rcsb pdb:2Z9A|rcsb pdb:3BQP|rcsb pdb:3BQQ|rcsb pdb:4DDJ|rcsb pdb:4UEX|rcsb pdb:4V2O|rcsb pdb:6SLR|reactome:R-HSA-114608|go:"GO:1905575"(ganglioside GM3 binding)|reactome:R-HSA-1660662|reactome:R-HSA-418594|reactome:R-HSA-6798695|reactome:R-HSA-375276|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|dip:DIP-29803N	go:"GO:0005764"(lysosome)	-	-	figure legend:Supp. Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cerebral_cortical_neuron)|taxid:10090(Mouse cerebral cortical neuron)	-	2019/04/18	2019/04/24	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rogid:DV9GeJ6/mtgv9nUhsCRYBo19d5g9606	rigid:Yp1tPRjxpBNcFkv6jhXTEuOx6yA	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)