#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P56817	uniprotkb:Q9UJY5	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	von et al. (2014)	imex:IM-27074|pubmed:26053850	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21017459|imex:IM-27074-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	-	crc64:377CE4C824ACEF05	-	figure legend:Figs. 3A, 3B, Supp. Fig. 2|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/01/11	2019/01/11	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rigid:j/hmzIA0mfYN62j+veS9MXWcZM4	false	ha tag:c-c|sufficient binding region:458..458-501,1-45..45	myc tag:?-?|necessary binding region:510-639(IPR008153)|mutation with no effect:355-355|mutation with no effect:355-355	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P56817	uniprotkb:Q9UJY4	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	intact:EBI-447646|uniprotkb:O14564|uniprotkb:Q9NYN2|uniprotkb:Q9UPS2|uniprotkb:D3DWF0|ensembl:ENSP00000311962	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:gga2_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 2(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 2(gene name synonym)|uniprotkb:VHS domain and ear domain of gamma-adaptin(gene name synonym)|uniprotkb:GGA2(gene name)|psi-mi:GGA2(display_short)|uniprotkb:KIAA1080(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	von et al. (2014)	imex:IM-27074|pubmed:26053850	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21017646|imex:IM-27074-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	refseq:NP_055859.1|dip:DIP-31601N|ensembl:ENSG00000103365(gene)|ensembl:ENST00000309859(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY4|rcsb pdb:1MHQ|reactome:R-HSA-8854214|reactome:R-HSA-977225	-	crc64:377CE4C824ACEF05	-	figure legend:Figs. 3A, 3B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/01/11	2019/01/12	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:VD3+z3TdZr7Ius0oloo8bnMhwjQ9606	rigid:7TBS/g822i856hgcSRuzxlldAU8	false	ha tag:c-c|sufficient binding region:458..458-501,1-45..45	myc tag:?-?|necessary binding region:484-613(IPR008153)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P56817	uniprotkb:Q9NZ52	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	intact:EBI-447404|uniprotkb:Q15017|uniprotkb:Q6IS16|uniprotkb:Q9UJY3|uniprotkb:B7Z7E2|uniprotkb:B7Z7M9|uniprotkb:J3KRN0|intact:EBI-28988067|ensembl:ENSP00000438085|ensembl:ENSP00000496890	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:gga3_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 3(gene name synonym)|uniprotkb:GGA3(gene name)|psi-mi:GGA3(display_short)|uniprotkb:KIAA0154(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	von et al. (2014)	imex:IM-27074|pubmed:26053850	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21017660|imex:IM-27074-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	refseq:NP_001278570.1|refseq:NP_001278571.1|refseq:NP_001166174.1|refseq:NP_054720.1|refseq:NP_619525.1|ensembl:ENST00000538886|ensembl:ENSP00000446421|ensembl:ENST00000578348|ensembl:ENSP00000463288|ensembl:ENST00000582717|ensembl:ENSP00000462081|ensembl:ENSP00000496890|ensembl:ENSP00000438085|refseq:NP_001166175.1|dip:DIP-31600N|ensembl:ENSG00000125447(gene)|ensembl:ENST00000537686(transcript)|ensembl:ENST00000649398(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR002014(VHS)|interpro:IPR044111|mint:Q9NZ52|rcsb pdb:1JPL|rcsb pdb:1JUQ|rcsb pdb:1LF8|rcsb pdb:1P4U|rcsb pdb:1WR6|rcsb pdb:1YD8|reactome:R-HSA-8854214|reactome:R-HSA-8875656|reactome:R-HSA-977225|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR027422|interpro:IPR038425|interpro:IPR041198	-	crc64:377CE4C824ACEF05	-	figure legend:Figs. 3A, 3B|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/01/11	2019/01/12	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:MuqZi22xY1lyDboND7/xRNCqJbc9606	rigid:BNo8J2oxyVqGvdFqAQUzXfOSJMk	false	ha tag:c-c|sufficient binding region:458..458-501,1-45..45	myc tag:?-?|necessary binding region:594-723(IPR008153)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P56817	uniprotkb:Q9NZ52	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	intact:EBI-447404|uniprotkb:Q15017|uniprotkb:Q6IS16|uniprotkb:Q9UJY3|uniprotkb:B7Z7E2|uniprotkb:B7Z7M9|uniprotkb:J3KRN0|intact:EBI-28988067|ensembl:ENSP00000438085|ensembl:ENSP00000496890	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:gga3_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 3(gene name synonym)|uniprotkb:GGA3(gene name)|psi-mi:GGA3(display_short)|uniprotkb:KIAA0154(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	von et al. (2014)	imex:IM-27074|pubmed:26053850	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21017681|imex:IM-27074-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	refseq:NP_001278570.1|refseq:NP_001278571.1|refseq:NP_001166174.1|refseq:NP_054720.1|refseq:NP_619525.1|ensembl:ENST00000538886|ensembl:ENSP00000446421|ensembl:ENST00000578348|ensembl:ENSP00000463288|ensembl:ENST00000582717|ensembl:ENSP00000462081|ensembl:ENSP00000496890|ensembl:ENSP00000438085|refseq:NP_001166175.1|dip:DIP-31600N|ensembl:ENSG00000125447(gene)|ensembl:ENST00000537686(transcript)|ensembl:ENST00000649398(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR002014(VHS)|interpro:IPR044111|mint:Q9NZ52|rcsb pdb:1JPL|rcsb pdb:1JUQ|rcsb pdb:1LF8|rcsb pdb:1P4U|rcsb pdb:1WR6|rcsb pdb:1YD8|reactome:R-HSA-8854214|reactome:R-HSA-8875656|reactome:R-HSA-977225|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR027422|interpro:IPR038425|interpro:IPR041198	-	crc64:377CE4C824ACEF05	-	figure legend:Figs. 3C|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/11	2019/01/12	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:MuqZi22xY1lyDboND7/xRNCqJbc9606	rigid:BNo8J2oxyVqGvdFqAQUzXfOSJMk	false	ha tag:c-c	myc tag:?-?|necessary binding region:594-723(IPR008153)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P56817	uniprotkb:Q9UJY5	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	von et al. (2014)	imex:IM-27074|pubmed:26053850	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21017695|imex:IM-27074-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	-	crc64:377CE4C824ACEF05	-	figure legend:Figs. 3C|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/11	2019/01/12	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rigid:j/hmzIA0mfYN62j+veS9MXWcZM4	false	ha tag:c-c|sufficient binding region:458..458-501,1-45..45	myc tag:?-?|necessary binding region:510-639(IPR008153)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P56817	uniprotkb:Q9UJY4	intact:EBI-2433139|uniprotkb:B0YIU9|uniprotkb:Q9BYB9|uniprotkb:Q9BYC0|uniprotkb:Q9BYC1|uniprotkb:Q9UJT5|uniprotkb:Q9ULS1|uniprotkb:E9PE65|uniprotkb:H7BXJ9|uniprotkb:A0M8W7|ensembl:ENSP00000318585	intact:EBI-447646|uniprotkb:O14564|uniprotkb:Q9NYN2|uniprotkb:Q9UPS2|uniprotkb:D3DWF0|ensembl:ENSP00000311962	psi-mi:bace1_human(display_long)|uniprotkb:BACE(gene name synonym)|uniprotkb:KIAA1149(gene name synonym)|uniprotkb:Beta-site amyloid precursor protein cleaving enzyme 1(gene name synonym)|uniprotkb:Membrane-associated aspartic protease 2(gene name synonym)|uniprotkb:Memapsin-2(gene name synonym)|uniprotkb:Aspartyl protease 2(gene name synonym)|uniprotkb:BACE1(gene name)|psi-mi:BACE1(display_short)	psi-mi:gga2_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 2(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 2(gene name synonym)|uniprotkb:VHS domain and ear domain of gamma-adaptin(gene name synonym)|uniprotkb:GGA2(gene name)|psi-mi:GGA2(display_short)|uniprotkb:KIAA1080(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	von et al. (2014)	imex:IM-27074|pubmed:26053850	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21017709|imex:IM-27074-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193978.1|refseq:NP_036236.1|refseq:NP_620427.1|refseq:NP_620428.1|refseq:NP_620429.1|dip:DIP-41388N|ensembl:ENSG00000186318(gene)|ensembl:ENST00000313005(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0008798"(beta-aspartyl-peptidase activity)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010288"(response to lead ion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0055037"(recycling endosome)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070931"(Golgi-associated vesicle lumen)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR009119(Peptidase A1, beta-site APP cleaving enzyme, BACE)|interpro:IPR009120(Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033874|mint:P56817|rcsb pdb:1FKN|rcsb pdb:1M4H|rcsb pdb:1PY1|rcsb pdb:1SGZ|rcsb pdb:1TQF|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1W50|rcsb pdb:1W51|rcsb pdb:1XN2|rcsb pdb:1XN3|rcsb pdb:1XS7|rcsb pdb:1YM2|rcsb pdb:1YM4|rcsb pdb:2B8L|rcsb pdb:2B8V|rcsb pdb:2F3E|rcsb pdb:2F3F|rcsb pdb:2FDP|rcsb pdb:2G94|rcsb pdb:2HIZ|rcsb pdb:2HM1|rcsb pdb:2IQG|rcsb pdb:2IRZ|rcsb pdb:2IS0|rcsb pdb:2NTR|rcsb pdb:2OAH|rcsb pdb:2OF0|rcsb pdb:2OHK|rcsb pdb:2OHL|rcsb pdb:2OHM|rcsb pdb:2OHN|rcsb pdb:2OHP|rcsb pdb:2OHQ|rcsb pdb:2OHR|rcsb pdb:2OHS|rcsb pdb:2OHT|rcsb pdb:2OHU|rcsb pdb:2P4J|rcsb pdb:2P83|rcsb pdb:2P8H|rcsb pdb:2PH6|rcsb pdb:2PH8|rcsb pdb:2Q11|rcsb pdb:2Q15|rcsb pdb:2QK5|rcsb pdb:2QMD|rcsb pdb:2QMF|rcsb pdb:2QMG|rcsb pdb:2QP8|rcsb pdb:2QU2|rcsb pdb:2QU3|rcsb pdb:2QZK|rcsb pdb:2QZL|rcsb pdb:2VA5|rcsb pdb:2VA6|rcsb pdb:2VA7|rcsb pdb:2VIE|rcsb pdb:2VIJ|rcsb pdb:2VIY|rcsb pdb:2VIZ|rcsb pdb:2VJ6|rcsb pdb:2VJ7|rcsb pdb:2VJ9|rcsb pdb:2VKM|rcsb pdb:2VNM|rcsb pdb:2VNN|rcsb pdb:2WEZ|rcsb pdb:2WF0|rcsb pdb:2WF1|rcsb pdb:2WF2|rcsb pdb:2WF3|rcsb pdb:2WF4|rcsb pdb:2WJO|rcsb pdb:2XFI|rcsb pdb:2XFJ|rcsb pdb:2XFK|rcsb pdb:2ZDZ|rcsb pdb:2ZE1|rcsb pdb:2ZHR|rcsb pdb:2ZHS|rcsb pdb:2ZHT|rcsb pdb:2ZHU|rcsb pdb:2ZHV|rcsb pdb:2ZJH|rcsb pdb:2ZJI|rcsb pdb:2ZJJ|rcsb pdb:2ZJK|rcsb pdb:2ZJL|rcsb pdb:2ZJM|rcsb pdb:2ZJN|rcsb pdb:3BRA|rcsb pdb:3BUF|rcsb pdb:3BUG|rcsb pdb:3BUH|rcsb pdb:3CIB|rcsb pdb:3CIC|rcsb pdb:3CID|rcsb pdb:3CKP|rcsb pdb:3CKR|rcsb pdb:3DM6|rcsb pdb:3DUY|rcsb pdb:3DV1|rcsb pdb:3DV5|rcsb pdb:3EXO|rcsb pdb:3FKT|rcsb pdb:3H0B|rcsb pdb:3HVG|rcsb pdb:3HW1|rcsb pdb:3I25|rcsb pdb:3IGB|rcsb pdb:3IN3|rcsb pdb:3IN4|rcsb pdb:3IND|rcsb pdb:3INE|rcsb pdb:3INF|rcsb pdb:3INH|rcsb pdb:3IVH|rcsb pdb:3IVI|rcsb pdb:3IXJ|rcsb pdb:3IXK|rcsb pdb:3K5C|rcsb pdb:3K5D|rcsb pdb:3K5F|rcsb pdb:3K5G|rcsb pdb:3KMX|rcsb pdb:3KMY|rcsb pdb:3KN0|rcsb pdb:3KYR|rcsb pdb:3L38|rcsb pdb:3L3A|rcsb pdb:3L58|rcsb pdb:3L59|rcsb pdb:3L5B|rcsb pdb:3L5C|rcsb pdb:3L5D|rcsb pdb:3L5E|rcsb pdb:3L5F|rcsb pdb:3LHG|rcsb pdb:3LNK|rcsb pdb:3LPI|rcsb pdb:3LPJ|rcsb pdb:3LPK|rcsb pdb:3MSJ|rcsb pdb:3MSK|rcsb pdb:3MSL|rcsb pdb:3N4L|rcsb pdb:3NSH|rcsb pdb:3OHF|rcsb pdb:3OHH|rcsb pdb:3OOZ|rcsb pdb:3PI5|rcsb pdb:3QBH|rcsb pdb:3QI1|rcsb pdb:3R1G|rcsb pdb:3R2F|rcsb pdb:3RSV|rcsb pdb:3RSX|rcsb pdb:3RTH|rcsb pdb:3RTM|rcsb pdb:3RTN|rcsb pdb:3RU1|rcsb pdb:3RVI|rcsb pdb:3S2O|rcsb pdb:3S7L|rcsb pdb:3S7M|rcsb pdb:3SKF|rcsb pdb:3TPJ|rcsb pdb:3TPL|rcsb pdb:3TPP|rcsb pdb:3TPR|rcsb pdb:3U6A|rcsb pdb:3UDH|rcsb pdb:3UDJ|rcsb pdb:3UDK|rcsb pdb:3UDM|rcsb pdb:3UDN|rcsb pdb:3UDP|rcsb pdb:3UDQ|rcsb pdb:3UDR|rcsb pdb:3UDY|rcsb pdb:3UFL|rcsb pdb:3UQP|rcsb pdb:3UQR|rcsb pdb:3UQU|rcsb pdb:3UQW|rcsb pdb:3UQX|rcsb pdb:3VEU|rcsb pdb:3VF3|rcsb pdb:3VG1|rcsb pdb:3VV6|rcsb pdb:3VV7|rcsb pdb:3VV8|rcsb pdb:3WB4|rcsb pdb:3WB5|rcsb pdb:3ZMG|rcsb pdb:3ZOV|rcsb pdb:4ACU|rcsb pdb:4ACX|rcsb pdb:4AZY|rcsb pdb:4B00|rcsb pdb:4B05|rcsb pdb:4B0Q|rcsb pdb:4B1C|rcsb pdb:4B1D|rcsb pdb:4B1E|rcsb pdb:4B70|rcsb pdb:4B72|rcsb pdb:4B77|rcsb pdb:4B78|rcsb pdb:4BEK|rcsb pdb:4BFD|rcsb pdb:4D83|rcsb pdb:4D85|rcsb pdb:4D88|rcsb pdb:4D89|rcsb pdb:4D8C|rcsb pdb:4DH6|rcsb pdb:4DI2|rcsb pdb:4DJU|rcsb pdb:4DJV|rcsb pdb:4DJW|rcsb pdb:4DJX|rcsb pdb:4DJY|rcsb pdb:4DPF|rcsb pdb:4DPI|rcsb pdb:4DUS|rcsb pdb:4DV9|rcsb pdb:4DVF|rcsb pdb:4EWO|rcsb pdb:4EXG|rcsb pdb:4FCO|rcsb pdb:4FGX|rcsb pdb:4FM7|rcsb pdb:4FM8|rcsb pdb:4FRI|rcsb pdb:4FRJ|rcsb pdb:4FRK|rcsb pdb:4FRS|rcsb pdb:4FS4|rcsb pdb:4FSE|rcsb pdb:4FSL|rcsb pdb:4GID|rcsb pdb:4GMI|rcsb pdb:4H1E|rcsb pdb:4H3F|rcsb pdb:4H3G|rcsb pdb:4H3I|rcsb pdb:4H3J|rcsb pdb:4HA5|rcsb pdb:4HZT|rcsb pdb:4I0D|rcsb pdb:4I0E|rcsb pdb:4I0F|rcsb pdb:4I0G|rcsb pdb:4I0H|rcsb pdb:4I0I|rcsb pdb:4I0J|rcsb pdb:4I0Z|rcsb pdb:4I10|rcsb pdb:4I11|rcsb pdb:3SKG|rcsb pdb:4I12|rcsb pdb:4I1C|rcsb pdb:4IVS|rcsb pdb:4IVT|rcsb pdb:4J0P|rcsb pdb:4J0T|rcsb pdb:4J0V|rcsb pdb:4J0Y|rcsb pdb:4J0Z|rcsb pdb:4J17|rcsb pdb:4J1C|rcsb pdb:4J1E|rcsb pdb:4J1F|rcsb pdb:4J1H|rcsb pdb:4J1I|rcsb pdb:4J1K|rcsb pdb:4JOO|rcsb pdb:4JP9|rcsb pdb:4JPC|rcsb pdb:4JPE|rcsb pdb:4K8S|rcsb pdb:4K9H|rcsb pdb:4KE0|rcsb pdb:4KE1|rcsb pdb:4L7G|rcsb pdb:4L7H|rcsb pdb:4L7J|rcsb pdb:4LC7|rcsb pdb:4LXA|rcsb pdb:4LXK|rcsb pdb:4LXM|rcsb pdb:4N00|rcsb pdb:4PZW|rcsb pdb:4PZX|rcsb pdb:4R5N|rcsb pdb:4R8Y|rcsb pdb:4R91|rcsb pdb:4R92|rcsb pdb:4R93|rcsb pdb:4R95|rcsb pdb:4RCD|rcsb pdb:4RCE|rcsb pdb:4RCF|rcsb pdb:4RRN|rcsb pdb:4RRO|rcsb pdb:4RRS|rcsb pdb:4TRW|rcsb pdb:4TRY|rcsb pdb:4TRZ|rcsb pdb:4WTU|rcsb pdb:4WY1|rcsb pdb:4WY6|rcsb pdb:4X2L|rcsb pdb:4X7I|rcsb pdb:4XKX|rcsb pdb:4XXS|rcsb pdb:4YBI|rcsb pdb:4ZPE|rcsb pdb:4ZPF|rcsb pdb:4ZPG|rcsb pdb:4ZSM|rcsb pdb:4ZSP|rcsb pdb:4ZSQ|rcsb pdb:4ZSR|rcsb pdb:5CLM|rcsb pdb:5DQC|rcsb pdb:5ENK|rcsb pdb:5ENM|rcsb pdb:5EZX|rcsb pdb:5EZZ|rcsb pdb:5F00|rcsb pdb:5F01|rcsb pdb:5HD0|rcsb pdb:5HDU|rcsb pdb:5HDV|rcsb pdb:5HDX|rcsb pdb:5HDZ|rcsb pdb:5HE4|rcsb pdb:5HE5|rcsb pdb:5HE7|rcsb pdb:5HTZ|rcsb pdb:5HU0|rcsb pdb:5HU1|rcsb pdb:5I3V|rcsb pdb:5I3W|rcsb pdb:5I3X|rcsb pdb:5I3Y|rcsb pdb:5IE1|rcsb pdb:5KQF|rcsb pdb:5KR8|rcsb pdb:5MBW|rcsb pdb:5MCO|rcsb pdb:5MCQ|rcsb pdb:5MXD|rcsb pdb:5QCO|rcsb pdb:5QCP|rcsb pdb:5QCQ|rcsb pdb:5QCR|rcsb pdb:5QCS|rcsb pdb:5QCT|rcsb pdb:5QCU|rcsb pdb:5QCV|rcsb pdb:5QCW|rcsb pdb:5QCX|rcsb pdb:5QCY|rcsb pdb:5QCZ|rcsb pdb:5QD0|rcsb pdb:5QD1|rcsb pdb:5QD2|rcsb pdb:5QD3|rcsb pdb:5QD4|rcsb pdb:5QD5|rcsb pdb:5QD6|rcsb pdb:5QD7|rcsb pdb:5QD8|rcsb pdb:5QD9|rcsb pdb:5QDA|rcsb pdb:5QDB|rcsb pdb:5QDC|rcsb pdb:5QDD|rcsb pdb:5T1U|rcsb pdb:5T1W|rcsb pdb:5TOL|rcsb pdb:5UYU|rcsb pdb:5V0N|rcsb pdb:5YGX|rcsb pdb:5YGY|rcsb pdb:6BFD|rcsb pdb:6BFE|rcsb pdb:6BFW|rcsb pdb:6BFX|rcsb pdb:6C2I|rcsb pdb:6DHC|rcsb pdb:6DMI|rcsb pdb:6E3Z|rcsb pdb:6EJ2|rcsb pdb:6EJ3|rcsb pdb:6EQM|rcsb pdb:6FGY|rcsb pdb:6JSE|rcsb pdb:6JSF|rcsb pdb:6JSG|rcsb pdb:6JSN|rcsb pdb:6JT3|rcsb pdb:6JT4|rcsb pdb:6NV7|rcsb pdb:6NV9|rcsb pdb:6NW3|rcsb pdb:6OD6|rcsb pdb:6PZ4|rcsb pdb:6UVP|rcsb pdb:6UVV|rcsb pdb:6UVY|rcsb pdb:6UWP|rcsb pdb:6UWV|rcsb pdb:6WNY|rcsb pdb:7B1E|rcsb pdb:7B1P|rcsb pdb:7B1Q|rcsb pdb:7D2V|rcsb pdb:7D2X|rcsb pdb:7D5A|rcsb pdb:7DCZ|reactome:R-HSA-977225	refseq:NP_055859.1|dip:DIP-31601N|ensembl:ENSG00000103365(gene)|ensembl:ENST00000309859(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY4|rcsb pdb:1MHQ|reactome:R-HSA-8854214|reactome:R-HSA-977225	-	crc64:377CE4C824ACEF05	-	figure legend:Figs. 3C|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/01/11	2019/01/12	rogid:3oEbxDI/Eu5LwK/3QKtUhS41n3o9606	rogid:VD3+z3TdZr7Ius0oloo8bnMhwjQ9606	rigid:7TBS/g822i856hgcSRuzxlldAU8	false	ha tag:c-c|sufficient binding region:458..458-501,1-45..45	myc tag:?-?|necessary binding region:484-613(IPR008153)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UJY5	uniprotkb:Q92673	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	von et al. (2014)	imex:IM-27074|pubmed:26053850	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21017736|imex:IM-27074-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	-	-	-	figure legend:Supp. Fig. 3|comment:A c-terminal gFP tag on SORL blocked the interaction|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2019/01/11	2019/01/12	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rigid:ff4BZdT0x3yLHSZaqZcgNmB02FM	false	myc tag:c-c|binding-associated region:17..17-147..147(IPR002014)	green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UJY5	uniprotkb:Q92673	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	intact:EBI-1171329|uniprotkb:Q92856|uniprotkb:B2RNX7|ensembl:ENSP00000260197	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:sorl_human(display_long)|uniprotkb:Sorting protein-related receptor containing LDLR class A repeats(gene name synonym)|uniprotkb:SorLA-1(gene name synonym)|uniprotkb:Low-density lipoprotein receptor relative with 11 ligand-binding repeats(gene name synonym)|uniprotkb:SORL1(gene name)|psi-mi:SORL1(display_short)|uniprotkb:C11orf32(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	von et al. (2014)	imex:IM-27074|pubmed:26053850	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-21017757|imex:IM-27074-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	refseq:NP_003096.1|ensembl:ENSG00000137642(gene)|ensembl:ENST00000260197(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014910"(regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0038020"(insulin receptor recycling)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051604"(protein maturation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1900168"(positive regulation of glial cell-derived neurotrophic factor production)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902771"(positive regulation of choline O-acetyltransferase activity)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|go:"GO:1902955"(positive regulation of early endosome to recycling endosome transport)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1902997"(negative regulation of neurofibrillary tangle assembly)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006581(VPS10)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR023415|interpro:IPR031777|interpro:IPR031778|interpro:IPR036055|interpro:IPR036116|mint:Q92673|rcsb pdb:2DM4|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3WSX|rcsb pdb:3WSY|rcsb pdb:3WSZ|reactome:R-HSA-977225|go:"GO:2001137"(positive regulation of endocytic recycling)|dip:DIP-41229N	-	-	-	figure legend:Supp. Fig. 3|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2019/01/11	2019/01/12	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rogid:JoB0wm+nsEc1vhUsfcaOrc9YwMc9606	rigid:ff4BZdT0x3yLHSZaqZcgNmB02FM	false	myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)