#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9BSQ5	uniprotkb:O00522	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fisher et al. (2015)	pubmed:25525273|imex:IM-27267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21987453|imex:IM-27267-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	-	-	-	figure legend:Figure 5f|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/08/16	2019/08/16	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rigid:D4TuNCybE4z1XQ1ZZRgZbRz+9Mo	false	mutation disrupting interaction strength:210-210|mutation disrupting interaction strength:136-136,139-139|flag tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BSQ5	uniprotkb:O00522	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fisher et al. (2015)	pubmed:25525273|imex:IM-27267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-22180638|imex:IM-27267-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	-	-	-	figure legend:Figure 2b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/08/16	2019/11/01	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rigid:D4TuNCybE4z1XQ1ZZRgZbRz+9Mo	false	flag tag:?-?	mutation with no effect:195-195|green fluorescent protein tag:?-?|mutation with no effect:234-234|mutation with no effect:252-252,253-253|mutation decreasing interaction strength:234-234,252-252,253-253	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BSQ5	uniprotkb:O00522	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fisher et al. (2015)	pubmed:25525273|imex:IM-27267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21987481|imex:IM-27267-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	-	-	-	figure legend:Figure 2c, 5b, 5c, 5d, 6c, 6d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/20	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rigid:D4TuNCybE4z1XQ1ZZRgZbRz+9Mo	false	mutation decreasing interaction strength:210-210|mutation decreasing interaction strength:136-136,139-139|mutation decreasing interaction strength:217-217|sufficient binding region:51-228|his tag:n-n	mutation disrupting interaction strength:248-248|mutation disrupting interaction strength:252-252,253-253|mutation decreasing interaction strength:244-244|glutathione s tranferase tag:?-?|sufficient binding region:244-256	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9BSQ5	uniprotkb:O00522	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Fisher et al. (2015)	pubmed:25525273|imex:IM-27267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21987508|pdbe:4WJ7|imex:IM-27267-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	-	-	-	figure legend:Table 2, Figure 3a|3d-resolution:2.75Å|3d-r-factors:"Rwork: 0.22  Rfree: 0.25"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/16	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rigid:D4TuNCybE4z1XQ1ZZRgZbRz+9Mo	false	sufficient binding region:51-228|his tag:n-n	sufficient binding region:244-256|glutathione s tranferase tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BSQ5	uniprotkb:O00522	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Fisher et al. (2015)	pubmed:25525273|imex:IM-27267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21987532|imex:IM-27267-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	-	-	-	figure legend:Figure 2e|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/16	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rigid:D4TuNCybE4z1XQ1ZZRgZbRz+9Mo	false	sufficient binding region:51-228|his tag:n-n	sufficient binding region:244-256|glutathione s tranferase tag:?-?	1	1	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:Q9BSQ5	uniprotkb:O00522	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Fisher et al. (2015)	pubmed:25525273|imex:IM-27267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21988615|imex:IM-27267-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	-	-	-	figure legend:Figure 5a, Table 4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:13.0x10^-6 ~2.5(molar)	2019/08/16	2019/08/20	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rigid:D4TuNCybE4z1XQ1ZZRgZbRz+9Mo	false	sufficient binding region:51-228|his tag:n-n	sufficient binding region:244-256|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BSQ5	uniprotkb:O00522	intact:EBI-1573056|uniprotkb:Q71RE5|uniprotkb:Q8TAT4|ensembl:ENSP00000258781|uniprotkb:B3KUV0|uniprotkb:E9PDJ3|uniprotkb:A4D2L4|uniprotkb:F5H0E1|uniprotkb:F5H551|uniprotkb:D3DVL4	intact:EBI-1573121|uniprotkb:O43894|uniprotkb:Q506L6|uniprotkb:Q6U276|uniprotkb:Q75N19|uniprotkb:Q9H180|uniprotkb:Q9H264|uniprotkb:Q9HAX5|uniprotkb:A6NNU0|ensembl:ENSP00000344668|ensembl:ENSP00000378013|ensembl:ENSP00000378015|ensembl:ENSP00000391675|ensembl:ENSP00000410909	psi-mi:ccm2_human(display_long)|uniprotkb:CCM2(gene name)|psi-mi:CCM2(display_short)|uniprotkb:C7orf22(gene name synonym)|uniprotkb:Malcavernin(gene name synonym)|uniprotkb:PP10187(orf name)	psi-mi:krit1_human(display_long)|uniprotkb:KRIT1(gene name)|psi-mi:KRIT1(display_short)|uniprotkb:CCM1(gene name synonym)|uniprotkb:Cerebral cavernous malformations 1 protein(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Fisher et al. (2015)	pubmed:25525273|imex:IM-27267	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21988641|imex:IM-27267-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161406.1|ensembl:ENSG00000136280(gene)|ensembl:ENST00000258781(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001885"(endothelial cell development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048839"(inner ear development)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060039"(pericardium development)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0061154"(endothelial tube morphogenesis)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR026159|interpro:IPR032375|rcsb pdb:4FQN|rcsb pdb:4TVQ|rcsb pdb:4WJ7|rcsb pdb:4Y5O|rcsb pdb:4YKC|rcsb pdb:4YKD|rcsb pdb:4YL6|refseq:NP_001025006.1|refseq:NP_001161407.1|refseq:NP_113631.1|dip:DIP-40609N	refseq:XP_006716224.1|refseq:XP_006716225.1|refseq:XP_006716226.1|refseq:XP_016868244.1|refseq:XP_016868245.1|refseq:XP_016868246.1|refseq:XP_011514958.1|refseq:XP_011514959.1|refseq:NP_004903.2|refseq:NP_919436.1|refseq:NP_919437.1|refseq:NP_919438.1|refseq:XP_011514953.1|refseq:XP_011514955.1|refseq:XP_011514956.1|refseq:XP_011514957.1|refseq:NP_001013424.1|refseq:XP_011514960.1|refseq:XP_011514961.1|refseq:XP_011514962.1|refseq:XP_011514963.1|refseq:XP_005250717.1|refseq:XP_005250719.1|refseq:XP_005250722.1|refseq:XP_005250723.1|refseq:XP_005250724.1|refseq:XP_005250725.1|refseq:XP_005250726.1|dip:DIP-40610N|ensembl:ENSG00000001631(gene)|ensembl:ENST00000340022(transcript)|ensembl:ENST00000394505(transcript)|ensembl:ENST00000394507(transcript)|ensembl:ENST00000412043(transcript)|ensembl:ENST00000458177(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR032022|interpro:IPR035963|interpro:IPR036770|interpro:IPR041791|interpro:IPR043058|rcsb pdb:3U7D|rcsb pdb:4DX8|rcsb pdb:4DXA|rcsb pdb:4HDO|rcsb pdb:4HDQ|rcsb pdb:4JIF|rcsb pdb:4TKN|rcsb pdb:5D68|rcsb pdb:6OQ3|rcsb pdb:6OQ4|rcsb pdb:6UZK	-	-	-	figure legend:Figure 5a, Table 4|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/16	2019/08/20	rogid:b/nQw8agXD8q1yU424GrscY0UA89606	rogid:uUIzAUn3VaZD5W4W29X5tgRQfzM9606	rigid:D4TuNCybE4z1XQ1ZZRgZbRz+9Mo	false	sufficient binding region:51-228|his tag:n-n	binding-associated region:241-254|biotin tag:n-n|binding-associated region:225-254	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)