#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19327	uniprotkb:Q04589	intact:EBI-6570156	intact:EBI-2480918	psi-mi:5ht1a_rat(display_long)|uniprotkb:Htr1a(gene name)|psi-mi:Htr1a(display_short)|uniprotkb:5ht1a(gene name synonym)|uniprotkb:Serotonin receptor 1A(gene name synonym)	psi-mi:fgfr1_rat(display_long)|uniprotkb:Fgfr1(gene name)|psi-mi:Fgfr1(display_short)|uniprotkb:Flg(gene name synonym)|uniprotkb:MFR(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Borroto-Escuela et al. (2015)	pubmed:25485703|imex:IM-27044	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21422344|imex:IM-27044-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014053"(negative regulation of gamma-aminobutyric acid secretion)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0035640"(exploration behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043203"(axon hillock)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0051378"(serotonin binding)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0001662"(behavioral fear response)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0001965"(G-protein alpha-subunit binding)|interpro:IPR000610(5-Hydroxytryptamine 1A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rgd:2845|refseq:NP_036717.1|reactome:R-RNO-390666	go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0005829"(cytosol)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001759"(organ induction)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0021837"(motogenic signaling involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043583"(ear development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048699"(generation of neurons)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048469"(cell maturation)|rgd:620713|refseq:NP_077060.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR028174|interpro:IPR013151(Immunoglobulin)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR036179|interpro:IPR041159|reactome:R-RNO-109704|reactome:R-RNO-1257604|reactome:R-RNO-190370|reactome:R-RNO-190373|reactome:R-RNO-190374|reactome:R-RNO-445144|reactome:R-RNO-5654219|reactome:R-RNO-5654687|reactome:R-RNO-5654688|reactome:R-RNO-5654689|reactome:R-RNO-5654693|reactome:R-RNO-5654726|reactome:R-RNO-5673001|reactome:R-RNO-6811558	-	-	-	figure legend:Figure 1|comment:positive red clusters were found in large numberof nerve cells of the dorsal and median raphe nuclei|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell)	-	2019/05/06	2019/05/28	rogid:mtLOH4idN6ihEekCAcgm3HO/h8s10116	rogid:J+4J96IkgLbGJ5DBggiKxyBJKtY10116	rigid:ft6/OMK11yGCqWdabvO+afs5doM	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P19327	uniprotkb:Q04589	intact:EBI-6570156	intact:EBI-2480918	psi-mi:5ht1a_rat(display_long)|uniprotkb:Htr1a(gene name)|psi-mi:Htr1a(display_short)|uniprotkb:5ht1a(gene name synonym)|uniprotkb:Serotonin receptor 1A(gene name synonym)	psi-mi:fgfr1_rat(display_long)|uniprotkb:Fgfr1(gene name)|psi-mi:Fgfr1(display_short)|uniprotkb:Flg(gene name synonym)|uniprotkb:MFR(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Borroto-Escuela et al. (2015)	pubmed:25485703|imex:IM-27044	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21423159|imex:IM-27044-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014053"(negative regulation of gamma-aminobutyric acid secretion)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0035640"(exploration behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043203"(axon hillock)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0051378"(serotonin binding)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0001662"(behavioral fear response)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0001965"(G-protein alpha-subunit binding)|interpro:IPR000610(5-Hydroxytryptamine 1A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rgd:2845|refseq:NP_036717.1|reactome:R-RNO-390666	go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0005829"(cytosol)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001759"(organ induction)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0021837"(motogenic signaling involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043583"(ear development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048699"(generation of neurons)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048469"(cell maturation)|rgd:620713|refseq:NP_077060.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR028174|interpro:IPR013151(Immunoglobulin)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR036179|interpro:IPR041159|reactome:R-RNO-109704|reactome:R-RNO-1257604|reactome:R-RNO-190370|reactome:R-RNO-190373|reactome:R-RNO-190374|reactome:R-RNO-445144|reactome:R-RNO-5654219|reactome:R-RNO-5654687|reactome:R-RNO-5654688|reactome:R-RNO-5654689|reactome:R-RNO-5654693|reactome:R-RNO-5654726|reactome:R-RNO-5673001|reactome:R-RNO-6811558	-	-	-	figure legend:Figure 2|agonist:FGF-2|agonist:"8-OH-DPAT (8-hydroxy-2(di-n-propylamino)tetralin) -a  5-HT1A receptor agonist"|agonist:"FGF-2 combined with 8-OH-DPAT:the number of PLA positive red clusters was  markedly enhanced by combined treatment."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-rn33b)|taxid:10116(RAT RN33B  neuronal SV40 large T antigen transfected)	-	2019/05/06	2019/05/28	rogid:mtLOH4idN6ihEekCAcgm3HO/h8s10116	rogid:J+4J96IkgLbGJ5DBggiKxyBJKtY10116	rigid:ft6/OMK11yGCqWdabvO+afs5doM	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P08908	uniprotkb:P11362	intact:EBI-6570214|ensembl:ENSP00000316244|uniprotkb:Q6LAE7	intact:EBI-1028277|uniprotkb:P17049|uniprotkb:Q02063|uniprotkb:Q02065|uniprotkb:Q14306|uniprotkb:Q14307|uniprotkb:Q8N685|uniprotkb:C1KBH8|uniprotkb:Q9UDF0|uniprotkb:Q9UDF1|uniprotkb:Q9UDF2|uniprotkb:Q59H40|uniprotkb:Q5BJG2|uniprotkb:A8K6T9|uniprotkb:A8K8V5|uniprotkb:Q53H63|uniprotkb:Q9UD50|intact:EBI-1058611|ensembl:ENSP00000400162	psi-mi:5ht1a_human(display_long)|uniprotkb:HTR1A(gene name)|psi-mi:HTR1A(display_short)|uniprotkb:ADRB2RL1(gene name synonym)|uniprotkb:ADRBRL1(gene name synonym)|uniprotkb:G-21(gene name synonym)|uniprotkb:Serotonin receptor 1A(gene name synonym)	psi-mi:fgfr1_human(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:N-sam(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Borroto-Escuela et al. (2015)	pubmed:25485703|imex:IM-27044	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21424184|imex:IM-27044-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000178394(gene)|ensembl:ENST00000323865(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0035640"(exploration behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0045202"(synapse)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051378"(serotonin binding)|go:"GO:0090722"(receptor-receptor interaction)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000610(5-Hydroxytryptamine 1A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|reactome:R-HSA-390666|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_000515.2	refseq:NP_001167534.1|refseq:NP_001167535.1|refseq:NP_001167536.1|refseq:NP_001167537.1|refseq:NP_001167538.1|refseq:NP_056934.2|refseq:NP_075593.1|refseq:NP_075594.1|refseq:NP_075598.2|ensembl:ENSG00000077782(gene)|ensembl:ENST00000447712(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P11362|rcsb pdb:1AGW|rcsb pdb:1CVS|rcsb pdb:1EVT|rcsb pdb:1FGI|rcsb pdb:1FGK|rcsb pdb:1FQ9|go:"GO:0045666"(positive regulation of neuron differentiation)|rcsb pdb:1XR0|rcsb pdb:2CR3|rcsb pdb:2FGI|rcsb pdb:3C4F|rcsb pdb:3DPK|rcsb pdb:3GQI|rcsb pdb:3GQL|rcsb pdb:3JS2|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3KXX|rcsb pdb:3KY2|rcsb pdb:3OJV|rcsb pdb:3RHX|rcsb pdb:3TT0|rcsb pdb:4F63|rcsb pdb:4F64|rcsb pdb:4F65|rcsb pdb:4NK9|rcsb pdb:4NKA|rcsb pdb:4NKS|rcsb pdb:4RWI|rcsb pdb:4RWJ|rcsb pdb:4RWK|rcsb pdb:4RWL|rcsb pdb:4UWC|rcsb pdb:4UWY|rcsb pdb:4V01|rcsb pdb:4V04|rcsb pdb:4V05|rcsb pdb:4WUN|rcsb pdb:4ZSA|rcsb pdb:5A46|rcsb pdb:5A4C|rcsb pdb:5AM6|rcsb pdb:5AM7|rcsb pdb:5B7V|rcsb pdb:5EW8|rcsb pdb:5FLF|rcsb pdb:5O49|rcsb pdb:5O4A|rcsb pdb:5UQ0|rcsb pdb:5UR1|rcsb pdb:5VND|rcsb pdb:5W21|rcsb pdb:5W59|rcsb pdb:5Z0S|rcsb pdb:5ZV2|rcsb pdb:6C18|rcsb pdb:6C19|rcsb pdb:6C1B|rcsb pdb:6C1C|rcsb pdb:6C1O|rcsb pdb:6ITJ|rcsb pdb:6MZQ|rcsb pdb:6MZW|rcsb pdb:6NVL|rcsb pdb:6P68|rcsb pdb:6P69|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839120|rcsb pdb:4UWB|reactome:R-HSA-1839122|reactome:R-HSA-190370|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-2219530|reactome:R-HSA-375165|reactome:R-HSA-445144|reactome:R-HSA-5654219|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853336|reactome:R-HSA-5654726|dip:DIP-4019N	-	-	-	figure legend:Figure 3|agonist:"FGF-2 and 8-OH-DPAT combined treatment. ( 8-OH-DPAT is 8-hydroxy-2(di-n-propylamino)tetralin) -a  5-HT1A receptor agonist)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/06	2019/05/28	rogid:EAQbnziwFuwqt4cDvISKLpVNQK49606	rogid:th/BEfNYh60oKK7G0HFX+O1pXh89606	rigid:DTxyTIJ8PvWNQ6+PvzGry57ac5I	false	yellow fluorescent protein tag:c-c	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P08908	uniprotkb:P08908	intact:EBI-6570214|ensembl:ENSP00000316244|uniprotkb:Q6LAE7	intact:EBI-6570214|ensembl:ENSP00000316244|uniprotkb:Q6LAE7	psi-mi:5ht1a_human(display_long)|uniprotkb:HTR1A(gene name)|psi-mi:HTR1A(display_short)|uniprotkb:ADRB2RL1(gene name synonym)|uniprotkb:ADRBRL1(gene name synonym)|uniprotkb:G-21(gene name synonym)|uniprotkb:Serotonin receptor 1A(gene name synonym)	psi-mi:5ht1a_human(display_long)|uniprotkb:HTR1A(gene name)|psi-mi:HTR1A(display_short)|uniprotkb:ADRB2RL1(gene name synonym)|uniprotkb:ADRBRL1(gene name synonym)|uniprotkb:G-21(gene name synonym)|uniprotkb:Serotonin receptor 1A(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Borroto-Escuela et al. (2015)	pubmed:25485703|imex:IM-27044	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21425217|imex:IM-27044-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000178394(gene)|ensembl:ENST00000323865(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0035640"(exploration behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0045202"(synapse)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051378"(serotonin binding)|go:"GO:0090722"(receptor-receptor interaction)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000610(5-Hydroxytryptamine 1A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|reactome:R-HSA-390666|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_000515.2	ensembl:ENSG00000178394(gene)|ensembl:ENST00000323865(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0035640"(exploration behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0045202"(synapse)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051378"(serotonin binding)|go:"GO:0090722"(receptor-receptor interaction)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000610(5-Hydroxytryptamine 1A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|reactome:R-HSA-390666|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_000515.2	-	-	-	figure legend:Figure 3-a|comment:"This interaction was observed with simultaneous  FGF-2 and 8-OH-DPAT combined treatment. ( 8-OH-DPAT is 8-hydroxy-2(di-n-propylamino)tetralin) -a  5-HT1A receptor agonist)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/06	2019/05/28	rogid:EAQbnziwFuwqt4cDvISKLpVNQK49606	rogid:EAQbnziwFuwqt4cDvISKLpVNQK49606	rigid:DTxyTIJ8PvWNQ6+PvzGry57ac5I	false	sufficient binding region:192-217	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P08908	uniprotkb:P11362	intact:EBI-6570214|ensembl:ENSP00000316244|uniprotkb:Q6LAE7	intact:EBI-1028277|uniprotkb:P17049|uniprotkb:Q02063|uniprotkb:Q02065|uniprotkb:Q14306|uniprotkb:Q14307|uniprotkb:Q8N685|uniprotkb:C1KBH8|uniprotkb:Q9UDF0|uniprotkb:Q9UDF1|uniprotkb:Q9UDF2|uniprotkb:Q59H40|uniprotkb:Q5BJG2|uniprotkb:A8K6T9|uniprotkb:A8K8V5|uniprotkb:Q53H63|uniprotkb:Q9UD50|intact:EBI-1058611|ensembl:ENSP00000400162	psi-mi:5ht1a_human(display_long)|uniprotkb:HTR1A(gene name)|psi-mi:HTR1A(display_short)|uniprotkb:ADRB2RL1(gene name synonym)|uniprotkb:ADRBRL1(gene name synonym)|uniprotkb:G-21(gene name synonym)|uniprotkb:Serotonin receptor 1A(gene name synonym)	psi-mi:fgfr1_human(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:N-sam(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Borroto-Escuela et al. (2015)	pubmed:25485703|imex:IM-27044	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21425217|imex:IM-27044-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000178394(gene)|ensembl:ENST00000323865(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0035640"(exploration behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0045202"(synapse)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051378"(serotonin binding)|go:"GO:0090722"(receptor-receptor interaction)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000610(5-Hydroxytryptamine 1A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|reactome:R-HSA-390666|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_000515.2	refseq:NP_001167534.1|refseq:NP_001167535.1|refseq:NP_001167536.1|refseq:NP_001167537.1|refseq:NP_001167538.1|refseq:NP_056934.2|refseq:NP_075593.1|refseq:NP_075594.1|refseq:NP_075598.2|ensembl:ENSG00000077782(gene)|ensembl:ENST00000447712(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P11362|rcsb pdb:1AGW|rcsb pdb:1CVS|rcsb pdb:1EVT|rcsb pdb:1FGI|rcsb pdb:1FGK|rcsb pdb:1FQ9|go:"GO:0045666"(positive regulation of neuron differentiation)|rcsb pdb:1XR0|rcsb pdb:2CR3|rcsb pdb:2FGI|rcsb pdb:3C4F|rcsb pdb:3DPK|rcsb pdb:3GQI|rcsb pdb:3GQL|rcsb pdb:3JS2|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3KXX|rcsb pdb:3KY2|rcsb pdb:3OJV|rcsb pdb:3RHX|rcsb pdb:3TT0|rcsb pdb:4F63|rcsb pdb:4F64|rcsb pdb:4F65|rcsb pdb:4NK9|rcsb pdb:4NKA|rcsb pdb:4NKS|rcsb pdb:4RWI|rcsb pdb:4RWJ|rcsb pdb:4RWK|rcsb pdb:4RWL|rcsb pdb:4UWC|rcsb pdb:4UWY|rcsb pdb:4V01|rcsb pdb:4V04|rcsb pdb:4V05|rcsb pdb:4WUN|rcsb pdb:4ZSA|rcsb pdb:5A46|rcsb pdb:5A4C|rcsb pdb:5AM6|rcsb pdb:5AM7|rcsb pdb:5B7V|rcsb pdb:5EW8|rcsb pdb:5FLF|rcsb pdb:5O49|rcsb pdb:5O4A|rcsb pdb:5UQ0|rcsb pdb:5UR1|rcsb pdb:5VND|rcsb pdb:5W21|rcsb pdb:5W59|rcsb pdb:5Z0S|rcsb pdb:5ZV2|rcsb pdb:6C18|rcsb pdb:6C19|rcsb pdb:6C1B|rcsb pdb:6C1C|rcsb pdb:6C1O|rcsb pdb:6ITJ|rcsb pdb:6MZQ|rcsb pdb:6MZW|rcsb pdb:6NVL|rcsb pdb:6P68|rcsb pdb:6P69|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839120|rcsb pdb:4UWB|reactome:R-HSA-1839122|reactome:R-HSA-190370|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-2219530|reactome:R-HSA-375165|reactome:R-HSA-445144|reactome:R-HSA-5654219|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853336|reactome:R-HSA-5654726|dip:DIP-4019N	-	-	-	figure legend:Figure 3-a|comment:"This interaction was observed with simultaneous  FGF-2 and 8-OH-DPAT combined treatment. ( 8-OH-DPAT is 8-hydroxy-2(di-n-propylamino)tetralin) -a  5-HT1A receptor agonist)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/06	2019/05/28	rogid:EAQbnziwFuwqt4cDvISKLpVNQK49606	rogid:th/BEfNYh60oKK7G0HFX+O1pXh89606	rigid:DTxyTIJ8PvWNQ6+PvzGry57ac5I	false	sufficient binding region:192-217	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P11362	uniprotkb:P08908	intact:EBI-1028277|uniprotkb:P17049|uniprotkb:Q02063|uniprotkb:Q02065|uniprotkb:Q14306|uniprotkb:Q14307|uniprotkb:Q8N685|uniprotkb:C1KBH8|uniprotkb:Q9UDF0|uniprotkb:Q9UDF1|uniprotkb:Q9UDF2|uniprotkb:Q59H40|uniprotkb:Q5BJG2|uniprotkb:A8K6T9|uniprotkb:A8K8V5|uniprotkb:Q53H63|uniprotkb:Q9UD50|intact:EBI-1058611|ensembl:ENSP00000400162	intact:EBI-6570214|ensembl:ENSP00000316244|uniprotkb:Q6LAE7	psi-mi:fgfr1_human(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:N-sam(gene name synonym)	psi-mi:5ht1a_human(display_long)|uniprotkb:HTR1A(gene name)|psi-mi:HTR1A(display_short)|uniprotkb:ADRB2RL1(gene name synonym)|uniprotkb:ADRBRL1(gene name synonym)|uniprotkb:G-21(gene name synonym)|uniprotkb:Serotonin receptor 1A(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Borroto-Escuela et al. (2015)	pubmed:25485703|imex:IM-27044	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21425826|imex:IM-27044-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001167534.1|refseq:NP_001167535.1|refseq:NP_001167536.1|refseq:NP_001167537.1|refseq:NP_001167538.1|refseq:NP_056934.2|refseq:NP_075593.1|refseq:NP_075594.1|refseq:NP_075598.2|ensembl:ENSG00000077782(gene)|ensembl:ENST00000447712(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR028174|interpro:IPR036179|interpro:IPR041159|mint:P11362|rcsb pdb:1AGW|rcsb pdb:1CVS|rcsb pdb:1EVT|rcsb pdb:1FGI|rcsb pdb:1FGK|rcsb pdb:1FQ9|go:"GO:0045666"(positive regulation of neuron differentiation)|rcsb pdb:1XR0|rcsb pdb:2CR3|rcsb pdb:2FGI|rcsb pdb:3C4F|rcsb pdb:3DPK|rcsb pdb:3GQI|rcsb pdb:3GQL|rcsb pdb:3JS2|rcsb pdb:3KRJ|rcsb pdb:3KRL|rcsb pdb:3KXX|rcsb pdb:3KY2|rcsb pdb:3OJV|rcsb pdb:3RHX|rcsb pdb:3TT0|rcsb pdb:4F63|rcsb pdb:4F64|rcsb pdb:4F65|rcsb pdb:4NK9|rcsb pdb:4NKA|rcsb pdb:4NKS|rcsb pdb:4RWI|rcsb pdb:4RWJ|rcsb pdb:4RWK|rcsb pdb:4RWL|rcsb pdb:4UWC|rcsb pdb:4UWY|rcsb pdb:4V01|rcsb pdb:4V04|rcsb pdb:4V05|rcsb pdb:4WUN|rcsb pdb:4ZSA|rcsb pdb:5A46|rcsb pdb:5A4C|rcsb pdb:5AM6|rcsb pdb:5AM7|rcsb pdb:5B7V|rcsb pdb:5EW8|rcsb pdb:5FLF|rcsb pdb:5O49|rcsb pdb:5O4A|rcsb pdb:5UQ0|rcsb pdb:5UR1|rcsb pdb:5VND|rcsb pdb:5W21|rcsb pdb:5W59|rcsb pdb:5Z0S|rcsb pdb:5ZV2|rcsb pdb:6C18|rcsb pdb:6C19|rcsb pdb:6C1B|rcsb pdb:6C1C|rcsb pdb:6C1O|rcsb pdb:6ITJ|rcsb pdb:6MZQ|rcsb pdb:6MZW|rcsb pdb:6NVL|rcsb pdb:6P68|rcsb pdb:6P69|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839120|rcsb pdb:4UWB|reactome:R-HSA-1839122|reactome:R-HSA-190370|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-2219530|reactome:R-HSA-375165|reactome:R-HSA-445144|reactome:R-HSA-5654219|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853336|reactome:R-HSA-5654726|dip:DIP-4019N	ensembl:ENSG00000178394(gene)|ensembl:ENST00000323865(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0035640"(exploration behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0045202"(synapse)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0050795"(regulation of behavior)|go:"GO:0051378"(serotonin binding)|go:"GO:0090722"(receptor-receptor interaction)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000610(5-Hydroxytryptamine 1A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|reactome:R-HSA-390666|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_000515.2	-	-	-	figure legend:Supplementary figure 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2019/05/06	2019/06/14	rogid:th/BEfNYh60oKK7G0HFX+O1pXh89606	rogid:EAQbnziwFuwqt4cDvISKLpVNQK49606	rigid:DTxyTIJ8PvWNQ6+PvzGry57ac5I	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P19327	uniprotkb:Q04589	intact:EBI-6570156	intact:EBI-2480918	psi-mi:5ht1a_rat(display_long)|uniprotkb:Htr1a(gene name)|psi-mi:Htr1a(display_short)|uniprotkb:5ht1a(gene name synonym)|uniprotkb:Serotonin receptor 1A(gene name synonym)	psi-mi:fgfr1_rat(display_long)|uniprotkb:Fgfr1(gene name)|psi-mi:Fgfr1(display_short)|uniprotkb:Flg(gene name synonym)|uniprotkb:MFR(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Borroto-Escuela et al. (2015)	pubmed:25485703|imex:IM-27044	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-21426357|imex:IM-27044-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007198"(adenylate cyclase-inhibiting serotonin receptor signaling pathway)|go:"GO:0007210"(serotonin receptor signaling pathway)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0014053"(negative regulation of gamma-aminobutyric acid secretion)|go:"GO:0014062"(regulation of serotonin secretion)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0035640"(exploration behavior)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043203"(axon hillock)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0051378"(serotonin binding)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0001662"(behavioral fear response)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0001965"(G-protein alpha-subunit binding)|interpro:IPR000610(5-Hydroxytryptamine 1A receptor)|interpro:IPR002231(5-Hydroxytryptamine receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rgd:2845|refseq:NP_036717.1|reactome:R-RNO-390666	go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0005829"(cytosol)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001759"(organ induction)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:0090272"(negative regulation of fibroblast growth factor production)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000830"(positive regulation of parathyroid hormone secretion)|go:"GO:2001239"(regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0021837"(motogenic signaling involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043583"(ear development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048699"(generation of neurons)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051174"(regulation of phosphorus metabolic process)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060117"(auditory receptor cell development)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0070640"(vitamin D3 metabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048469"(cell maturation)|rgd:620713|refseq:NP_077060.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR028174|interpro:IPR013151(Immunoglobulin)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR036179|interpro:IPR041159|reactome:R-RNO-109704|reactome:R-RNO-1257604|reactome:R-RNO-190370|reactome:R-RNO-190373|reactome:R-RNO-190374|reactome:R-RNO-445144|reactome:R-RNO-5654219|reactome:R-RNO-5654687|reactome:R-RNO-5654688|reactome:R-RNO-5654689|reactome:R-RNO-5654693|reactome:R-RNO-5654726|reactome:R-RNO-5673001|reactome:R-RNO-6811558	-	-	-	figure legend:Supplementary Figure 2|comment:"Extensive co-localization of FGFR1 and 5-HT1A  was observed in the nerve cells of the dorsal raphe (ventral subnucleus) and the median raphe."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell)	-	2019/05/06	2019/05/28	rogid:mtLOH4idN6ihEekCAcgm3HO/h8s10116	rogid:J+4J96IkgLbGJ5DBggiKxyBJKtY10116	rigid:ft6/OMK11yGCqWdabvO+afs5doM	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)