#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q5T9L3	uniprotkb:P56704	intact:EBI-2868748|uniprotkb:Q8NC43|uniprotkb:Q7Z2Z9|uniprotkb:B2RNT2|intact:EBI-11046890|uniprotkb:Q5JRS7|ensembl:ENSP00000262348	intact:EBI-6173037|ensembl:ENSP00000284523|uniprotkb:Q3SY80|uniprotkb:Q969P2|uniprotkb:Q3SY79	psi-mi:wls_human(display_long)|uniprotkb:WLS(gene name)|psi-mi:WLS(display_short)|uniprotkb:C1orf139(gene name synonym)|uniprotkb:GPR177(gene name synonym)|uniprotkb:Integral membrane protein GPR177(gene name synonym)|uniprotkb:Protein evenness interrupted homolog(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 373(gene name synonym)|uniprotkb:UNQ85/PRO18667(orf name)	psi-mi:wnt3a_human(display_long)|uniprotkb:WNT3A(gene name)|psi-mi:WNT3A(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yu et al. (2014)	imex:IM-27771|pubmed:24768165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-22119357|imex:IM-27771-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180263.1|refseq:NP_001002292.3|refseq:NP_079187.3|ensembl:ENSG00000116729(gene)|ensembl:ENST00000262348(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001707"(mesoderm formation)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0061355"(Wnt protein secretion)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0012505"(endomembrane system)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR009551(Protein of unknown function DUF1171)|mint:Q5T9L3|rcsb pdb:7KC4|reactome:R-HSA-3238698|go:"GO:0070062"(extracellular exosome)	ensembl:ENSG00000154342(gene)|ensembl:ENST00000284523(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0005576"(extracellular region)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_149122.1|dip:DIP-58592N	go:"GO:0005783"(endoplasmic reticulum)	-	-	figure legend:Fig. 1H, Supp. Fig. 1G|antagonist:"PORCN inhibitor C59 (inhibits palmityolation)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/10/08	2019/10/30	rogid:YRPwj0Ix8X5++/p3MVKVPm3viWs9606	rogid:rYpTGWi5cUzJcIyzMor27nheDOE9606	rigid:xGm11BjUxV29RgXmxGsJnayEDfA	false	-	v5 tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T9L3	uniprotkb:P56704	intact:EBI-2868748|uniprotkb:Q8NC43|uniprotkb:Q7Z2Z9|uniprotkb:B2RNT2|intact:EBI-11046890|uniprotkb:Q5JRS7|ensembl:ENSP00000262348	intact:EBI-6173037|ensembl:ENSP00000284523|uniprotkb:Q3SY80|uniprotkb:Q969P2|uniprotkb:Q3SY79	psi-mi:wls_human(display_long)|uniprotkb:WLS(gene name)|psi-mi:WLS(display_short)|uniprotkb:C1orf139(gene name synonym)|uniprotkb:GPR177(gene name synonym)|uniprotkb:Integral membrane protein GPR177(gene name synonym)|uniprotkb:Protein evenness interrupted homolog(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 373(gene name synonym)|uniprotkb:UNQ85/PRO18667(orf name)	psi-mi:wnt3a_human(display_long)|uniprotkb:WNT3A(gene name)|psi-mi:WNT3A(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yu et al. (2014)	imex:IM-27771|pubmed:24768165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-22119388|imex:IM-27771-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180263.1|refseq:NP_001002292.3|refseq:NP_079187.3|ensembl:ENSG00000116729(gene)|ensembl:ENST00000262348(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001707"(mesoderm formation)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0061355"(Wnt protein secretion)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0012505"(endomembrane system)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR009551(Protein of unknown function DUF1171)|mint:Q5T9L3|rcsb pdb:7KC4|reactome:R-HSA-3238698|go:"GO:0070062"(extracellular exosome)	ensembl:ENSG00000154342(gene)|ensembl:ENST00000284523(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0005576"(extracellular region)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_149122.1|dip:DIP-58592N	-	-	-	figure legend:Fig. 4I|antagonist:"PORCN inhibitor C59 (inhibits palmityolation)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2019/10/08	2019/10/30	rogid:YRPwj0Ix8X5++/p3MVKVPm3viWs9606	rogid:rYpTGWi5cUzJcIyzMor27nheDOE9606	rigid:xGm11BjUxV29RgXmxGsJnayEDfA	false	mutation with no effect:425-425|mutation with no effect:536-541	v5 tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5T9L3	uniprotkb:Q9JJJ7	intact:EBI-2868748|uniprotkb:Q8NC43|uniprotkb:Q7Z2Z9|uniprotkb:B2RNT2|intact:EBI-11046890|uniprotkb:Q5JRS7|ensembl:ENSP00000262348	intact:EBI-16579859|ensembl:ENSMUSP00000076790|uniprotkb:A2AC30|uniprotkb:A2AC32|uniprotkb:A2AC33|uniprotkb:Q9CWT0|uniprotkb:Q9JJJ8|uniprotkb:Q9JJJ9|uniprotkb:Q9JJK0	psi-mi:wls_human(display_long)|uniprotkb:WLS(gene name)|psi-mi:WLS(display_short)|uniprotkb:C1orf139(gene name synonym)|uniprotkb:GPR177(gene name synonym)|uniprotkb:Integral membrane protein GPR177(gene name synonym)|uniprotkb:Protein evenness interrupted homolog(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 373(gene name synonym)|uniprotkb:UNQ85/PRO18667(orf name)	psi-mi:porcn_mouse(display_long)|uniprotkb:Porcn(gene name)|psi-mi:Porcn(display_short)|uniprotkb:Porc(gene name synonym)|uniprotkb:Ppn(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Yu et al. (2014)	imex:IM-27771|pubmed:24768165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0486"(UniProt)	intact:EBI-22187854|imex:IM-27771-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180263.1|refseq:NP_001002292.3|refseq:NP_079187.3|ensembl:ENSG00000116729(gene)|ensembl:ENST00000262348(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001707"(mesoderm formation)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0061355"(Wnt protein secretion)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0012505"(endomembrane system)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR009551(Protein of unknown function DUF1171)|mint:Q5T9L3|rcsb pdb:7KC4|reactome:R-HSA-3238698|go:"GO:0070062"(extracellular exosome)	ensembl:ENSMUSG00000031169(gene)|ensembl:ENSMUST00000077595(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0009100"(glycoprotein metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030258"(lipid modification)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0045234"(protein palmitoleylation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061355"(Wnt protein secretion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1990698"(palmitoleoyltransferase activity)|interpro:IPR004299(Membrane bound O-acyl transferase, MBOAT)|refseq:NP_001295403.1|refseq:NP_058609.1|refseq:NP_076127.1|refseq:NP_665914.1|refseq:NP_665915.1	-	-	-	figure legend:Fig. 1I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2019/10/08	2019/11/11	rogid:YRPwj0Ix8X5++/p3MVKVPm3viWs9606	rogid:e9YB0bkOS9bJC/RrsjndcWpSGqM10090	rigid:AR9eVrncfeRlgNGPiuFLXwH97+E	false	-	ha tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q5T9L3	uniprotkb:P56704	intact:EBI-2868748|uniprotkb:Q8NC43|uniprotkb:Q7Z2Z9|uniprotkb:B2RNT2|intact:EBI-11046890|uniprotkb:Q5JRS7|ensembl:ENSP00000262348	intact:EBI-6173037|ensembl:ENSP00000284523|uniprotkb:Q3SY80|uniprotkb:Q969P2|uniprotkb:Q3SY79	psi-mi:wls_human(display_long)|uniprotkb:WLS(gene name)|psi-mi:WLS(display_short)|uniprotkb:C1orf139(gene name synonym)|uniprotkb:GPR177(gene name synonym)|uniprotkb:Integral membrane protein GPR177(gene name synonym)|uniprotkb:Protein evenness interrupted homolog(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 373(gene name synonym)|uniprotkb:UNQ85/PRO18667(orf name)	psi-mi:wnt3a_human(display_long)|uniprotkb:WNT3A(gene name)|psi-mi:WNT3A(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Yu et al. (2014)	imex:IM-27771|pubmed:24768165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-22187947|imex:IM-27771-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180263.1|refseq:NP_001002292.3|refseq:NP_079187.3|ensembl:ENSG00000116729(gene)|ensembl:ENST00000262348(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001707"(mesoderm formation)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0061355"(Wnt protein secretion)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0012505"(endomembrane system)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR009551(Protein of unknown function DUF1171)|mint:Q5T9L3|rcsb pdb:7KC4|reactome:R-HSA-3238698|go:"GO:0070062"(extracellular exosome)	ensembl:ENSG00000154342(gene)|ensembl:ENST00000284523(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0005576"(extracellular region)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_149122.1|dip:DIP-58592N	-	-	-	figure legend:Supp. Fig. 2A-F|antagonist:"PORCN inhibitor C59 (inhibits palmityolation)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/10/08	2019/11/11	rogid:YRPwj0Ix8X5++/p3MVKVPm3viWs9606	rogid:rYpTGWi5cUzJcIyzMor27nheDOE9606	rigid:xGm11BjUxV29RgXmxGsJnayEDfA	false	mutation with no effect:536-536|mutation disrupting interaction strength:537-537|mutation with no effect:538-538|mutation with no effect:540-540|mutation with no effect:541-541	v5 tag:c-c	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)
uniprotkb:Q5T9L3	uniprotkb:Q9JJJ7	intact:EBI-2868748|uniprotkb:Q8NC43|uniprotkb:Q7Z2Z9|uniprotkb:B2RNT2|intact:EBI-11046890|uniprotkb:Q5JRS7|ensembl:ENSP00000262348	intact:EBI-16579859|ensembl:ENSMUSP00000076790|uniprotkb:A2AC30|uniprotkb:A2AC32|uniprotkb:A2AC33|uniprotkb:Q9CWT0|uniprotkb:Q9JJJ8|uniprotkb:Q9JJJ9|uniprotkb:Q9JJK0	psi-mi:wls_human(display_long)|uniprotkb:WLS(gene name)|psi-mi:WLS(display_short)|uniprotkb:C1orf139(gene name synonym)|uniprotkb:GPR177(gene name synonym)|uniprotkb:Integral membrane protein GPR177(gene name synonym)|uniprotkb:Protein evenness interrupted homolog(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 373(gene name synonym)|uniprotkb:UNQ85/PRO18667(orf name)	psi-mi:porcn_mouse(display_long)|uniprotkb:Porcn(gene name)|psi-mi:Porcn(display_short)|uniprotkb:Porc(gene name synonym)|uniprotkb:Ppn(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Yu et al. (2014)	imex:IM-27771|pubmed:24768165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-25474258|imex:IM-27771-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001180263.1|refseq:NP_001002292.3|refseq:NP_079187.3|ensembl:ENSG00000116729(gene)|ensembl:ENST00000262348(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001707"(mesoderm formation)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0031017"(exocrine pancreas development)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0061355"(Wnt protein secretion)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0012505"(endomembrane system)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR009551(Protein of unknown function DUF1171)|mint:Q5T9L3|rcsb pdb:7KC4|reactome:R-HSA-3238698|go:"GO:0070062"(extracellular exosome)	ensembl:ENSMUSG00000031169(gene)|ensembl:ENSMUST00000077595(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0009100"(glycoprotein metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030258"(lipid modification)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0045234"(protein palmitoleylation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061355"(Wnt protein secretion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1990698"(palmitoleoyltransferase activity)|interpro:IPR004299(Membrane bound O-acyl transferase, MBOAT)|refseq:NP_001295403.1|refseq:NP_058609.1|refseq:NP_076127.1|refseq:NP_665914.1|refseq:NP_665915.1	go:"GO:0005783"(endoplasmic reticulum)	-	-	figure legend:Supp Fig. 1H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2019/10/08	2020/03/20	rogid:YRPwj0Ix8X5++/p3MVKVPm3viWs9606	rogid:e9YB0bkOS9bJC/RrsjndcWpSGqM10090	rigid:AR9eVrncfeRlgNGPiuFLXwH97+E	false	-	ha tag:?-?	-	-	psi-mi:"MI:1201"(anti-tag immunocytochemistry)	psi-mi:"MI:1201"(anti-tag immunocytochemistry)