#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q2MKA7	uniprotkb:Q5SSZ7	intact:EBI-10045219|uniprotkb:A2A420|uniprotkb:Q0H8S6|uniprotkb:Q14C72|uniprotkb:Q5T0F2|uniprotkb:Q8N7L5|ensembl:ENSP00000348944|ensembl:ENSP00000383846	intact:EBI-21993315|uniprotkb:B2RXA5|uniprotkb:Q3V095|ensembl:ENSMUSP00000105493	psi-mi:rspo1_human(display_long)|uniprotkb:RSPO1(gene name)|psi-mi:RSPO1(display_short)|uniprotkb:Roof plate-specific spondin-1(gene name synonym)	psi-mi:znrf3_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:Znrf3(gene name)|psi-mi:Znrf3(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Peng et al. (2012)	imex:IM-27333|pubmed:24349440	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-21993359|imex:IM-27333-1|wwpdb:4CDK|wwpdb:4CDJ	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033722.1|refseq:NP_001229837.1|refseq:NP_001229838.1|refseq:NP_001229839.1|refseq:XP_006710646.1|ensembl:ENSG00000169218(gene)|ensembl:ENST00000356545(transcript)|ensembl:ENST00000401068(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0008201"(heparin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036383|interpro:IPR042991|interpro:IPR043601|rcsb pdb:4BSO|rcsb pdb:4BSP|rcsb pdb:4BSR|rcsb pdb:4BSS|rcsb pdb:4BST|rcsb pdb:4BSU|rcsb pdb:4CDK|rcsb pdb:4KNG|rcsb pdb:4KT1|rcsb pdb:4LI2|rcsb pdb:4QXF|reactome:R-HSA-4641263|dip:DIP-59895N	refseq:NP_001074393.1|refseq:NP_001277430.1|ensembl:ENSMUSG00000041961(gene)|ensembl:ENSMUST00000109867(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4C86|rcsb pdb:4C8A|rcsb pdb:4C8C|rcsb pdb:4C8F|rcsb pdb:4C8P|rcsb pdb:4C99|rcsb pdb:4C9A|rcsb pdb:4C9E|rcsb pdb:4CDJ|rcsb pdb:4CDK|rcsb pdb:4UFS|reactome:R-MMU-4641263	-	-	-	figure legend:Figure 2, Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/31	2020/02/21	rogid:+NBHcmOpvY9I2ubG2O8bLiGzmUk9606	rogid:Qxjt00TkVd8tl9L7cGsP0UUGslY10090	rigid:rqnL9r2CsRQeeyRH1kum8Mb+W3s	false	binding-associated region:31-145	binding-associated region:53-205	1	1	psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:2287"(identification by structure determination)
uniprotkb:Q5SSZ7	uniprotkb:O75473	intact:EBI-21993315|uniprotkb:B2RXA5|uniprotkb:Q3V095|ensembl:ENSMUSP00000105493	intact:EBI-4402067|uniprotkb:D8MCT0|uniprotkb:Q4VAM0|uniprotkb:Q4VAM2|uniprotkb:Q9UP75|ensembl:ENSP00000266674	psi-mi:znrf3_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:Znrf3(gene name)|psi-mi:Znrf3(display_short)	psi-mi:lgr5_human(display_long)|uniprotkb:LGR5(gene name)|psi-mi:LGR5(display_short)|uniprotkb:GPR49(gene name synonym)|uniprotkb:GPR67(gene name synonym)|uniprotkb:G-protein coupled receptor 49(gene name synonym)|uniprotkb:G-protein coupled receptor 67(gene name synonym)|uniprotkb:G-protein coupled receptor HG38(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Peng et al. (2012)	imex:IM-27333|pubmed:24349440	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25432063|imex:IM-27333-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074393.1|refseq:NP_001277430.1|ensembl:ENSMUSG00000041961(gene)|ensembl:ENSMUST00000109867(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4C86|rcsb pdb:4C8A|rcsb pdb:4C8C|rcsb pdb:4C8F|rcsb pdb:4C8P|rcsb pdb:4C99|rcsb pdb:4C9A|rcsb pdb:4C9E|rcsb pdb:4CDJ|rcsb pdb:4CDK|rcsb pdb:4UFS|reactome:R-MMU-4641263	refseq:NP_001264156.1|refseq:NP_003658.1|refseq:NP_001264155.1|ensembl:ENSG00000139292(gene)|ensembl:ENST00000266674(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009994"(oocyte differentiation)|go:"GO:0016500"(protein-hormone receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0048839"(inner ear development)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002131(Glycoprotein hormone receptor)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR032675|rcsb pdb:4BSR|rcsb pdb:4BSS|rcsb pdb:4BST|rcsb pdb:4BSU|rcsb pdb:4KNG|rcsb pdb:4UFR|rcsb pdb:4UFS|reactome:R-HSA-4641263	-	-	comment:"For the this protein and featurs please refer to reference 18 mentioned in the text. (PubMed: 23809763)"	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/31	2020/02/21	rogid:Qxjt00TkVd8tl9L7cGsP0UUGslY10090	rogid:vr9w3DGBW36fsvM+M0/jfktA3/09606	rigid:faGuQi0vcCTKSeZoO0+dZCKfQy4	false	binding-associated region:53-205|biotin tag:c-c	binding-associated region:22-543	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5SSZ7	uniprotkb:Q2MKA7	intact:EBI-21993315|uniprotkb:B2RXA5|uniprotkb:Q3V095|ensembl:ENSMUSP00000105493	intact:EBI-10045219|uniprotkb:A2A420|uniprotkb:Q0H8S6|uniprotkb:Q14C72|uniprotkb:Q5T0F2|uniprotkb:Q8N7L5|ensembl:ENSP00000348944|ensembl:ENSP00000383846	psi-mi:znrf3_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:Znrf3(gene name)|psi-mi:Znrf3(display_short)	psi-mi:rspo1_human(display_long)|uniprotkb:RSPO1(gene name)|psi-mi:RSPO1(display_short)|uniprotkb:Roof plate-specific spondin-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Peng et al. (2012)	imex:IM-27333|pubmed:24349440	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-25432063|imex:IM-27333-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074393.1|refseq:NP_001277430.1|ensembl:ENSMUSG00000041961(gene)|ensembl:ENSMUST00000109867(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4C86|rcsb pdb:4C8A|rcsb pdb:4C8C|rcsb pdb:4C8F|rcsb pdb:4C8P|rcsb pdb:4C99|rcsb pdb:4C9A|rcsb pdb:4C9E|rcsb pdb:4CDJ|rcsb pdb:4CDK|rcsb pdb:4UFS|reactome:R-MMU-4641263	refseq:NP_001033722.1|refseq:NP_001229837.1|refseq:NP_001229838.1|refseq:NP_001229839.1|refseq:XP_006710646.1|ensembl:ENSG00000169218(gene)|ensembl:ENST00000356545(transcript)|ensembl:ENST00000401068(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0008201"(heparin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036383|interpro:IPR042991|interpro:IPR043601|rcsb pdb:4BSO|rcsb pdb:4BSP|rcsb pdb:4BSR|rcsb pdb:4BSS|rcsb pdb:4BST|rcsb pdb:4BSU|rcsb pdb:4CDK|rcsb pdb:4KNG|rcsb pdb:4KT1|rcsb pdb:4LI2|rcsb pdb:4QXF|reactome:R-HSA-4641263|dip:DIP-59895N	-	-	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/31	2020/02/21	rogid:Qxjt00TkVd8tl9L7cGsP0UUGslY10090	rogid:+NBHcmOpvY9I2ubG2O8bLiGzmUk9606	rigid:faGuQi0vcCTKSeZoO0+dZCKfQy4	false	binding-associated region:53-205|biotin tag:c-c	binding-associated region:31-145	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q2MKA7	uniprotkb:Q5SSZ7	intact:EBI-10045219|uniprotkb:A2A420|uniprotkb:Q0H8S6|uniprotkb:Q14C72|uniprotkb:Q5T0F2|uniprotkb:Q8N7L5|ensembl:ENSP00000348944|ensembl:ENSP00000383846	intact:EBI-21993315|uniprotkb:B2RXA5|uniprotkb:Q3V095|ensembl:ENSMUSP00000105493	psi-mi:rspo1_human(display_long)|uniprotkb:RSPO1(gene name)|psi-mi:RSPO1(display_short)|uniprotkb:Roof plate-specific spondin-1(gene name synonym)	psi-mi:znrf3_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:Znrf3(gene name)|psi-mi:Znrf3(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Peng et al. (2012)	imex:IM-27333|pubmed:24349440	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25433963|imex:IM-27333-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033722.1|refseq:NP_001229837.1|refseq:NP_001229838.1|refseq:NP_001229839.1|refseq:XP_006710646.1|ensembl:ENSG00000169218(gene)|ensembl:ENST00000356545(transcript)|ensembl:ENST00000401068(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0008201"(heparin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036383|interpro:IPR042991|interpro:IPR043601|rcsb pdb:4BSO|rcsb pdb:4BSP|rcsb pdb:4BSR|rcsb pdb:4BSS|rcsb pdb:4BST|rcsb pdb:4BSU|rcsb pdb:4CDK|rcsb pdb:4KNG|rcsb pdb:4KT1|rcsb pdb:4LI2|rcsb pdb:4QXF|reactome:R-HSA-4641263|dip:DIP-59895N	refseq:NP_001074393.1|refseq:NP_001277430.1|ensembl:ENSMUSG00000041961(gene)|ensembl:ENSMUST00000109867(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4C86|rcsb pdb:4C8A|rcsb pdb:4C8C|rcsb pdb:4C8F|rcsb pdb:4C8P|rcsb pdb:4C99|rcsb pdb:4C9A|rcsb pdb:4C9E|rcsb pdb:4CDJ|rcsb pdb:4CDK|rcsb pdb:4UFS|reactome:R-MMU-4641263	-	-	-	figure legend:Figure 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2019/08/31	2020/02/21	rogid:+NBHcmOpvY9I2ubG2O8bLiGzmUk9606	rogid:Qxjt00TkVd8tl9L7cGsP0UUGslY10090	rigid:rqnL9r2CsRQeeyRH1kum8Mb+W3s	false	binding-associated region:31-145	binding-associated region:53-205|biotin tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)